Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine.

Abstract:

:The effects of rilmenidine [(N-dicyclopropylmethyl) amino-2-oxazoline; S 3341], an alpha 2 agonist, on the hypertensive rat heart have been compared with those of propranolol, using a model of deoxycorticosterone acetate (DOCA)-salt hypertension. One week after nephrectomy and initial treatment with DOCA-salt, which was continued for an additional 7 weeks, the two drugs were added to the rats drinking water at a concentration of 10 mg/kg per day for rilmenidine and 15 mg/kg per day for propranolol. Both drugs had a slight and similarly significant antihypertensive effect at their respective concentrations [systolic blood pressure in controls, 141 +/- 15 mmHg (n = 20); after DOCA-salt, 209 +/- 22 mmHg (n = 24); after propranolol, 182 +/- 19 mmHg (n = 20, P less than 0.01); after rilmenidine, 192 +/- 15 mmHg (n = 19, P less than 0.05)]. They also lowered the systolic blood pressure x frequency product (P less than 0.001). Propranolol, but not rilmenidine, significantly reduced the left ventricular weight: body weight ratio [in controls, 2.00 +/- 0.2 mg/g; after DOCA-salt, 3.04 +/- 0.5 mg/g; after propranolol, 2.67 +/- 0.4 mg/g (P less than 0.05); after rilmenidine, 3.13 +/- 0.6 mg/g (P = NS)]. However, both propranolol and rilmenidine reduced left ventricular weight [in controls, 676 +/- 57 mg; after DOCA-salt, 827 +/- 114 mg; after propranolol, 732 +/- 108 mg (P less than 0.01); after rilmenidine, 760 +/- 100 mg (P less than 0.05)].(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Callens-el Amrani F,Paolaggi F,Swynghedauw B

doi

10.1097/00004872-198912000-00004

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

947-54

issue

12

eissn

0263-6352

issn

1473-5598

journal_volume

7

pub_type

杂志文章
  • Multivitamin use and the risk of hypertension in a prospective cohort study of women.

    abstract:OBJECTIVE:Despite the widespread use of multivitamin supplements, little is known regarding their effects on blood pressure (BP) and the development of hypertension. We, therefore, sought to prospectively investigate how multivitamin use was associated with incident hypertension among middle-aged and older women. METH...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000973

    authors: Rautiainen S,Wang L,Lee IM,Manson JE,Gaziano JM,Buring JE,Sesso HD

    更新日期:2016-08-01 00:00:00

  • Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease - the SFC BP multicentre study in China.

    abstract:OBJECTIVES:Cardiovascular dysautonomia can be present at early, late and even prodromal stages of Parkinson's disease. This study aimed to describe the characteristics of 24-h ambulatory blood pressure (BP) monitoring and investigate the frequency of cardiovascular dysautonomia in Parkinson's disease without an abnorma...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002536

    authors: Chen SW,Wang YK,Dou RH,Xie XY,Hu YB,Ding N,Zhang GH,Jing HF,Zhao WD,Xue Y,Li Y,Wang G

    更新日期:2020-11-01 00:00:00

  • Effects of blood-pressure-lowering treatment in hypertension: 9. Discontinuations for adverse events attributed to different classes of antihypertensive drugs: meta-analyses of randomized trials.

    abstract:BACKGROUND:Choice of antihypertensive drugs is also based on the expected burden of adverse events associated with each class of agents, and we have recently identified treatment discontinuation for adverse events as a measure of treatment tolerability frequently reported in randomized controlled trials (RCTs). OBJECT...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HJH.0000000000001052

    authors: Thomopoulos C,Parati G,Zanchetti A

    更新日期:2016-10-01 00:00:00

  • Is atrial natriuretic peptide-guanosine 3',5' cyclic monophosphate coupling a determinant of urinary sodium excretion in essential hypertension?

    abstract:OBJECTIVES:(1) To compare urinary guanosine 3',5' cyclic monophosphate (cyclic GMP) excretion between normotensive subjects and essential hypertensive patients; (2) to determine the influence of changes in sodium intake on urinary cyclic GMP excretion in response to the neutral endopeptidase inhibitor candoxatril in es...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-199204000-00005

    authors: Sagnella GA,Singer DR,Markandu ND,Buckley MG,MacGregor GA

    更新日期:1992-04-01 00:00:00

  • Within-visit BP variability, cardiovascular risk factors, and BP control in central and eastern Europe: findings from the BP-CARE study.

