The combined effects of aerobic exercise and alcohol restriction on blood pressure and serum lipids: a two-way factorial study in sedentary men.

Abstract:

OBJECTIVES:To determine whether vigorous exercise and alcohol restriction have additive and independent effects in reducing blood pressure in sedentary male alcohol drinkers. Also to assess whether 4 weeks of vigorous exercise could offset the fall in high-density lipoprotein cholesterol (HDL-cholesterol) usually observed after alcohol restriction. DESIGN:Seventy-five sedentary men were randomly assigned to drink low-alcohol beer or continue their normal drinking habits. Within these two groups subjects were further assigned either to a vigorous exercise programme of three 30-min sessions a week of cycling at 60-70% of maximum workload or to a control light-exercise programme. RESULTS:Seventy-two subjects completed the trial. Alcohol consumption fell by 85% in the low-alcohol group. Fitness increased by 10% following vigorous exercise, with a significant improvement in maximum oxygen uptake. After adjustment for weight loss, a significant effect of alcohol restriction in reducing both systolic and diastolic blood pressure was demonstrated. There was no effect of vigorous exercise on blood pressure. Serum total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B were not influenced by alcohol restriction or vigorous exercise. However, alcohol restriction significantly reduced triglyceride, HDL-cholesterol, its subfractions HDL2-cholesterol and HDL3-cholesterol, and its major apolipoproteins apo A-I and apo A-II. These reductions were unaffected by moderate exercise. CONCLUSIONS:This study provides further evidence that alcohol restriction results in reductions in blood pressure in men who are regular alcohol drinkers. However, a simultaneous increase in fitness did not lead to lower blood pressures than those achieved with alcohol restriction alone, and was unable to offset alcohol-related falls in HDL-cholesterol, its subfractions and its major apolipoproteins.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Cox KL,Puddey IB,Morton AR,Beilin LJ,Vandongen R,Masarei JR

doi

10.1097/00004872-199302000-00012

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

191-201

issue

2

eissn

0263-6352

issn

1473-5598

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Jansson T,Lambert GW

    更新日期:1999-09-01 00:00:00

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    abstract:BACKGROUND:Inflammatory processes may play a pivotal role in the pathogenesis of cerebrovascular injury in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP). Thromboxane A2 (TP) receptor stimulation by 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) is involved in the process of vascular inflammation. O...

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    更新日期:2007-04-01 00:00:00

  • A systematic review of calcium channel blocker use and cognitive decline/dementia in the elderly.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

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    authors: Peters R,Booth A,Peters J

    更新日期:2014-10-01 00:00:00

  • PROGRESS - Perindopril Protection Against Recurrent Stroke Study: characteristics of the study population at baseline. Progress Management Committee.

    abstract:OBJECTIVE:The primary aim of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) is to determine the effects of a long-term angiotensin converting enzyme (ACE)-inhibitor-based blood-pressure-lowering regimen on the risk of stroke among patients with a history of stroke or transient ischaemic attack (TI...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1999-11-01 00:00:00

  • Isolation of T-cell clones with specificity for arterial antigen from spontaneously hypertensive rats.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199312000-00002

    authors: Ofosu-Appiah W,Ruggiero C,Huang LY

    更新日期:1993-12-01 00:00:00

  • Withdrawal of hormonal therapy for 4 weeks decreases arterial compliance in postmenopausal women.

    abstract:BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    更新日期:1999-03-01 00:00:00

  • Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    更新日期:2012-07-01 00:00:00

  • Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    authors: Furuhashi M,Ura N,Takizawa H,Yoshida D,Moniwa N,Murakami H,Higashiura K,Shimamoto K

    更新日期:2004-10-01 00:00:00

  • Multiparametric carotid and cardiac ultrasound compared with clinical risk scores for the prediction of angiographic coronary artery disease: a multicenter prospective study.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/HJH.0000000000000543

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  • Thiazide diuretics, endothelial function, and vascular oxidative stress.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    更新日期:2008-03-01 00:00:00

  • Lessons from an unpleasant surprise: a biochemical strategy for the diagnosis of pheochromocytoma.

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    pub_type: 杂志文章

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  • A population-based study of reduced sleep duration and hypertension: the strongest association may be in premenopausal women.

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    pub_type: 杂志文章

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    更新日期:2010-05-01 00:00:00

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    更新日期:2020-01-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2018-01-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    更新日期:2017-05-01 00:00:00

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    pub_type: 杂志文章

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    authors: Bustos P,Amigo H,Bangdiwala SI,Pizarro T,Rona RJ

    更新日期:2016-06-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2010-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1996-03-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198704000-00014

    authors: Tamura M,Inagami T,Kinoshita T,Kuwano H

    更新日期:1987-04-01 00:00:00

  • Adjustment for current weight and the relationship between birth weight and blood pressure in childhood.

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-200018080-00003

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    更新日期:2000-08-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199917080-00004

    authors: Millar JA,Lever AF,Burke V

    更新日期:1999-08-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Agewall S,Wikstrand J,Dahlöf C,Fagerberg B

    更新日期:1995-12-01 00:00:00

  • Multivitamin use and the risk of hypertension in a prospective cohort study of women.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000973

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    更新日期:2016-08-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198807000-00006

    authors: Chao J,Chao L

    更新日期:1988-07-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001012

    authors: van Mil AC,Greyling A,Zock PL,Geleijnse JM,Hopman MT,Mensink RP,Reesink KD,Green DJ,Ghiadoni L,Thijssen DH

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    pub_type: 杂志文章

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  • Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure.

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    pub_type: 杂志文章

    doi:10.1097/00004872-200104000-00014

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000133719.94075.e2

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    更新日期:2004-08-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Stewart MJ,Gough K,Padfield PL

    更新日期:1995-03-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282f465d2

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    更新日期:2008-04-01 00:00:00