Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women.

Abstract:

OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- and community-matched normotensives aged 32 to 83 years. METHODS:Polymorphisms of the angiotensinogen gene detected by an allele-specific polymerase chain reaction. A priori hypothesis is individuals with 174M (threonine-to-methionine substitution) or 235T (methionine-to-threonine substitution) allelic variations may have an elevated risk of hypertension when they have a high sodium intake, estimated by 24-h urine collection and a dietary questionnaire. RESULTS:The genotypic frequency of the haplotype including both the 174M and 235T alleles was higher among hypertensives than among normotensives (23 versus 14%, P= 0.02). The frequency of the 174M allele was specifically higher among hypertensives than normotensives (12 versus 7%, P=0.01), and the odds ratio of hypertension associated with the 174M (versus 174T) allele was 1.8 [95% confidence interval (CI) 1.1-3.0, P=0.01]. The frequency of the 235T allele did not vary between the two groups (80 versus 82%, P= 0.40). The relationship between the 174M allele and hypertension was more evident among persons who had higher urinary sodium excretion (> = 166 mmol/day) than those with lower excretion (< 166 mmol/day): odds ratio 2.5 (95% CI, 1.2-5.2), P=0.01 versus 1.5 (95% CI, 0.7-3.1), P= 0.31; P for interaction = 0.04, and this trend was primarily observed for early-onset hypertension (< 55 years at onset). A similar but nonsignificant association was observed when stratified using present and past sodium intake scores derived from questionnaires. CONCLUSION:Angiotensinogen genotype may affect the development of early-onset hypertension among Japanese, particularly in those who have a high sodium intake.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Iso H,Harada S,Shimamoto T,Sato S,Kitamura A,Sankai T,Tanigawa T,Iida M,Komachi Y

doi

10.1097/00004872-200018090-00005

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

1197-206

issue

9

eissn

0263-6352

issn

1473-5598

journal_volume

18

pub_type

杂志文章
  • Superior hypertension control with betablockade in the European Sleep Apnea Database.

    abstract:AIMS:Arterial hypertension is highly prevalent and difficult to control in patients with obstructive sleep apnea (OSA). High sympathoadrenergic activity is a hallmark physiological phenomenon in OSA. We hypothesized that an antihypertensive drug with inhibitory properties on this activity, such as beta blockers (BBs), ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002629

    authors: Svedmyr S,Hedner J,Zou D,Parati G,Ryan S,Hein H,Pepin JL,Tkáčová R,Marrone O,Schiza S,Basoglu OK,Grote L,European Sleep Apnea Database (ESADA) study group.

    更新日期:2021-02-01 00:00:00

  • Differences in aortic response to vasoactive stimuli in Japanese and Lyon rats. The role of hypertension.

    abstract:OBJECTIVE:We have previously shown that conduit arteries of normotensive (WKY) and hypertensive (SHR) Japanese rats differ from normotensive (LN) and hypertensive (LH) Lyon rats in terms of lower aortic thickness and higher collagen III content, whereas differences in vasoactive properties are unknown. METHODS:Aortic ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917100-00007

    authors: Chamiot-Clerc P,Legrand M,Sassard J,Safar ME,Renaud JF

    更新日期:1999-10-01 00:00:00

  • Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice.

    abstract:BACKGROUND:Telmisartan is a unique AT1 receptor blocker with a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonistic action. Activation of PPAR-gamma could prevent inflammation and brain damage. METHOD:We investigated the beneficial effect of telmisartan on ischemic brain damage via PPAR-gamma activa...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833a551a

    authors: Iwanami J,Mogi M,Tsukuda K,Min LJ,Sakata A,Jing F,Iwai M,Horiuchi M

    更新日期:2010-08-01 00:00:00

  • Nitric oxide production by human umbilical vessels in severe pre-eclampsia.

    abstract:OBJECTIVE:Pre-eclampsia is characterized by an increased vascular tone which might be related to an abnormal endothelial cell function. As representatives of the fetal circulation, we compared the nitric oxide (NO)-releasing capacity of human umbilical vessels from normal and pre-eclamptic pregnancies. METHODS:Normal ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Akar F,Ark M,Uydeş BS,Soysal ME,Saraçoğlu F,Abacioğlu N,Van de Voorde J,Kanzik I

    更新日期:1994-11-01 00:00:00

  • Twenty-four-hour ambulatory blood pressure in adult women with urinary tract infection in childhood.

