Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity.

abstract：OBJECTIVE:Gap junctions, formed by connexins (Cx), are important in the regulation of vascular tone. Previously, we reported two closely linked polymorphisms (-44G --> A and +71A --> G) within regulatory regions of the gene for Cx40, a major connexin in the vascular wall and the kidney. In the present study, we examine...

journal_title：Journal of hypertension

authors： Firouzi M,Kok B,Spiering W,Busjahn A,Bezzina CR,Ruijter JM,Koeleman BP,Schipper M,Groenewegen WA,Jongsma HJ,de Leeuw PW

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Across ethnicities, offspring of hypertensive parents (OH) have higher risk of hypertension than offspring of normotensive parents (ON). Sympathetic hyperactivity and reduced nitric oxide availability have been reported in normotensive OH; but the role of vasodilator cyclooxygenase (COX) products is unclear....

journal_title：Journal of hypertension

authors： Hirst A,Marshall JM

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Salt sensitivity and the magnitude of systolic blood pressure have been linked to haptoglobin (Hp) polymorphism in normotensives. The aim of the present study was to investigate the indices of hypertension, the severity of complications and the occurrence of coronary and peripheral artery disease for the vari...

journal_title：Journal of hypertension

authors： Delanghe JR,Duprez DA,De Buyzere ML,Bergez BM,Callens BY,Leroux-Roels GG,Clement DL

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:We attempted to determine a valid pharmacological approach for the control of high blood pressure in obese hypertensive patients using two antihypertensive agents with different pharmacological actions. DESIGN:Thirty-two obese hypertensive black women were randomly treated with chlorthalidone or clonidine to...

journal_title：Journal of hypertension

authors： Reisin E,Weed SG

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:The radial artery pulse waveform is a continuous measure of pressure throughout the cardiac cycle, and thus can provide more information than just systolic and diastolic blood pressures. New indices based on a Windkessel model of the waveform, PTC1 and PTC2, are related to arterial compliance and add informa...

journal_title：Journal of hypertension

authors： Brumback LC,Andrews LIB,Jacobs DR Jr,Duprez DA,Shah SJ,Dougherty CM,Denenberg JO,Allison MA

更新日期：2020-11-24 00:00:00

abstract：OBJECTIVES:Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we study isolated and combined effects of hypertension and aging on central...

journal_title：Journal of hypertension

authors： Spronck B,Ferruzzi J,Bellini C,Caulk AW,Murtada SI,Humphrey JD

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Mineralocorticoid receptor antagonists are increasingly used in patients with treatment-resistant hypertension (TRH). There is experimental evidence for blood pressure (BP) independent effects of mineralocorticoid receptor blockade on cardiovascular target organ damage. We hypothesized that low-dose eplereno...

journal_title：Journal of hypertension

authors： Schneider A,Schwab J,Karg MV,Kalizki T,Reinold A,Schneider MP,Schmieder RE,Schmidt BM

更新日期：2017-05-01 00:00:00

abstract：:Microvascular alterations associated with reversal of hypertension by exposure to simulated high altitude were investigated in the gracilis muscle of the spontaneously hypertensive rat (SHR). Male, 4-week-old SHR were either placed in a hypobaric chamber (SHR-HA) at 430 mmHg or maintained at ambient barometric pressur...

journal_title：Journal of hypertension

authors： Prewitt RL,Cardoso SS,Wood WB

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

journal_title：Journal of hypertension

authors： Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy (LVH). We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated...

journal_title：Journal of hypertension

authors： Huber M,Völler H,Jakob S,Reibis R,Do V,Bolbrinker J,Zergibel I,Schmieder RE,Treszl A,Wegscheider K,Kreutz R

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Aldosterone is produced in the ventricle of patients with hypertension. The present study was designed to examine whether adrenocorticotropic hormone (ACTH) and cortisol are also produced from the heart in patients with essential hypertension. METHODS:The study population consisted of 57 patients with essent...

journal_title：Journal of hypertension

authors： Mizuno Y,Yasue H,Yoshimura M,Harada E,Fujii H,Nakamura S,Yamamoto N,Ogawa H,Nakao K

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secreti...

journal_title：Journal of hypertension

authors： van Twist DJ,Houben AJ,de Haan MW,de Leeuw PW,Kroon AA

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To determine whether the decision to treat uncomplicated mild hypertension with drugs, in accordance with the World Health Organization - International Society of Hypertension (WHO/ISH) guidelines based on a series of blood pressure (BP) measurements over 6 months, resulted in the treatment of patients at hig...

journal_title：Journal of hypertension

authors： Abergel E,Chatellier G,Battaglia C,Menard J

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the 24-h urinary sodium excretion in children of 10-12 years at a school in the north of Portugal and to examine the influence on salt intake and blood pressure of three different educational interventions for 6 months. METHODS:Blood pressure (BP) and sodium excretion in ...

journal_title：Journal of hypertension

authors： Cotter J,Cotter MJ,Oliveira P,Cunha P,Polónia J

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Angiotensin (Ang) II increases reactive oxygen species (ROS), decreases nitric oxide (NO) bioavailability and promotes cardiovascular remodeling. ROS have been identified as critical second messengers of the trophic responses by Ang II. In rats with Ang II-induced hypertension, we investigated the role of ROS...

