Angiotensin converting enzyme inhibition reduces the expression of transforming growth factor-beta1 and type IV collagen in diabetic vasculopathy.

abstract：OBJECTIVE:Adults with obesity or obesity-related type 2 diabetes (T2DM) are at higher risk for cardiovascular disease possibly due to increased arterial stiffness. We sought to determine if arterial stiffness is increased in youth with obesity or T2DM as compared with lean controls. METHODS:Youth age 10-24 years (N = ...

journal_title：Journal of hypertension

authors： Urbina EM,Kimball TR,Khoury PR,Daniels SR,Dolan LM

更新日期：2010-08-01 00:00:00

abstract：:Angioplasty of renal artery stenosis has been used extensively in the last two decades for treating renovascular hypertension, and, more recently, for preserving the jeopardized renal function. A large body of evidence has accumulated indicating that this approach is by far the most convenient for patients with fibrom...

journal_title：Journal of hypertension

authors： Morganti A

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The aim of the study was to assess the role of angiotensin II (Ang II) in the maintenance of cardiovascular hypertrophy and the abnormal vascular amplifier properties in spontaneously hypertensive rats (SHR) with established hypertension. Losartan, a type 1 Ang II receptor antagonist, was administe...

journal_title：Journal of hypertension

authors： Oddie CJ,Dilley RJ,Kanellakis P,Bobik A

更新日期：1993-07-01 00:00:00

abstract：:The purpose of this study was to examine pressor responsiveness in a rabbit model with adrenal perturbation. Adrenals in rabbits were stabbed with a needle, and the rabbits were given water (adrenal-water group) or 0.9% NaCl (adrenal-salt) to drink; additional rabbits were sham-operated and given water (sham-water gro...

journal_title：Journal of hypertension

authors： Siripaisarnpipat S,Johnson JA,Fowler WL Jr,Zeigler DW,Payne CG

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this observational study, we evaluated aortic stiffness in MFS and its association with ascending aorta diameters and fibrillin-1 genotype. METHODS:A ...

journal_title：Journal of hypertension

authors： Salvi P,Grillo A,Marelli S,Gao L,Salvi L,Viecca M,Di Blasio AM,Carretta R,Pini A,Parati G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:As a new category of blood pressure (BP) classification according to the Seventh Report of The Joint National Committee, prehypertension has aroused people's great concern in recent years due to its associations with increased incidence of cardiovascular disease. However, there is little information about th...

journal_title：Journal of hypertension

authors： Dong GH,Wang D,Liu MM,Liu YQ,Zhao Y,Yang M,Meng XJ,Tian S,Meng X,Zhang HY

更新日期：2012-03-01 00:00:00

abstract：:Recently, there has been an explosion of knowledge on vasopressin, including its neuro-anatomy, biochemistry and physiology. Recent work demonstrates extensive extra-hypothalamic vasopressinergic projections from the SON and PVN. Of particular importance are projections to the cardiovascular medullary centres. Convers...

journal_title：Journal of hypertension

authors： Johnston CI

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic variation across the human CTSL1 locus and probed its functional effe...

journal_title：Journal of hypertension

authors： Mbewe-Campbell N,Wei Z,Zhang K,Friese RS,Mahata M,Schork AJ,Rao F,Chiron S,Biswas N,Kim HS,Mahata SK,Waalen J,Nievergelt CM,Hook VY,O'Connor DT

更新日期：2012-10-01 00:00:00

abstract：:Microvascular alterations associated with reversal of hypertension by exposure to simulated high altitude were investigated in the gracilis muscle of the spontaneously hypertensive rat (SHR). Male, 4-week-old SHR were either placed in a hypobaric chamber (SHR-HA) at 430 mmHg or maintained at ambient barometric pressur...

journal_title：Journal of hypertension

authors： Prewitt RL,Cardoso SS,Wood WB

更新日期：1986-12-01 00:00:00

abstract：INTRODUCTION:QT interval prolongation increases the risk of sudden death in several medical conditions. Patients with primary aldosteronism and salt-sensitive hypertension experience more cardiovascular events than those with normal-renin essential hypertension. QT interval prolongation might represent one of the risk ...

