Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.


OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (PAI-1) gene expression than mice receiving Ang II, N-nitro-L-arginine methyl ester (L-NAME), apelin plus L-NAME or apelin plus Ang II plus L-NAME. In-vitro analysis using a luciferase construct driven by 3.1 kb of the human PAI-1 promoter revealed that apelin blocked Ang II-mediated PAI-1 gene expression. Immunoblotting for phosphorylated myosin phosphatase subunit and myosin light chain revealed that apelin blocked Ang II activation of the Rho kinase pathway, which is associated with induction of PAI-1 gene expression by Ang II. In addition, treatment of human aortic smooth muscle cells with apelin reduced PAI-1 mRNA and protein production in the presence and absence of Ang II. Conversely, L-NAME treatment attenuated the downregulation of PAI-1 by apelin in cells. CONCLUSION:Apelin protects against cardiac fibrosis and vascular remodeling through direct regulation of PAI-1 gene expression. This protective effect is mediated through the synergistic inhibition of Ang II signaling and increased production of nitric oxide by apelin. Our data extend previous findings and provide new insight into the molecular mechanisms by which apelin elicits a cardioprotective effect.


J Hypertens


Journal of hypertension


Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH




Has Abstract


2011-04-01 00:00:00












  • Pulse wave velocity is increased in patients with transient myocardial ischemia.

    abstract:OBJECTIVE:We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischem...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Baulmann J,Homsi R,Uen S,Düsing R,Fimmers R,Vetter H,Mengden T

    更新日期:2006-10-01 00:00:00

  • Cardiovascular responsivity to stress in adolescents with and without persistently elevated blood pressure.

    abstract:OBJECTIVES:The goal of this study was to compare the cardiovascular responses to behavioural stressors of three groups of adolescents who differed in blood pressure status across assessments. DESIGN:Casual blood pressure of adolescents who were identified as having elevated blood pressure during a school screen was re...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Saab PG,Llabre MM,Ma M,DiLillo V,McCalla JR,Fernander-Scott A,Copen R,Gellman M,Schneiderman N

    更新日期:2001-01-01 00:00:00

  • Seasonal trends of blood pressure during pregnancy in Japan: the babies and their parents' longitudinal observation in Suzuki Memorial Hospital in Intrauterine Period study.

    abstract:OBJECTIVE:Blood pressure (BP) increases both in winter and in the last trimester of pregnancy. Some interaction seems to exist between season and gestational age. The present study observed home BP values during pregnancy with adjustment for seasonal variation and gestational age. METHODS:We observed 10353 home BP mea...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Metoki H,Ohkubo T,Watanabe Y,Nishimura M,Sato Y,Kawaguchi M,Hara A,Hirose T,Obara T,Asayama K,Kikuya M,Yagihashi K,Matsubara Y,Okamura K,Mori S,Suzuki M,Imai Y,BOSHI Study Group.

    更新日期:2008-12-01 00:00:00

  • Evaluation of miR-34b/c polymorphisms to the risk of ischemic stroke.

    abstract:OBJECTIVES:Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. METHODS:MiR-34b/c rs2187473 and rs4938723 polymorphisms were genotyped by Snapshot assay among 495 controls and 492 ischemic ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Wei G,Liao C,Jian C,Liang L,Liu J,Tang Y,Wei Y

    更新日期:2020-08-01 00:00:00

  • Isolation of T-cell clones with specificity for arterial antigen from spontaneously hypertensive rats.

    abstract:OBJECTIVE:It has been postulated that hypertension in the spontaneously hypertensive rat (SHR) results from autoimmune damage to the SHR vasculature. The objective of this study was to isolate autoreactive T-cells specific for arterial antigens, and to characterize these cells. DESIGN:The presence of autoreactive T-ce...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Ofosu-Appiah W,Ruggiero C,Huang LY

    更新日期:1993-12-01 00:00:00

  • Impaired expression of duodenal iron transporters in Dahl salt-sensitive heart failure rats.

    abstract:OBJECTIVE:Anemia is common in patients with heart failure and several factors have been thought to cause anemia in heart failure. Despite vigorous studies, the mechanism underlying the pathophysiology of anemia in heart failure is unknown. We investigated the iron regulating system in Dahl salt-sensitive heart failure ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Naito Y,Tsujino T,Fujimori Y,Sawada H,Akahori H,Hirotani S,Ohyanagi M,Masuyama T

