Abstract:
OBJECTIVE:To investigate the role of ouabain in human hypertension and to establish whether immunoreactive endogenous ouabain is secreted by the adrenal gland under the influence of dopaminergic regulation. METHODS:We measured plasma levels of endogenous ouabain by immunoassay, together with other variables, including plasma renin activity and aldosterone levels, in 91 clinically selected hypertensives and 19 healthy volunteers. We also measured endogenous ouabain in adrenal venous blood and the effect of DA2 dopaminergic receptor blockade and stimulation. After a thorough clinical evaluation, 64 patients were diagnosed with essential hypertension and 24 with primary aldosteronism. RESULTS:Plasma levels of endogenous ouabain were higher in essential hypertensives than in controls. Multiple regression analysis showed a significant relationship of mean blood pressure with plasma endogenous ouabain, age and body mass index, but not with other measured parameters. The plasma levels of endogenous ouabain were more than two standard deviations above the mean value for normotensives in 45% of patients with essential hypertension in whom plasma renin activity was normal. Higher plasma levels of endogenous ouabain were found in patients with aldosterone excess, specifically affecting 56% of 17 patients with surgically confirmed adrenal cortical adenoma and one (14%) of seven patients with idiopathic causes. Removal of adenomas lowered blood pressure in half of the patients in whom plasma levels of endogenous ouabain normalized after surgery. Plasma endogenous ouabain levels were similar in venous blood from the adrenal and inferior vena cava, and plasma levels were not influenced by DA2 dopaminergic blockade and stimulation. CONCLUSION:Approximately half of Caucasian patients with essential hypertension and with hyperaldosteronism exhibit elevated circulating levels of endogenous ouabain. The latter do not appear to be secondary to hypertension, are unrelated to plasma renin activity, and may not involve adrenal type-2 dopaminergic receptors.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Rossi G,Manunta P,Hamlyn JM,Pavan E,De Toni R,Semplicini A,Pessina ACdoi
10.1097/00004872-199510000-00013subject
Has Abstractpub_date
1995-10-01 00:00:00pages
1181-91issue
10eissn
0263-6352issn
1473-5598journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Inflammatory processes may play a pivotal role in the pathogenesis of cerebrovascular injury in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP). Thromboxane A2 (TP) receptor stimulation by 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) is involved in the process of vascular inflammation. O...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3280464dc8
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To determine the effects of capillary rarefaction on cardiovascular reactivity and microcirculatory functioning in essential hypertension. DESIGN:Hypertension is associated with abnormal cardiovascular reactivity and increased vasoconstriction. Capillary rarefaction amplifies these abnormalities, which modif...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200312000-00018
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To determine the suitability of a new logistic curve fitting procedure to measure the diurnal rates of transition from the active to the asleep periods separately. METHOD:We applied this method to 24-h telemetry recordings of systolic, mean, diastolic arterial pressure (SAP, MAP, DAP, respectively), heart ra...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200411000-00008
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:An increased inter-arm SBP difference (IASBPD) is associated with mortality and cardiovascular events, as well as peripheral vascular disease, which is attributed to subclavian stenosis. The aim of the present study was to investigate the association between the IASBPD and incident chronic kidney disease (CKD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001931
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:The present study aimed to assess the effect of the specific dipeptidyl peptidase IV (DPPIV) inhibitor sitagliptin on blood pressure and renal function in young prehypertensive (5-week-old) and adult spontaneously hypertensive rats (SHRs; 14-week-old). METHODS:Sitagliptin (40 mg/kg twice daily) was given by...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328341939d
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that insulin differently modifies vasoconstriction and recovery from vasoconstriction induced by endogenously released versus circulating norepinephrine, and to investigate the time-dependency of its effect METHODS:Healthy male subjects were studied. Norepinephrine was infused for 10 m...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:Functional sex differences are described in several vascular beds. In the case of renal vessels, sex differences could influence processes like regulation of blood pressure and ion balance. Angiotensin II and nitric oxide are important regulators of renal vascular tone. Females have higher nitric oxide syntha...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835731dd
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:In familial hyperaldosteronism type I (FH-I), glucocorticoid treatment suppresses adrenocorticotrophic hormone-regulated hybrid gene expression and corrects hyperaldosteronism. OBJECTIVE:To determine whether the wild-type aldosterone synthase genes, thereby released from chronic suppression, are capable of ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715120-00080
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. The primary object of the paper is to verify this possible associati...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200105000-00007
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Arterial hypertension is recurrently associated with inflammation of the endothelium as an effect of the upregulation of functional molecules, including cytokines, adhesion molecules and chemokines. However, the role of monocyte chemoattractant protein-1 (MCP-1) in maintaining the inflammatory state of endoth...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000234111.31239.c3
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing hypertension in primary care. METHODS:Two hundred and forty-seven consecutive participants with raised (≥130 mmHg systolic) BP measured by their general practitioner from four primary care practices in...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000489
