Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.

Abstract:

OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (PAI-1) gene expression than mice receiving Ang II, N-nitro-L-arginine methyl ester (L-NAME), apelin plus L-NAME or apelin plus Ang II plus L-NAME. In-vitro analysis using a luciferase construct driven by 3.1 kb of the human PAI-1 promoter revealed that apelin blocked Ang II-mediated PAI-1 gene expression. Immunoblotting for phosphorylated myosin phosphatase subunit and myosin light chain revealed that apelin blocked Ang II activation of the Rho kinase pathway, which is associated with induction of PAI-1 gene expression by Ang II. In addition, treatment of human aortic smooth muscle cells with apelin reduced PAI-1 mRNA and protein production in the presence and absence of Ang II. Conversely, L-NAME treatment attenuated the downregulation of PAI-1 by apelin in cells. CONCLUSION:Apelin protects against cardiac fibrosis and vascular remodeling through direct regulation of PAI-1 gene expression. This protective effect is mediated through the synergistic inhibition of Ang II signaling and increased production of nitric oxide by apelin. Our data extend previous findings and provide new insight into the molecular mechanisms by which apelin elicits a cardioprotective effect.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH

doi

10.1097/HJH.0b013e32834347de

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

724-31

issue

4

eissn

0263-6352

issn

1473-5598

journal_volume

29

pub_type

杂志文章
  • Relationship between baroreflex sensitivity, renin suppression and natriuresis in salt-sensitive rabbits.

    abstract::This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199109000-00005

    authors: Weinstock M,Borosh M,Kafri O,Kaczmarczyk G

    更新日期:1991-09-01 00:00:00

  • Does the association between birth weight and blood pressure increase with age? A longitudinal study in young adults.

    abstract:OBJECTIVES:To assess whether the association between birth weight and blood pressure (BP) increases with age using three different statistical methods. METHODS:A representative sample of 1232 study participants born between 1974-1978 in Limache, Chile were assessed in 2000-2002, of whom 796 were reassessed in 2010-201...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000912

    authors: Bustos P,Amigo H,Bangdiwala SI,Pizarro T,Rona RJ

    更新日期:2016-06-01 00:00:00

  • Management of cardiovascular risk factors in advanced type 2 diabetic nephropathy: a comparative analysis in nephrology, diabetology and primary care settings.

    abstract:OBJECTIVES:Advanced diabetic nephropathy (DN) is characterized by a marked development of cardiovascular and renal disease. These patients are frequently managed by different health professionals with the consequence that the quality of care may differ substantially. To compare the management of cardiovascular risk fac...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.hjh.0000239303.93872.31

    authors: Minutolo R,Sasso FC,Chiodini P,Cianciaruso B,Carbonara O,Zamboli P,Tirino G,Pota A,Torella R,Conte G,De Nicola L

    更新日期:2006-08-01 00:00:00

  • Severe obstructive sleep apnea elicits concentric left ventricular geometry.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) has several negative effects on the heart including increase in myocardial end-systolic stress, venous return and sympathetic activity, all potential stimuli of left ventricular (LV) hypertrophy. The impact of the severity of OSA on LV geometry is unknown. We hypothesized that O...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e328336c90a

    authors: Cioffi G,Russo TE,Stefenelli C,Selmi A,Furlanello F,Cramariuc D,Gerdts E,de Simone G

    更新日期:2010-05-01 00:00:00

  • Aging and vascular responses to flavanol-rich cocoa.

    abstract:OBJECTIVES:Strong evidence has secured aging as a powerful predictor of both cardiovascular risk and endothelial dysfunction, yet specific treatment is not available. We tested the hypothesis that vascular responsiveness to flavanol-rich cocoa increases with advancing age. We have previously shown that flavanol-rich co...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000239293.40507.2a

    authors: Fisher ND,Hollenberg NK

    更新日期:2006-08-01 00:00:00

  • Baroreflex sensitivity and sympatho-vagal balance during intradialytic hypotensive episodes.

