Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase.

abstract：OBJECTIVES:Recently, the nanomechanical properties (i.e. stiffness) of endothelial cells have been identified as crucial for appropriate endothelial function. One major determinant of endothelial stiffness is the endothelial sodium channel (EnNaC). EnNaC-dependent stiffening leads to reduced nitric oxide release, which...

journal_title：Journal of hypertension

authors： Lenders M,Hofschröer V,Schmitz B,Kasprzak B,Rohlmann A,Missler M,Pavenstädt H,Oberleithner H,Brand SM,Kusche-Vihrog K,Brand E

更新日期：2015-12-01 00:00:00

abstract：:Pinacidil is a new vasodilating compound claimed to increase renal perfusion and function. A preliminary study showed that pinacidil did not sustain renal perfusion through a period of increasing renal vascular resistance in pig-to-rabbit renal xenotransplantation. Accordingly, the effect of pinacidil on renal functio...

journal_title：Journal of hypertension

authors： Dieperink H,Kemp E,Jørgensen KA,Starklint H

更新日期：1983-12-01 00:00:00

abstract：:Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension. The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of nitric oxide within the endothelium. Loss of eNOS cofactor tetrahydrobiopterin to initial increase in oxidative stress leads to unco...

journal_title：Journal of hypertension

authors： Li Q,Youn JY,Cai H

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To compare estimates of mean population salt intake in North and South India derived from spot urine samples versus 24-h urine collections. METHODS:In a cross-sectional survey, participants were sampled from slum, urban and rural communities in North and in South India. Participants provided 24-h urine colle...

journal_title：Journal of hypertension

authors： Petersen KS,Johnson C,Mohan S,Rogers K,Shivashankar R,Thout SR,Gupta P,He FJ,MacGregor GA,Webster J,Santos JA,Krishnan A,Maulik PK,Reddy KS,Gupta R,Prabhakaran D,Neal B

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:There is ongoing discussion on how best to screen for diabetes mellitus. Previous studies suggest that an abnormal oral glucose tolerance test (OGTT) is better than fasting glucose levels in predicting cardiovascular mortality, which is largely determined by macrovascular complications in type 2 diabetes. We ...

journal_title：Journal of hypertension

authors： Schneider MP,Ott C,Ritt M,Raff U,Schlaich MP,Schmieder RE

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hypertension-induced renal injury is characterized by inflammation, fibrosis and proteinuria. Previous studies have demonstrated that N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) inhibits renal damage following diabetes mellitus and antiglomerular basement membrane nephritis. However, its effects on low-renin hyperten...

journal_title：Journal of hypertension

authors： Rhaleb NE,Pokharel S,Sharma U,Carretero OA

更新日期：2011-02-01 00:00:00

abstract：:Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

journal_title：Journal of hypertension

authors： Williams B

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:There have been very few studies on life prognosis of cardiovascular disease according to blood pressure stratification in the Japanese. Therefore, in Japan, although treatment of hypertension is possible, albeit at times difficult, due to the availability of various antihypertensive medications, the appropr...

journal_title：Journal of hypertension

authors： Takagi S,Saitoh S,Nakano M,Hayashi Y,Obara F,Onishi H,Shimamoto K

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:In familial hyperaldosteronism type I (FH-I), glucocorticoid treatment suppresses adrenocorticotrophic hormone-regulated hybrid gene expression and corrects hyperaldosteronism. OBJECTIVE:To determine whether the wild-type aldosterone synthase genes, thereby released from chronic suppression, are capable of ...

journal_title：Journal of hypertension

authors： Stowasser M,Taylor WL,Gartside MG,Tunny TJ,Gordon RD

更新日期：1997-12-01 00:00:00

abstract：:To investigate the effects of changes in sodium balance on blood pressure and leucocyte sodium transport, normotensive first-degree relatives of hypertensive patients and control subjects were randomized to receive low- and high-salt diets for 2 weeks, separated by a wash-out period of 2 weeks. High-salt intake failed...