    abstract:OBJECTIVE:To study 24-h ambulatory blood pressure (BP) and development of hypertension over four decades in women with childhood urinary tract infection (UTI) associated with renal damage. METHODS:A population-based group of 111 women was followed from their first UTI in childhood. The cohort was investigated at a med...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000234

    authors: Gebäck C,Hansson S,Himmelmann A,Sandberg T,Sixt R,Jodal U

    更新日期:2014-08-01 00:00:00

  • Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension: a randomized active-controlled trial.

    abstract:OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple combination compared with the component dual combinations, in patients with moderate-to-severe hypertension. METHODS:This 8-week, double-blind, randomized, activ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/HJH.0b013e328356b8ea

    authors: Lacourcière Y,Taddei S,Konis G,Fang H,Severin T,Zhang J

    更新日期:2012-10-01 00:00:00

  • Marital status, dipping and nocturnal blood pressure: results from the Dietary Approaches to Stop Hypertension trial.

    abstract:OBJECTIVE:Blood pressure normally declines during the night ('dipping'); a blunted nocturnal decline is an important cardiovascular risk factor. Marriage may be associated with lower ambulatory blood pressure, although this may be confounded by socio-economic and dietary factors. We examined the association of marital ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/HJH.0000000000000107

    authors: Causland FR,Sacks FM,Forman JP

    更新日期:2014-04-01 00:00:00

  • A systematic review of calcium channel blocker use and cognitive decline/dementia in the elderly.

    abstract:OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000000273

    authors: Peters R,Booth A,Peters J

    更新日期:2014-10-01 00:00:00

  • The kidney and essential hypertension: a link to osteoporosis?

    abstract:INTRODUCTION:Abnormalities of calcium metabolism independent of changes in intracellular calcium have been described in patients with essential hypertension. These include increased urinary calcium excretion for a given salt intake, a raised parathyroid hormone level, an increase in urinary cyclic AMP, a tendency for a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199308000-00003

    authors: MacGregor GA,Cappuccio FP

    更新日期:1993-08-01 00:00:00

  • Hypertension and overweight/obesity in Ghanaians and Nigerians living in West Africa and industrialized countries: a systematic review.

    abstract:CONTEXT:There is a growing prevalence of cardiovascular disease (CVD) risk factors in West Africa and among its migrants to industrialized countries. Despite this, no study has reviewed CVD risk factor prevalence among West Africans in Africa and industrialized countries. OBJECTIVE:To appraise studies on the prevalenc...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000000061

    authors: Commodore-Mensah Y,Samuel LJ,Dennison-Himmelfarb CR,Agyemang C

    更新日期:2014-03-01 00:00:00

  • The cardiovascular responses to sequential inhibition of alpha-adrenoceptors, the renin-angiotensin system and vasopressin in rats with adrenal regeneration hypertension.

    abstract::The cardiovascular responses to selective alpha 1- and alpha 2-adrenoceptor antagonism (with prazosin and idazoxan, respectively) were assessed in rats 4 weeks after unilateral nephro-adrenalectomy, contralateral adrenal enucleation and the provision of a 1% NaCl solution as drinking fluid (AEN rats) and in sham-opera...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Foulkes R,Gardiner SM,Bennett T

    更新日期:1988-04-01 00:00:00

  • Blood pressure and the global burden of disease 2000. Part II: estimates of attributable burden.

    abstract:OBJECTIVES:To provide estimates of the global burden of disease attributable to non-optimal blood pressure by age and sex for adults aged > or = 30 years, by WHO subregion. METHODS:Estimates of attributable burden were made using population impact fractions, which used data on mean systolic blood pressure levels, dise...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000209973.67746.f0

    authors: Lawes CM,Vander Hoorn S,Law MR,Elliott P,MacMahon S,Rodgers A

    更新日期:2006-03-01 00:00:00

  • Spectral analysis of the systolic blood pressure signal in secondary hypertension: a method for the identification of phaeochromocytoma.

    abstract:OBJECTIVE:To seek in hypertensive patients rhythmic variations of the systolic blood pressure signal obtained by ambulatory blood pressure monitoring of any inherent cycle of intermediate value between 1 and 24 h. DESIGN:Subjects (62 hypertensive, 39 normotensive) were evaluated by 24-h ambulatory blood pressure monit...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Meisel SR,Mor-Avi V,Rosenthal T,Akselrod S

    更新日期:1994-03-01 00:00:00

  • The Bergen blood pressure study: offspring of two hypertensive parents have significantly higher blood pressures than offspring of one hypertensive and one normotensive parent.

    abstract:OBJECTIVE:To study blood pressure and antihypertensive drug treatment in subjects with contrasting family histories of hypertension. SUBJECTS AND METHODS:We grouped 520 offspring examined in 1990 (mean +/- SD age 36 +/- 7 years) according to their parents' blood pressure screened in 1963-1964 as offspring of two normo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Mo R,Omvik P,Lund-Johansen P

