Abstract:
AIM:The aim of this study was to assess the prevalence of ascending aortic dilatation and to evaluate the possible association between proximal aorta dilatation and structural or functional markers of cardiac organ damage in hypertensive patients. BACKGROUND:Dilatation of the sinus of valsalva (SoV) is a common finding in clinical practice and it is associated with an increased cardiovascular risk in hypertensive patients: less is known about the dilatation prevalence of the subsequent portion, the proper ascending aorta and its relationship with cardiovascular organ damage. METHODS:This multicentric study included 582 hypertensive and 104 normotensive control individuals. All individuals underwent clinical evaluation and two-dimensional transthoracic echocardiography focused on the evaluation of the aorta. Aortic diameters at three levels were measured: SoV, sinotubular junction and ascending aorta. RESULTS:The prevalence of ascending aorta dilatation was 13%. Patients with ascending aorta dilatation were on average 10 years older than hypertensive patients without aortic dilatation and control individuals.Left ventricular mass was significantly increased (P < 0.0001) in patients with ascending aorta dilatation with (113.29 ± 3 g/m) or without (109.16 ± 3 g/m) SoV dilatation compared with patients with isolated SoV dilatation (98.80 ± 21.8 g/m) or normal aorta (96.04 ± 26.5 g/m), with left ventricular hypertrophy (LVH) being twice as common in this group compared with the latter (60 vs. 28%, P < 0.0001). CONCLUSION:Prevalence of ascending aorta dilatation in hypertensive patients reaches 13%. Hypertensive individuals with enlarged ascending aorta showed significantly increased left ventricular mass, a well known sign of hypertension related cardiac damage and could thus represent a subset of hypertensive patients at an increased cardiovascular risk.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Milan A,Degli Esposti D,Salvetti M,Izzo R,Moreo A,Pucci G,Bruno G,Pareo I,Parini A,Paini A,Laurino FI,Sormani P,Sgariglia R,Avenatti E,De Luca N,Working Group on Heart and Hypertension of the Italian Society of Hypertensiondoi
10.1097/HJH.0000000000001844subject
Has Abstractpub_date
2019-01-01 00:00:00pages
57-64issue
1eissn
0263-6352issn
1473-5598journal_volume
37pub_type
杂志文章,多中心研究abstract:OBJECTIVE:The upward trends in the prevalence and control of hypertension in Chinese adults have been described, but recent trends based on the most recent guidelines are unavailable. We examined recent trends in the prevalence, awareness, treatment and control of hypertension among Chinese adults from 1991 to 2015 bas...
journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2020-11-11 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
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abstract:BACKGROUND:Recent reports have demonstrated increased cardiac risk, and an association with essential hypertension in patients with panic disorder. The cause is not known, but possibly involves sympathetic nervous activation. In this study, we evaluated the arterial baroreflex control of vascular sympathetic nervous ou...
journal_title:Journal of hypertension
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doi:10.1097/00004872-200212000-00025
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Mechanisms involved in hypertension in homozygous mice for the defective endothelial nitric oxide synthase gene (eNOS-/-) have not been fully elucidated. As NO is a potent vasodilator agent and possibly promotes angiogenesis, we investigated whether vasoconstriction and/or microvascular rarefaction could exp...
journal_title:Journal of hypertension
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doi:10.1097/00004872-200208000-00021
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:We assessed hypertension prevalence, blood pressure (BP)-lowering treatment and control in obese adults compared with lean/normal-weight individuals in France. METHODS:Multistage stratified random sample of 2075 adults from the French Nutrition and Health Survey (ENNS), a cross-sectional national survey carr...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283593010
更新日期:2012-12-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328341939d
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The current standard for arterial stiffness assessment, aortic pulse wave velocity (aPWV), is measured at diastolic pressure. Arterial stiffness, however, is pressure dependent. At the carotid artery level, the degree of this dependency can be quantified as the difference (ΔPWV) between systolic and diastoli...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834e4b75
更新日期:2012-02-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002524
更新日期:2020-11-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328361461e
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:In essential hypertensive patients, blunted renal plasma flow responsiveness to angiotensin II suggests a pathologic increase in angiotensin II in the kidneys. This blunting has been associated with the angiotensinogen 235TT genotype. As several measures of renal function decline with age, we sought to determ...
journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816110-00006
更新日期:1998-11-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917070-00003
更新日期:1999-07-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200308000-00020
更新日期:2003-08-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198310000-00015
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journal_title:Journal of hypertension
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journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:Journal of hypertension
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doi:
更新日期:1999-11-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200401000-00028
更新日期:2004-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832e49a8
更新日期:2009-09-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199304000-00003
更新日期:1993-04-01 00:00:00