    abstract:INTRODUCTION AND OBJECTIVE:Blood pressure variability (BPV) within 24 h or between visits has been found to represent an independent risk factor for cardiovascular disease. The present study was aimed at determining whether a clinical significance can be given also to the BP variations occurring within a single clinica...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000700

    authors: Grassi G,Seravalle G,Maloberti A,Facchetti R,Cuspidi C,Bombelli M,Laurent S,Redon J,Mancia G

    更新日期:2015-11-01 00:00:00

  • Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells.

    abstract:BACKGROUND:Several cytokines and adhesion molecules released from endothelium play an important role in inflammation, immune responses, and probably atherogenesis. OBJECTIVE:To determine whether the transcription factor nuclear factor-kappaB mediated expression of these genes involved in the inflammatory response of e...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816070-00013

    authors: Tomita N,Morishita R,Tomita S,Yamamoto K,Aoki M,Matsushita H,Hayashi S,Higaki J,Ogihara T

    更新日期:1998-07-01 00:00:00

  • Long-term effects of antihypertensive therapy on cardiovascular events and new-onset diabetes mellitus in high-risk hypertensive patients in Japan.

    abstract:OBJECTIVE:During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year fol...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001780

    authors: Liu J,Yasuno S,Oba K,Konda M,Ichihara C,Kitao H,Kuwabara Y,Ueshima K

    更新日期:2018-09-01 00:00:00

  • Increased platelet size and release reaction in essential hypertension.

    abstract::Basal platelet function was measured in 35 40-year-old men with untreated mild essential hypertension and compared with 44 age-matched normotensive men. The groups differed significantly with respect to platelet size in venous blood (hypertensive, 7.46 +/- 0.10 X 10(-15) l versus normotensive, 7.11 +/- 0.09 X 10(-15) ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Lande K,Os I,Kjeldsen SE,Westheim A,Hjermann I,Eide I,Gjesdal K

    更新日期:1987-08-01 00:00:00

  • The vascular response to vasodilators is related to the membrane content of polyunsaturated fatty acids in hypertensive patients.

    abstract:OBJECTIVE:Abnormal vascular reactivity contributes to the pathophysiology of hypertension and hypertension-related organ damage. As the dietary content of fatty acids may affect the vascular responses, we investigated the relationship of endothelium-independent and endothelium-dependent vasodilation with the fatty acid...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000495

    authors: Colussi G,Catena C,Dialti V,Mos L,Sechi LA

    更新日期:2015-05-01 00:00:00

  • Non-invasive ultrasound assessment of renal artery stenosis by means of the Gosling pulsatility index.

    abstract:OBJECTIVE:To gauge the effectiveness of a new Doppler test for renal artery stenosis (RAS), based on the pulsatility index of the blood flow velocity spectrum within several interlobar arteries of both kidneys. METHODS:Twenty normotensive volunteers and 49 hypertensive patients were investigated with ultrasound. Patie...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Bardelli M,Jensen G,Volkmann R,Aurell M

    更新日期:1992-09-01 00:00:00

  • Plasma arginine-vasopressin levels during infusion of synthetic atrial natriuretic peptide on different sodium intakes in man.

    abstract::The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopress...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198610000-00016

    authors: Gnädinger MP,Weidmann P,Rascher W,Lang RE,Hellmüller B,Uehlinger DE

    更新日期:1986-10-01 00:00:00

  • Alterations in capillary morphology are found in mild blood pressure elevation.

    abstract:OBJECTIVES:Remodeling of small resistance arteries is an early sign of target organ damage in hypertension. Peripheral capillary morphology abnormalities in hypertension are not well studied. The study objective was to determine whether altered capillary morphology is associated with SBP, DBP, or both in individuals wi...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833e113b

    authors: Cheng C,Daskalakis C,Falkner B

    更新日期:2010-11-01 00:00:00

  • High-salt diet increases plasma adiponectin levels independent of blood pressure in hypertensive rats: the role of the renin-angiotensin-aldosterone system.

    abstract:BACKGROUND:High sodium intake is associated with increased risk of end-organ damage, independent of blood pressure (BP) levels. The protective peptide adiponectin may play a role in the pathogenesis of hypertension and particularly in salt-loaded conditions. Furthermore, increased adiponectin levels were observed in sa...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283325eee

    authors: Kamari Y,Shimoni N,Koren F,Peleg E,Sharabi Y,Grossman E

    更新日期:2010-01-01 00:00:00

  • Blood pressure is the major driving force for plaque formation in aortic-constricted ApoE-/- mice.

