Power spectra of arterial pressure and heart rate in streptozotocin-induced diabetes in rats.

Abstract:

BACKGROUND:Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. OBJECTIVE:To examine chronic diabetic rats to determine the autonomic modulation of arterial pressure and heart rate variabilities in the time and frequency domain. MATERIALS AND METHODS:Diabetes was induced in rats by a single injection of streptozotocin, and 30 min of pulsatile arterial pressure was recorded in conscious rats, 5, 10-20 days and 12-18 weeks after the streptozotocin injection. Control rats were injected with vehicle. Beat-by-beat systolic arterial pressure and heart rate were obtained from pulsatile pressure. The spectral density powers of systolic arterial pressure and heart rate were calculated using fast Fourier transformation, and integrated in low-(0.015-0.25 Hz), mid- (0.25-0.75 Hz) and high- (0.75-3.0 Hz) frequency bands. The standard deviations of systolic arterial pressure and heart rate were also calculated. RESULTS:Basal systolic arterial pressure and heart rate were reduced in diabetic animals studied 10-20 days and 12-18 weeks after the streptozotocin injection. The standard deviations of systolic arterial pressure and heart rate were also reduced in the chronically diabetic animals. Diabetes reduced low- and mid-frequency variability but not the high-frequency variability of systolic arterial pressure. The low-frequency variability, but not the mid-frequency variability, of the heart rate was also reduced, while the high-frequency variability of the heart rate was reduced in the more chronically diabetic rats. CONCLUSION:Our findings that the mid-frequency band variability of arterial pressure was reduced in diabetic patients suggest that sympathetic modulation of the cardiovascular system is impaired, corroborating other studies in such patients using this and other approaches.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Fazan R Jr,Dias da Silva VJ,Ballejo G,Salgado HC

doi

10.1097/00004872-199917040-00006

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

489-95

issue

4

eissn

0263-6352

issn

1473-5598

journal_volume

17

pub_type

杂志文章
  • Incidence of hypertension in individuals with different blood pressure salt-sensitivity: results of a 15-year follow-up study.

    abstract:OBJECTIVE:To evaluate the incidence of hypertension and the rate of decline in renal function in a sample of 47 Olivetti Heart Study (OHS) participants whose blood pressure (BP) salt-sensitivity and renal tubular sodium handling had been assessed in 1987-88. METHODS:During the 2002-04 OHS follow-up examination, medica...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3281139ebd

    authors: Barba G,Galletti F,Cappuccio FP,Siani A,Venezia A,Versiero M,Della Valle E,Sorrentino P,Tarantino G,Farinaro E,Strazzullo P

    更新日期:2007-07-01 00:00:00

  • Association of genetic polymorphisms of ACADSB and COMT with human hypertension.

    abstract:OBJECTIVES:Genetically hypertensive rats provide an excellent model to investigate the genetic mechanisms of hypertension. We previously identified three differentially expressed genes, Acadsb (short/branched chain acyl-CoA dehydrogenase), Comt (catecholamine-O-methyltransferase), and Pnpo (pyridoxine 5'-phosphate oxid...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3280103a40

    authors: Kamide K,Kokubo Y,Yang J,Matayoshi T,Inamoto N,Takiuchi S,Horio T,Miwa Y,Yoshii M,Tomoike H,Tanaka C,Banno M,Okuda T,Kawano Y,Miyata T

    更新日期:2007-01-01 00:00:00

  • Kinetic study of the Ca2+ pump in erythrocytes from essential hypertensive patients.

    abstract::Ca2+ pump kinetics were investigated in erythrocytes from 22 essential hypertensive patients and 20 normotensive controls (under initial-rate and steady-state conditions, using Sr2+ as a Ca2+ analogue). The mean value of the apparent dissociation constant for total internal Ca2+ (KCa) was slightly but significantly in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: de la Sierra A,Hannaert P,Ollivier JP,Senn N,Garay R

    更新日期:1990-03-01 00:00:00

  • Nailfold capillary density in salt-sensitive and salt-resistant borderline hypertension.

    abstract:OBJECTIVE:Nailfold capillary density was measured at rest and after 4 min circulatory arrest in order to investigate the relationship between sodium-sensitive hypertension and microvessel density. DESIGN:Seventeen sodium-sensitive and 28 sodium-resistant young borderline hypertensive males and 10 normotensive controls...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Draaijer P,de Leeuw PW,van Hooff JP,Leunissen KM

    更新日期:1993-11-01 00:00:00

  • Anthropometric and lifestyle factors associated with white-coat, masked and sustained hypertension in a Chinese population.

