Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging.

abstract：OBJECTIVE:BPH/2J hypertensive mice have an exaggerated sympathetic contribution to blood pressure (BP). Premotor sympathetic neurons within the rostroventrolateral medulla (RVLM) are a major source of sympathetic vasomotor tone and major site of action of the centrally acting sympatholytic agent, rilmenidine. The relat...

journal_title：Journal of hypertension

authors： Jackson KL,Palma-Rigo K,Nguyen-Huu TP,Davern PJ,Head GA

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Development of internally quenched fluorogenic substrates for sensitive and continuous assays of angiotensin I-converting enzyme (ACE). DESIGN:We synthesized internally quenched fluorogenic bradykinin-related peptides introducing Abz (ortho-aminobenzoic acid) and EDDnp (N-[2,4-dinitrophenyl]-ethylenediamine)...

journal_title：Journal of hypertension

authors： Araujo MC,Melo RI,Del Nery E,Alves MF,Juliano MA,Casarini DE,Juliano L,Carmona AK

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:Blood pressure changes during menopausal transition have not been studied previously using a biracial sample. We investigated whether menopausal transition was associated with change in blood pressure in African-American or white women. DESIGN, SETTING AND PARTICIPANTS:The prospective multicenter study, the ...

journal_title：Journal of hypertension

authors： Luoto R,Sharrett AR,Schreiner P,Sorlie PD,Arnett D,Ephross S

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To investigate the role of angiotensin II in the pathogenesis of hyperinsulinemia-induced hypertension in rats. MATERIALS AND METHODS:Chronic hyperinsulinemia was achieved by infusing insulin (3 mU/kg per min) subcutaneously by an osmotic minipump for 6 weeks. An angiotensin converting enzyme inhibitor (fosi...

journal_title：Journal of hypertension

authors： Fang TC,Huang WC

更新日期：1998-12-01 00:00:00

abstract：INTRODUCTION:QT interval prolongation increases the risk of sudden death in several medical conditions. Patients with primary aldosteronism and salt-sensitive hypertension experience more cardiovascular events than those with normal-renin essential hypertension. QT interval prolongation might represent one of the risk ...

journal_title：Journal of hypertension

authors： Maule S,Mulatero P,Milan A,Leotta G,Caserta M,Bertello C,Rabbia F,Veglio F

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Cross-sectional evidence indicates that eating frequency correlates with blood pressure, hypertension, and related target organ damage. The aim of the present study was to prospectively assess eating frequency as a predictor of arteriosclerosis progression and new onset hypertension over a follow-up period o...

journal_title：Journal of hypertension

authors： Karatzi K,Georgiopoulos G,Yannakoulia M,Efthimiou E,Voidonikola P,Mitrakou A,Manios E,Alevizaki M,Papamichael C,Stamatelopoulos K

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:In essential hypertensive patients, blunted renal plasma flow responsiveness to angiotensin II suggests a pathologic increase in angiotensin II in the kidneys. This blunting has been associated with the angiotensinogen 235TT genotype. As several measures of renal function decline with age, we sought to determ...

journal_title：Journal of hypertension

authors： Patel TV,Williams GH,Fisher ND

更新日期：2008-07-01 00:00:00

abstract：:: Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and sometimes life- threatening sequelae. Tremendous progress in biochemical testing, imaging, genetics and pathophysiological understanding of the tumours has far-...

journal_title：Journal of hypertension

authors： Lenders JWM,Kerstens MN,Amar L,Prejbisz A,Robledo M,Taieb D,Pacak K,Crona J,Zelinka T,Mannelli M,Deutschbein T,Timmers HJLM,Castinetti F,Dralle H,Widimský J,Gimenez-Roqueplo AP,Eisenhofer G

更新日期：2020-08-01 00:00:00

abstract：AIMS:The addition of an aldosterone receptor antagonist on top of current optimal therapy (based on angiotensin II inhibition) has demonstrated an important clinical benefit in heart failure patients with systolic dysfunction. Whether this finding also applies to heart failure patients with preserved systolic function ...

journal_title：Journal of hypertension

authors： Muñoz-Pacheco P,Ortega-Hernández A,Caro-Vadillo A,Casanueva-Eliceiry S,Aragoncillo P,Egido J,Fernández-Cruz A,Gómez-Garre D

更新日期：2013-11-01 00:00:00

abstract：:The effects of age on the circadian blood pressure rhythm of patients with untreated essential hypertension (n = 133, World Health Organization stage I or II) were compared with those of normotensive subjects (n = 91). Subjects were classified into three groups by age: young (less than 40 years old), adult (40-59 year...

