Increased platelet size and release reaction in essential hypertension.

abstract：OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...

journal_title：Journal of hypertension

authors： Palmer AJ,Fletcher AE,Bulpitt CJ,Beevers DG,Coles EC,Ledingham JG,Petrie JC,Webster J,Dollery CT

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:The pregnant spontaneously hypertensive rat (SHR) exhibits a decrease in arterial blood pressure shortly before delivery; however, the mechanisms are unknown. Nitric oxide may be involved. DESIGN:Blood pressure in stroke-prone SHR (SHRSP) and Wistar-Kyoto control rats (WKY) was telemetrically measured. Four ...

journal_title：Journal of hypertension

authors： Gompf H,Luft FC,Morano I

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the wave reflection characteristics in the aortic arch and common carotid artery of ex-preterm adolescents and assess their relationship to central blood pressure in a cohort followed prospectively since birth. METHODS:Central blood pressures, pulse wave velocity, augmentation index, microvascula...

journal_title：Journal of hypertension

authors： Kowalski RR,Beare R,Mynard JP,Cheong JLY,Doyle LW,Smolich JJ,Cheung MMH

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Telmisartan is a unique AT1 receptor blocker with a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonistic action. Activation of PPAR-gamma could prevent inflammation and brain damage. METHOD:We investigated the beneficial effect of telmisartan on ischemic brain damage via PPAR-gamma activa...

journal_title：Journal of hypertension

authors： Iwanami J,Mogi M,Tsukuda K,Min LJ,Sakata A,Jing F,Iwai M,Horiuchi M

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:The increase in blood pressure that accompanies the obese state is almost invariably associated with alterations in metabolism (insulin resistance and dyslipidaemia) and the neurohumoral profile (activation of the renin-angiotensin system, sympathetic overactivity), which potentiate the cardiovascular risk as...

journal_title：Journal of hypertension

authors： Grassi G,Seravalle G,Dell'Oro R,Trevano FQ,Bombelli M,Scopelliti F,Facchini A,Mancia G,CROSS Study.

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Despite the widespread use of multivitamin supplements, little is known regarding their effects on blood pressure (BP) and the development of hypertension. We, therefore, sought to prospectively investigate how multivitamin use was associated with incident hypertension among middle-aged and older women. METH...

journal_title：Journal of hypertension

authors： Rautiainen S,Wang L,Lee IM,Manson JE,Gaziano JM,Buring JE,Sesso HD

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:Genetically hypertensive rats provide an excellent model to investigate the genetic mechanisms of hypertension. We previously identified three differentially expressed genes, Acadsb (short/branched chain acyl-CoA dehydrogenase), Comt (catecholamine-O-methyltransferase), and Pnpo (pyridoxine 5'-phosphate oxid...

journal_title：Journal of hypertension

authors： Kamide K,Kokubo Y,Yang J,Matayoshi T,Inamoto N,Takiuchi S,Horio T,Miwa Y,Yoshii M,Tomoike H,Tanaka C,Banno M,Okuda T,Kawano Y,Miyata T

更新日期：2007-01-01 00:00:00

abstract：:The function of the renin-angiotensin system (RAS) is influenced by changes in sodium balance and angiotensin II (ANG II) levels. In previous studies it has been difficult to assess the physiological effects on blood pressure homeostasis of different rates of ANG II infusion and of different levels of sodium in the di...

journal_title：Journal of hypertension

authors： Olsen ME,Meydrech EF

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. METHODS:MiR-34b/c rs2187473 and rs4938723 polymorphisms were genotyped by Snapshot assay among 495 controls and 492 ischemic ...

journal_title：Journal of hypertension

authors： Wei G,Liao C,Jian C,Liang L,Liu J,Tang Y,Wei Y

更新日期：2020-08-01 00:00:00

abstract：:This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...

