Can echocardiography identify mildly hypertensive patients at high risk, left untreated based on current guidelines?

abstract：OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...

journal_title：Journal of hypertension

authors： Cohen-Solal A,Caviezel B,Himbert D,Gourgon R

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Anandamide (AEA), one of the endocannabinoid compounds, has an important regulatory function by serving as an autocrine/paracrine or endocrine factor throughout the body via activation of the cannabinoid receptor 1 (CB1) and/or the transient receptor potential vanilloid type 1 (TRPV1) channels. However, the ...

journal_title：Journal of hypertension

authors： Li J,Wang DH

更新日期：2006-11-01 00:00:00

abstract：:The effect on blood pressure (BP) of acute and chronic suppression of angiotensin (ANG) II was studied in the two-kidney, one clip hypertensive rat. Conscious, chronically catheterized rats were given a bolus injection of captopril (2.5 mg/kg) followed by a chronic infusion of either dextrose or captopril (1 mg/kg per...

journal_title：Journal of hypertension

authors： Wallace EC,Balmforth AJ,Morton JJ

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:Prior to the discovery of chloride channel Kb with a variant threonine change to serine at position 481 (CLCNKB-T481S) there were no variants or clinical disorders associated with gain-of-function defects in thick ascending limb of the kidney channels or transporters. CLCNKB-T481S is a novel gain-of-function ...

journal_title：Journal of hypertension

authors： Sile S,Velez DR,Gillani NB,Narsia T,Moore JH,George AL Jr,Vanoye CG,Williams SM

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To determine the blood pressure responses in elderly normotensive men and women to dietary sodium and to the diunsaturated fatty acid dihomogammalinolenic acid (DGLA), which is derived from linoleic acid. DESIGN:Blood pressure responses were assessed in 66 subjects (36 male, 30 female; mean age 65 years) on ...

journal_title：Journal of hypertension

authors： Nestel PJ,Clifton PM,Noakes M,McArthur R,Howe PR

更新日期：1993-12-01 00:00:00

abstract：:The effects of i.v. injection of intact digoxin antibody (0.3 mg/rat) and of its Fab fragment (40 mg/rat) on blood pressure, cardiac output and total peripheral resistance were measured in conscious spontaneously hypertensive and deoxycorticosterone hypertensive rats. In vitro findings showed that Fab fragment bound r...

journal_title：Journal of hypertension

authors： Mann JF,Miemietz R,Ganten U,Ritz E

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:To determine whether the development of arterial hypertension due to occlusion of the central adrenal vein in the rat is strain-dependent DESIGN AND METHODS:The experiments were performed on male rats weighing 300-400 g each, of the following strains: Wistar outbred, Wistar Glaxo, Lewis, Wistar-Kyoto (WKY) r...

journal_title：Journal of hypertension

authors： Abramczyk P,Lisiecka A,Papierski K,Ziecina R,Przybylski J

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In 68 randomized controlled trials (RCTs), blood pressure (BP) lowering was obtained by using drugs of different classes. We have investigated whether BP lowering by any of the major drug classes is effective in reducing the cardiovascular outcomes. METHODS:A total of 55 RCTs (19,5 267 indivi...

journal_title：Journal of hypertension

authors： Thomopoulos C,Parati G,Zanchetti A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Across ethnicities, offspring of hypertensive parents (OH) have higher risk of hypertension than offspring of normotensive parents (ON). Sympathetic hyperactivity and reduced nitric oxide availability have been reported in normotensive OH; but the role of vasodilator cyclooxygenase (COX) products is unclear....

journal_title：Journal of hypertension

authors： Hirst A,Marshall JM

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Cardiovascular diseases represent the most common cause of death in the English-speaking Caribbean, and hypertension represents the most important predisposing condition. However, direct between-country comparative studies in the Caribbean have not previously been undertaken. OBJECTIVE:To obtain estimates o...

journal_title：Journal of hypertension

authors： Freeman V,Fraser H,Forrester T,Wilks R,Cruickshank J,Rotimi C,Cooper R

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVES:The goal of this study was to compare the cardiovascular responses to behavioural stressors of three groups of adolescents who differed in blood pressure status across assessments. DESIGN:Casual blood pressure of adolescents who were identified as having elevated blood pressure during a school screen was re...