    abstract:OBJECTIVES:The role of the baroreflex function in the pathogenesis of hemodialysis-associated hypotension is controversial. Complex demodulation technique (CDM), providing continuous assessment of the amplitude of cardiovascular oscillation over time, is particularly suitable to assess dynamic changes in autonomic nerv...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328332b7af

    authors: Sapoznikov D,Backenroth R,Rubinger D

    更新日期:2010-02-01 00:00:00

  • Prostaglandins and renal function in hypertensive patients with unilateral renal artery stenosis and patients with essential hypertension.

    abstract:OBJECTIVE:This study was designed to compare the effects of prostaglandin synthesis inhibition on calculated preglomerular and postglomerular resistance in hypertensive patients with unilateral renal artery stenosis (RAS) and in patients with essential hypertension. DESIGN AND METHODS:Sixteen patients with suspected r...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199606000-00013

    authors: Milot A,Lambert R,Lebel M,Cusson JR,Larochelle P

    更新日期:1996-06-01 00:00:00

  • Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment.

    abstract::The mechanisms resulting in the greater predisposition of male subjects towards hypertension were investigated in different strains of rats with genetic hypertension [spontaneously hypertensive rats of the stroke-prone strain (SHRSP) and spontaneously hypertensive rats (SHR)] and their respective normotensive controls...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Ganten U,Schröder G,Witt M,Zimmermann F,Ganten D,Stock G

    更新日期:1989-09-01 00:00:00

  • Effects of alcohol withdrawal on blood pressure in hypertensive heavy drinkers.

    abstract:BACKGROUND:Epidemiological investigations have demonstrated a close association between heavy alcohol consumption and hypertension. The mechanisms of this association, however, remain elusive. We studied the effects of alcohol withdrawal on blood pressure, hormonal parameters, and circulating markers of endothelial act...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000239283.35562.15

    authors: Soardo G,Donnini D,Varutti R,Milocco C,Basan L,Esposito W,Casaccio D,Isola M,Soldano F,Sechi LA

    更新日期:2006-08-01 00:00:00

  • Downregulation of glomerular and vascular atrial natriuretic factor receptor subtypes by angiotensin II.

    abstract::We have previously reported that pressor doses of angiotensin II induce atrial natriuretic factor (ANF) release. Since the number of glomerular and vascular ANF receptors may vary inversely with plasma ANF levels, we investigated whether they are modified by angiotensin II. Male rats were infused intraperitoneally for...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Gauquelin G,Schiffrin EL,Garcia R

    更新日期:1991-12-01 00:00:00

  • Haemorheological abnormalities in arterial hypertension and their relation to cardiac hypertrophy.

    abstract::Haemorheological characteristics were measured in a group of 52 patients with essential arterial hypertension (HT), and were compared with those of a group of normotensive subjects. The relationships between the arterial blood pressure (BP), the echocardiographic indices of left ventricular hypertrophy (LVH), and the ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Zannad F,Voisin P,Brunotte F,Bruntz JF,Stoltz JF,Gilgenkrantz JM

    更新日期:1988-04-01 00:00:00

  • Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older age.

    abstract:OBJECTIVE:It is not well known which exercise intensity is needed to obtain blood pressure reductions in response to endurance training. We therefore compared the effect of training at lower and higher intensity on blood pressure, and, in addition on other cardiovascular risk factors, in at least 55-year-old sedentary ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/HJH.0b013e328322cf60

    authors: Cornelissen VA,Arnout J,Holvoet P,Fagard RH

    更新日期:2009-04-01 00:00:00

  • Persistence of baroreceptor control of cerebral blood flow velocity at a simulated altitude of 5000 m.

    abstract:OBJECTIVE:To assess the effects of acute exposure to simulated high altitude on baroreflex control of mean cerebral blood flow velocity (MCFV). PATIENTS AND METHODS:We compared beat-to-beat changes in RR interval, arterial blood pressure, mean MCFV (by transcranial Doppler velocimetry in the middle cerebral artery), e...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32826f49a3

    authors: Passino C,Cencetti S,Spadacini G,Quintana R,Parker D,Robergs R,Appenzeller O,Bernardi L

    更新日期:2007-09-01 00:00:00

  • Frailty and the relationship between blood pressure and mortality in elderly patients with type 2 diabetes (Zwolle Outpatient Diabetes project Integrating Available Care-34).

