Abstract:
OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- and community-matched normotensives aged 32 to 83 years. METHODS:Polymorphisms of the angiotensinogen gene detected by an allele-specific polymerase chain reaction. A priori hypothesis is individuals with 174M (threonine-to-methionine substitution) or 235T (methionine-to-threonine substitution) allelic variations may have an elevated risk of hypertension when they have a high sodium intake, estimated by 24-h urine collection and a dietary questionnaire. RESULTS:The genotypic frequency of the haplotype including both the 174M and 235T alleles was higher among hypertensives than among normotensives (23 versus 14%, P= 0.02). The frequency of the 174M allele was specifically higher among hypertensives than normotensives (12 versus 7%, P=0.01), and the odds ratio of hypertension associated with the 174M (versus 174T) allele was 1.8 [95% confidence interval (CI) 1.1-3.0, P=0.01]. The frequency of the 235T allele did not vary between the two groups (80 versus 82%, P= 0.40). The relationship between the 174M allele and hypertension was more evident among persons who had higher urinary sodium excretion (> = 166 mmol/day) than those with lower excretion (< 166 mmol/day): odds ratio 2.5 (95% CI, 1.2-5.2), P=0.01 versus 1.5 (95% CI, 0.7-3.1), P= 0.31; P for interaction = 0.04, and this trend was primarily observed for early-onset hypertension (< 55 years at onset). A similar but nonsignificant association was observed when stratified using present and past sodium intake scores derived from questionnaires. CONCLUSION:Angiotensinogen genotype may affect the development of early-onset hypertension among Japanese, particularly in those who have a high sodium intake.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Iso H,Harada S,Shimamoto T,Sato S,Kitamura A,Sankai T,Tanigawa T,Iida M,Komachi Ydoi
10.1097/00004872-200018090-00005subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1197-206issue
9eissn
0263-6352issn
1473-5598journal_volume
18pub_type
杂志文章abstract:AIMS:Arterial hypertension is highly prevalent and difficult to control in patients with obstructive sleep apnea (OSA). High sympathoadrenergic activity is a hallmark physiological phenomenon in OSA. We hypothesized that an antihypertensive drug with inhibitory properties on this activity, such as beta blockers (BBs), ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002629
更新日期:2021-02-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917100-00007
更新日期:1999-10-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32833a551a
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:Pre-eclampsia is characterized by an increased vascular tone which might be related to an abnormal endothelial cell function. As representatives of the fetal circulation, we compared the nitric oxide (NO)-releasing capacity of human umbilical vessels from normal and pre-eclamptic pregnancies. METHODS:Normal ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To study 24-h ambulatory blood pressure (BP) and development of hypertension over four decades in women with childhood urinary tract infection (UTI) associated with renal damage. METHODS:A population-based group of 111 women was followed from their first UTI in childhood. The cohort was investigated at a med...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000234
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple combination compared with the component dual combinations, in patients with moderate-to-severe hypertension. METHODS:This 8-week, double-blind, randomized, activ...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e328356b8ea
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Blood pressure normally declines during the night ('dipping'); a blunted nocturnal decline is an important cardiovascular risk factor. Marriage may be associated with lower ambulatory blood pressure, although this may be confounded by socio-economic and dietary factors. We examined the association of marital ...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/HJH.0000000000000107
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000000273
更新日期:2014-10-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199308000-00003
更新日期:1993-08-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000000061
更新日期:2014-03-01 00:00:00
abstract::The cardiovascular responses to selective alpha 1- and alpha 2-adrenoceptor antagonism (with prazosin and idazoxan, respectively) were assessed in rats 4 weeks after unilateral nephro-adrenalectomy, contralateral adrenal enucleation and the provision of a 1% NaCl solution as drinking fluid (AEN rats) and in sham-opera...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVES:To provide estimates of the global burden of disease attributable to non-optimal blood pressure by age and sex for adults aged > or = 30 years, by WHO subregion. METHODS:Estimates of attributable burden were made using population impact fractions, which used data on mean systolic blood pressure levels, dise...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000209973.67746.f0
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To seek in hypertensive patients rhythmic variations of the systolic blood pressure signal obtained by ambulatory blood pressure monitoring of any inherent cycle of intermediate value between 1 and 24 h. DESIGN:Subjects (62 hypertensive, 39 normotensive) were evaluated by 24-h ambulatory blood pressure monit...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:To study blood pressure and antihypertensive drug treatment in subjects with contrasting family histories of hypertension. SUBJECTS AND METHODS:We grouped 520 offspring examined in 1990 (mean +/- SD age 36 +/- 7 years) according to their parents' blood pressure screened in 1963-1964 as offspring of two normo...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::The effects of rilmenidine [(N-dicyclopropylmethyl) amino-2-oxazoline; S 3341], an alpha 2 agonist, on the hypertensive rat heart have been compared with those of propranolol, using a model of deoxycorticosterone acetate (DOCA)-salt hypertension. One week after nephrectomy and initial treatment with DOCA-salt, which w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198912000-00004
更新日期:1989-12-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000174972.46663.5e
更新日期:2005-08-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200301000-00028
更新日期:2003-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-199917090-00012
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:Genetically hypertensive rats provide an excellent model to investigate the genetic mechanisms of hypertension. We previously identified three differentially expressed genes, Acadsb (short/branched chain acyl-CoA dehydrogenase), Comt (catecholamine-O-methyltransferase), and Pnpo (pyridoxine 5'-phosphate oxid...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3280103a40
更新日期:2007-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199310000-00010
更新日期:1993-10-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002536
更新日期:2020-11-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章,实务指引
doi:10.1097/HJH.0b013e32832f4f6b
更新日期:2009-09-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001142
更新日期:2017-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002375
更新日期:2020-07-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200307000-00021
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES AND DESIGN:Angiotensinogen (AGT) gene variants influence angiotensinogen plasma levels in children and young adults. The angiotensinogen promoter (-6)A variant facilitates gene transcription in human tissues and it has been associated with high blood pressure in older adults. A young adult population can be ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200112000-00009
更新日期:2001-12-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000407
更新日期:2015-02-01 00:00:00
abstract::Emotional stress acutely and repetitively causing blood pressure increase or aggravating existing hypertension is usually not reflected by norepinephrine and epinephrine increase but by a sudden rise of dopamine, the third "defensive" catecholamine coping with the damaging neuropsychological and cardiovascular actions...
journal_title:Journal of hypertension
pub_type: 历史文章,杂志文章
doi:10.1097/01.hjh.0000052462.40108.fb
更新日期:2003-03-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715110-00015
更新日期:1997-11-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917121-00012
更新日期:1999-12-01 00:00:00