    更新日期:1995-12-01 00:00:00

  • Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine.

    abstract::The effects of rilmenidine [(N-dicyclopropylmethyl) amino-2-oxazoline; S 3341], an alpha 2 agonist, on the hypertensive rat heart have been compared with those of propranolol, using a model of deoxycorticosterone acetate (DOCA)-salt hypertension. One week after nephrectomy and initial treatment with DOCA-salt, which w...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198912000-00004

    authors: Callens-el Amrani F,Paolaggi F,Swynghedauw B

    更新日期:1989-12-01 00:00:00

  • The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats.

    abstract:OBJECTIVE:We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin recep...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000174972.46663.5e

    authors: Kopkan L,Kramer HJ,Husková Z,Vanourková Z,Skaroupková P,Thurmová M,Cervenka L

    更新日期:2005-08-01 00:00:00

  • Chronic antioxidant treatment improves sympathetic functions and beta-adrenergic pathway in the spontaneously hypertensive rats.

    abstract:BACKGROUND:Correlations have been found between oxidative stress and hypertension. OBJECTIVE:To determine whether antioxidants can normalize sympathetic dysfunction at pre- or postsynaptic levels in spontaneously hypertensive rats (SHRs). METHODS AND RESULTS:Untreated SHRs and Wistar-Kyoto (WKY) rats were compared wi...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200301000-00028

    authors: Girouard H,Chulak C,LeJossec M,Lamontagne D,de Champlain J

    更新日期:2003-01-01 00:00:00

  • Plasma human atrial natriuretic peptide, endothelin-1, aldosterone and plasma-renin activity in pregnancy-induced hypertension.

    abstract:OBJECTIVE:To determine the relationship between endothelin-1 (ET-1), human atrial natriuretic peptide (hANP), plasma-renin activity (PRA) and 24-h urinary excretion of aldosterone (U-Ald) in pregnancy-induced hypertension (PIH). DESIGN AND METHODS:Plasma hANP (pg/ml), ET-1 (pg/ml), PRA (ng/ml per h) and U-Ald (microg/...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199917090-00012

    authors: Zafirovska KG,Maleska VT,Bogdanovska SV,Lozance LA,Masin-Paneva J,Gerasimovska BD

    更新日期:1999-09-01 00:00:00

  • Association of genetic polymorphisms of ACADSB and COMT with human hypertension.

    abstract:OBJECTIVES:Genetically hypertensive rats provide an excellent model to investigate the genetic mechanisms of hypertension. We previously identified three differentially expressed genes, Acadsb (short/branched chain acyl-CoA dehydrogenase), Comt (catecholamine-O-methyltransferase), and Pnpo (pyridoxine 5'-phosphate oxid...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3280103a40

    authors: Kamide K,Kokubo Y,Yang J,Matayoshi T,Inamoto N,Takiuchi S,Horio T,Miwa Y,Yoshii M,Tomoike H,Tanaka C,Banno M,Okuda T,Kawano Y,Miyata T

    更新日期:2007-01-01 00:00:00

  • Decreased ATP sensitivity of a K+ channel and enhanced vascular smooth muscle relaxation in genetically hypertensive rats.

    abstract:OBJECTIVE:To characterize an ATP-sensitive K+ channel at the single-channel and tissue level in the vascular smooth muscle of normotensive and genetically hypertensive rats. METHODS:Age- and sex-matched Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were used. Patch-clamp single-chann...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199310000-00010

    authors: Furspan PB,Webb RC

    更新日期:1993-10-01 00:00:00

  • Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease - the SFC BP multicentre study in China.

    abstract:OBJECTIVES:Cardiovascular dysautonomia can be present at early, late and even prodromal stages of Parkinson's disease. This study aimed to describe the characteristics of 24-h ambulatory blood pressure (BP) monitoring and investigate the frequency of cardiovascular dysautonomia in Parkinson's disease without an abnorma...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002536

    authors: Chen SW,Wang YK,Dou RH,Xie XY,Hu YB,Ding N,Zhang GH,Jing HF,Zhao WD,Xue Y,Li Y,Wang G

    更新日期:2020-11-01 00:00:00

  • Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension.

    abstract::Hypertension in children and adolescents has gained ground in cardiovascular medicine, thanks to the progress made in several areas of pathophysiological and clinical research. These guidelines represent a consensus among specialists involved in the detection and control of high blood pressure in children and adolesce...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,实务指引

    doi:10.1097/HJH.0b013e32832f4f6b

    authors: Lurbe E,Cifkova R,Cruickshank JK,Dillon MJ,Ferreira I,Invitti C,Kuznetsova T,Laurent S,Mancia G,Morales-Olivas F,Rascher W,Redon J,Schaefer F,Seeman T,Stergiou G,Wühl E,Zanchetti A,European Society of Hypertension.

