Influence of converting enzyme inhibition on the hormonal and renal adaptation to hyper- and hyponatraemic dehydration.

Abstract:

:The present study was designed to investigate in rats the influence of converting enzyme inhibition with captopril on blood pressure, plasma urea, plasma renin concentration (PRC), plasma aldosterone and plasma vasopressin, and to define the interrelationships between PRC and these variables during equal degrees of either hyponatraemic (furosemide, 40 mg/kg for 2 days) or hypernatraemic (48-h water deprivation) dehydration. Chronic treatment with captopril (40 mg/kg daily) decreased blood pressure by 19% in normally hydrated treated rats, by 27% in water-deprived treated rats and by 40% in furosemide-treated rats. Plasma renin concentration, plasma aldosterone and plasma vasopressin were increased during both hypo- and hypernatraemic dehydration. Captopril decreased plasma aldosterone in water-deprived and furosemide-treated rats, whereas plasma vasopressin was unchanged. The significant correlation observed between plasma aldosterone and PRC in non-treated rats persisted in treated rats, the same level of plasma aldosterone being observed at values of PRC 10 times higher. On the other hand, the correlation between plasma vasopressin and PRC did not persist in captopril-treated rats. An increase in plasma urea was observed in both water-deprived treated rats and furosemide-treated rats. These data indicate that during hypo- and hypernatraemic dehydration, the renin-angiotensin system plays a role in regulating blood pressure, urea elimination and plasma aldosterone, but vasopressin regulation is not modified by its inhibition.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Gardes J,Gonzalez MF,Corvol P,Ménard J

doi

10.1097/00004872-198604000-00008

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

189-96

issue

2

eissn

0263-6352

issn

1473-5598

journal_volume

4

pub_type

杂志文章
  • Trends in hypertension prevalence, awareness, treatment and control rates among Chinese adults, 1991-2015.

    abstract:OBJECTIVE:The upward trends in the prevalence and control of hypertension in Chinese adults have been described, but recent trends based on the most recent guidelines are unavailable. We examined recent trends in the prevalence, awareness, treatment and control of hypertension among Chinese adults from 1991 to 2015 bas...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002698

    authors: Ma S,Yang L,Zhao M,Magnussen CG,Xi B

    更新日期:2020-11-11 00:00:00

  • Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism.

    abstract:RATIONALE:Cicletanine (CIC), an anti-hypertensive compound with direct vascular and natriuretic actions, is especially effective in salt-sensitive hypertension, in which dysregulation of the sodium pump plays an important pathogenic role, and digitalis-like cardiotonic steroids contribute to increased vascular tone. Th...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018020-00012

    authors: Bagrov AY,Dmitrieva RI,Dorofeeva NA,Fedorova OV,Lopatin DA,Lakatta EG,Droy-Lefaix MT

    更新日期:2000-02-01 00:00:00

  • Chronic ouabain treatment exacerbates blood pressure elevation in spontaneously hypertensive rats: the role of vascular mechanisms.

    abstract:OBJECTIVE:Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normotensive rats. We analyzed the effect of chronic ouabain (approximately 8.0 microg/day, 5 weeks) treatment on the blood pressure of spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats and the contribution of vascula...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32832a391f

    authors: Xavier FE,Davel AP,Fukuda LE,Rossoni LV

    更新日期:2009-06-01 00:00:00

  • Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II.

    abstract:OBJECTIVE:The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT1 receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, n...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200412000-00018

    authors: Roks AJ,Nijholt J,van Buiten A,van Gilst WH,de Zeeuw D,Henning RH

    更新日期:2004-12-01 00:00:00

  • Soft drink consumption, mainly diet ones, is associated with increased blood pressure in adolescents.

    abstract:OBJECTIVE:The aim of this cross-sectional study was to investigate the association between consumption of sugar-sweetened and diet soft drinks with blood pressure (BP) in adolescents. METHODS:Fifth graders of 20 public schools were invited to participate in an intervention aimed at behavioral dietary changes and had t...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000800

    authors: Souza Bda S,Cunha DB,Pereira RA,Sichieri R

    更新日期:2016-02-01 00:00:00

  • An age-related decline in endothelial function is not associated with alterations in L-arginine transport in humans.

