Internally quenched fluorogenic substrates for angiotensin I-converting enzyme.

abstract：BACKGROUND:The usefulness of the hypertensive retinopathy classification by Keith-Wagener-Barker (KWB) in clinical practice remains controversial. The simplified Mitchell-Wong grading, combining the two initial KWB' grades in one stage, is proposed as an alternative method; both systems are poorly validated regarding t...

journal_title：Journal of hypertension

authors： Aissopou EK,Papathanassiou M,Nasothimiou EG,Konstantonis GD,Tentolouris N,Theodossiadis PG,Papaioannou TG,Sfikakis PP,Protogerou AD

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To examine the regulation by angiotensin II and by steroids of the expression of the angiotensin II AT1a and AT1b receptor genes in rat hearts. METHODS:Endogenous levels of angiotensin II in the rats were increased either by unilateral 0.2-mm renal artery clips or by subcutaneous infusions of frusemide (12 m...

journal_title：Journal of hypertension

authors： Della Bruna R,Ries S,Himmelstoss C,Kurtz A

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To examine the influence of genetic factors on plasma leptin levels. SUBJECTS AND METHODS:We measured plasma leptin levels, body mass index and body fat distribution in healthy young female monozygotic (n = 19) and dizygotic (n = 14) twins. The twin zygosity was verified by determination of short tandem repe...

journal_title：Journal of hypertension

authors： Narkiewicz K,Szczech R,Winnicki M,Chrostowska M,Pawlowski R,Lysiak-Szydlowska W,Choe I,Kato M,Sivitz WI,Krupa-Wojciechowska B,Somers VK

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of the sympathetic nervous system to the hypertension in patients with longstanding essential hypertension. DESIGN:Overall sympathetic function, presynaptic adrenoceptors and neuronal re-uptake were examined after withdrawal of medication for at least 3 weeks in eight patients with...

journal_title：Journal of hypertension

authors： Chang PC,Kriek E,van Brummelen P

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...

journal_title：Journal of hypertension

authors： Raji A,Williams GH,Jeunemaitre X,Hopkins PN,Hunt SC,Hollenberg NK,Seely EW

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty ac...

journal_title：Journal of hypertension

authors： Miura K,Stamler J,Brown IJ,Ueshima H,Nakagawa H,Sakurai M,Chan Q,Appel LJ,Okayama A,Okuda N,Curb JD,Rodriguez BL,Robertson C,Zhao L,Elliott P,INTERMAP Research Group.

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To gain insight into the mechanisms which contribute to the development of vascular hypertrophy in the spontaneously hypertensive rat (SHR). DESIGN:These experiments were performed under conditions which most closely mimic the growth of smooth muscle in blood vessels, i.e. once cell-cell contact has been ach...

journal_title：Journal of hypertension

authors： Saltis J,Bobik A

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the influence of renal sympathetic nerves on the production of interleukin (IL)-6 in the kidney of normotensive Wistar rats and spontaneously hypertensive rats (SHR). DESIGN:In acute studies, the left kidney was exposed and the renal nerves were electrically stimulated to...

journal_title：Journal of hypertension

authors： Nakamura A,Kohsaka T,Johns EJ

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Arterial stiffness is an independent predictor of cardiovascular events and mortality in hypertensive patients. The influence of different antihypertensive drug classes on improving arterial stiffness beyond blood pressure reduction is not widely available. We aimed to determine whether the artery stiffness ...

journal_title：Journal of hypertension

authors： Ong KT,Delerme S,Pannier B,Safar ME,Benetos A,Laurent S,Boutouyrie P,investigators.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...

journal_title：Journal of hypertension

authors： Peters R,Booth A,Peters J

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Urocortin 1 (Ucn1) and the sympathetic nervous system both participate in cardiac and circulatory regulation, but little is known about their possible interactions. METHODS:We report the effects of Ucn1 on the cardiac sympathetic nerve activity (CSNA), haemodynamics and plasma catecholamines in normal sheep...