    abstract:OBJECTIVE:We investigated to what extent anthropometric and lifestyle factors contributed to the classification of Chinese individuals into groups with white-coat, masked and sustained hypertension (HT). METHODS:We measured the office and ambulatory blood pressure (BP) in 694 Chinese enrolled in the JingNing populatio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282efeee7

    authors: Wang GL,Li Y,Staessen JA,Lu L,Wang JG

    更新日期:2007-12-01 00:00:00

  • An index of peripheral vascular resistance.

    abstract::An index of peripheral vascular resistance, derived from directly measured arterial pressure, has been developed and tested in an animal model. Assuming a mono-exponential character for diastole, the time constant for direct arterial pressure decay in the central aorta was obtained with high-fidelity recording techniq...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198512000-00009

    authors: Walsh JT,Mehta SK,Topham WS,Goldberg AD

    更新日期:1985-12-01 00:00:00

  • Hypertension without cardiac hypertrophy does not induce a cardiac baroreflex deficit.

    abstract:OBJECTIVE:To investigate the effects of prolonged hypertension in the absence of cardiac hypertrophy on the blood pressure-heart rate reflex during acute and chronic NO synthase blockade. METHODS:Male Wistar rats were treated acutely with N omega-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg intraperitoneally) or ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199610000-00009

    authors: Banting JD,Wiseman SL,Adams MA

    更新日期:1996-10-01 00:00:00

  • The predictive role of systolic, diastolic and mean blood pressures on cardiovascular and all causes of death.

    abstract::Systolic (SBP), diastolic (DBP) and mean [MBP = diastolic + 1/3 (systolic - diastolic)] blood pressures were compared as predictors of all causes of death (ALL) and of deaths from atherosclerotic cardiovascular disease (ACVD) in 2480 men, aged 40-59 years, belonging to three cohorts followed up for 20 years. Both univ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198907000-00011

    authors: Menotti A,Seccareccia F,Giampaoli S,Giuli B

    更新日期:1989-07-01 00:00:00

  • The accuracy of automated blood pressure measuring devices in patients with controlled atrial fibrillation.

    abstract:OBJECTIVE:To determine whether automated blood pressure measuring devices can measure blood pressure accurately in patients with atrial fibrillation. DESIGN:Comparison of the accuracy of two electronic sphygmomanometers [Takeda UA-751 (Takeda) and Copal UA-251 (Copal)] and two ambulatory blood pressure monitors [Accut...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Stewart MJ,Gough K,Padfield PL

    更新日期:1995-03-01 00:00:00

  • Internally quenched fluorogenic substrates for angiotensin I-converting enzyme.

    abstract:OBJECTIVE:Development of internally quenched fluorogenic substrates for sensitive and continuous assays of angiotensin I-converting enzyme (ACE). DESIGN:We synthesized internally quenched fluorogenic bradykinin-related peptides introducing Abz (ortho-aminobenzoic acid) and EDDnp (N-[2,4-dinitrophenyl]-ethylenediamine)...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917050-00010

    authors: Araujo MC,Melo RI,Del Nery E,Alves MF,Juliano MA,Casarini DE,Juliano L,Carmona AK

    更新日期:1999-05-01 00:00:00

  • Molecular biology of smooth muscle.

    abstract::Several myosin isoforms are expressed in smooth muscle, based upon both heavy and light chain polymorphisms. These myosin isoenzymes reveal distinct detachment rate constants, thus regulating the responsiveness of the VSMC contractile apparatus to Ca2+, as well as its energetical and mechanical behavior. ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199205000-00002

    authors: Morano IL

    更新日期:1992-05-01 00:00:00

  • Multiparametric carotid and cardiac ultrasound compared with clinical risk scores for the prediction of angiographic coronary artery disease: a multicenter prospective study.

    abstract:OBJECTIVE:Cardiovascular risk prediction is deemed fundamental and the assessment of organ damage is emerging as a potentially 'downstream' picture of individual risk. Our aim was to assess the feasibility and value of prediction of coronaropathy [coronary artery disease (CAD)] of integrated cardiovascular ultrasound e...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/HJH.0000000000000543

    authors: Moreo A,Gaibazzi N,Faggiano P,Mohammed M,Carerj S,Mureddu G,Pigazzani F,Muiesan L,Salvetti M,Cesana F,Faden G,Facchetti R,Giannattasio C,Rigo F

    更新日期:2015-06-01 00:00:00

  • Evaluating interventions to reduce central aortic pressure, arterial stiffness and morbidity--mortality.

    abstract::Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e328353e523

    authors: Williams B

    更新日期:2012-06-01 00:00:00

  • Assessment of prevalence of left ventricular hypertrophy in hypertension.

    abstract::The reported prevalence of left ventricular hypertrophy (LVH) in human hypertension is much lower than that among animals with experimental hypertension. With current methods of determining left ventricular mass by M-mode echocardiography, the standard error of a single estimate is high and consequently so is the SD o...

