Abstract:
OBJECTIVE:Dietary sodium and potassium intakes are factors known to influence blood pressure (BP) through different pathways. These mechanisms likely result in differential effects on parameters characterizing BP. The aim of the study was to evaluate relationships between both sodium and potassium intake and all BP parameters--namely systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP)--simultaneously in a large general population. METHODS:The present cross-sectional analysis was performed on 4919 middle-aged men and women, participants in the SU.VI.MAX study. Dietary intake was assessed through at least three 24-h dietary records. SBP and DBP were measured twice at a single visit after 10 min rest and averaged. Analysis of covariance was used to test for difference in BP parameters across tertiles of dietary sodium and potassium intakes. RESULTS:In univariate analysis, increased dietary sodium and potassium intakes were both significantly associated with increased BP parameters (P < 0.0001). After relevant adjustments, sodium intake remained positively associated with PP (P = 0.006), whereas potassium intake became negatively associated with SBP, DBP and MAP (P < or = 0.02) but was not linked to PP (P = 0.56). CONCLUSION:The positive association between dietary sodium intake and PP observed in the present study provides further evidence for the current concept linking sodium to rise in BP through modification and stiffening of the arterial wall, whereas negative associations between dietary potassium intake and both SBP and DBP, hence MAP, support the vasodilator properties of this latter nutrient.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Buyck JF,Blacher J,Kesse-Guyot E,Castetbon K,Galan P,Safar M,Hercberg S,Czernichow Sdoi
10.1097/hjh.0b013e328329bc08subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1158-64issue
6eissn
0263-6352issn
1473-5598journal_volume
27pub_type
杂志文章,多中心研究,随机对照试验abstract::Systolic (SBP), diastolic (DBP) and mean [MBP = diastolic + 1/3 (systolic - diastolic)] blood pressures were compared as predictors of all causes of death (ALL) and of deaths from atherosclerotic cardiovascular disease (ACVD) in 2480 men, aged 40-59 years, belonging to three cohorts followed up for 20 years. Both univ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198907000-00011
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the utility of the generalized transfer function (GTF) and the late systolic shoulder of the radial pressure waveform (SBP2) for estimating seated central systolic blood pressure (c-SBP) and seated c-augmentation index (c-AIx). METHODS:In 199 participants (182 cardiovasc...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835c1d45
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To estimate the arterial blood pressure, left ventricular function and insulin secretion in alcoholics. DESIGN:We examined hospitalized patients between the second and seventh day of acute alcohol withdrawal and after a month of abstinence by 24 h ambulatory blood pressure monitoring, a standard oral glucose...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715110-00005
更新日期:1997-11-01 00:00:00
abstract::Two formulations of felodipine, conventional and extended release (ER) tablets, were compared in a double-blind, crossover study of patients whose blood pressure was not being controlled using metoprolol 100 mg once daily. Nineteen patients with a supine diastolic blood pressure greater than or equal to 95 mmHg after ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1097/00004872-198908000-00008
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:There is ongoing discussion on how best to screen for diabetes mellitus. Previous studies suggest that an abnormal oral glucose tolerance test (OGTT) is better than fasting glucose levels in predicting cardiovascular mortality, which is largely determined by macrovascular complications in type 2 diabetes. We ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834e38b6
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The aldosterone synthase gene (CYP1B2) locus is a candidate region involved in the development of hypertension. OBJECTIVE:To study the relationship between the C-344T CYP1B2 polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population. DESIGN:Population-based, cross-sect...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200410000-00011
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Nailfold capillary density was measured at rest and after 4 min circulatory arrest in order to investigate the relationship between sodium-sensitive hypertension and microvessel density. DESIGN:Seventeen sodium-sensitive and 28 sodium-resistant young borderline hypertensive males and 10 normotensive controls...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To investigate the characteristics and expression of transforming growth factor (TGF)-beta receptor subtypes on vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. METHODS:The effects of TGF-beta 1 on DNA synthesis were evaluated by [3H]-th...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199508000-00003
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVES:Endothelial dysfunction is associated to cardiovascular risk factors and predicts cardiovascular events. Peripheral arterial tonometry (PAT) is a novel noninvasive method to assess endothelial function. However, there is a paucity of data about its reproducibility. The aim of this study was to assess the fea...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328362d913
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the influence of renal sympathetic nerves on the production of interleukin (IL)-6 in the kidney of normotensive Wistar rats and spontaneously hypertensive rats (SHR). DESIGN:In acute studies, the left kidney was exposed and the renal nerves were electrically stimulated to...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199305000-00004
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To examine the influence of genetic factors on plasma leptin levels. SUBJECTS AND METHODS:We measured plasma leptin levels, body mass index and body fat distribution in healthy young female monozygotic (n = 19) and dizygotic (n = 14) twins. The twin zygosity was verified by determination of short tandem repe...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917010-00005
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associat...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200201000-00013
