Abstract:
OBJECTIVE:To investigate whether the clinic-daytime blood pressure difference can provide information on vascular reactivity to stress comparable to that of simple noninvasive stimuli such as a cold pressor test and isometric exercise, and whether there is any relationship between this blood pressure difference and noninvasive measurements of the left ventricular mass and carotid arterial wall. DESIGN:Patients with newly discovered, never-treated, sustained hypertension were included in the study after a 1 month run-in, during which time their blood pressure was measured three times at 2 week intervals. METHODS:Blood pressure was measured by a noninvasive procedure at rest and during a cold pressor test and an isometric exercise. The difference was calculated for systolic, diastolic and mean blood pressure as resting minus daytime ambulatory blood pressure. Parameters of the posterior wall and septal thickness of the left ventricle, aortic root and left atrium were studied by M-mode echocardiography. Carotid wall thickness and diameter were measured using ultrasound. RESULTS:The 90 patients enrolled in the study were divided into tertiles of clinic-daytime blood pressure difference. The composition of the groups differed in sex, since the majority of women were in the highest tertile, but was comparable for age, body mass index, renin-aldosterone axis and lipid and carbohydrate metabolism. Blood pressure responses to cold and isometric exercise were more pronounced in patients in the lowest tertile of blood pressure difference. No intergroup differences were detected in echocardiographic parameters of ventricular (left ventricular mass, tertiles I-III: 46.5 +/- 10, 42.3 +/- 8, 44.8 +/- 13 g/m2.7, respectively) and carotid (intima-media thickness, tertiles I-III 0.58 +/- 0.1, 0.54 +/- 0.1, 0.62 +/- 0.1 mm, respectively) structure. CONCLUSIONS:The present study indicates that the clinic-daytime blood pressure difference provides different information on cardiovascular reactivity compared with that obtained from the cold pressor test and isometric exercise. Moreover, it does not seem to have any relationship with ventricular hypertrophy and/or carotid wall thickening.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Guida L,Iannuzzi R,Crivaro M,Gaeta I,Pasanisi F,Celentano A,Marotta T,Ferrara LAdoi
10.1097/00004872-199917030-00005subject
Has Abstractpub_date
1999-03-01 00:00:00pages
331-7issue
3eissn
0263-6352issn
1473-5598journal_volume
17pub_type
杂志文章abstract::: The term 'cardiorenal syndrome' (CRS) was introduced to describe problems related to the simultaneous existence of heart and renal insufficiency. The prevalence of anaemia in CRS is high and increases the risk of hospitalizations and death. Renin-angiotensin system (RAS) inhibition is the cornerstone therapy in card...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000002111
更新日期:2019-11-01 00:00:00
abstract::Although the blood vessels are exposed to high pressures in hypertension, the main complications of hypertension (stroke and myocardial infarction) are paradoxically thrombotic rather than haemorrhagic. In keeping with Virchow's triad, patients with hypertension do demonstrate abnormalities of vessel wall (endothelial...
journal_title:Journal of hypertension
pub_type: 评论,社论,评审
doi:10.1097/00004872-199816070-00003
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:Globally, healthcare policy promotes supported self-management as a strategy for people with long-term conditions. This meta-review aimed to explore how people with hypertension make sense of their condition, to assess the effectiveness of supported self-management in hypertension, and to identify effective ...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000001867
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000000273
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year fol...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001780
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Similar to cancer, pulmonary arterial hypertension (PAH) is characterized by vascular remodeling, which leads to obliteration of the small pulmonary arteriole, with marked proliferation of pulmonary artery smooth muscle cells (PASMC) and/or endothelial cells dysfunction. Aberrant expression of tumor suppresso...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001475
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:Epidemiological studies suggest that intrauterine growth restriction (IUGR) due to maternal undernutrition during pregnancy represents a major risk factor for hypertension and diabetes in adult age. However, placental insufficiency, rather than maternal malnutrition, is the main cause of IUGR in the Western w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917090-00002
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:There are no studies that relate BsmI polymorphism of the vitamin D receptor (VDR) gene and with vitamin D to blood pressure (BP). OBJECTIVE:To analyze if this polymorphism and 25-hydroxyvitamin D levels (25OHD3) influence BP in a population of healthy subjects. DESIGN:Transversal study on healthy populati...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000098139.70956.21
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To determine the degree to which hypertension is a risk factor for macrovascular and microvascular complications in type 2 diabetes. DESIGN:Observational prospective study. SUBJECTS:Newly diagnosed Type 2 diabetic patients recruited into the UK Prospective Diabetes Study (n = 3648; mean age 52 years), 40% o...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199303000-00013
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). METHODS:We evaluated 96 patients with resistant hypertension, defined as clinic BP at least 140/90 mmHg despite treat...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e32833b9c63
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The oral contraceptive pill (OCP) is widely prescribed throughout the world. Although it is associated with a small but significant increase in blood pressure, the influence of the OCP on large artery stiffness and wave reflection is unclear. The aim of this study was to determine the relationship between us...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328346a5af
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To verify the benefit of renin-angiotensin system blockade in hypertension, the effects of 24 weeks' losartan and ramipril treatment, both alone and in combination, on urinary albumin excretion (UAE) and circulating transforming growth factor beta1 (TGF beta1) have been evaluated in hypertensive subjects with...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.hjh.0000160225.01845.26
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND AIM:The prevalence and associated risks of white-coat hypertension (WCH) are still a matter of debate. We aimed to assess differences in prevalence and associated conditions of WCH defined on the basis of the normality of all daytime, night-time, and 24-h blood pressure (BP), only daytime, or only 24-h B...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001493