journal_title：Journal of hypertension

authors： Weinstock M,Borosh M,Kafri O,Kaczmarczyk G

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:To determine plasma aldosterone concentration (PAC) and plasma renin concentration (PRC) and aldosterone-to-renin ratio (ARR) values in a population attending a Clinic for Cardiovascular Risk Assessment in Children. METHODS:We assessed ARR and associated factors in a cohort of 287 children (137 female, 4-18 ...

journal_title：Journal of hypertension

authors： Genovesi S,Antolini L,Orlando A,Tassistro E,Giussani M,Nava E,Turolo L,Manolopoulou J,Parati G,Morganti A

更新日期：2018-02-01 00:00:00

abstract：:Systolic blood pressure was measured on a total of 1855 occasions in 1307 children aged four and five years, and compared with values obtained since birth in the same children. There was a rapid rise in blood pressure in the first month of life. The mean blood pressure then only rose from 93 mmHg at six months to 98 m...

journal_title：Journal of hypertension

authors： de Swiet M,Fayers PM,Shinebourne EA

更新日期：1984-10-01 00:00:00

abstract：AIM:Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exoge...

journal_title：Journal of hypertension

authors： Montero D,Pierce GL,Stehouwer CD,Padilla J,Thijssen DH

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:An excess morning blood pressure surge (MBPS) may portend an increased cardiovascular risk, but the mechanisms thereof have been little investigated. The link between MBPS, short-term blood pressure (BP) variability, and arterial stiffness has not been entirely defined. METHODS:In 602 consecutive untreated h...

journal_title：Journal of hypertension

authors： Pucci G,Battista F,Anastasio F,Schillaci G

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Increased arterial stiffness is associated with cardiovascular morbidity and mortality among hypertensive patients. OBJECTIVES:To assess the relationship between ambulatory arterial stiffness index (AASI) and subclinical left ventricular (LV) systolic dysfunction assessed by 2-D speckle-tracking echocardiog...

journal_title：Journal of hypertension

authors： Ahmed TAN,Shams-Eddin H,Fathy MA,El-Naggar HM,Kishk YT

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:Enhanced central sympathetic outflow is an indicator of the prognosis of heart failure. Although the central sympatholytic drug moxonidine is an established therapeutic strategy for hypertension, its benefits for hypertensive heart failure are poorly understood. In the present study, we investigated the effe...

journal_title：Journal of hypertension

authors： Honda N,Hirooka Y,Ito K,Matsukawa R,Shinohara K,Kishi T,Yasukawa K,Utsumi H,Sunagawa K

更新日期：2013-11-01 00:00:00

abstract：:Normotensives with hypertensive parents have been reported to exhibit enhanced cardiovascular reactions to mental stress. We have examined the question of why this result was not confirmed in all studies. In addition we have investigated whether appropriate tests can be performed under clinical rather than laboratory ...

journal_title：Journal of hypertension

authors： Neus H,Gödderz W,Otten H,Rüddel H,von Eiff AW

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:Whether the C-344T polymorphism of the aldosterone synthase gene is important for blood pressure control remains controversial. It has been proposed that an association between this polymorphism and blood pressure might be evident in elderly subjects. The aim of the present study was to test this hypothesis ...

journal_title：Journal of hypertension

authors： Casiglia E,Tikhonoff V,Mazza A,Rynkiewicz A,Limon J,Caffi S,Guglielmi F,Martini B,Basso G,Winnicki M,Pessina AC,Somers VK

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To find an objective, sensitive method for quantifying microvascular alterations associated with level of blood pressure and age. DESIGN:A prospective cross-sectional study. SUBJECTS AND METHODS:Seventy-four previously untreated hypertensive patients, referred to a hospital outpatients department, and 26 no...

journal_title：Journal of hypertension

authors： Stanton AV,Mullaney P,Mee F,O'Brien ET,O'Malley K

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Similar to cancer, pulmonary arterial hypertension (PAH) is characterized by vascular remodeling, which leads to obliteration of the small pulmonary arteriole, with marked proliferation of pulmonary artery smooth muscle cells (PASMC) and/or endothelial cells dysfunction. Aberrant expression of tumor suppresso...

