Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population.

abstract：OBJECTIVE:In essential hypertensive patients, blunted renal plasma flow responsiveness to angiotensin II suggests a pathologic increase in angiotensin II in the kidneys. This blunting has been associated with the angiotensinogen 235TT genotype. As several measures of renal function decline with age, we sought to determ...

journal_title：Journal of hypertension

authors： Patel TV,Williams GH,Fisher ND

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To investigate the interrelationship between arrhythmias provoked by acute pressure changes, and the presence of left ventricular hypertrophy and electrolyte imbalances. DESIGN:An isolated working rat heart model was used in a prospective comparison of the effects of acute pressure changes in hypertensive an...

journal_title：Journal of hypertension

authors： James MA,Jones JV

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies suggest that intrauterine growth restriction (IUGR) due to maternal undernutrition during pregnancy represents a major risk factor for hypertension and diabetes in adult age. However, placental insufficiency, rather than maternal malnutrition, is the main cause of IUGR in the Western w...

journal_title：Journal of hypertension

authors： Jansson T,Lambert GW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels. METHODS AND RESULTS:To investigate whether this relates to differences in the contribution of the ACE C-domain and N-domain, we quantified, u...

journal_title：Journal of hypertension

authors： van Esch JH,van Gool JM,de Bruin RJ,Payne JR,Montgomery HE,Hectors M,Deinum J,Dive V,Jan Danser AH

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Familial hyperkalaemic hypertension (FHH) is a Mendelian form of low-renin hypertension characterized by hyperkalaemia and hyperchloraemic acidosis despite a normal glomerular filtration rate. To date, three different loci have been identified, on chromosomes 1, 17 and 12. OBJECTIVE:To test for genetic link...

journal_title：Journal of hypertension

authors： Disse-Nicodeme S,Desitter I,Fiquet-Kempf B,Houot AM,Stern N,Delahousse M,Potier J,Ader JL,Jeunemaitre X

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether nondipping and diabetes are independently related to metabolic risk profile and prevalence of target organ damage in a population setting. METHODS:A population-based cohort of 70-year-old men (n = 1057) was examined with 24-h ambulatory blood pressure monitoring, euglycemic hyperinsuli...

journal_title：Journal of hypertension

authors： Björklund K,Lind L,Andrén B,Lithell H

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To determine the suitability of a new logistic curve fitting procedure to measure the diurnal rates of transition from the active to the asleep periods separately. METHOD:We applied this method to 24-h telemetry recordings of systolic, mean, diastolic arterial pressure (SAP, MAP, DAP, respectively), heart ra...

journal_title：Journal of hypertension

authors： Head GA,Lukoshkova EV,Mayorov DN,van den Buuse M

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:To estimate the trend in arterial hypertension's prevalence, awareness, treatment, and control in Romania, starting from the latest national survey Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in Romania III that has a crucial importance for the development of prevention str...

journal_title：Journal of hypertension

authors： Dorobantu M,Tautu OF,Dimulescu D,Sinescu C,Gusbeth-Tatomir P,Arsenescu-Georgescu C,Mitu F,Lighezan D,Pop C,Babes K,Giuca A,Branza I,Udrescu M,Herdea V,Darabont R

更新日期：2018-03-01 00:00:00

abstract：:We have studied the norepinephrine (NE) uptake processes directly in synaptosomes isolated from the hypothalamus of both Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats. Both DS and DR rats were divided into two dietary groups, one high salt diet group and one low salt diet group. NE uptake was highly sodiu...

journal_title：Journal of hypertension

authors： Rho JH,Hough K

更新日期：1984-10-01 00:00:00

abstract：:To investigate the effects of changes in sodium balance on blood pressure and leucocyte sodium transport, normotensive first-degree relatives of hypertensive patients and control subjects were randomized to receive low- and high-salt diets for 2 weeks, separated by a wash-out period of 2 weeks. High-salt intake failed...