    更新日期:2011-04-01 00:00:00

  • Renal sodium handling in acute and chronic salt loading/depletion protocols: the confounding influence of acute water loading.

    abstract:OBJECTIVES:Renal tubular sodium handling was measured in healthy subjects submitted to acute and chronic salt-repletion/salt-depletion protocols. The goal was to compare the changes in proximal and distal sodium handling induced by the two procedures using the lithium clearance technique. METHODS:In nine subjects, acu...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burnier M,Monod ML,Chioléro A,Maillard M,Nussberger J,Brunner HR

    更新日期:2000-11-01 00:00:00

  • Aging and vascular responses to flavanol-rich cocoa.

    abstract:OBJECTIVES:Strong evidence has secured aging as a powerful predictor of both cardiovascular risk and endothelial dysfunction, yet specific treatment is not available. We tested the hypothesis that vascular responsiveness to flavanol-rich cocoa increases with advancing age. We have previously shown that flavanol-rich co...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Fisher ND,Hollenberg NK

    更新日期:2006-08-01 00:00:00

  • The association between blood pressure and lipid levels in Europe: European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice.

    abstract:OBJECTIVES:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Borghi C,Rodriguez-Artalejo F,De Backer G,Dallongeville J,Medina J,Guallar E,Perk J,Banegas JR,Tubach F,Roy C,Halcox JP

    更新日期:2016-11-01 00:00:00

  • Long-term efficacy of a new, fixed, very-low-dose angiotensin-converting enzyme-inhibitor/diuretic combination as first-line therapy in elderly hypertensive patients.

    abstract:OBJECTIVE:To determine the long-term efficacy and safety of a fixed, very-low-dose tablet combining one-half the standard dose of perindopril with one-quarter the standard dose of indapamide as first-line treatment in elderly patients. DESIGN:Double-blind, randomized, placebo-controlled study in an outpatient setting....

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Chalmers J,Castaigne A,Morgan T,Chastang C

    更新日期:2000-03-01 00:00:00

  • Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study.

    abstract:OBJECTIVE:The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR). DESIGN:SBP, heart: and left ventricle: body weight ratios, the cross-sectional area of cardiocytes, and the ultrastructur...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Ferrante F,Bronzetti E,Ciriaco E,Felici L,Amenta F

    更新日期:1992-06-01 00:00:00

  • Screening for orthostatic hypotension using home blood pressure measurements.

    abstract:OBJECTIVE:Orthostatic hypotension is a common condition associated with adverse cardiovascular and cognitive prognosis. Screening for orthostatic hypotension consists of blood pressure measurements in supine (or sitting) and standing position during clinical consultations. As orthostatic hypotension is a poorly reprodu...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Cremer A,Rousseau AL,Boulestreau R,Kuntz S,Tzourio C,Gosse P

    更新日期:2019-05-01 00:00:00

  • Prevalence, awareness, treatment and control of hypertension in four Middle East countries.

    abstract:OBJECTIVE:We report the prevalence, awareness, treatment, and control of hypertension across four Middle Eastern countries (Iran, Occupied Palestinian Territory, Saudi Arabia, and United Arab Emirates), using a standardized and uniform method. METHODS:The Prospective Urban Rural Epidemiology study enrolled participant...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Yusufali AM,Khatib R,Islam S,Alhabib KF,Bahonar A,Swidan HM,Khammash U,Alshamiri MQ,Rangarajan S,Yusuf S

    更新日期:2017-07-01 00:00:00

  • Frailty and the relationship between blood pressure and mortality in elderly patients with type 2 diabetes (Zwolle Outpatient Diabetes project Integrating Available Care-34).

    abstract:OBJECTIVE:We aimed to investigate whether adjustment for frailty influences the relationship of blood pressure with mortality in elderly patients with type 2 diabetes mellitus (T2DM). METHODS:Patients aged 60 years and older (n = 858) were selected from a prospective observational cohort study of primary care patients...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: van Hateren KJ,Hendriks SH,Groenier KH,Bakker SJ,Bilo HJ,Kleefstra N,Landman GW