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. METHODS:MiR-34b/c rs2187473 and rs4938723 polymorphisms were genotyped by Snapshot assay among 495 controls and 492 ischemic ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002413
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:It is estimated that there are more than 16 million adults with drug-resistant hypertension in China. Nevertheless, the prevalence of and risk factors for primary aldosteronism, a highly curable condition among adults with drug-resistant hypertension, has not been fully investigated. METHODS:Between January...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328360ddf6
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypert...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001218
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:In a previous study, we found that neonatal sympathectomy prevented the development of angiotensin II (ANG II)-induced hypertension but not the development of structural changes in small mesenteric arteries. OBJECTIVES:To investigate further the dissociation between hypertension and structural vascular chan...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816010-00012
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Increased arterial stiffness is associated with cardiovascular morbidity and mortality among hypertensive patients. OBJECTIVES:To assess the relationship between ambulatory arterial stiffness index (AASI) and subclinical left ventricular (LV) systolic dysfunction assessed by 2-D speckle-tracking echocardiog...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002330
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:This study aimed to explore the predictive role of CHA2DS2-VASc score between venous thromboembolism (VTE) and ischemic stroke. METHODS:The current study was analyzed from the in-patient claims data of the Taiwan National Health Insurance Research Database. We identified the patients diagnosed with VTE (for St...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001539
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/01.hjh.0000163154.35577.8e
更新日期:2005-04-01 00:00:00
abstract::The haemodynamic effects associated with the onset of hypertension induced by infusion of adrenocorticotrophin (ACTH) were investigated in sheep. Analysis of haemodynamic data collected over 24 h by a computer-based monitoring system revealed that mean arterial pressure (MAP) was significantly increased after 4 h. Car...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To examine in a population with a high prevalence of hypertension, the association between six cardiovascular polymorphisms, arterial stiffness and medication use. METHODS:In this cross-sectional study (Hypertension: Interaction and Prevalence of POlymorphisms related to Cardiovascular Risk and the Associati...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/hjh.0b013e328317f215
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:A recent editorial published by Verma and Strauss, entitled 'Angiotensin receptor blockers and myocardial infarction', examined, through a partial analysis of individual trials, the use of angiotensin receptor blockers (ARBs) in a variety of clinical settings. This editorial was reported widely in the lay pr...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.hjh.0000194114.12228.16
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To examine a possible involvement of a regulatory protein of Na+/H+ exchanger (NHE) in the increased renal NHE activity in spontaneously hypertensive rats (SHR), we investigated mRNA expression of inhibitory members of the NHE regulatory protein family, NHERF1 and NHERF2, in the kidney. DESIGN:Prehypertensiv...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200409000-00016
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To determine if the contribution of the sympathetic nervous system to blood pressure could be evidenced by low-frequency oscillations of systolic blood pressure (LF(SBP)), reflecting vascular sympathetic modulation, or by the decrease in blood pressure after autonomic blockade. DESIGN:We studied multiple sys...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-200309000-00017
更新日期:2003-09-01 00:00:00
abstract::Recently, there has been an explosion of knowledge on vasopressin, including its neuro-anatomy, biochemistry and physiology. Recent work demonstrates extensive extra-hypothalamic vasopressinergic projections from the SON and PVN. Of particular importance are projections to the cardiovascular medullary centres. Convers...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-198512000-00001
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:To assess the contribution of the sympathetic nervous system to the hypertension in patients with longstanding essential hypertension. DESIGN:Overall sympathetic function, presynaptic adrenoceptors and neuronal re-uptake were examined after withdrawal of medication for at least 3 weeks in eight patients with...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::: Primary aldosteronism is a frequent cause of secondary hypertension requiring a specific pharmacological treatment with mineralocorticoid receptor antagonist or with unilateral adrenalectomy. These treatments have shown to reduce the excess of cardiovascular risk characteristically associated with this disease. In p...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002520
更新日期:2020-06-25 00:00:00
abstract:OBJECTIVE:To evaluate the effects of angiotensins acting at the rostral ventrolateral medulla (RVLM) on the cardiovascular adjustments following haemorrhage. DESIGN:Changes in mean arterial pressure (MAP) and heart rate (HR) produced by micro-injections of angiotensin II (Ang II) and angiotensin (Ang)-(1-7) and differ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917080-00014
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:Normotensive rats fed a high fructose diet (HFD) develop hypertriglyceridemia, hyperinsulinemia and hypertension. The glomerular changes observed in the kidneys of these animals are similar to those observed in diabetic rats. The aim of this study was to evaluate whether lacidipine could be effective not only...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917070-00013
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000986
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:Unlike the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) guideline, the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline has recommended a shift in hypertension definition from blood pressure (BP) 140/90-130/80 mmHg. Further, they proposed so...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002065
更新日期:2019-07-01 00:00:00