journal_title：Journal of hypertension

authors： Munakata M,Imai Y,Abe K,Sasaki S,Minami N,Hashimoto J,Sakuma H,Ichijo T,Yoshizawa M,Sekino H

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:To investigate whether NADPH oxidase 2 (NOX2), a major source of reactive oxygen species (ROS), contributes to the emergence of arterial hypertension in a murine model of sleep apnea. BACKGROUND:Obstructive sleep apnea (OSA) is a risk factor for arterial hypertension and it is linked to oxidative stress. M...

journal_title：Journal of hypertension

authors： Schulz R,Murzabekova G,Egemnazarov B,Kraut S,Eisele HJ,Dumitrascu R,Heitmann J,Seimetz M,Witzenrath M,Ghofrani HA,Schermuly RT,Grimminger F,Seeger W,Weissmann N

更新日期：2014-02-01 00:00:00

abstract：:: Hypertension is a growing health concern worldwide. Established hypertension is a causative factor of heart failure, which is characterized by increased vascular resistance and intractable uncontrolled blood pressure. Hypertension and heart failure have multiple causes and complex pathophysiology but cellular immuni...

journal_title：Journal of hypertension

authors： Rai A,Narisawa M,Li P,Piao L,Li Y,Yang G,Cheng XW

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:In this study, we tested the hypothesis that long-term Rho-kinase inhibition would reverse nitro-L-arginine methyl ester-exacerbated nephrosclerosis in spontaneously hypertensive rats and attempted to elucidate the mechanism involved. METHODS:Five groups (each n = 8) were studied: untreated spontaneously hy...

journal_title：Journal of hypertension

authors： Koshikawa S,Nishikimi T,Inaba C,Akimoto K,Matsuoka H

更新日期：2008-09-01 00:00:00

abstract：:The activity of renal Na-K-ATPase was compared in hypertension-prone (SBH) and hypertension-resistant (SBN) Sabra rats on regular sodium intake and 2-3 weeks after a high sodium diet. ATPase activity was determined in single nephron segments by a micromethod. The activity profile was found to be similar in the two sub...

journal_title：Journal of hypertension

authors： Doucet A,Mekler J,el Mernissi G,Ben-Ishay D

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVES:Patients with end-stage renal-disease under hemodialysis have increased cardiovascular risk and experience severe blood pressure (BP) fluctuations during the dialysis session and the subsequent interdialytic period. BP variability (BPV) may be an additional risk factor for cardiovascular events and prelimina...

journal_title：Journal of hypertension

authors： Karpetas A,Loutradis C,Bikos A,Tzanis G,Koutroumpas G,Lazaridis AA,Mavromatidis K,Liakopoulos V,Papagianni A,Zebekakis P,Ruilope LM,Parati G,Sarafidis PA

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Dipeptidyl peptidase-4 (DPP4) is a key protein in glucose homeostasis and a pharmacological target in type 2 diabetes mellitus. This study explored whether the novel adipokine soluble DPP4 (sDPP4) can cause endothelial dysfunction, an early marker of impaired vascular reactivity. METHOD:Reactivity was studi...

journal_title：Journal of hypertension

authors： Romacho T,Vallejo S,Villalobos LA,Wronkowitz N,Indrakusuma I,Sell H,Eckel J,Sánchez-Ferrer CF,Peiró C

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Recent studies indicated that central SBP could be estimated by radial late-SBP (rSBP2) with a small disparity. However, most of these studies were conducted by SphygmoCor with a transfer function. The agreement between rSBP2 and central SBP was also tested in several invasive studies, but with inconsistent ...

journal_title：Journal of hypertension

authors： Zhang Y,Agnoletti D,Protogerou AD,Wang JG,Topouchian J,Salvi P,Safar ME,Blacher J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. OBJ...

journal_title：Journal of hypertension

authors： Fazan R Jr,Dias da Silva VJ,Ballejo G,Salgado HC

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Patients with type-2 diabetes have a high prevalence of hypertension and show an elevated incidence of cardiovascular events and nephropathy. OBJECTIVES:Recent randomized trials of antihypertensive therapy providing information about cardiovascular and renal risk in diabetes, blood pressure goals and best s...

journal_title：Journal of hypertension

authors： Zanchetti A,Ruilope LM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To compare retinal arterial bifurcation geometry in normotensive and hypertensive subjects. DESIGN:A retrospective observational study. METHODS:Fluorescein angiograms of normotensive (n = 13) and hypertensive (n = 12) subjects aged 30-80 years with uni-ocular retinal pathology were compared. Quantification ...