    journal_title:Journal of hypertension

    pub_type: 社论,评审

    doi:10.1097/00004872-199816060-00001

    authors: Korner PI,Jennings GL

    更新日期:1998-06-01 00:00:00

  • Simultaneous radioimmunoassay of six angiotensin peptides in arterial and venous plasma of man.

    abstract::Using antibodies raised against angiotensin I and II, and high-performance liquid chromatography (HPLC) of plasma extracts, we have quantified six angiotensin peptides in venous (cubital vein) and arterial (brachial) plasma of normal male subjects. The concentrations of venous plasma (fmol/ml, mean +/- s.d., n = 29) f...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199002000-00011

    authors: Campbell DJ,Kladis A

    更新日期:1990-02-01 00:00:00

  • Enhanced blood pressure response to dietary salt in elderly women, especially those with small waist: hip ratio.

    abstract:OBJECTIVE:To determine the blood pressure responses in elderly normotensive men and women to dietary sodium and to the diunsaturated fatty acid dihomogammalinolenic acid (DGLA), which is derived from linoleic acid. DESIGN:Blood pressure responses were assessed in 66 subjects (36 male, 30 female; mean age 65 years) on ...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-199312000-00011

    authors: Nestel PJ,Clifton PM,Noakes M,McArthur R,Howe PR

    更新日期:1993-12-01 00:00:00

  • Obesity and daytime pulse pressure are predictors of left ventricular hypertrophy in true normotensive individuals.

    abstract:OBJECTIVE:To investigate predictors of left ventricular mass corrected for height2.7 (LVMI) and left ventricular hypertrophy in patients who were found to be normotensive with both office and 24-h ambulatory blood pressure (BP) measurements. METHODS:A total of 805 consecutive patients were analyzed. All patients under...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e3283370e5e

    authors: Kotsis V,Stabouli S,Toumanidis S,Tsivgoulis G,Rizos Z,Trakateli C,Zakopoulos N,Sion M

    更新日期:2010-05-01 00:00:00

  • Alterations in erythrocyte Na+,K+-cotransport in normal and hypertensive human pregnancy.

    abstract::Many physiological variables known or thought to affect erythrocyte Na+,K+-cotransport are altered in pregnancy. The interrelationships of Na+,K+-cotransport and pregnancy were therefore examined. Values were elevated by more than 30% in both second and third trimesters with a return towards non-pregnant levels in the...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Gallery ED,Esber RP,Brown MA,Hawkins MR,Ross M

    更新日期:1988-02-01 00:00:00

  • Patients' and healthcare providers' perceptions and practices regarding hypertension, pharmacy-based care, and mHealth in Lagos, Nigeria: a mixed methods study.

    abstract:BACKGROUND:In sub-Saharan Africa, cardiovascular disease is becoming a leading cause of death, with high blood pressure as number one risk factor. In Nigeria, access and adherence to hypertension care are poor. A pharmacy-based hypertension care model with remote monitoring by cardiologists through mHealth was piloted ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001877

    authors: Cremers AL,Alege A,Nelissen HE,Okwor TJ,Osibogun A,Gerrets R,Van't Hoog AH

    更新日期:2019-02-01 00:00:00

  • Pinacidil--effects on function and perfusion of normal kidneys and renal xenografts.

    abstract::Pinacidil is a new vasodilating compound claimed to increase renal perfusion and function. A preliminary study showed that pinacidil did not sustain renal perfusion through a period of increasing renal vascular resistance in pig-to-rabbit renal xenotransplantation. Accordingly, the effect of pinacidil on renal functio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198312000-00006

    authors: Dieperink H,Kemp E,Jørgensen KA,Starklint H

    更新日期:1983-12-01 00:00:00

  • Baroreflex sensitivity and sympatho-vagal balance during intradialytic hypotensive episodes.

    abstract:OBJECTIVES:The role of the baroreflex function in the pathogenesis of hemodialysis-associated hypotension is controversial. Complex demodulation technique (CDM), providing continuous assessment of the amplitude of cardiovascular oscillation over time, is particularly suitable to assess dynamic changes in autonomic nerv...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328332b7af

    authors: Sapoznikov D,Backenroth R,Rubinger D

    更新日期:2010-02-01 00:00:00

  • Pulse wave velocity is increased in patients with transient myocardial ischemia.

    abstract:OBJECTIVE:We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischem...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000244959.92856.7e

    authors: Baulmann J,Homsi R,Uen S,Düsing R,Fimmers R,Vetter H,Mengden T

    更新日期:2006-10-01 00:00:00

  • The change in arterial stiffness over the cardiac cycle rather than diastolic stiffness is independently associated with left ventricular mass index in healthy middle-aged individuals.