    abstract:OBJECTIVES:Endothelial dysfunction is established in aged individuals; however, the mechanism(s) are not fully elucidated. We have previously identified l-arginine transport as a potential rate-limiting factor in nitric oxide (NO) production in heart-failure patients, characterized with endothelial dysfunction. We ther...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-200402000-00016

    authors: Ahlers BA,Parnell MM,Chin-Dusting JP,Kaye DM

    更新日期:2004-02-01 00:00:00

  • Acute effects of transdermal estrogen on hemodynamic and vascular reactivity in elderly postmenopausal healthy women.

    abstract:OBJECTIVE:The acute effects of estrogen on hemodynamic responses were studied with emphasis on the sympathoadrenal system and peripheral circulation. DESIGN:Eleven healthy postmenopausal women recruited from the population-based study BEDA were included in this randomized, double-blind, cross-over, placebo-controlled ...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200302000-00031

    authors: Manhem K,Brandin L,Ghanoum B,Rosengren A,Gustafsson H

    更新日期:2003-02-01 00:00:00

  • Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress.

    abstract:OBJECTIVES:Recent studies have revealed an association between coronary risk factors and both the number and function of bone marrow-derived endothelial progenitor cell (EPC). We investigated the effect of angiotensin II (Ang II) on EPC senescence, leading to the impairment of proliferative activity. METHODS AND RESUL...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200501000-00018

    authors: Imanishi T,Hano T,Nishio I

    更新日期:2005-01-01 00:00:00

  • A gene expression analysis in rat kidney following high and low salt intake.

    abstract:BACKGROUND:The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys. METHODS:Eight Sprague-Dawley rats were divided into two groups. One group received a 6% salt (by weight) diet...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200206000-00022

    authors: Barta P,Monti J,Maass PG,Gorzelniak K,Müller DN,Dechend R,Luft FC,Hübner N,Sharma AM

    更新日期:2002-06-01 00:00:00

  • The prognostic value of blood pressure control delay in newly diagnosed hypertensive patients.

    abstract:OBJECTIVE:Various studies have suggested that a delay in the time between diagnosing hypertension and its correct control (D-C, diagnostic-control time) is linked to a worse prognosis. The aim of this study was to examine the relationship between D-C time and all-cause mortality, or the incidence of cardiovascular even...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001896

    authors: Martín-Fernández M,Vinyoles E,Real J,Soldevila N,Muñoz MÁ,Del-Val JL,Verdú JM,Domingo M,Mundet X

    更新日期:2019-02-01 00:00:00

  • Uric acid and other renal function parameters in patients with stable angina pectoris participating in the ACTION trial: impact of nifedipine GITS (gastro-intestinal therapeutic system) and relation to outcome.

    abstract:BACKGROUND:Little data is available concerning the prognostic implications of renal function abnormalities, their evolution over time and the effects of nifedipine on such abnormalities in patients with stable angina pectoris. METHODS:The previously published ACTION trial compared long-acting nifedipine GITS 60 mg onc...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/HJH.0b013e3281c49d93

    authors: Ruilope LM,Kirwan BA,de Brouwer S,Danchin N,Fox KA,Wagener G,Segura J,Poole-Wilson PA,Lubsen J,ACTION investigators.

    更新日期:2007-08-01 00:00:00

  • Hypertension in blacks: insights from Africa.

    abstract::Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001171

    authors: Rayner BL,Spence JD

    更新日期:2017-02-01 00:00:00

  • Intrarenal beta-receptor and renal baroreceptor interaction in the control of the renin response to transient reduction of the renal perfusion pressure in man.

    abstract::We have examined the mechanisms mediating the release of renin elicited in man by reduction of renal perfusion pressure. Fifteen patients with essential hypertension and six normotensive subjects were investigated during diagnostic renal arteriography. Renal neural receptors were inhibited by propranolol (10 mg i.v.) ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198502000-00007

    authors: Guazzi MD,Barbier P,Loaldi A,Montorsi P,Polese A,Tosi E,Fiorentini C

    更新日期:1985-02-01 00:00:00

  • Trends in the prevalence, detection, treatment and control of arterial hypertension in the Belgian adult population.

    abstract:OBJECTIVES:To discuss changes during the past decades in the prevalence and in the patterns of detection, treatment and control of arterial hypertension in the general Belgian population aged 25-64 years. DESIGN:Data from two cross-sectional cardiovascular disease risk factor surveys of the general population aged 25-...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816030-00004

    authors: De Henauw S,De Bacquer D,Fonteyne W,Stam M,Kornitzer M,De Backer G

    更新日期:1998-03-01 00:00:00

  • Orthostatic hypotension: a marker of blood pressure variability and arterial stiffness: a cross-sectional study on an elderly population: the 3-City study.

