Abstract:
OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calculated for mortality from ischaemic heart disease, stroke, non-circulatory and all causes. RESULTS:At presentation 76% of the men and 48% of the women reported recent alcohol consumption. Compared with drinkers, non-drinkers were older, less likely to smoke and had a higher untreated blood pressure. After adjustment for confounding factors, male drinkers had a reduced risk of stroke mortality and possibly of ischaemic heart disease mortality. Similar results were observed in women for stroke mortality but not for ischaemic heart disease mortality. The trend remained after adjustment for previous cardiovascular disease. In men the lowest risk of ischaemic heart disease mortality occurred at intakes of > 21 units per week and stroke mortality was lowest at 1-10 units per week. Men consuming > 21 units per week had a twofold higher non-circulatory mortality. Total mortality was lowest in men who drank 1-10 units per week. Similar effects of alcohol on cardiovascular mortality were observed in women. CONCLUSIONS:Alcohol intake may reduce stroke mortality in treated hypertensives. Ischaemic heart disease mortality in men may also be reduced, especially at higher intakes ( > 21 units per week). The beneficial effects were offset by increasing incidence of non-circulatory causes of death. Alcohol consumption of 1-10 units per week was associated with the lowest mortality in men.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Palmer AJ,Fletcher AE,Bulpitt CJ,Beevers DG,Coles EC,Ledingham JG,Petrie JC,Webster J,Dollery CTdoi
10.1097/00004872-199509000-00004subject
Has Abstractpub_date
1995-09-01 00:00:00pages
957-64issue
9eissn
0263-6352issn
1473-5598journal_volume
13pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to examine the utility of the generalized transfer function (GTF) and the late systolic shoulder of the radial pressure waveform (SBP2) for estimating seated central systolic blood pressure (c-SBP) and seated c-augmentation index (c-AIx). METHODS:In 199 participants (182 cardiovasc...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835c1d45
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:Hypertensive nephropathy is one of the major causes of chronic kidney disease (CKD). Bisphenol A (BPA) is associated with elevated blood pressure and urinary albuminuria. The aim of this study is to evaluate the association between serum BPA with the progression of CKD in patients with primary hypertension. ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000780
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the optimal schedule for home blood pressure (HBP) measurement based on a clinical approach. METHODS:Four hundred and sixty-four participants underwent HBP measurement for 7 days (duplicate measurements in the morning and in the evening), ambulatory blood pressure (ABP)...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328332fa5e
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To investigate the role of the renal medulla in early hypertension in spontaneously hypertensive rats (SHR), and to explore whether the attenuated increase of pressure induced by enalapril treatment is affected by chemical medullectomy. DESIGN:Forty-four male SHR were studied from 5 to 18 weeks of age: 22 re...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199211000-00006
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:In the nineteenth century, prior to the introduction of the cuff sphygmomanometer, stiffening of arteries was recognized as an indicator of vascular ageing and cardiovascular risk. Through the twentieth century, views on vascular ageing came to focus on brachial blood pressures and on occlusive atherosclerot...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0b013e32835ed5b9
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To determine whether taurine reduces blood pressure by stimulating the renal kallikrein-kinin system. METHODS:The effects of taurine on blood pressure, urinary kallikrein activity and renal kallikrein gene expression were investigated in Dahl salt-sensitive (Dahl-S) rats. The specificity of the action of tau...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVES:Aldosterone is synthesized in extra-adrenal tissues such as the vasculature, heart and brain. The mechanisms underlying the effect of high salt intake on the development and acceleration of vascular injury and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rats (SHRSP) are still not clear...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200103001-00017
更新日期:2001-03-01 00:00:00
abstract::It is widely believed that salt-dependent hypertension is induced and maintained by expansion of intravascular fluid volume resulting from excessive retention of sodium. The purpose of this brief article is to present a series of arguments in support of the thesis that volume overload per se does not raise the arteria...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0b013e32834f6de1
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Smoking is a risk factor for increased carotid artery intima-media thickness (IMT). The apolipoprotein E (apoE) 4 allele has been associated with cardiovascular diseases, but the role of apoE in regard to intima-media thickness (IMT) has remained controversial. The objective was to investigate whether there i...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200212000-00015
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Sodium is the mineral that has been, mainly, linked to hypertension and cardiovascular disease. It is found naturally in many foods, but is also used in the food industry and manufacturing. Identification of total sodium intake, as well as 'hidden' sodium intake from food sources early in life is necessary. ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328345ef35
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:In essential hypertension, the mechanical properties of the radial artery have been shown to be largely unaltered, whereas more controversial and less reliable data have been obtained for the common carotid artery. We therefore examined the distensibility/pressure relationships of the predominantly elastic co...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715120-00070
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:Primary aldosteronism (PA) is characterized by the onset of both cardiac and gluco-metabolic alterations. The aim of this study was to evaluate the impact of aldosterone excess on the development of such complications, and the effects of surgical and pharmacological treatment on their long-term outcome. METH...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3280108e6f
更新日期:2007-01-01 00:00:00
abstract::Current opinions on the relationships between erythrocyte sodium-lithium countertransport kinetics and primary hypertension, hyperlipidaemia and diabetic nephropathy are reviewed. Problems associated with the assay are analysed. Some possible mechanisms that could modify the kinetics of ion exchange are examined. The ...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199816010-00002
更新日期:1998-01-01 00:00:00
abstract::We studied 56 patients with essential hypertension to determine whether responses to standardized laboratory mental and physical challenges accurately reflect blood pressure variability during routine daily activities. Four activities were performed in the laboratory: mental arithmetic, a reaction time test, isometric...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198712000-00014
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Across ethnicities, offspring of hypertensive parents (OH) have higher risk of hypertension than offspring of normotensive parents (ON). Sympathetic hyperactivity and reduced nitric oxide availability have been reported in normotensive OH; but the role of vasodilator cyclooxygenase (COX) products is unclear....