journal_title：Journal of hypertension

authors： Charles CJ,Jardine DL,Nicholls MG,Rademaker MT,Richards AM

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Circulating biomarkers of endothelial dysfunction and inflammation are elevated in late pregnancy in women with preeclampsia. We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia. METHODS:In a prospective longitudinal s...

journal_title：Journal of hypertension

authors： Carty DM,Anderson LA,Freeman DJ,Welsh PI,Brennand JE,Dominiczak AF,Delles C

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS:We investigated the autonomic cardiovascular control of 15 women w...

journal_title：Journal of hypertension

authors： Jacob G,Barbic F,Glago M,Dipaola F,Porta A,Furlan R

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:The antihypertensive effect of thiazide diuretics in angiotensin II induced hypertension has never been characterized. In the current study, we sought to determine the effect of a thiazide diuretic on arterial pressure and renal fluid excretion in rats receiving a chronic intravenous infusion of angiotensin ...

journal_title：Journal of hypertension

authors： Ballew JR,Fink GD

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:Exercise training has antihypertensive and renoprotective effects in humans and rats. However, the effects of exercise training on renal disorders that occur with salt-sensitive hypertension remains unclear. The study aim was to investigate the effects and mechanisms of exercise training on renal function in ...

journal_title：Journal of hypertension

authors： Ogawa Y,Takahashi J,Sakuyama A,Xu L,Miura T,Muroya Y,Ito D,Kohzuki M,Ito O

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between hematocrit, blood pressure and other known cardiovascular risk factors. DESIGN:The Tecumseh Blood Pressure Study includes a cohort of subjects of average age 29.5 years (346 male, 277 female) who reside in Tecumseh, Michigan, USA. METHODS:The body weight; home, work a...

journal_title：Journal of hypertension

authors： Smith S,Julius S,Jamerson K,Amerena J,Schork N

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVES:Current evidence demonstrates that both genetic and environmental factors influence blood pressure. The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hype...

journal_title：Journal of hypertension

authors： Binder A,Garcia E,Wallace C,Gbenga K,Ben-Shlomo Y,Yarnell J,Brown P,Caulfield M,Skrabal F,Kotanko P,Munroe P

更新日期：2006-03-01 00:00:00

abstract：:We have demonstrated high concentrations of inactive renin in mouse amniotic fluid compared with mouse plasma and other organs. Its molecular weight was similar to that of prorenin from the mouse submaxillary gland (42 000 daltons). The activated renin had a Km value of 1.48 greater than M which is identical to that o...

journal_title：Journal of hypertension

authors： Jacobsen J,Poulsen K

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:To assess the trends in blood pressure (BP) and in body mass index (BMI) in the hypertensive and normotensive population in Finland during 1982-1997. DESIGN:Four independent cross-sectional standardized population surveys were conducted in 1982, 1987, 1992 and 1997. SETTING:The provinces of North Karelia an...

journal_title：Journal of hypertension

authors： Kastarinen MJ,Nissinen AM,Vartiainen EA,Jousilahti PJ,Korhonen HJ,Puska PM,Tuomilehto

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:In arteries, agonists such as acetylcholine release an endothelium-derived hyperpolarizing factor (EDHF) that is neither nitric oxide nor prostacyclin. OBJECTIVES:To examine the responses to acetylcholine in segments of forearm veins from patients with chronic renal failure who either had never received dia...

journal_title：Journal of hypertension

authors： Martinez-León JB,Segarra G,Medina P,Vila JM,Lluch P,Peiró M,Otero E,Lluch S

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To estimate the compliance rate and associated factors among a population of hypertensive subjects registered in hospitals and primary health care centres. DESIGN:A prospective study carried out on a sample of hypertensive subjects. METHOD:Compliance with treatment by the study sample was measured using the...

journal_title：Journal of hypertension

authors： Khalil SA,Elzubier AG

更新日期：1997-05-01 00:00:00

abstract：:Brachial and carotid artery diameters, blood velocities and blood flows were determined by a pulsed-Doppler flowmeter in 22 normotensive and 74 mild to moderate essential hypertensive subjects, aged 46 +/- 8 years. The product age x MAP/1000 (where MAP is mean arterial blood pressure), called 'arterial age' (expressed...