    abstract:BACKGROUND:Orthostatic hypotension, blood pressure (BP) variability, and arterial stiffness are three markers of cardiovascular risk beyond the average BP. However, the relationships between these three parameters are not well known. AIM:To examine the relationships between orthostatic hypotension, BP variability, and...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002374

    authors: Cremer A,Boutouyrie P,Laurent S,Gosse P,Tzourio C

    更新日期:2020-06-01 00:00:00

  • Impact of transiently elevated diastolic pressure on cause of death: 29-year follow-up from the General Practice Hypertension Study Group.

    abstract:OBJECTIVES:High blood pressure is known to be associated with higher cardiovascular risk. The emphasis has shifted over time from diastolic pressure to systolic pressure and variability in blood pressure. This study examined the impact of transient and sustained diastolic hypertension on later mortality. METHODS:In th...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835a4dd8

    authors: Peters R,Wells F,Bulpitt C,Beckett N

    更新日期:2013-01-01 00:00:00

  • Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension.

    abstract:BACKGROUND:Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholami...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-200207000-00020

    authors: O'Connor DT,Kailasam MT,Kennedy BP,Ziegler MG,Yanaihara N,Parmer RJ

    更新日期:2002-07-01 00:00:00

  • Hypertension in South African adults: results from the Demographic and Health Survey, 1998.

    abstract:OBJECTIVES:To determine the prevalence and treatment status of hypertension in South Africa. DESIGN:National cross-sectional survey. SETTING:13 802 randomly selected South Africans, 15 years and older, were visited in their homes in 1998. METHODS:Trained fieldworkers completed questionnaires on lifestyle and chronic...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200110000-00004

    authors: Steyn K,Gaziano TA,Bradshaw D,Laubscher R,Fourie J,South African Demographic and Health Coordinating Team.

    更新日期:2001-10-01 00:00:00

  • The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients.

    abstract:OBJECTIVE:The platelet GPIIIa plays a pivotal role in platelet aggregation. Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. We explored the possibility that this polymorphism represents a risk fa...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328013cd67

    authors: Lanni F,Santulli G,Izzo R,Rubattu S,Zanda B,Volpe M,Iaccarino G,Trimarco B

    更新日期:2007-03-01 00:00:00

  • Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.

    abstract:BACKGROUND:The retinal microvasculature provides a window to the cerebral vasculature and enables examination of changes in retinal caliber that may mimic those occurring in cerebrovascular disease. The association of central arterial stiffness and retinal vessel caliber in a population sample is not fully understood. ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002252

    authors: Meyer ML,Klein BE,Klein R,Palta P,Sharrett AR,Heiss G,Nambi V,Wong TY,Tanaka H

    更新日期:2020-02-01 00:00:00

  • Incremental value of carotid elasticity modulus using shear wave elastography for identifying coronary artery disease in patients without carotid plaque.

    abstract:BACKGROUND:Shear wave elastography (SWE) directly quantifies the local arterial wall stiffness by calculating the elastic modulus. However, whether carotid wall elastic modulus can predict obstructive coronary artery disease (CAD) is not well known. We aimed to investigate the value of carotid wall elastic modulus meas...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002773

    authors: Wang Y,Zhao C,Meng P,Yu Y,Li G,Kong F,Mu L,Yang J,Ma C

    更新日期:2020-12-14 00:00:00

  • Microalbuminuria, renal function and development of sustained hypertension: a longitudinal study in the early stage of hypertension.

    abstract:OBJECTIVE:Microalbuminuria (MA) is a marker of adverse outcome in hypertension. The aim of this study was to investigate the association of MA with cardiovascular risk factors and glomerular hyperfiltration in the early stage of hypertension and to assess its predictive value for the development of sustained hypertensi...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200501000-00028

    authors: Palatini P,Mormino P,Mos L,Mazzer A,Dorigatti F,Zanata G,Longo D,Garbelotto R,De Toni R,Graniero G,Pessina AC,HARVEST Study Group.