    abstract:BACKGROUND:The current standard for arterial stiffness assessment, aortic pulse wave velocity (aPWV), is measured at diastolic pressure. Arterial stiffness, however, is pressure dependent. At the carotid artery level, the degree of this dependency can be quantified as the difference (ΔPWV) between systolic and diastoli...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32834e4b75

    authors: Hermeling E,Vermeersch SJ,Rietzschel ER,de Buyzere ML,Gillebert TC,van de Laar RJ,Ferreira I,Hoeks AP,van Bortel LM,Reneman RS,Segers P,Reesink KD

    更新日期:2012-02-01 00:00:00

  • Prostaglandins and renal function in hypertensive patients with unilateral renal artery stenosis and patients with essential hypertension.

    abstract:OBJECTIVE:This study was designed to compare the effects of prostaglandin synthesis inhibition on calculated preglomerular and postglomerular resistance in hypertensive patients with unilateral renal artery stenosis (RAS) and in patients with essential hypertension. DESIGN AND METHODS:Sixteen patients with suspected r...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199606000-00013

    authors: Milot A,Lambert R,Lebel M,Cusson JR,Larochelle P

    更新日期:1996-06-01 00:00:00

  • Relationship between inappropriate left ventricular hypertrophy and ejection fraction independent of absolute or indexed mass in a community sample of black African ancestry.

    abstract:AIM:We determined whether left ventricular hypertrophy (LVH) which exceeds that predicted from workload [inappropriate LV mass (LVM(inappr))] is associated with reduced left ventricle (LV) systolic chamber function independent of and more closely than absolute or indexed left ventricular mass (LVM). METHODS:In 626 ran...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835a8696

    authors: Libhaber CD,Norton GR,Maseko MJ,Majane OH,Millen AM,Maunganidze F,Michel FS,Brooksbank R,Libhaber E,Sareli P,Woodiwiss AJ

    更新日期:2013-01-01 00:00:00

  • Isolated diastolic hypertension as defined by the 2017 American College of Cardiology/American Heart Association blood pressure guideline and incident cardiovascular events in Chinese.

    abstract:OBJECTIVE:The new arterial hypertension guidelines by the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) changed the definition of isolated diastolic hypertension (IDH). We assessed and compared in a Chinese population the IDH prevalence, newly defined by the 2017 ACC/AHA guidelines versus t...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002659

    authors: Wu S,Ji C,Shi J,Chen S,Huang Z,Jonas JB

    更新日期:2020-10-06 00:00:00

  • Systemic and regional haemodynamic effects of renal denervation in spontaneously hypertensive rats.

    abstract::Systemic and regional haemodynamic effects of renal denervation were evaluated in adult (six-month-old) male spontaneously hypertensive rats (SHR) using the Fick procedure and electromagnetic flowmetry technique. Renal denervation (bilateral, 10% phenol in ethanol), performed five to eight days before the experiment, ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198312000-00010

    authors: Lee JY,Walsh GM

    更新日期:1983-12-01 00:00:00

  • The combined effects of aerobic exercise and alcohol restriction on blood pressure and serum lipids: a two-way factorial study in sedentary men.

    abstract:OBJECTIVES:To determine whether vigorous exercise and alcohol restriction have additive and independent effects in reducing blood pressure in sedentary male alcohol drinkers. Also to assess whether 4 weeks of vigorous exercise could offset the fall in high-density lipoprotein cholesterol (HDL-cholesterol) usually obser...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-199302000-00012

    authors: Cox KL,Puddey IB,Morton AR,Beilin LJ,Vandongen R,Masarei JR

    更新日期:1993-02-01 00:00:00

  • Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women.

    abstract:OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018090-00005

    authors: Iso H,Harada S,Shimamoto T,Sato S,Kitamura A,Sankai T,Tanigawa T,Iida M,Komachi Y

    更新日期:2000-09-01 00:00:00

  • Prevalence of proximal ascending aorta and target organ damage in hypertensive patients: the multicentric ARGO-SIIA project (Aortic RemodellinG in hypertensiOn of the Italian Society of Hypertension).

    abstract:AIM:The aim of this study was to assess the prevalence of ascending aortic dilatation and to evaluate the possible association between proximal aorta dilatation and structural or functional markers of cardiac organ damage in hypertensive patients. BACKGROUND:Dilatation of the sinus of valsalva (SoV) is a common findin...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/HJH.0000000000001844

    authors: Milan A,Degli Esposti D,Salvetti M,Izzo R,Moreo A,Pucci G,Bruno G,Pareo I,Parini A,Paini A,Laurino FI,Sormani P,Sgariglia R,Avenatti E,De Luca N,Working Group on Heart and Hypertension of the Italian Society of Hypertension

    更新日期:2019-01-01 00:00:00