journal_title：Journal of hypertension

authors： Maule S,Mulatero P,Milan A,Leotta G,Caserta M,Bertello C,Rabbia F,Veglio F

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:The inverse association between socioeconomic status (SES) and cardiovascular disease (CVD) risk is well documented. Aortic stiffness assessed by aortic pulse wave velocity (PWV) is a strong predictor of CVD events. However, no previous study has examined the effect of SES on arterial stiffening over time. Th...

journal_title：Journal of hypertension

authors： Trudel X,Shipley MJ,McEniery CM,Wilkinson IB,Brunner EJ

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. The primary object of the paper is to verify this possible associati...

journal_title：Journal of hypertension

authors： Olivieri O,Stranieri C,Girelli D,Pizzolo F,Grazioli S,Russo C,Pignatti PF,Corrocher R

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:To investigate whether glucose or insulin is the cause of increases in oxidative stress and blood pressure in insulin-resistant animals, and to evaluate the effects of alpha-lipoic acid (LA) on the production of the superoxide anion (O2-) in the aorta and blood pressure elevations in various models of diabet...

journal_title：Journal of hypertension

authors： El Midaoui A,de Champlain J

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To explore the mechanisms for augmented neutral endopeptidase inhibitor-induced natriuresis in deoxycorticosterone acetate (DOCA)-salt rats. METHODS:We examined effects of a neutral endopeptidase-inhibitor, candoxatril, on plasma and urinary brain natriuretic peptide (BNP) levels, the influence of a specific...

journal_title：Journal of hypertension

authors： Hirata Y,Suzuki Y,Suzuki E,Hayakawa H,Kimura K,Goto A,Omata M,Minamino N,Kangawa K,Matsuo H

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:This study tests the hypothesis that the transient receptor potential vanilloid subtype 1 channel induced neuropeptide secretion and depressor response are mediated by, at least in part, activation of endoplasmic reticulum associated Ca release receptors, leading to increased cytosolic Ca in dorsal root gangl...

journal_title：Journal of hypertension

authors： Huang W,Wang H,Galligan JJ,Wang DH

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Transport activities of cardiac sodium-calcium exchange and sarcoplasmic reticulum calcium ATPase were measured biochemically in spontaneously hypertensive rats (SHR) with hypertrophied myocardium and in normotensive Wistar-Kyoto (WKY) rats and it was tested whether possible differences have consequences for ...

journal_title：Journal of hypertension

authors： Lammerich A,Günther J,Pfitzer G,Storch E,Vetter R

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...

journal_title：Journal of hypertension

authors： Cohen-Solal A,Caviezel B,Himbert D,Gourgon R

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:It has been postulated that hypertension in the spontaneously hypertensive rat (SHR) results from autoimmune damage to the SHR vasculature. The objective of this study was to isolate autoreactive T-cells specific for arterial antigens, and to characterize these cells. DESIGN:The presence of autoreactive T-ce...

journal_title：Journal of hypertension

authors： Ofosu-Appiah W,Ruggiero C,Huang LY

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In 68 randomized controlled trials (RCTs), blood pressure (BP) lowering was obtained by using drugs of different classes. We have investigated whether BP lowering by any of the major drug classes is effective in reducing the cardiovascular outcomes. METHODS:A total of 55 RCTs (19,5 267 indivi...

journal_title：Journal of hypertension

authors： Thomopoulos C,Parati G,Zanchetti A

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Current evidence demonstrates that both genetic and environmental factors influence blood pressure. The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hype...

journal_title：Journal of hypertension

authors： Binder A,Garcia E,Wallace C,Gbenga K,Ben-Shlomo Y,Yarnell J,Brown P,Caulfield M,Skrabal F,Kotanko P,Munroe P

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year fol...