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001794
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018090-00005
更新日期:2000-09-01 00:00:00
abstract:AIMS:Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biom...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002504
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:We hypothesized that addressing the 24-h relationship between RR interval and systolic arterial pressure (SAP) during ambulatory blood pressure monitoring could detect alterations in circadian arterial pressure and heart rate profile and could also be linked to the ambulatory arterial stiffness index. METHO...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832a12c7
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus is associated with an increased risk of hypertension, and cardiovascular and renal disease, and it has been recommended that management of hypertension should be more aggressive in presence than in absence of diabetes mellitus, but the matter is controversial at present. OBJECTIVES:...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000001276
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:Cardiovascular reactivity to mental stress has been used as a tool to predict short-term hypertension risk in adults but the impact of cardiovascular reactivity in childhood on hypertension in adulthood is unknown. Using the 1970 British Cohort study, we examined the association between pulse rate reactivity in...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001023
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:Ethnic minority populations (EMPs) are disproportionally affected by hypertension-mediated complications compared with European host populations (EHPs), which might be due to disparities in hypertension awareness, treatment and control. We conducted a systematic review and meta-analysis to compare awareness, ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002651
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:To determine the long-term efficacy and safety of a fixed, very-low-dose tablet combining one-half the standard dose of perindopril with one-quarter the standard dose of indapamide as first-line treatment in elderly patients. DESIGN:Double-blind, randomized, placebo-controlled study in an outpatient setting....
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00004872-200018030-00013
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:To determine whether vigorous exercise and alcohol restriction have additive and independent effects in reducing blood pressure in sedentary male alcohol drinkers. Also to assess whether 4 weeks of vigorous exercise could offset the fall in high-density lipoprotein cholesterol (HDL-cholesterol) usually obser...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-199302000-00012
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. We investigated w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002497
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Lacidipine is a widely used calcium-channel blocker, which has both long-lasting antihypertensive activity and also antioxidant properties. Previous studies have demonstrated the ability of lacidipine to reduce the development of atherosclerotic lesions in several animal models. OBJECTIVE:The present study ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018100-00010
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To compare the effects of the angiotensin II receptor antagonist candesartan with the angiotensin-converting enzyme inhibitor enalapril on myocardial fibrosis evaluated by echoreflectivity analysis. METHODS:Hypertensive patients (n = 196) with echocardigraphically documented left ventricular hypertrophy were...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e3283232838
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:Mechanisms involved in hypertension in homozygous mice for the defective endothelial nitric oxide synthase gene (eNOS-/-) have not been fully elucidated. As NO is a potent vasodilator agent and possibly promotes angiogenesis, we investigated whether vasoconstriction and/or microvascular rarefaction could exp...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200208000-00021
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:Blood pressure (BP) increases both in winter and in the last trimester of pregnancy. Some interaction seems to exist between season and gestational age. The present study observed home BP values during pregnancy with adjustment for seasonal variation and gestational age. METHODS:We observed 10353 home BP mea...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32831364a7
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:The current study aimed to investigate the value of the computed tomography-based left-versus-right adrenal gland volume ratio (L/Rv) in screening patients with unilateral primary aldosteronism. METHODS:The current study recruited 114 patients who underwent successful adrenal venous sampling (AVS) and adren...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002271
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:Several studies have shown lower carotid-femoral pulse wave velocity (cfPWV) levels in women compared to men, a difference that could partially explain the increased longevity in women. However, these studies have been performed in industrial countries while few data are available in emerging populations. We...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283639460
更新日期:2013-11-01 00:00:00