    更新日期:2009-09-01 00:00:00

  • Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: results from the Global SYMPLICITY Registry.

    abstract:BACKGROUND:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluate...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001142

    authors: Linz D,Mancia G,Mahfoud F,Narkiewicz K,Ruilope L,Schlaich M,Kindermann I,Schmieder RE,Ewen S,Williams B,Böhm M,Global SYMPLICITY Registry Investigators.

    更新日期:2017-01-01 00:00:00

  • Hypertension: evolving from standardized to individualized care.

    abstract::: The hypertension paradigm has contributed to a dramatic reduction in CVD mortality. This has been achieved by applying average results of population studies to identify a target population and design a common intervention to achieve a BP goal. Progressive lowering of the BP threshold has expanded the fraction of per...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002375

    authors: Alderman MH,Blumenfeld JD

    更新日期:2020-07-01 00:00:00

  • Effect of acute hyperglycemia on erythrocyte membrane ion transport in offspring of hypertensive parents.

    abstract:OBJECTIVE:Patients with essential hypertension exhibit several red blood cell (RBC) ion transport abnormalities, insulin resistance (IR) and increased risk of developing type 2 diabetes. The aims of this study were to assess RBC ion transport activities under basal conditions and to test the in vivo effect of acute hyp...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200307000-00021

    authors: Suchánková G,Vlasáková Z,Zicha J,Vokurková M,Dobesová Z,Pelikánová T

    更新日期:2003-07-01 00:00:00

  • Cardiovascular phenotype of young adults and angiotensinogen alleles.

    abstract:OBJECTIVES AND DESIGN:Angiotensinogen (AGT) gene variants influence angiotensinogen plasma levels in children and young adults. The angiotensinogen promoter (-6)A variant facilitates gene transcription in human tissues and it has been associated with high blood pressure in older adults. A young adult population can be ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200112000-00009

    authors: Sarzani R,Dessì-Fulgheri P,Mazzara D,Catalini R,Cola G,Bersigotti G,Siragusa N,Salvi F,Ercolani P,Spagnolo D,Zingaretti O,Serenelli M,Pupita M,Magni CM,Giantomassi L,Pasquini R,Gesuita R,Carle F,Rappelli A

    更新日期:2001-12-01 00:00:00

  • Pressure-dependence of arterial stiffness: potential clinical implications.

    abstract:BACKGROUND:Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age. METHODS:Using a n...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000407

    authors: Spronck B,Heusinkveld MH,Vanmolkot FH,Roodt JO,Hermeling E,Delhaas T,Kroon AA,Reesink KD

    更新日期:2015-02-01 00:00:00

  • Mental stress and hypertension, an evolutionary framework: some historical perspectives of the 1960 World Health Organization Prague Hypertension Meeting.

    abstract::Emotional stress acutely and repetitively causing blood pressure increase or aggravating existing hypertension is usually not reflected by norepinephrine and epinephrine increase but by a sudden rise of dopamine, the third "defensive" catecholamine coping with the damaging neuropsychological and cardiovascular actions...

    journal_title:Journal of hypertension

    pub_type: 历史文章,杂志文章

    doi:10.1097/01.hjh.0000052462.40108.fb

    authors: Kuchel O

    更新日期:2003-03-01 00:00:00

  • Renal and vascular actions of equol in the rat.

    abstract:BACKGROUND:The urinary isoflavonoid equol inhibits membrane Na-K-Cl cotransporters at similar concentrations to those at which furosemide inhibits them, but the significance of this action is not known. OBJECTIVE:To investigate the potential salidiuretic and vascular actions of equol in the rat. METHODS:Renal functio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715110-00015

    authors: Gimenez I,Lou M,Vargas F,Alvarez-Guerra M,Mayoral JA,Martinez RM,Garay RP,Alda JO

    更新日期:1997-11-01 00:00:00

  • Hypertension aggregates in families of kidney stone patients with high urinary excretion of uric acid.

    abstract:OBJECTIVE:To determine whether kidney stone disease (KSD) and hypertension (HTN) share a common familial component that is determined by a specific urinary biochemical abnormality. DESIGN:Familial aggregation study. PATIENTS:Two hundred and twelve KSD patients, aged 18-50 years, collected a 24-h urine sample to measu...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917121-00012

    authors: Tisler A,Pierratos A,Honey JD,Bull SB,Logan AG

    更新日期:1999-12-01 00:00:00