journal_title：Journal of hypertension

authors： Heagerty AM,Alton SM,el-Ashry A,Bing RF,Thurston H,Swales JD

更新日期：1986-06-01 00:00:00

abstract：:This paper describes the kinetics of the Na(+)-K+ pump and the Na(+)-K(+)-Cl- cotransport in sodium-loaded erythrocytes and of the Na(+)-K(+)-Cl- cotransport in erythrocyte inside-out vesicles (IOV) from Milan hypertensive (MHS) and normotensive (MNS) rats in order to evaluate the possible role of intracellular factor...

journal_title：Journal of hypertension

authors： Ferrari P,Torielli L,Cirillo M,Salardi S,Bianchi G

更新日期：1991-08-01 00:00:00

abstract：AIMS:The addition of an aldosterone receptor antagonist on top of current optimal therapy (based on angiotensin II inhibition) has demonstrated an important clinical benefit in heart failure patients with systolic dysfunction. Whether this finding also applies to heart failure patients with preserved systolic function ...

journal_title：Journal of hypertension

authors： Muñoz-Pacheco P,Ortega-Hernández A,Caro-Vadillo A,Casanueva-Eliceiry S,Aragoncillo P,Egido J,Fernández-Cruz A,Gómez-Garre D

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the influence of renal sympathetic nerves on the production of interleukin (IL)-6 in the kidney of normotensive Wistar rats and spontaneously hypertensive rats (SHR). DESIGN:In acute studies, the left kidney was exposed and the renal nerves were electrically stimulated to...

journal_title：Journal of hypertension

authors： Nakamura A,Kohsaka T,Johns EJ

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

journal_title：Journal of hypertension

authors： Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:End-stage renal disease (ESRD) is characterized by markedly increased sympathetic outflow that contributes to increased cardiovascular mortality in these patients. The central sympatholytic drug moxonidine (MOX) has been shown to reduce muscle sympathetic nerve activity (MSNA) in initial stages of chronic kid...

journal_title：Journal of hypertension

authors： Hausberg M,Tokmak F,Pavenstädt H,Krämer BK,Rump LC

更新日期：2010-09-01 00:00:00

abstract：:: In 2010, 1.4 billion people globally had hypertension, with 14% controlled to systolic blood pressure (SBP, mmHg) below 140, which contributes to 18 million cardiovascular deaths annually. Recent hypertension guidelines endorsed SBP targets below 130 or lower for all or some hypertensive patients to reduce cardiovas...

journal_title：Journal of hypertension

authors： Egan BM,Kjeldsen SE,Grassi G,Esler M,Mancia G

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. AngIII, one of the main effector peptides of the brain renin-Ang system, exerts a tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopepti...

journal_title：Journal of hypertension

authors： Marc Y,Hmazzou R,Balavoine F,Flahault A,Llorens-Cortes C

更新日期：2018-03-01 00:00:00

abstract：:Plasma atrial natriuretic peptide (ANP) concentrations were measured by both direct radio-immunoassay and with pre-extraction of the peptide from plasma using C18 reverse phase columns. Peptide concentrations were measured in normal subjects (including a group of eight volunteers who received an intravenous infusion o...

journal_title：Journal of hypertension

authors： Richards AM,Tonolo G,McIntyre GD,Leckie BJ,Robertson JI

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent...

journal_title：Journal of hypertension

authors： Almoosawi S,Prynne CJ,Hardy R,Stephen AM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Obstructive sleep apnea (OSA) and hypertension (HYP) frequently coexist and have additive harmful effects on the cardiovascular system. There is also growing evidence that short sleep duration may contribute independently to poor cardiovascular outcome. The aim of this study was to evaluate the potential infl...

journal_title：Journal of hypertension

authors： Nerbass FB,Pedrosa RP,Genta PR,Drager LF,Lorenzi-Filho G

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that insulin differently modifies vasoconstriction and recovery from vasoconstriction induced by endogenously released versus circulating norepinephrine, and to investigate the time-dependency of its effect METHODS:Healthy male subjects were studied. Norepinephrine was infused for 10 m...

