Abstract：
OBJECTIVE:Smoking is a risk factor for increased carotid artery intima-media thickness (IMT). The apolipoprotein E (apoE) 4 allele has been associated with cardiovascular diseases, but the role of apoE in regard to intima-media thickness (IMT) has remained controversial. The objective was to investigate whether there is some gene-environment interaction between smoking and apoE polymorphism. DESIGN Cross-sectional case-control study. METHODS:IMTs of 511 hypertensive and control men were measured ultrasonographically and the apoE genotypes were determined. Genotypes with the 4 allele were pooled into one group and the genotypes without it into another. RESULTS:A significant interaction between the 4 allele and smoking affecting IMT was observed among the hypertensive smokers, as assessed by analysis of covariance. The mean carotid IMT was significantly greater (1.01 versus 0.90 mm, P = 0.003) in the 4 carriers than in the subjects without 4 among the hypertensive smokers. The number of plaques was also significantly higher. No differences were found in the other subjects (hypertensive non-smokers or controls). Linear regression analysis indicated that the 4 allele was an independent determinant of IMT in the hypertensive smokers but not in the other subjects. The estimated average effect of the 4 allele on the mean IMT in the hypertensive smokers was 0.088 mm (P < 0.001). In the oldest age group, the interaction of smoking and 4 was also seen in the control subjects. CONCLUSION:The findings suggest that the 4 carriers are particularly susceptible to the atherogenic effects of smoking. This interaction is particularly clear in hypertensive subjects.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Karvonen J,Kauma H,Kervinen K,Ukkola O,Rantala M,Päivänsalo M,Savolainen MJ,Kesäniemi YAdoi
10.1097/00004872-200212000-00015subject
Has Abstractpub_date
2002-12-01 00:00:00pages
2371-8issue
12eissn
0263-6352issn
1473-5598journal_volume
20pub_type
杂志文章abstract：OBJECTIVE:To investigate the role of ouabain in human hypertension and to establish whether immunoreactive endogenous ouabain is secreted by the adrenal gland under the influence of dopaminergic regulation. METHODS:We measured plasma levels of endogenous ouabain by immunoassay, together with other variables, including...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199510000-00013
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVE:The major advantage of dual inhibitors of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) is their ability to lower blood pressure irrespective of renin or volume status. The aim of this study was to determine whether dual NEP/ACE inhibition produces different effects on cardiovascular str...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-200018060-00013
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE(S):To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment. DESIGN:The study was carried out in a total of 25 subjects--11 healt...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1097/00004872-200403000-00027
更新日期：2004-03-01 00:00:00
abstract：:Haemorheological characteristics were measured in a group of 52 patients with essential arterial hypertension (HT), and were compared with those of a group of normotensive subjects. The relationships between the arterial blood pressure (BP), the echocardiographic indices of left ventricular hypertrophy (LVH), and the ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：OBJECTIVE:Recent studies have demonstrated that stimulating autoantibodies against the angiotensin II type 1 receptor (AT1R-AA) are frequently detected in the sera from women with preeclampsia, suggesting that they may play an important role in the pathogenesis of this disease. Nevertheless, the real clinical significa...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3283376cc6
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:The relationship between sodium intake and cardiovascular events is controversial, but most large epidemiological studies estimated sodium intake using formulae based on single urine samples, the validity of which is debated. We evaluated sodium intake estimating formulae in a large cohort of adult patients. ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001609
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:(1) To compare urinary guanosine 3',5' cyclic monophosphate (cyclic GMP) excretion between normotensive subjects and essential hypertensive patients; (2) to determine the influence of changes in sodium intake on urinary cyclic GMP excretion in response to the neutral endopeptidase inhibitor candoxatril in es...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004872-199204000-00005
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial, and the presence of insulin resistance is recognized as the pathophysiological hallmark of this condition. Arterial hypertension is referred as an insulin-resistant state, and insulin resistance may substantially contribute to the...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32830dfe4b
更新日期：2008-11-01 00:00:00
abstract：DESIGN AND METHODS:Levels of dietary and serum potassium are thought to correlate inversely with vascular resistance and blood pressure. This study examined renal vascular resistance in perfused rat kidneys partially preconstricted with 10 micromol/ phenylephrine, quantifying changes in the resistance when levels of po...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199917100-00017
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Reductions in albuminuria of more than 30% are considered a strong marker of delay of chronic kidney disease (CKD) progression. Single renin-angiotensin system (RAS) blockade represents the cornerstone of CKD treatment. However, as CKD progression still occurs, other nephroprotective options were explored; m...