    abstract:OBJECTIVE:We aimed to investigate whether adjustment for frailty influences the relationship of blood pressure with mortality in elderly patients with type 2 diabetes mellitus (T2DM). METHODS:Patients aged 60 years and older (n = 858) were selected from a prospective observational cohort study of primary care patients...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000555

    authors: van Hateren KJ,Hendriks SH,Groenier KH,Bakker SJ,Bilo HJ,Kleefstra N,Landman GW

    更新日期:2015-06-01 00:00:00

  • Neonatal sympathectomy of normotensive Wistar-Kyoto and spontaneously hypertensive rats with 6-hydroxydopamine: effects on resistance vessel structure and sensitivity to calcium.

    abstract::6-Hydroxydopamine (6-OHDA) was injected on alternate days from birth to 3 weeks of age into spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) control rats. The effects of this neonatal treatment on cardiovascular structure and mesenteric resistance vessel calcium sensitivity was studied in young (6 ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198608000-00010

    authors: Nyborg NC,Korsgaard N,Mulvany MJ

    更新日期:1986-08-01 00:00:00

  • Protection of retinal vasculature by losartan against apoptosis and vasculopathy in rats with spontaneous hypertension.

    abstract:OBJECTIVES:Retinal blood vessels may develop vasculopathy and apoptosis in response to hypertension. The present study was aimed at testing the role of losartan, a specific antagonist of angiotensin II receptor type 1 receptor in regulation of vascular apoptosis in retinal vasculature with hypertension. METHODS:Losart...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328333663f

    authors: Yang D,Zhang M,Huang X,Fang F,Chen B,Wang S,Cai J,Shi X,Qu J,Geng YJ

    更新日期:2010-03-01 00:00:00

  • Does home blood pressure allow for a better assessment of the white-coat effect than ambulatory blood pressure?

    abstract:BACKGROUND:The difference between clinic and ambulatory blood pressure (BP) is a poor estimate of the true white-coat effect (WCE) measured with beat-to-beat recording. METHOD:We investigated whether the difference between clinic and home BP (home WCE) was a better estimate of true WCE than ambulatory WCE. In 73 young...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283589ee6

    authors: Saladini F,Benetti E,Malipiero G,Casiglia E,Palatini P

    更新日期:2012-11-01 00:00:00

  • Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study.

    abstract:OBJECTIVES:To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS:Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimate...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001749

    authors: Viazzi F,Ceriello A,Fioretto P,Giorda C,Guida P,Russo G,Greco E,De Cosmo S,Pontremoli R,AMD-Annals Study Group.

    更新日期:2018-08-01 00:00:00

  • Antihypertensive treatment in patients with type-2 diabetes mellitus: what guidance from recent controlled randomized trials?

    abstract:BACKGROUND:Patients with type-2 diabetes have a high prevalence of hypertension and show an elevated incidence of cardiovascular events and nephropathy. OBJECTIVES:Recent randomized trials of antihypertensive therapy providing information about cardiovascular and renal risk in diabetes, blood pressure goals and best s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-200211000-00001

    authors: Zanchetti A,Ruilope LM

    更新日期:2002-11-01 00:00:00

  • Left ventricular-arterial coupling in systemic hypertension: analysis by means of arterial effective and left ventricular elastances.

    abstract:OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Cohen-Solal A,Caviezel B,Himbert D,Gourgon R

    更新日期:1994-05-01 00:00:00

  • Systemic and renal effects of a new angiotensin converting enzyme inhibitor, benazepril, in essential hypertension.

    abstract::Seventeen essential hypertensive patients with normal renal function were treated with a new non-sulphydryl orally active angiotensin converting enzyme (ACE) inhibitor, benazepril, 10 mg given once or twice daily, according to diastolic blood pressure levels, for 6 weeks. In all patients, changes in blood pressure, sy...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199011000-00003

    authors: Valvo E,Casagrande P,Bedogna V,Antiga L,Alberti D,Zamboni M,Perobelli L,Dal Santo F,Maschio G

    更新日期:1990-11-01 00:00:00

  • Linkage analysis of 2q14-q23 and 5q32 with blood pressure quantitative traits in Chinese sib pairs.