journal_title：Journal of hypertension

authors： Nie X,Dai Y,Tan J,Chen Y,Qin G,Mao W,Zou J,Chang Y,Wang Q,Chen J

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To determine the role of current weight in mediating the relationship between birth weight and blood pressure within the context of the 'fetal origins' hypothesis. DESIGN:Prospective cohort study of 2507 pregnant women and their singleton offspring, delivered live at term, in Perth, Western Australia between...

journal_title：Journal of hypertension

authors： Blake KV,Gurrin LC,Evans SF,Beilin LJ,Stanley FJ,Landau LI,Newnham JP

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Few data are available comparing the effects of monotherapy and combination therapy on target organ damage. The PICXEL study compared the efficacy of a strategy based on first-line combination with perindopril/indapamide versus monotherapy with enalapril in reducing left ventricular hypertrophy (LVH) in hyper...

journal_title：Journal of hypertension

authors： Dahlöf B,Gosse P,Guéret P,Dubourg O,de Simone G,Schmieder R,Karpov Y,García-Puig J,Matos L,De Leeuw PW,Degaute JP,Magometschnigg D,PICXEL Investigators.

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...

journal_title：Journal of hypertension

authors： Nishikimi T,Horio T,Kohmoto Y,Yoshihara F,Nagaya N,Inenaga T,Saito M,Teranishi M,Nakamura M,Ohrui M,Kawano Y,Matsuo H,Ishimitsu T,Takishita S,Matsuoka H,Kangawa K

更新日期：2001-04-01 00:00:00

abstract：:The diagnosis of high risk of cardiovascular disease (CVD) in subjects without clinically overt CVD has been somewhat improved by integrating multiple traditional risk factors via appropriate risk score programs. Nevertheless, novel measures of CVD risk are being proposed and debated to further improve high-risk detec...

journal_title：Journal of hypertension

authors： Simon A,Levenson J

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pneumonia hospitalization in patients with stroke history in Taiwan. METHODS:We conducted a case-crossover study using the National Health Insurance Research Database in Taiwan during the period from...

journal_title：Journal of hypertension

authors： Liu CL,Shau WY,Wu CS,Lai MS

更新日期：2012-11-01 00:00:00

abstract：:Recent investigations have delineated the renal microvascular responsiveness to pressure, by using isolated afferent arterioles, juxtamedullary nephrons, and isolated perfused hydronephrotic kidneys. Both afferent arterioles and interlobular arteries (ILA) manifest pressure-dependent vasoconstrictor responses to eleva...

journal_title：Journal of hypertension

authors： Hayashi K,Epstein M,Saruta T

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

journal_title：Journal of hypertension

authors： Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Familial hyperkalaemic hypertension (FHH) is a Mendelian form of low-renin hypertension characterized by hyperkalaemia and hyperchloraemic acidosis despite a normal glomerular filtration rate. To date, three different loci have been identified, on chromosomes 1, 17 and 12. OBJECTIVE:To test for genetic link...

journal_title：Journal of hypertension

authors： Disse-Nicodeme S,Desitter I,Fiquet-Kempf B,Houot AM,Stern N,Delahousse M,Potier J,Ader JL,Jeunemaitre X

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Obstructive sleep apnoea (OSA) and hypertension frequently coexist, and both are associated with higher night-time than daytime urine sodium excretion rate (UNaV). However, the relative contribution of each condition is unknown. We compared the circadian pattern of UNaV in hypertensive and normotensive patie...

journal_title：Journal of hypertension

authors： White LH,Bradley TD,Logan AG

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:We have previously reported that hearts from N-[omega]-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats exhibited an enhanced expression of Gi proteins. Since, losartan, an AT1 receptor antagonist, has been shown to attenuate the L-NAME-induced increase in blood pressure, we undertook the pres...

journal_title：Journal of hypertension

authors： Hashim S,Anand-Srivastava MB

更新日期：2004-01-01 00:00:00