Adjustment for current weight and the relationship between birth weight and blood pressure in childhood.

Abstract:

OBJECTIVE:To determine the role of current weight in mediating the relationship between birth weight and blood pressure within the context of the 'fetal origins' hypothesis. DESIGN:Prospective cohort study of 2507 pregnant women and their singleton offspring, delivered live at term, in Perth, Western Australia between 1989 and 1992. The study commenced at 16 weeks gestation with serial weight and blood pressure measurements recorded through early childhood. RESULTS:Inverse associations were found between birth weight and systolic blood pressure at ages 1, 3 and 6. The effect of birth weight on systolic blood pressure at age 6 reached statistical significance and was increased fourfold in magnitude to -2.3 mmHg [95% confidence interval = (-3.3 to -1.3), P < 0.01] after adjustment for current weight. The interaction term for birth weight and current weight was not statistically significant. Including intermediate weights did not produce a statistically significantly better model but did increase the magnitude of the estimated regression coefficient of birth weight on blood pressure, and only the birth weight and current weight terms were significant CONCLUSIONS:Adjustment for current weight serves to highlight the relationship between birth weight and blood pressure in childhood. Nevertheless, birth weight, rather than birth weight adjusted for current weight, is still the relevant predictor of later blood pressure within the context of the 'fetal origins' hypothesis.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Blake KV,Gurrin LC,Evans SF,Beilin LJ,Stanley FJ,Landau LI,Newnham JP

doi

10.1097/00004872-200018080-00003

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

1007-12

issue

8

eissn

0263-6352

issn

1473-5598

journal_volume

18

pub_type

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