journal_title：Journal of hypertension

authors： Zhou MS,Jaimes EA,Raij L

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Arterial stiffness is associated with excess morbidity and mortality, independently of other cardiovascular risk factors. Age is the main determinant responsible for arterial wall changes leading to arterial stiffening. Environmental and genetic factors may however influence the magnitude of the effects of a...

journal_title：Journal of hypertension

authors： Lajemi M,Labat C,Gautier S,Lacolley P,Safar M,Asmar R,Cambien F,Benetos A

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:To investigate whether combined treatment with lisinopril, an angiotensin-converting enzyme (ACE) inhibitor and exercise training would have an additive effect in enhancing the capillary supply of the left ventricular (LV) myocardium in spontaneously hypertensive rats (SHR). DESIGN:Twelve-week-old male SHR ...

journal_title：Journal of hypertension

authors： Ziada AM,Hassan MO,Tahlilkar KI,Inuwa IM

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Genetic variants that influence large conductance calcium-activated potassium channel's function may alter arterial function and contribute to the known heritability of arterial stiffness and blood pressure. The beta1-subunit (KCNMB1) of the large conductance calcium-activated potassium channel includes two ...

journal_title：Journal of hypertension

authors： Kelley-Hedgepeth A,Peter I,Montefusco MC,Levy D,Benjamin EJ,Vasan RS,Mendelsohn ME,Housman D,Huggins GS,Mitchell GF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Anandamide (AEA), one of the endocannabinoid compounds, has an important regulatory function by serving as an autocrine/paracrine or endocrine factor throughout the body via activation of the cannabinoid receptor 1 (CB1) and/or the transient receptor potential vanilloid type 1 (TRPV1) channels. However, the ...

journal_title：Journal of hypertension

authors： Li J,Wang DH

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:In experimental animal models, exogenous aldosterone excess has been linked to the progression of renal disease. However, the evidence of an increased risk of renal damage in patients affected by primary aldosteronism remains controversial. We aimed at evaluating the association between primary aldosteronism...

journal_title：Journal of hypertension

authors： Monticone S,Sconfienza E,D'Ascenzo F,Buffolo F,Satoh F,Sechi LA,Veglio F,Mulatero P

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS:The study included 80 sedentary, overweight patients (43 female and 37 male) with unmedicated high normal bloo...

journal_title：Journal of hypertension

authors： Pierson LM,Bacon SL,Sherwood A,Hinderliter AL,Babyak M,Gullette EC,Waugh R,Blumenthal JA

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To investigate the characteristics and expression of transforming growth factor (TGF)-beta receptor subtypes on vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. METHODS:The effects of TGF-beta 1 on DNA synthesis were evaluated by [3H]-th...

journal_title：Journal of hypertension

authors： Fukuda N,Kubo A,Izumi Y,Soma M,Kanmatsuse K

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:To compare the prediction of mortality by ambulatory blood pressure monitoring and screening blood pressure measurements in a general population. DESIGN:A prospective cohort study. PATIENTS AND METHODS:We obtained blood pressure data for 1542 subjects (565 men and 977 women) aged > or = 40 years who were fo...

journal_title：Journal of hypertension

authors： Ohkubo T,Imai Y,Tsuji I,Nagai K,Watanabe N,Minami N,Itoh O,Bando T,Sakuma M,Fukao A,Satoh H,Hisamichi S,Abe K

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...

journal_title：Journal of hypertension

authors： Schmidlin O,Tanaka M,Sebastian A,Morris RC Jr

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor. METHO...

journal_title：Journal of hypertension

authors： Esler M,Lambert G,Esler D,Ika Sari C,Guo L,Jennings G

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To determine whether kidney stone disease (KSD) and hypertension (HTN) share a common familial component that is determined by a specific urinary biochemical abnormality. DESIGN:Familial aggregation study. PATIENTS:Two hundred and twelve KSD patients, aged 18-50 years, collected a 24-h urine sample to measu...

journal_title：Journal of hypertension

authors： Tisler A,Pierratos A,Honey JD,Bull SB,Logan AG

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP)-lowering trials studying efficacy mostly assesses binary outcome events, for example stroke/no stroke. Analysis of ordered categorical vascular events (e.g. three levels: fatal stroke/nonfatal stroke/no stroke) provides information on severity and is more powerful statistically than analy...

journal_title：Journal of hypertension

authors： Geeganage CM,Tracy M,Bath MW,Bath PM

更新日期：2010-10-01 00:00:00

abstract：:If ambulatory blood pressure measurement is not possible because the upper-arm circumference is so great that even the largest cuff provided with the monitor will not encircle the arm, satisfactory measurements can be obtained by applying a cuff to the forearm. ...

journal_title：Journal of hypertension

authors： O'Brien E

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) may lead to the development of hypertension and therapy with continuous positive airway pressure (CPAP) can promote reduction in blood pressure. OBJECTIVE:The objective of this study is to review systematically the effects of CPAP on blood pressure in patients with OSA. METHOD...

journal_title：Journal of hypertension

authors： Schein AS,Kerkhoff AC,Coronel CC,Plentz RD,Sbruzzi G

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Studies in genetically hypertensive rats and their normotensive Wistar-Kyoto control rats have revealed a linkage of a chromosomal region containing the angiotensin converting enzyme (ACE) gene with blood pressure. This led to the hypothesis that ACE is a possible candidate gene for primary hypertension in hu...

journal_title：Journal of hypertension

authors： Schmidt S,van Hooft IM,Grobbee DE,Ganten D,Ritz E

更新日期：1993-04-01 00:00:00