journal_title：Journal of hypertension

authors： Heagerty AM,Alton SM,el-Ashry A,Bing RF,Thurston H,Swales JD

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology. That ...

journal_title：Journal of hypertension

authors： Dell'Omo G,Penno G,Pucci L,Fotino C,Lucchesi D,Del Prato S,Pedrinelli R

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:To follow the changes in blood pressure and echocardiographically determined left ventricular mass in offspring of mothers who had hypertension during pregnancy. DESIGN:Longitudinal study with a 5-year follow-up. METHODS:Nineteen offspring of mothers who had hypertension during pregnancy, and sustained hype...

journal_title：Journal of hypertension

authors： Himmelmann A,Svensson A,Hansson L

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. DESIGN:Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperin...

journal_title：Journal of hypertension

authors： Holness MJ,Sugden MC

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:The sleep apnea syndrome (SAS) is a common health problem with a 30% prevalence among patients with so-called essential hypertension. OBJECTIVE:Prompted by this epidemiologic link we tried to find out whether there is a cause-effect relationship between SAS and systemic hypertension. DESIGN:We developed an...

journal_title：Journal of hypertension

authors： Lesske J,Fletcher EC,Bao G,Unger T

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. METHODS:CRP, as well as multiple facets of the metabolic syndrome, were measured in a series o...

journal_title：Journal of hypertension

authors： Wessel J,Moratorio G,Rao F,Mahata M,Zhang L,Greene W,Rana BK,Kennedy BP,Khandrika S,Huang P,Lillie EO,Shih PA,Smith DW,Wen G,Hamilton BA,Ziegler MG,Witztum JL,Schork NJ,Schmid-Schönbein GW,O'Connor DT

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies of the association between hypertension (HTN) and brain atrophy have shown reductions in prefrontal, temporal, and hippocampal volumes, and have identified thinner cortices across the cortical mantle. METHOD:In the current study, we followed 96 participants enrolled in the Baltimore ...

journal_title：Journal of hypertension

authors： Gonzalez CE,Pacheco J,Beason-Held LL,Resnick SM

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To assess the dilatory effectiveness of nitric oxide donors in resistance arteries of patients with arterial hypertension in comparison with that in those of normotensive controls. BACKGROUND:Endothelium-dependent vasodilation has been demonstrated to be impaired in arterial hypertension. Besides disturbance...

journal_title：Journal of hypertension

authors： Preik M,Kelm M,Feelisch M,Strauer BE

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:Endothelial dysfunction and arterial stiffness are early vascular alterations, linked to oxidative stress and inflammation, with prognostic significance in essential hypertensive patients. P2X7 receptors (P2X7R), responding to extracellular ATP, are encoded by a highly polymorphic gene and modulate inflammato...

journal_title：Journal of hypertension

authors： Ghiadoni L,Rossi C,Duranti E,Santini E,Bruno RM,Salvati A,Taddei S,Solini A

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To determine whether 'slow pressor' hypertension from systemic angiotensin (Ang II) infusion was associated with renal vascular structural remodeling of the renal resistance vessels and glomerulus. METHODS:Ang II (4.5-10 ng/kg per min) or vehicle was infused for 10 days. Renal resistance vascular lumen chan...

journal_title：Journal of hypertension

authors： Edgley AJ,Kett MM,Anderson WP

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To investigate whether the clinic-daytime blood pressure difference can provide information on vascular reactivity to stress comparable to that of simple noninvasive stimuli such as a cold pressor test and isometric exercise, and whether there is any relationship between this blood pressure difference and non...

journal_title：Journal of hypertension

authors： Guida L,Iannuzzi R,Crivaro M,Gaeta I,Pasanisi F,Celentano A,Marotta T,Ferrara LA

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:In patients with type 2 diabetes mellitus (T2DM), blocking of the renin-angiotensin-aldosterone system (RAAS) has demonstrated efficacy in lowering blood pressure (BP) and urinary albumin excretion rate (UAER). Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...