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Familial hyperkalaemic hypertension (FHH) is a Mendelian form of low-renin hypertension characterized by hyperkalaemia and hyperchloraemic acidosis despite a normal glomerular filtration rate. To date, three different loci have been identified, on chromosomes 1, 17 and 12. OBJECTIVE:To test for genetic link...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200111000-00005
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:Although an exaggerated systolic blood pressure (SBP) response to exercise is a predictor of future hypertension and cardiovascular mortality, the underlying mechanisms are not fully understood. We tested the hypothesis that an exaggerated SBP response is associated with carotid atherosclerosis in a cross-sec...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000222758.54111.e2
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:Previous studies have demonstrated that the time rate of blood pressure (BP) variation was associated with early carotid atherosclerosis, independent of peripheral and central BP levels. We evaluated the association between the rate of BP variation, derived from ambulatory BP monitoring (ABPM) data analysis,...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283454ff4
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations. METHODS:NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200112000-00019
更新日期:2001-12-01 00:00:00
abstract::The activity of renal Na-K-ATPase was compared in hypertension-prone (SBH) and hypertension-resistant (SBN) Sabra rats on regular sodium intake and 2-3 weeks after a high sodium diet. ATPase activity was determined in single nephron segments by a micromethod. The activity profile was found to be similar in the two sub...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVES:Local atrial tissue angiotensin II (AngII) level is elevated in atrial fibrillation (AF), but the mechanism is unknown. We hypothesized that atrial myocytes express all components of the renin-angiotensin system (RAS) and investigated whether rapid depolarization alone is sufficient to increase paracrine Ang...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f34a4a
更新日期:2008-03-01 00:00:00
abstract:AIMS:Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biom...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002504
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Hypertension in midlife adults is associated with cognitive decline later in life. In individuals treated for hypertension, blood pressure (BP) loads have been associated with end organ damages. This study examines whether BP load inversely correlates with performance in cognitive tasks in normotensive or ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002155
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys. METHODS:Eight Sprague-Dawley rats were divided into two groups. One group received a 6% salt (by weight) diet...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200206000-00022
更新日期:2002-06-01 00:00:00
abstract::The present study was designed to investigate in rats the influence of converting enzyme inhibition with captopril on blood pressure, plasma urea, plasma renin concentration (PRC), plasma aldosterone and plasma vasopressin, and to define the interrelationships between PRC and these variables during equal degrees of ei...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198604000-00008
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:The Fas-Fas ligand (FasL) system is involved in apoptosis in many types of cells. Recently, the expression of FasL on endothelial cells was reported. FasL is cleaved by a metalloproteinase and released in serum as soluble FasL (sFasL). Vasoactive substances, including metalloproteinase, are modulated by endo...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200205000-00024
更新日期:2002-05-01 00:00:00
abstract:AIM:The aim of this study was to assess the prevalence of ascending aortic dilatation and to evaluate the possible association between proximal aorta dilatation and structural or functional markers of cardiac organ damage in hypertensive patients. BACKGROUND:Dilatation of the sinus of valsalva (SoV) is a common findin...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/HJH.0000000000001844
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The role of the baroreflex function in the pathogenesis of hemodialysis-associated hypotension is controversial. Complex demodulation technique (CDM), providing continuous assessment of the amplitude of cardiovascular oscillation over time, is particularly suitable to assess dynamic changes in autonomic nerv...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328332b7af
更新日期:2010-02-01 00:00:00
abstract::The effects of i.v. injection of intact digoxin antibody (0.3 mg/rat) and of its Fab fragment (40 mg/rat) on blood pressure, cardiac output and total peripheral resistance were measured in conscious spontaneously hypertensive and deoxycorticosterone hypertensive rats. In vitro findings showed that Fab fragment bound r...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198710000-00006
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVE:It has been postulated that hypertension in the spontaneously hypertensive rat (SHR) results from autoimmune damage to the SHR vasculature. The objective of this study was to isolate autoreactive T-cells specific for arterial antigens, and to characterize these cells. DESIGN:The presence of autoreactive T-ce...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199312000-00002
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:Hypertension is a major risk factor for cardiovascular disease. Polymorphism in the beta2-adrenergic receptor (ADRB2) and nitric oxide synthase 3 (NOS3) genes is associated with clinical cardiovascular phenotypes. The Arg16Gly and Glu298Asp polymorphisms of ADRB2 and NOS3 genes, respectively, have been report...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832b7ead
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To determine whether kidney stone disease (KSD) and hypertension (HTN) share a common familial component that is determined by a specific urinary biochemical abnormality. DESIGN:Familial aggregation study. PATIENTS:Two hundred and twelve KSD patients, aged 18-50 years, collected a 24-h urine sample to measu...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917121-00012
更新日期:1999-12-01 00:00:00
abstract::Precapillary resistance arteries from spontaneously hypertensive rats (SHR) and Wistar-Kyoto normotensive rats (WKY) were found to contain three inositol lipids and to produce five inositol phosphate peaks. These were assessed by a highly sensitive procedure which involved the separation of radiolabelled inositol-cont...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199006000-00009
更新日期:1990-06-01 00:00:00