    abstract:OBJECTIVE:Using an aortic constriction model in mice, we studied whether the increase in pressure or the activation of the renin-angiotensin system (RAS) and its main receptors is the main driving force for plaque progression. METHODS:Male ApoE mice underwent sham surgery or placement of a suprarenal silver clip aroun...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000244949.65040.de

    authors: Johansson ME,Wickman A,Skøtt O,Gan LM,Bergström G

    更新日期:2006-10-01 00:00:00

  • Angiotensin converting enzyme inhibition prevents proto-oncogene expression in the vascular wall after injury.

    abstract:OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

    更新日期:1995-01-01 00:00:00

  • Eplerenone enhances cardioprotective effects of standard heart failure therapy through matricellular proteins in hypertensive heart failure.

    abstract:AIMS:The addition of an aldosterone receptor antagonist on top of current optimal therapy (based on angiotensin II inhibition) has demonstrated an important clinical benefit in heart failure patients with systolic dysfunction. Whether this finding also applies to heart failure patients with preserved systolic function ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328364abd6

    authors: Muñoz-Pacheco P,Ortega-Hernández A,Caro-Vadillo A,Casanueva-Eliceiry S,Aragoncillo P,Egido J,Fernández-Cruz A,Gómez-Garre D

    更新日期:2013-11-01 00:00:00

  • Genetics of experimental hypertension.

    abstract::Experimental models of genetic hypertension are used to develop paradigms to study human essential hypertension while removing some of the complexity inherent in the study of human subjects. Since 1991 several quantitative trait loci responsible for blood pressure regulation have been identified in various rat crosses...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199816121-00003

    authors: Dominiczak AF,Clark JS,Jeffs B,Anderson NH,Negrin CD,Lee WK,Brosnan MJ

    更新日期:1998-12-01 00:00:00

  • Arterial hypertension in urban Africa: an epidemiological study on a representative sample of Dakar inhabitants in Senegal.

    abstract:OBJECTIVE:To assess the prevalence and risk markers of arterial hypertension in the context of a rapidly growing urbanization in Africa. DESIGN:A cross-sectional study was performed on a representative sample of inhabitants of Pikine, an urban suburb of Dakar, Senegal. METHODS:Blood pressure was measured by properly ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Astagneau P,Lang T,Delarocque E,Jeannee E,Salem G

    更新日期:1992-09-01 00:00:00

  • Effect of D3 dopamine receptor on dopamine D4 receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats and spontaneously hypertensive rats.

    abstract:BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000986

    authors: Chen X,Liu Y,Wang WE,Chen C,Ren H,Zheng S,Zhou L,Zeng C

    更新日期:2016-08-01 00:00:00

  • Effects of deoxycorticosterone on arterial wall properties in two-kidney rats.

    abstract::The contribution of deoxycorticosterone acetate (DOCA) and salt to arterial pressure and hypertension-related arterial wall changes was assessed in Wistar rats. One group of two-kidney DOCA-treated animals was given a high salt diet and another group a low salt diet. After 16 weeks of treatment, the animals on low sal...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198610000-00007

    authors: Cox RH

    更新日期:1986-10-01 00:00:00

  • The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat.

    abstract:OBJECTIVE:Corticotrophin (ACTH)-induced hypertension in the rat is prevented by L- but not D-arginine. We examined the effects of exogenous corticosterone in the male Sprague Dawley (SD) rat to determine whether ACTH-induced hypertension is mediated by corticosterone. METHODS:Exogenous corticosterone (10, 20 or 40 mg/...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018120-00020

    authors: Mangos GJ,Turner SW,Fraser TB,Whitworth JA

    更新日期:2000-12-01 00:00:00

  • Bradykinin metabolism in the isolated perfused rabbit heart.

    abstract:BACKGROUND:Bradykinin is a potent cardioprotective hormone, the beneficial role of which in vivo appears to be limited by its rapid metabolism. Inhibitors of peptidases that degrade endogenously formed bradykinin are themselves cardioprotective, presumably by increasing local bradykinin concentrations. As bradykinin-de...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200107000-00015

    authors: Taylor-McCabe KJ,Erşahin C,Simmons WH

    更新日期:2001-07-01 00:00:00

  • Adrenocorticotrophin dose-response relationships in the rat: haemodynamic, metabolic and hormonal effects.