更新日期:2017-12-01 00:00:00
abstract::Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 week...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198712000-00015
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVE:To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. DESIGN:Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperin...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816030-00014
更新日期:1998-03-01 00:00:00
abstract:RATIONALE:Cicletanine (CIC), an anti-hypertensive compound with direct vascular and natriuretic actions, is especially effective in salt-sensitive hypertension, in which dysregulation of the sodium pump plays an important pathogenic role, and digitalis-like cardiotonic steroids contribute to increased vascular tone. Th...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018020-00012
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normotensive rats. We analyzed the effect of chronic ouabain (approximately 8.0 microg/day, 5 weeks) treatment on the blood pressure of spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats and the contribution of vascula...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832a391f
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Corticotrophin (ACTH)-induced hypertension in the rat is prevented by L- but not D-arginine. We examined the effects of exogenous corticosterone in the male Sprague Dawley (SD) rat to determine whether ACTH-induced hypertension is mediated by corticosterone. METHODS:Exogenous corticosterone (10, 20 or 40 mg/...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018120-00020
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Hypertension control is often inadequate in HIV patients. In a contemporary, nationwide cohort of Italian HIV-infected adults, we assessed time trends in hypertension prevalence, awareness, treatment, and control. We also evaluated predictors of cardiovascular events and of new-onset hypertension. METHODS:M...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/HJH.0000000000001150
更新日期:2017-02-01 00:00:00
abstract::Systolic (SBP), diastolic (DBP) and mean [MBP = diastolic + 1/3 (systolic - diastolic)] blood pressures were compared as predictors of all causes of death (ALL) and of deaths from atherosclerotic cardiovascular disease (ACVD) in 2480 men, aged 40-59 years, belonging to three cohorts followed up for 20 years. Both univ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198907000-00011
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:Increased wall-to-lumen ratio of small arteries is a predictor of adverse cardiovascular prognosis. We aimed to analyze retinal arteriolar structure in never-treated patients with essential hypertension and to test whether elevated blood pressure is associated with an increased wall-to-lumen ratio of retinal ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282ffdc66
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence of hypertension and the rate of decline in renal function in a sample of 47 Olivetti Heart Study (OHS) participants whose blood pressure (BP) salt-sensitivity and renal tubular sodium handling had been assessed in 1987-88. METHODS:During the 2002-04 OHS follow-up examination, medica...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3281139ebd
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:Advanced diabetic nephropathy (DN) is characterized by a marked development of cardiovascular and renal disease. These patients are frequently managed by different health professionals with the consequence that the quality of care may differ substantially. To compare the management of cardiovascular risk fac...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/01.hjh.0000239303.93872.31
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Arterial stiffness is an independent predictor of cardiovascular events and mortality in hypertensive patients. The influence of different antihypertensive drug classes on improving arterial stiffness beyond blood pressure reduction is not widely available. We aimed to determine whether the artery stiffness ...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析
doi:10.1097/HJH.0b013e328346a583
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Aldosterone has essential roles in regulating intravascular volume and blood pressure, and is suggested to influence cardiac structure. However, the association of polymorphisms in the aldosterone synthase gene (CYP11B2) with hypertension or cardiac hypertrophy remains controversial. OBJECTIVE:To evaluate t...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000170377.00591.7e
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Despite data from animal models and observational studies that are generally supportive for the soy/isoflavones lowering blood pressure (BP) and improving vascular function, the current findings from clinical trials are still inconclusive. OBJECTIVES:To examine whether soy protein with isoflavones or isofla...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e32835c0905
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Familial hyperkalaemic hypertension (FHH) is a Mendelian form of low-renin hypertension characterized by hyperkalaemia and hyperchloraemic acidosis despite a normal glomerular filtration rate. To date, three different loci have been identified, on chromosomes 1, 17 and 12. OBJECTIVE:To test for genetic link...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200111000-00005
更新日期:2001-11-01 00:00:00
abstract::This study focuses on the relationship between some aspects of intra-erythrocytic sodium metabolism (intra-erythrocytic Na content, Na,Li-countertransport), blood pressure, and family history of hypertension, in a group of 84 randomly selected school children (45 males, 39 females). Na,Li-countertransport was signific...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198803000-00007
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:Caffeine is the most widely used pharmacologically active substance. Aortic elastic properties and arterial wave reflection are important factors for the efficient performance of the cardiovascular system, as well as prognosticators of cardiovascular risk. We investigated the effect of caffeine on aortic elas...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200303000-00022
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:Several renal denervation (RDN) systems are currently under investigation for treatment of hypertension by ablation of renal sympathetic nerves. The procedural efficacy of devices, however, is variable and incompletely understood. This study aimed at investigating procedural and anatomical predictors of RD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001840
更新日期:2018-12-01 00:00:00