    更新日期:2015-06-01 00:00:00

  • Pharmacogenomics of blood pressure response to antihypertensive treatment.

    abstract:UNLABELLED:PURPOSE IDENTIFICATION: Inter-individual variability in blood pressure response to treatment is well documented, but a clinically useful means to distinguish responders from non-responders has been elusive. With the advent of new technologies and genomic knowledge, more investigators are seeking to identify ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Mellen PB,Herrington DM

    更新日期:2005-07-01 00:00:00

  • Regression of left ventricular hypertrophy and microalbuminuria changes during antihypertensive treatment.

    abstract:OBJECTIVE:The objective of the present study was to assess the regression of left ventricular hypertrophy (LVH) during antihypertensive treatment, and its relationship with the changes in microalbuminuria. INDIVIDUALS AND METHODS:One hundred and sixty-eight previously untreated patients with echocardiographic LVH, 46 ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Rodilla E,Pascual JM,Costa JA,Martin J,Gonzalez C,Redon J

    更新日期:2013-08-01 00:00:00

  • Hypertension without cardiac hypertrophy does not induce a cardiac baroreflex deficit.

    abstract:OBJECTIVE:To investigate the effects of prolonged hypertension in the absence of cardiac hypertrophy on the blood pressure-heart rate reflex during acute and chronic NO synthase blockade. METHODS:Male Wistar rats were treated acutely with N omega-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg intraperitoneally) or ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Banting JD,Wiseman SL,Adams MA

    更新日期:1996-10-01 00:00:00

  • Subtype diagnosis, treatment, complications and outcomes of primary aldosteronism and future direction of research: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension.

    abstract::: Primary aldosteronism is a frequent cause of secondary hypertension requiring a specific pharmacological treatment with mineralocorticoid receptor antagonist or with unilateral adrenalectomy. These treatments have shown to reduce the excess of cardiovascular risk characteristically associated with this disease. In p...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Mulatero P,Sechi LA,Williams TA,Lenders JWM,Reincke M,Satoh F,Januszewicz A,Naruse M,Doumas M,Veglio F,Wu VC,Widimsky J

    更新日期:2020-06-25 00:00:00

  • Interarm blood pressure difference and target organ damage in the general population.

    abstract:OBJECTIVE:The objective of the study was to investigate interarm differences of blood pressure (BP) and its determinants, and to clarify whether both arms are equally good in assessing BP and target organ damage in the general population. METHODS:We studied a representative sample of Finnish adult population with 484 ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Johansson JK,Puukka PJ,Jula AM

    更新日期:2014-02-01 00:00:00

  • Patients' and healthcare providers' perceptions and practices regarding hypertension, pharmacy-based care, and mHealth in Lagos, Nigeria: a mixed methods study.

    abstract:BACKGROUND:In sub-Saharan Africa, cardiovascular disease is becoming a leading cause of death, with high blood pressure as number one risk factor. In Nigeria, access and adherence to hypertension care are poor. A pharmacy-based hypertension care model with remote monitoring by cardiologists through mHealth was piloted ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Cremers AL,Alege A,Nelissen HE,Okwor TJ,Osibogun A,Gerrets R,Van't Hoog AH

    更新日期:2019-02-01 00:00:00

  • Prognostic role of flow-mediated dilatation of the brachial artery in hypertensive patients.

    abstract:BACKGROUND:The prognostic role of endothelial dysfunction, as evaluated by flow-mediated vasodilatation of the brachial artery, has been demonstrated in patients at very high risk. We aimed to investigate whether flow-mediated vasodilatation predicts cardiovascular events in uncomplicated hypertensive patients. METHOD...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Muiesan ML,Salvetti M,Paini A,Monteduro C,Galbassini G,Poisa P,Porteri E,Agabiti-Rosei C,Paderno V,Belotti E,Rizzoni D,Castellano M,Agabiti-Rosei E

    更新日期:2008-08-01 00:00:00

  • Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats.

    abstract::Isolated tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP), but not from normotensive Wistar-Kyoto rats (WKY), exhibit oscillatory contractions in response to norepinephrine. Previous studies indicate that the mechanism for these oscillations involves altered membrane calcium and/or potassium han...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Bruner CA,Webb RC