journal_title：Journal of hypertension

authors： van Veen S,Chang PC

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND AIM:The prevalence and associated risks of white-coat hypertension (WCH) are still a matter of debate. We aimed to assess differences in prevalence and associated conditions of WCH defined on the basis of the normality of all daytime, night-time, and 24-h blood pressure (BP), only daytime, or only 24-h B...

journal_title：Journal of hypertension

authors： de la Sierra A,Vinyoles E,Banegas JR,Segura J,Gorostidi M,de la Cruz JJ,Ruilope LM

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (...

journal_title：Journal of hypertension

authors： Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The effect of nifedipine, a 1,4-dihydropyridine calcium antagonist, on the expression of monocyte chemoattractant protein 1 (MCP-1) induced by angiotensin II (Ang II) was examined using vascular smooth muscle cells (VSMC) isolated from rat thoracic aorta. METHODS AND RESULTS:Ang II increased the expression o...

journal_title：Journal of hypertension

authors： Wu L,Iwai M,Li Z,Li JM,Mogi M,Horiuchi M

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Arterial stiffness is an independent cardiovascular risk factor. Aging, high blood pressure and increased renin-angiotensin system activity contribute to increased arterial stiffness in patients with atherosclerotic renovascular hypertension (aRVH). A literature search failed to identify any study related to ...

journal_title：Journal of hypertension

authors： Fodor L,Premužić V,Ivković V,Perkov D,Laganović M,Vrkić TZ,Dika Z,Zivko M,Jelaković B

更新日期：2014-11-01 00:00:00

abstract：:Several myosin isoforms are expressed in smooth muscle, based upon both heavy and light chain polymorphisms. These myosin isoenzymes reveal distinct detachment rate constants, thus regulating the responsiveness of the VSMC contractile apparatus to Ca2+, as well as its energetical and mechanical behavior. ...

journal_title：Journal of hypertension

authors： Morano IL

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:The interactions between eNOS or oxidative stress and bradykinin under long-term treatment of angiotensin II type 1 receptor antagonists (ATRA) remain unknown. To elucidate the molecular mechanisms of the cardioprotective effect of ATRA, we evaluated whether valsartan affects the bradykinin-eNOS and nicotina...

journal_title：Journal of hypertension

authors： Yoshida K,Kobayashi N,Ohno T,Fukushima H,Matsuoka H

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:To assess the consequences of malignant hypertension and its evolution with antihypertensive treatment. BACKGROUND:Malignant hypertension can be considered as a model of the effects of very high blood pressure and renin-angiotensin levels on target organs. However, the consequences on the heart have been li...

journal_title：Journal of hypertension

authors： Gosse P,Coulon P,Papaioannou G,Litalien J,Lemetayer P

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:In familial hyperaldosteronism type I (FH-I), glucocorticoid treatment suppresses adrenocorticotrophic hormone-regulated hybrid gene expression and corrects hyperaldosteronism. OBJECTIVE:To determine whether the wild-type aldosterone synthase genes, thereby released from chronic suppression, are capable of ...

journal_title：Journal of hypertension

authors： Stowasser M,Taylor WL,Gartside MG,Tunny TJ,Gordon RD

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To study the interaction between the C(-344)T polymorphism and known determinants (age, body mass and dietary sodium) of blood pressure and plasma aldosterone. DESIGN:Cross-sectional and longitudinal (1980-1995) survey of male workers in southern Italy. SETTING:Medical centre of the Olivetti factories. PAR...

journal_title：Journal of hypertension

authors： Russo P,Siani A,Venezia A,Iacone R,Russo O,Barba G,D'Elia L,Cappuccio FP,Strazzullo P

更新日期：2002-09-01 00:00:00