    abstract:OBJECTIVES:Several genome-wide scans recently accomplished in the ethnic Chinese revealed a number of candidate loci possibly contributing to essential hypertension, and some appeared to be replicable in 2q14-q23 and 5q32. The current study aimed to examine the linkage of qualitative and blood pressure quantitative tra...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200302000-00021

    authors: Ge D,Yang W,Huang J,Yao C,Xu X,Gan W,Zhao J,Liu D,Wang X,Duan X,Hui R,Shen Y,Yao Z,Qiang B,Gu D

    更新日期:2003-02-01 00:00:00

  • Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension.

    abstract:OBJECTIVE:Secondary activation of the renin-angiotensin system plays a major role in the progression of chronic nephropathies, and blockade of endothelin (ET) receptors has been shown to confer nephroprotection in experimental models of proteinuric renal disease. We tested the nephroprotective potential of selective en...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200312000-00028

    authors: Rothermund L,Kossmehl P,Neumayer HH,Paul M,Kreutz R

    更新日期:2003-12-01 00:00:00

  • Renal sodium handling in acute and chronic salt loading/depletion protocols: the confounding influence of acute water loading.

    abstract:OBJECTIVES:Renal tubular sodium handling was measured in healthy subjects submitted to acute and chronic salt-repletion/salt-depletion protocols. The goal was to compare the changes in proximal and distal sodium handling induced by the two procedures using the lithium clearance technique. METHODS:In nine subjects, acu...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200018110-00018

    authors: Burnier M,Monod ML,Chioléro A,Maillard M,Nussberger J,Brunner HR

    更新日期:2000-11-01 00:00:00

  • Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease.

    abstract:OBJECTIVE:Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. The primary object of the paper is to verify this possible associati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200105000-00007

    authors: Olivieri O,Stranieri C,Girelli D,Pizzolo F,Grazioli S,Russo C,Pignatti PF,Corrocher R

    更新日期:2001-05-01 00:00:00

  • Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes.

    abstract:AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000680

    authors: Walraven I,Mast MR,Hoekstra T,Jansen AP,Rauh SP,Rutters FR,van der Heijden AA,Elders PJ,Moll AC,Polak BC,Dekker JM,Nijpels G

    更新日期:2015-10-01 00:00:00

  • Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.

    abstract:OBJECTIVE:The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical determinant of endothelial nitric oxide synthase (eNOS) activity. When BH4 availability is limited, eNOS does not produce nitric oxide (NO) but instead generates superoxide. BH4 may reverse endothelial dysfunction due to cardiovascular...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000173520.13976.7d

    authors: Kase H,Hashikabe Y,Uchida K,Nakanishi N,Hattori Y

    更新日期:2005-07-01 00:00:00

  • The association between arterial stiffness and the angiotensin II type 1 receptor (A1166C) polymorphism is influenced by the use of cardiovascular medication.

    abstract:OBJECTIVE:To examine in a population with a high prevalence of hypertension, the association between six cardiovascular polymorphisms, arterial stiffness and medication use. METHODS:In this cross-sectional study (Hypertension: Interaction and Prevalence of POlymorphisms related to Cardiovascular Risk and the Associati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e328317f215

    authors: Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA

    更新日期:2009-01-01 00:00:00

  • Hypertension without cardiac hypertrophy does not induce a cardiac baroreflex deficit.

    abstract:OBJECTIVE:To investigate the effects of prolonged hypertension in the absence of cardiac hypertrophy on the blood pressure-heart rate reflex during acute and chronic NO synthase blockade. METHODS:Male Wistar rats were treated acutely with N omega-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg intraperitoneally) or ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199610000-00009

    authors: Banting JD,Wiseman SL,Adams MA

    更新日期:1996-10-01 00:00:00

  • Platelet aggregation and dense granule secretion in a colony of dogs with spontaneous hypertension.

    abstract:AIM:Since canine hereditary essential hypertension has been previously reported in a colony of Siberian husky dogs, we tested the suitability of this model for use in studies on the platelet defect identified in humans with essential hypertension. METHODS:Platelet aggregation and dense granule ATP secretion were measu...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199210120-00009

    authors: Thomas JS,McConnell MF,Bell TG,Padgett GA

    更新日期:1992-12-01 00:00:00