journal_title：Journal of hypertension

authors： Weir MR,Hollenberg NK,Remuzzi G,Zappe DH,Meng X,Parving HH

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Cardiovascular diseases represent the most common cause of death in the English-speaking Caribbean, and hypertension represents the most important predisposing condition. However, direct between-country comparative studies in the Caribbean have not previously been undertaken. OBJECTIVE:To obtain estimates o...

journal_title：Journal of hypertension

authors： Freeman V,Fraser H,Forrester T,Wilks R,Cruickshank J,Rotimi C,Cooper R

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS:The study included 80 sedentary, overweight patients (43 female and 37 male) with unmedicated high normal bloo...

journal_title：Journal of hypertension

authors： Pierson LM,Bacon SL,Sherwood A,Hinderliter AL,Babyak M,Gullette EC,Waugh R,Blumenthal JA

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Activated coagulation Factor XII (FXIIa) infusion increases peripheral resistance (TPR) and mean arterial pressure (MAP) of Brown Norway but not plasma kininogen deficient Brown Norway Katholiek (BNK) rats. FXIIa concentrations are elevated in hypertensive end-stage renal disease patients receiving conventio...

journal_title：Journal of hypertension

authors： Papageorgiou PC,Chan CT,Yeo EL,Backx PH,Floras JS

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Pre-eclampsia is characterized by an increased vascular tone which might be related to an abnormal endothelial cell function. As representatives of the fetal circulation, we compared the nitric oxide (NO)-releasing capacity of human umbilical vessels from normal and pre-eclamptic pregnancies. METHODS:Normal ...

journal_title：Journal of hypertension

authors： Akar F,Ark M,Uydeş BS,Soysal ME,Saraçoğlu F,Abacioğlu N,Van de Voorde J,Kanzik I

更新日期：1994-11-01 00:00:00

abstract：:An Na+,K+-ATPase inhibitor possessing inhibitory activity against the specific binding of ouabain to Na+,K+-ATPase has been purified from the plasma of acutely saline-infused hogs. The purification was performed by a combination of Amberlite XAD-2 adsorption chromatography and five steps of high-pressure liquid chroma...

journal_title：Journal of hypertension

authors： Tamura M,Inagami T,Kinoshita T,Kuwano H

更新日期：1987-04-01 00:00:00

abstract：INTRODUCTION:Chronic kidney disease (CKD) in which the disease cannot be attributed to any known cause is named CKD of uncertain aetiology (CKDu). The main aims of this analysis were to estimate the prevalence of hypertension and to identify the associated factors in a rural community vulnerable to CKDu and to identify...

journal_title：Journal of hypertension

authors： Senanayake S,Ruwanpathirana T,Gunawardena N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The aim of the study was to assess the role of angiotensin II (Ang II) in the maintenance of cardiovascular hypertrophy and the abnormal vascular amplifier properties in spontaneously hypertensive rats (SHR) with established hypertension. Losartan, a type 1 Ang II receptor antagonist, was administe...

journal_title：Journal of hypertension

authors： Oddie CJ,Dilley RJ,Kanellakis P,Bobik A

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Reversibility of the systemic and renal alterations induced by N(omega)-nitro-L-arginine-methyl ester(L-NAME) was assessed by treatment with irbesartan and enalapril (30 and 10 mg/kg per 24 h, respectively) alone or in combination. DESIGN:L-NAME (20 mg/kg per 24 h) was given to rats for 6 weeks and treatment...

journal_title：Journal of hypertension

authors： Jover B,Herizi A,Casellas D,Mimran A

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:We previously showed that young transgenic mice overexpressing preproendothelin-1 specifically in endothelial cells had hypertrophic remodeling, endothelial dysfunction, increased vascular NADPH oxidase activity, and inflammation in mesenteric small arteries without blood pressure (BP) elevation compared to ...

journal_title：Journal of hypertension

authors： Amiri F,Ko EA,Javeshghani D,Reudelhuber TL,Schiffrin EL

更新日期：2010-06-01 00:00:00