journal_title：Journal of hypertension

authors： Stanton AV,Wasan B,Cerutti A,Ford S,Marsh R,Sever PP,Thom SA,Hughes AD

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of cyclosporine A (CsA; Sandimmun Neoral) on systemic and renal hemodynamics, tubular function, and sodium excretion in healthy volunteers. Furthermore, we studied whether CsA enhances the systemic and renal hemodynamic sensitivity to norepinephrine. METHODS:Eighteen healthy volunte...

journal_title：Journal of hypertension

authors： Hansen JM,Fogh-Andersen N,Christensen NJ,Strandgaard S

更新日期：1997-03-01 00:00:00

abstract：:The mechanisms resulting in the greater predisposition of male subjects towards hypertension were investigated in different strains of rats with genetic hypertension [spontaneously hypertensive rats of the stroke-prone strain (SHRSP) and spontaneously hypertensive rats (SHR)] and their respective normotensive controls...

journal_title：Journal of hypertension

authors： Ganten U,Schröder G,Witt M,Zimmermann F,Ganten D,Stock G

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...

journal_title：Journal of hypertension

authors： Nishikimi T,Horio T,Kohmoto Y,Yoshihara F,Nagaya N,Inenaga T,Saito M,Teranishi M,Nakamura M,Ohrui M,Kawano Y,Matsuo H,Ishimitsu T,Takishita S,Matsuoka H,Kangawa K

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To examine the association of blood pressure (BP) with cardiovascular mortality in real-world settings and investigate whether that association varied by use of antihypertensive medication at baseline. METHODS:Data from 27 728 Japanese men and women, aged 40-79 years, free of stroke, coronary heart disease, ...

journal_title：Journal of hypertension

authors： Yamagishi K,Sawachi S,Tamakoshi A,Iso H,JACC Study Group.

更新日期：2019-07-01 00:00:00

abstract：:: The term 'cardiorenal syndrome' (CRS) was introduced to describe problems related to the simultaneous existence of heart and renal insufficiency. The prevalence of anaemia in CRS is high and increases the risk of hospitalizations and death. Renin-angiotensin system (RAS) inhibition is the cornerstone therapy in card...

journal_title：Journal of hypertension

authors： Vlahakos DV,Tsioufis C,Manolis A,Filippatos G,Marathias KP,Papademetriou V,Mancia G

更新日期：2019-11-01 00:00:00

abstract：AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...

journal_title：Journal of hypertension

authors： Walraven I,Mast MR,Hoekstra T,Jansen AP,Rauh SP,Rutters FR,van der Heijden AA,Elders PJ,Moll AC,Polak BC,Dekker JM,Nijpels G

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Activated coagulation Factor XII (FXIIa) infusion increases peripheral resistance (TPR) and mean arterial pressure (MAP) of Brown Norway but not plasma kininogen deficient Brown Norway Katholiek (BNK) rats. FXIIa concentrations are elevated in hypertensive end-stage renal disease patients receiving conventio...

journal_title：Journal of hypertension

authors： Papageorgiou PC,Chan CT,Yeo EL,Backx PH,Floras JS

更新日期：2014-07-01 00:00:00

abstract：:The effects of rilmenidine [(N-dicyclopropylmethyl) amino-2-oxazoline; S 3341], an alpha 2 agonist, on the hypertensive rat heart have been compared with those of propranolol, using a model of deoxycorticosterone acetate (DOCA)-salt hypertension. One week after nephrectomy and initial treatment with DOCA-salt, which w...

journal_title：Journal of hypertension

authors： Callens-el Amrani F,Paolaggi F,Swynghedauw B

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between arterial function (stiffness and wave reflection) and glomerular hemodynamics. METHODS:In 49 healthy normotensive individuals, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by urinary clearances of 99mTC-DTPA and 131I-hippuran, res...

journal_title：Journal of hypertension

authors： Fesler P,du Cailar G,Ribstein J,Mimran A

更新日期：2010-12-01 00:00:00

abstract：:Blood pressure, plethysmographically determined muscle blood flow in the calf at rest and during maximal dilatation, plasma renin activity, angiotensin II and plasma and urinary aldosterone were determined in normotensive men with a positive family history of hypertension (n = 17) and in an age- and weight-matched con...

journal_title：Journal of hypertension

authors： Gudmundsson O,Andersson OK,Aurell M,Wikstrand JM,Berglund GL

更新日期：1984-06-01 00:00:00