journal_title：Journal of hypertension

authors： Nguyen PC,Levenson J,Simon A

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:Cardiovascular risk prediction is deemed fundamental and the assessment of organ damage is emerging as a potentially 'downstream' picture of individual risk. Our aim was to assess the feasibility and value of prediction of coronaropathy [coronary artery disease (CAD)] of integrated cardiovascular ultrasound e...

journal_title：Journal of hypertension

authors： Moreo A,Gaibazzi N,Faggiano P,Mohammed M,Carerj S,Mureddu G,Pigazzani F,Muiesan L,Salvetti M,Cesana F,Faden G,Facchetti R,Giannattasio C,Rigo F

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Genetically hypertensive rats provide an excellent model to investigate the genetic mechanisms of hypertension. We previously identified three differentially expressed genes, Acadsb (short/branched chain acyl-CoA dehydrogenase), Comt (catecholamine-O-methyltransferase), and Pnpo (pyridoxine 5'-phosphate oxid...

journal_title：Journal of hypertension

authors： Kamide K,Kokubo Y,Yang J,Matayoshi T,Inamoto N,Takiuchi S,Horio T,Miwa Y,Yoshii M,Tomoike H,Tanaka C,Banno M,Okuda T,Kawano Y,Miyata T

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To compare blood pressure (BP) in adolescence (11-12 years) among the offspring of preeclamptic and normotensive pregnancies. METHOD:SBP and DBP of 181 girls and boys born after pregnancies with preeclampsia were measured and compared with the BP of 356 age-matched girls and boys of normotensive pregnancies....

journal_title：Journal of hypertension

authors： Øglaend B,Forman MR,Romundstad PR,Nilsen ST,Vatten LJ

更新日期：2009-10-01 00:00:00

abstract：:The contribution of deoxycorticosterone acetate (DOCA) and salt to arterial pressure and hypertension-related arterial wall changes was assessed in Wistar rats. One group of two-kidney DOCA-treated animals was given a high salt diet and another group a low salt diet. After 16 weeks of treatment, the animals on low sal...

journal_title：Journal of hypertension

authors： Cox RH

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:To determine the plasma cofactor which is required by diuretics (hydrochlorothiazide, chlorthalidone, indapamide, and furosemide) for direct vasorelaxant effects in vitro. DESIGN:A randomized, double-blind, vehicle-control design was used to avoid experimenter bias. METHODS:We plotted concentration-response...

journal_title：Journal of hypertension

authors： Abrahams Z,Pang MY,Lam EK,Wright JM

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Besides its capacity to regulate organ and tissue growth, the insulin-like growth factor I exerts biologic actions that resemble those of insulin. Tissue access of the factor depends on the distribution of the circulating bound factor between its binding protein 3 that remains within the intravascular space ...

journal_title：Journal of hypertension

authors： Laviades C,Gil MJ,Monreal I,González A,Díez J

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The aim of this cross-sectional study was to investigate the association between consumption of sugar-sweetened and diet soft drinks with blood pressure (BP) in adolescents. METHODS:Fifth graders of 20 public schools were invited to participate in an intervention aimed at behavioral dietary changes and had t...

journal_title：Journal of hypertension

authors： Souza Bda S,Cunha DB,Pereira RA,Sichieri R

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Losartan is a new angiotensin II type 1 (AT1) receptor antagonist and an antihypertensive drug. Nitric oxide is a vasodilating agent and endothelins are powerful vasoconstrictors, both synthesized by and released from endothelial cells. Angiotensin II promotes the release of endothelins in cultured cells and...

journal_title：Journal of hypertension

authors： Sacerdote A,Cosenzi A,Bocin E,Molino R,Seculin P,Plazzotta N,Luxich E,Bellini G

更新日期：1995-12-01 00:00:00