journal_title：Journal of hypertension

authors： Saab PG,Llabre MM,Ma M,DiLillo V,McCalla JR,Fernander-Scott A,Copen R,Gellman M,Schneiderman N

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To estimate the sensitivity and specificity of self-reported hypertension (HTN) as compared with the clinical diagnosis in epidemiological studies. METHODS:We searched MEDLINE, Embase, Scopus, Web of Science, LILACS, Google Scholar, and ProQuest Dissertations & Theses Global: Health & Medicine databases. In ...

journal_title：Journal of hypertension

authors： Gonçalves VSS,Andrade KRC,Carvalho KMB,Silva MT,Pereira MG,Galvao TF

更新日期：2018-05-01 00:00:00

abstract：DESIGN:Because of uncertainties regarding the complete antihypertensive mechanism of action of beta-adrenoceptor antagonists, the present study determined whether vagal afferent neurons of humans and rats possess beta-adrenoceptors. Such a location would provide an appropriate target for beta-blockers to modulate neuro...

journal_title：Journal of hypertension

authors： Lawrence AJ,Watkins D,Jarrott B

更新日期：1995-06-01 00:00:00

abstract：:: Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of BP changes in AIS is complex and only partially understood. The available evidence indicates that extremely high BP during AIS is associated with a poor outcome. Im...

journal_title：Journal of hypertension

authors： Gąsecki D,Coca A,Cunha P,Hering D,Manios E,Lovic D,Zaninelli A,Sierra C,Kwarciany M,Narkiewicz K,Karaszewski B

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:To investigate the mechanism of angiotensin II-induced apoptosis in cultured cardiomyocytes by determining which receptor subtype is involved, and what is the relationship between intracellular Ca2+ changes and apoptosis. DESIGN AND METHODS:Neonatal rat cardiomyocytes were pretreated with either the AT1 ant...

journal_title：Journal of hypertension

authors： Goldenberg I,Grossman E,Jacobson KA,Shneyvays V,Shainberg A

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:To examine the health risks associated with smoking and blood pressure in Chinese hypertensive patients and to compare the benefit of antihypertensive drug treatment with the risk attributable to smoking. METHODS:We used multiple Cox regression to correlate outcome with blood pressure and smoking status in ...

journal_title：Journal of hypertension

authors： Wang JG,Staessen JA,Fagard R,Gong L,Liu L,Systolic Hypertension in China (Syst-China) Trial Collaborative Group.

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:Reflection of the finger pulse wave form is a valid measure of arterial stiffness, which may be continuously assessed during sleep. We investigated the relationships between sleep, sleep-disordered breathing, hypertension, and pulse propagation time (PPT) in patients with suspected sleep apnea. METHODS:The ...

journal_title：Journal of hypertension

authors： Svedmyr S,Zou D,Sommermeyer D,Ficker JH,Randerath W,Fietze I,Sanner B,Hedner J,Grote L

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Endothelial dysfunction and arterial stiffness are early vascular alterations, linked to oxidative stress and inflammation, with prognostic significance in essential hypertensive patients. P2X7 receptors (P2X7R), responding to extracellular ATP, are encoded by a highly polymorphic gene and modulate inflammato...

journal_title：Journal of hypertension

authors： Ghiadoni L,Rossi C,Duranti E,Santini E,Bruno RM,Salvati A,Taddei S,Solini A

更新日期：2013-12-01 00:00:00

abstract：:Normotensives with hypertensive parents have been reported to exhibit enhanced cardiovascular reactions to mental stress. We have examined the question of why this result was not confirmed in all studies. In addition we have investigated whether appropriate tests can be performed under clinical rather than laboratory ...

journal_title：Journal of hypertension

authors： Neus H,Gödderz W,Otten H,Rüddel H,von Eiff AW

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associat...

journal_title：Journal of hypertension

authors： Zureik M,Temmar M,Adamopoulos C,Bureau JM,Courbon D,Thomas F,Bean K,Touboul PJ,Ducimetière P,Benetos A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The retinal microvasculature provides a window to the cerebral vasculature and enables examination of changes in retinal caliber that may mimic those occurring in cerebrovascular disease. The association of central arterial stiffness and retinal vessel caliber in a population sample is not fully understood. ...