    abstract:OBJECTIVE:To determine adrenocorticotrophin dose-response relationships for increase of blood pressure and metabolic parameters of the Sprague-Dawley rat. METHODS:We injected 120 male Sprague-Dawley rats twice daily subcutaneously for 10 days with 0.5, 1, 5, 50, 100, 200 or 500 microg/kg synthetic adrenocorticotrophin...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816050-00006

    authors: Turner SW,Wen C,Li M,Fraser TB,Whitworth JA

    更新日期:1998-05-01 00:00:00

  • Angiotensin-converting enzyme inhibition restores endothelial but not medial connexin expression in hypertensive rats.

    abstract:OBJECTIVE AND DESIGN:Remodelling in the media and decreases in connexin (Cx) expression and size of endothelial cells occur in the caudal artery of spontaneously hypertensive rats (SHR). The objective of this study was to determine whether similar changes are found in the aorta and whether effects in both aorta and cau...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200502000-00014

    authors: Rummery NM,Grayson TH,Hill CE

    更新日期:2005-02-01 00:00:00

  • Morning pressor surge, blood pressure variability, and arterial stiffness in essential hypertension.

    abstract:OBJECTIVE:An excess morning blood pressure surge (MBPS) may portend an increased cardiovascular risk, but the mechanisms thereof have been little investigated. The link between MBPS, short-term blood pressure (BP) variability, and arterial stiffness has not been entirely defined. METHODS:In 602 consecutive untreated h...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001153

    authors: Pucci G,Battista F,Anastasio F,Schillaci G

    更新日期:2017-02-01 00:00:00

  • Vascular smooth muscle growth in genetic hypertension: evidence for multiple abnormalities in growth regulatory pathways.

    abstract:OBJECTIVE:To gain insight into the mechanisms which contribute to the development of vascular hypertrophy in the spontaneously hypertensive rat (SHR). DESIGN:These experiments were performed under conditions which most closely mimic the growth of smooth muscle in blood vessels, i.e. once cell-cell contact has been ach...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Saltis J,Bobik A

    更新日期:1992-07-01 00:00:00

  • Accuracy of self-monitored blood pressure for diagnosing hypertension in primary care.

    abstract:OBJECTIVE:To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing hypertension in primary care. METHODS:Two hundred and forty-seven consecutive participants with raised (≥130 mmHg systolic) BP measured by their general practitioner from four primary care practices in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000489

    authors: Nunan D,Thompson M,Heneghan CJ,Perera R,McManus RJ,Ward A

    更新日期:2015-04-01 00:00:00

  • Renin-angiotensin system component expression in the HL-1 atrial cell line and in a pig model of atrial fibrillation.

    abstract:OBJECTIVES:Local atrial tissue angiotensin II (AngII) level is elevated in atrial fibrillation (AF), but the mechanism is unknown. We hypothesized that atrial myocytes express all components of the renin-angiotensin system (RAS) and investigated whether rapid depolarization alone is sufficient to increase paracrine Ang...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282f34a4a

    authors: Tsai CT,Lai LP,Hwang JJ,Chen WP,Chiang FT,Hsu KL,Tseng CD,Tseng YZ,Lin JL

    更新日期:2008-03-01 00:00:00

  • Uric acid and other renal function parameters in patients with stable angina pectoris participating in the ACTION trial: impact of nifedipine GITS (gastro-intestinal therapeutic system) and relation to outcome.

    abstract:BACKGROUND:Little data is available concerning the prognostic implications of renal function abnormalities, their evolution over time and the effects of nifedipine on such abnormalities in patients with stable angina pectoris. METHODS:The previously published ACTION trial compared long-acting nifedipine GITS 60 mg onc...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/HJH.0b013e3281c49d93

    authors: Ruilope LM,Kirwan BA,de Brouwer S,Danchin N,Fox KA,Wagener G,Segura J,Poole-Wilson PA,Lubsen J,ACTION investigators.

    更新日期:2007-08-01 00:00:00

  • The impact of genetic hypertension on insulin secretion and glucoregulatory control in vivo: studies with the TGR(mRen2)27 transgenic rat.

    abstract:OBJECTIVE:To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. DESIGN:Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperin...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816030-00014

    authors: Holness MJ,Sugden MC

    更新日期:1998-03-01 00:00:00