journal_title：Journal of hypertension
pub_type： 杂志文章,meta分析
doi：10.1097/HJH.0000000000002187
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:The genetic background of orthostatic hypotension, an important risk factor for future cardiovascular morbidity and mortality, was investigated. DESIGN AND METHODS:The study subjects comprised 415 community-dwelling individuals, who were free from any cardiovascular complications, aged 50 years or older (mea...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-200204000-00022
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVES:We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD:The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blo...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1097/HJH.0b013e328361732c
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:To determine the blood pressure responses in elderly normotensive men and women to dietary sodium and to the diunsaturated fatty acid dihomogammalinolenic acid (DGLA), which is derived from linoleic acid. DESIGN:Blood pressure responses were assessed in 66 subjects (36 male, 30 female; mean age 65 years) on ...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004872-199312000-00011
更新日期：1993-12-01 00:00:00
abstract：:Basal platelet function was measured in 35 40-year-old men with untreated mild essential hypertension and compared with 44 age-matched normotensive men. The groups differed significantly with respect to platelet size in venous blood (hypertensive, 7.46 +/- 0.10 X 10(-15) l versus normotensive, 7.11 +/- 0.09 X 10(-15) ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32834347de
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:Exercise training has antihypertensive and renoprotective effects in humans and rats. However, the effects of exercise training on renal disorders that occur with salt-sensitive hypertension remains unclear. The study aim was to investigate the effects and mechanisms of exercise training on renal function in ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000002409
更新日期：2020-07-01 00:00:00
abstract：:Pinacidil is a new vasodilating compound claimed to increase renal perfusion and function. A preliminary study showed that pinacidil did not sustain renal perfusion through a period of increasing renal vascular resistance in pig-to-rabbit renal xenotransplantation. Accordingly, the effect of pinacidil on renal functio...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-198312000-00006
更新日期：1983-12-01 00:00:00
abstract：:Recently, there has been an explosion of knowledge on vasopressin, including its neuro-anatomy, biochemistry and physiology. Recent work demonstrates extensive extra-hypothalamic vasopressinergic projections from the SON and PVN. Of particular importance are projections to the cardiovascular medullary centres. Convers...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/00004872-198512000-00001
更新日期：1985-12-01 00:00:00
abstract：BACKGROUND:Primary hypertension is a hereditary disorder characterized by a complex etiological interplay of multiple genetic and environmental factors, until now defying attempts at identifying pathogenetically important genes. The marriage of classical genetics and molecular techniques is now offering a powerful set ...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/00004872-199202000-00002
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To assess cardiac function, myocardial mechanoenergetic efficiency (MEE), and ventricular-arterial coupling (VAC) longitudinally during normal pregnancy, and to study if there was an association between cardiac structure and function, and fetal growth. METHODS:Cardiac structure and function, MEE, and ventric...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001612
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:Remodeling of small resistance arteries is an early sign of target organ damage in hypertension. Peripheral capillary morphology abnormalities in hypertension are not well studied. The study objective was to determine whether altered capillary morphology is associated with SBP, DBP, or both in individuals wi...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32833e113b
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVES:High blood pressure is known to be associated with higher cardiovascular risk. The emphasis has shifted over time from diastolic pressure to systolic pressure and variability in blood pressure. This study examined the impact of transient and sustained diastolic hypertension on later mortality. METHODS:In th...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32835a4dd8
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To analyze the natriuretic and diuretic response to frusemide in 33 male essential hypertensive patients as a function of basal renal sodium handling and erythrocyte transport system. METHODS:The natriuretic and diuretic response to an oral dose of frusemide (25 mg) was assessed with a simplified method. Uri...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. OBJ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199917040-00006
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:Patients with end-stage renal-disease under hemodialysis have increased cardiovascular risk and experience severe blood pressure (BP) fluctuations during the dialysis session and the subsequent interdialytic period. BP variability (BPV) may be an additional risk factor for cardiovascular events and prelimina...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001478
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:The objective of the study was to investigate interarm differences of blood pressure (BP) and its determinants, and to clarify whether both arms are equally good in assessing BP and target organ damage in the general population. METHODS:We studied a representative sample of Finnish adult population with 484 ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000040
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:To examine: (1) in how many treated hypertensive patients it was possible to discontinue drug treatment; (2) the time-course for redevelopment of hypertension after discontinuation of therapy; and (3) whether drug withdrawal was associated with an increase in left ventricular mass (LVM). DESIGN:Fifty-four m...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199206000-00012
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVE:To assess the contribution of the sympathetic nervous system to the hypertension in patients with longstanding essential hypertension. DESIGN:Overall sympathetic function, presynaptic adrenoceptors and neuronal re-uptake were examined after withdrawal of medication for at least 3 weeks in eight patients with...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy (LVH). We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32833aa356
更新日期：2010-06-01 00:00:00