journal_title：Journal of hypertension

authors： Meyer ML,Klein BE,Klein R,Palta P,Sharrett AR,Heiss G,Nambi V,Wong TY,Tanaka H

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Elevated blood pressure (BP) is associated with cardiovascular mortality. BP variability (BPV) is also associated with cardiovascular mortality. However, most studies evaluated hypertensive patients with a relatively short follow-up. We investigated in male workers the association between BPV and long-term al...

journal_title：Journal of hypertension

authors： Goldbourt U,Grossman E

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The early phase of weight loss induced by fasting is associated with diuresis, natriuresis and reduction in blood pressure through unclear mechanisms. Atrial natriuretic peptide (ANP) is a cardiac hormone with potent natriuretic, diuretic and hypotensive effects mediated by 'biologically active' re...

journal_title：Journal of hypertension

authors： Sarzani R,Paci VM,Zingaretti CM,Pierleoni C,Cinti S,Cola G,Rappelli A,Dessì-Fulgheri P

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. METHODS:CRP, as well as multiple facets of the metabolic syndrome, were measured in a series o...

journal_title：Journal of hypertension

authors： Wessel J,Moratorio G,Rao F,Mahata M,Zhang L,Greene W,Rana BK,Kennedy BP,Khandrika S,Huang P,Lillie EO,Shih PA,Smith DW,Wen G,Hamilton BA,Ziegler MG,Witztum JL,Schork NJ,Schmid-Schönbein GW,O'Connor DT

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Blood pressure changes during menopausal transition have not been studied previously using a biracial sample. We investigated whether menopausal transition was associated with change in blood pressure in African-American or white women. DESIGN, SETTING AND PARTICIPANTS:The prospective multicenter study, the ...

journal_title：Journal of hypertension

authors： Luoto R,Sharrett AR,Schreiner P,Sorlie PD,Arnett D,Ephross S

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Inflammation is necessary for successful pregnancy; however, excessive inflammation plays a central role in the development of the pregnancy-specific hypertensive disorder preeclampsia. Numerous anti-inflammatory cytokines are decreased in women with preeclampsia but the role of individual cytokines in blood ...

journal_title：Journal of hypertension

authors： Chatterjee P,Kopriva SE,Chiasson VL,Young KJ,Tobin RP,Newell-Rogers K,Mitchell BM

更新日期：2013-07-01 00:00:00

abstract：:This study focuses on the relationship between some aspects of intra-erythrocytic sodium metabolism (intra-erythrocytic Na content, Na,Li-countertransport), blood pressure, and family history of hypertension, in a group of 84 randomly selected school children (45 males, 39 females). Na,Li-countertransport was signific...

journal_title：Journal of hypertension

authors： Trevisan M,Strazzullo P,Cappuccio FP,Di Muro MR,De Colle S,Franzese A,Iacone R,Krogh V

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...

journal_title：Journal of hypertension

authors： Nishikimi T,Horio T,Kohmoto Y,Yoshihara F,Nagaya N,Inenaga T,Saito M,Teranishi M,Nakamura M,Ohrui M,Kawano Y,Matsuo H,Ishimitsu T,Takishita S,Matsuoka H,Kangawa K

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Hydroxymethylglutaryl coenzyme A (HMGCoA) reductase inhibitors have beneficial effects beyond their cholesterol-lowering properties. The antioxidant mechanism of HMGCoA reductase inhibitors is not completely understood. OBJECTIVES:To elucidate the antioxidant effect of simvastatin. METHODS:We studied the i...

journal_title：Journal of hypertension

authors： Carneado J,Alvarez de Sotomayor M,Perez-Guerrero C,Jimenez L,Herrera MD,Pamies E,Martin-Sanz MD,Stiefel P,Miranda M,Bravo L,Marhuenda E

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Recent studies indicated that central SBP could be estimated by radial late-SBP (rSBP2) with a small disparity. However, most of these studies were conducted by SphygmoCor with a transfer function. The agreement between rSBP2 and central SBP was also tested in several invasive studies, but with inconsistent ...

journal_title：Journal of hypertension

authors： Zhang Y,Agnoletti D,Protogerou AD,Wang JG,Topouchian J,Salvi P,Safar ME,Blacher J

更新日期：2011-04-01 00:00:00