    更新日期:2005-01-01 00:00:00

  • Renal effects of fenoldopam in refractory hypertension.

    abstract::Fenoldopam, a dopamine-1 (D1) agonist, was administered by a 6-h intravenous infusion to patients with refractory hypertension [diastolic blood pressure (DBP) greater than 115 mmHg while on triple therapy] in order to achieve a fall in DBP of 30 mmHg. The evolution of blood pressure, heart rate, glomerular filtration ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198808000-00010

    authors: Ruilope LM,Robles RG,Miranda B,Tovar J,Alcazar JM,Sancho J,Rodicio JL,Martinez A,Astorga A,Beck T

    更新日期:1988-08-01 00:00:00

  • Effect of glycaemic control on the vascular nitric oxide system in patients with type 1 diabetes.

    abstract:OBJECTIVE:The mechanisms underlying the relationship between the vascular complications of diabetes and the glycaemic control are not well understood. We tested whether glycaemic control influences the functioning of the nitric oxide system in type 1 diabetic patients and the role for oxidative stress. METHODS:The cha...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-200306000-00013

    authors: Rodríguez-Mañas L,López-Dóriga P,Petidier R,Neira M,Solís J,Pavón I,Peiró C,Sánchez-Ferrer CF

    更新日期:2003-06-01 00:00:00

  • Arterial stiffness in inflammatory bowel disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:Arterial stiffness is increased with chronic inflammatory disorders. The reduction of inflammation by immunomodulatory therapy is associated with a restoration of arterial function. The aims of the study were to perform a meta-analysis to determine whether arterial stiffness is increased in patients with inf...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1097/HJH.0000000000000867

    authors: Zanoli L,Rastelli S,Granata A,Inserra G,Empana JP,Boutouyrie P,Laurent S,Castellino P

    更新日期:2016-05-01 00:00:00

  • Influence of irbesartan and enalapril on changes of renal function associated with the established phase of l-NAME hypertension.

    abstract:OBJECTIVE:Reversibility of the systemic and renal alterations induced by N(omega)-nitro-L-arginine-methyl ester(L-NAME) was assessed by treatment with irbesartan and enalapril (30 and 10 mg/kg per 24 h, respectively) alone or in combination. DESIGN:L-NAME (20 mg/kg per 24 h) was given to rats for 6 weeks and treatment...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200111000-00015

    authors: Jover B,Herizi A,Casellas D,Mimran A

    更新日期:2001-11-01 00:00:00

  • Supporting self-management for people with hypertension: a meta-review of quantitative and qualitative systematic reviews.

    abstract:OBJECTIVES:Globally, healthcare policy promotes supported self-management as a strategy for people with long-term conditions. This meta-review aimed to explore how people with hypertension make sense of their condition, to assess the effectiveness of supported self-management in hypertension, and to identify effective ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000001867

    authors: Shahaj O,Denneny D,Schwappach A,Pearce G,Epiphaniou E,Parke HL,Taylor SJC,Pinnock H

    更新日期:2019-02-01 00:00:00

  • Effects of haemorrhagic hypotension on brain and liver metabolism in normotensive (WKY) and spontaneously hypertensive rats (SHR).

    abstract::Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198310000-00005

    authors: Wennberg E,Hagberg H,Haljamäe H,Johansson BB

    更新日期:1983-10-01 00:00:00

  • Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.

    abstract:OBJECTIVES:Nonsteroidal anti-inflammatory drugs vary in their impact on blood pressure and the effect of lumiracoxib 100 mg once daily has not been studied previously. To examine whether lumiracoxib 100 mg once daily would result in lower 24-h mean systolic ambulatory blood pressure than ibuprofen 600 mg three times da...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/HJH.0b013e328302c9fe

    authors: MacDonald TM,Reginster JY,Littlejohn TW,Richard D,Lheritier K,Krammer G,Rebuli R

    更新日期:2008-08-01 00:00:00

  • Ambulatory blood pressure monitoring and development of cardiovascular events in high-risk patients included in the Spanish ABPM registry: the CARDIORISC Event study.

    abstract:BACKGROUND AND AIM:Ambulatory blood pressure monitoring (ABPM) is superior to conventional BP measurement in predicting outcome, with baseline 24-h, daytime and night-time absolute values, as well as relative nocturnal decline, as powerful determinants of prognosis. We aimed to evaluate ABPM estimates on the appearance...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328350bb40

    authors: de la Sierra A,Banegas JR,Segura J,Gorostidi M,Ruilope LM,CARDIORISC Event Investigators.

    更新日期:2012-04-01 00:00:00