    更新日期:1989-01-01 00:00:00

  • Childhood pulse pressure predicts subclinical vascular damage in adulthood: the Beijing Blood Pressure Cohort Study.

    abstract:OBJECTIVE:We aimed to investigate associations of childhood pulse pressure (PP) and change in PP status with adult subclinical vascular damage. METHODS:Data were obtained from a population-based cohort of children aged 6-18 years started in 1987. The study constituted 1254 participants who were followed up in 2010-201...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Hou D,Yan Y,Liu J,Zhao X,Cheng H,Mi J

    更新日期:2018-08-01 00:00:00

  • Arterial pressure: agreement between a brachial cuff-based device and radial tonometry.

    abstract:OBJECTIVES:Aortic (central) blood pressure (BP) differs from brachial BP and may be a superior predictor of cardiovascular events. However, its measurement is currently restricted to research settings, owing to a moderate level of operator dependency. We tested a new noninvasive device in a large UK cohort. The device ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Park CM,Korolkova O,Davies JE,Parker KH,Siggers JH,March K,Tillin T,Chaturvedi N,Hughes AD

    更新日期:2014-04-01 00:00:00

  • Genetics of experimental hypertension.

    abstract::Experimental models of genetic hypertension are used to develop paradigms to study human essential hypertension while removing some of the complexity inherent in the study of human subjects. Since 1991 several quantitative trait loci responsible for blood pressure regulation have been identified in various rat crosses...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Dominiczak AF,Clark JS,Jeffs B,Anderson NH,Negrin CD,Lee WK,Brosnan MJ

    更新日期:1998-12-01 00:00:00

  • Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.

    abstract:OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats with angiotensin II (ANG II)-dependent hypertension. METHODS:Ren-2 tra...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Červenka L,Husková Z,Kopkan L,Kikerlová S,Sedláková L,Vaňourková Z,Alánová P,Kolář F,Hammock BD,Hwang SH,Imig JD,Falck JR,Sadowski J,Kompanowska-Jezierska E,Neckář J

    更新日期:2018-06-01 00:00:00

  • Blood pressure and the global burden of disease 2000. Part II: estimates of attributable burden.

    abstract:OBJECTIVES:To provide estimates of the global burden of disease attributable to non-optimal blood pressure by age and sex for adults aged > or = 30 years, by WHO subregion. METHODS:Estimates of attributable burden were made using population impact fractions, which used data on mean systolic blood pressure levels, dise...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Lawes CM,Vander Hoorn S,Law MR,Elliott P,MacMahon S,Rodgers A

    更新日期:2006-03-01 00:00:00

  • Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7.

    abstract:OBJECTIVE:Neuropeptide W (NPW), an endogenous ligand for the G protein-coupled receptor 7 (GPR7), was first found to make important roles in central nerve system. In periphery, NPW was also present and regulated intracellular calcium homeostasis by L-type calcium channels. This study was designed to discover the effect...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Ji L,Zhu H,Chen H,Fan W,Chen J,Chen J,Zhu G,Wang J

    更新日期:2015-12-01 00:00:00

  • Internally quenched fluorogenic substrates for angiotensin I-converting enzyme.

    abstract:OBJECTIVE:Development of internally quenched fluorogenic substrates for sensitive and continuous assays of angiotensin I-converting enzyme (ACE). DESIGN:We synthesized internally quenched fluorogenic bradykinin-related peptides introducing Abz (ortho-aminobenzoic acid) and EDDnp (N-[2,4-dinitrophenyl]-ethylenediamine)...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Araujo MC,Melo RI,Del Nery E,Alves MF,Juliano MA,Casarini DE,Juliano L,Carmona AK

    更新日期:1999-05-01 00:00:00

  • Blood pressure reduction in acute ischemic stroke according to time to treatment: a subgroup analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial.

    abstract:OBJECTIVE:The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS:We randomly assigned...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Xu T,Zhang Y,Bu X,Wang D,Sun Y,Chen CS,Wang J,Peng H,Ju Z,Peng Y,Xu T,Li Q,Geng D,Zhang J,Li D,Zhang F,Guo L,Wang X,Cui Y,Li Y,Ma D,Zhang D,Yang G,Gao Y,Yuan X,Chen J,He J,CATIS investigators.

    更新日期:2017-06-01 00:00:00