Abstract:
BACKGROUND:Despite data from animal models and observational studies that are generally supportive for the soy/isoflavones lowering blood pressure (BP) and improving vascular function, the current findings from clinical trials are still inconclusive. OBJECTIVES:To examine whether soy protein with isoflavones or isoflavones alone reduce BP and endothelial cytokines, and whether the effects differed by baseline BP level. METHODS:A double-blind randomized, placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. Participants were randomly assigned to one of the three arms to receive either 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months. RESULTS:No significant difference was observed in the change and %change of BP and endothelial cytokine levels among the three study groups. However, a subgroup analysis among 130 pre and hypertensive women suggested that soy protein and isoflavones significantly reduced SBP [-4.25%, 95% confidence interval (CI) -7.9 to -0.6%, P = 0.02] and the level of soluble intercellular adhesion molecule (sICAM)-1 (-22.6%, 95% CI -42.8 to -2.3%, P = 0.02) relative to milk protein after 6-month intervention. CONCLUSIONS:: Our 6-month randomized controlled trial in prediabetic postmenopausal women indicated that soy protein and isoflavones had no significant effect on BP and endothelial molecules; however, a favorable reduction on SBP, sICAM-1 and E-selectin was observed among women with initial elevated BP.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Liu ZM,Ho SC,Chen YM,Woo Jdoi
10.1097/HJH.0b013e32835c0905subject
Has Abstractpub_date
2013-02-01 00:00:00pages
384-92issue
2eissn
0263-6352issn
1473-5598journal_volume
31pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Type 2 diabetes mellitus is associated with an increased risk of hypertension, and cardiovascular and renal disease, and it has been recommended that management of hypertension should be more aggressive in presence than in absence of diabetes mellitus, but the matter is controversial at present. OBJECTIVES:...
journal_title:Journal of hypertension
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doi:10.1097/HJH.0000000000001276
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journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/hjh.0b013e328329bc08
更新日期:2009-06-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198807000-00006
更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835414df
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更新日期:2010-02-01 00:00:00
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更新日期:2003-11-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001654
更新日期:2018-05-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0000000000000793
更新日期:2016-02-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 评论,社论,评审
doi:10.1097/00004872-199816070-00003
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abstract::Pinacidil is a new vasodilating compound claimed to increase renal perfusion and function. A preliminary study showed that pinacidil did not sustain renal perfusion through a period of increasing renal vascular resistance in pig-to-rabbit renal xenotransplantation. Accordingly, the effect of pinacidil on renal functio...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198312000-00006
更新日期:1983-12-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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更新日期:2010-06-01 00:00:00
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更新日期:2020-11-16 00:00:00
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更新日期:2000-02-01 00:00:00