journal_title：Journal of hypertension

authors： Liu J,Yasuno S,Oba K,Konda M,Ichihara C,Kitao H,Kuwabara Y,Ueshima K

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Increased endothelial production of reactive oxygen species and decreased nitric oxide bioactivity, associated with the upregulation of monocyte chemoattractant protein (MCP)-1 and lectin-like oxidized low-density lipoprotein receptor (LOX)-1, link hypertension with atherogenesis. We investigated whether the...

journal_title：Journal of hypertension

authors： Zhou MS,Schulman IH,Jaimes EA,Raij L

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:The genes responsible for obesity are also candidate genes for obesity-related conditions, such as hypertension and type 2 diabetes. A functional polymorphism in the uncoupling protein 2 (UCP2) promoter has been reported to be associated with obesity in Caucasians. To clarify the contribution of this polymor...

journal_title：Journal of hypertension

authors： Ji Q,Ikegami H,Fujisawa T,Kawabata Y,Ono M,Nishino M,Ohishi M,Katsuya T,Rakugi H,Ogihara T

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effects of acute hyperhomocysteinemia on distensibility and compliance of large peripheral arteries. Isoprostanes generation and antioxidant vitamins were used to assess the role of oxidative stress. DESIGN:A cross-over, double-blind study on distensibility (DC: diste...

journal_title：Journal of hypertension

authors： Arcaro G,Fava C,Dagradi R,Faccini G,Gaino S,Degan M,Lechi C,Lechi A,Minuz P

更新日期：2004-04-01 00:00:00

abstract：:Elevated large artery stiffness and pulse pressure have emerged as important risk factors for cardiovascular disease. The genders differ in large artery biomechanical properties throughout the lifespan with females displaying higher stiffness than males during the prepubertal years and a dramatic increase after menopa...

journal_title：Journal of hypertension

authors： Rossi P,Francès Y,Kingwell BA,Ahimastos AA

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To assess the antihypertensive efficacy and safety of the novel AT1 receptor antagonist, telmisartan, compared with that of enalapril in elderly patients with mild to moderate hypertension. DESIGN:A 26-week, multicenter, double-blind, parallel-group, dosage titration study. METHODS:A total of 278 patients a...

journal_title：Journal of hypertension

authors： Karlberg BE,Lins LE,Hermansson K

更新日期：1999-02-01 00:00:00

abstract：:The European Society of Hypertension and the European Society of Cardiology have started the preparation of the third edition of their joint guidelines on the management of arterial hypertension. The authors have focused on the new edition of the UK NICE guidelines to learn about the difficulties of disentangling evid...

journal_title：Journal of hypertension

authors： Zanchetti A,Mancia G

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Melatonin, an endogenous neurohormone secreted predominately by the pineal gland, has a variety of physiological functions. However, its protective role in atherosclerosis is not clear. In this study, we sought to investigate the potential effects of melatonin in modulating atherosclerotic plaque stability in...

journal_title：Journal of hypertension

authors： Li H,Li J,Jiang X,Liu S,Liu Y,Chen W,Yang J,Zhang C,Zhang W

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Mineralocorticoid receptor antagonists are increasingly used in patients with treatment-resistant hypertension (TRH). There is experimental evidence for blood pressure (BP) independent effects of mineralocorticoid receptor blockade on cardiovascular target organ damage. We hypothesized that low-dose eplereno...

journal_title：Journal of hypertension

authors： Schneider A,Schwab J,Karg MV,Kalizki T,Reinold A,Schneider MP,Schmieder RE,Schmidt BM

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the associations of high awake blood pressure (BP), high asleep BP, and nondipping BP, determined by ambulatory BP monitoring (ABPM), with left ventricular hypertrophy (LVH) and geometry. METHODS:Black and white participants (n = 687) in the Coronary Artery Risk Development in Young Adults study...

journal_title：Journal of hypertension

authors： Bello NA,Jaeger BC,Booth JN 3rd,Abdalla M,Anstey DE,Pugliese DN,Lewis CE,Gidding SS,Lloyd-Jones D,Shah SJ,Schwartz JE,Shikany JM,Muntner P,Shimbo D

更新日期：2020-01-01 00:00:00