Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats.

abstract：BACKGROUND:Hypertension is associated with endothelial dysfunction characterized by decreased endothelium-dependent relaxations and increased endothelium-dependent contractions. Angiotensin converting enzyme inhibitors and thromboxane A2 receptor antagonists decreased the endothelium dysfunction in hypertensive animals...

journal_title：Journal of hypertension

authors： Rodrigo E,Maeso R,Muñoz-García R,Navarro-Cid J,Ruilope LM,Cachofeiro V,Lahera V

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To compare the effects of a cardioselective beta-blocker (nebivolol) with those of an angiotensin-converting enzyme inhibitor (enalapril) on parameters of insulin sensitivity, peripheral blood flow and arterial stiffness during one extended glucose clamp experiment. DESIGN:A randomized, double-blind crossove...

journal_title：Journal of hypertension

authors： Kaiser T,Heise T,Nosek L,Eckers U,Sawicki PT

更新日期：2006-07-01 00:00:00

abstract：:The effects of essential fatty acid deficiency (EFAD) on vascular reactivity to vasoconstrictor stimuli were studied in rat autoperfused hindquarters. Weanling male Sprague-Dawley rats (aged 21 days) were fed diets containing 8% (weight/weight) of stearax plus 2% safflower oil (control diet) or 10% stearax (EFAD diet)...

journal_title：Journal of hypertension

authors： Kudo K,Dusting GJ,Loiacono RE,Sinclair AJ

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...

journal_title：Journal of hypertension

authors： Palmer AJ,Fletcher AE,Bulpitt CJ,Beevers DG,Coles EC,Ledingham JG,Petrie JC,Webster J,Dollery CT

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To assess the dilatory effectiveness of nitric oxide donors in resistance arteries of patients with arterial hypertension in comparison with that in those of normotensive controls. BACKGROUND:Endothelium-dependent vasodilation has been demonstrated to be impaired in arterial hypertension. Besides disturbance...

journal_title：Journal of hypertension

authors： Preik M,Kelm M,Feelisch M,Strauer BE

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:Several genome-wide scans recently accomplished in the ethnic Chinese revealed a number of candidate loci possibly contributing to essential hypertension, and some appeared to be replicable in 2q14-q23 and 5q32. The current study aimed to examine the linkage of qualitative and blood pressure quantitative tra...

journal_title：Journal of hypertension

authors： Ge D,Yang W,Huang J,Yao C,Xu X,Gan W,Zhao J,Liu D,Wang X,Duan X,Hui R,Shen Y,Yao Z,Qiang B,Gu D

更新日期：2003-02-01 00:00:00

abstract：:Measurements of exchangeable sodium, arterial pressure and plasma concentrations of active renin, angiotensin II, aldosterone, sodium and potassium were made in 35 hypertensive patients with renal artery stenosis, 30 having unilateral renal arterial lesions. Plasma urea was below 7 mmol/l in 24 of the patients with un...

journal_title：Journal of hypertension

authors： McAreavey D,Brown JJ,Cumming AM,Davies DL,Fraser R,Lever AF,Mackay A,Morton JJ,Robertson JI

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations. METHODS:NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (...

journal_title：Journal of hypertension

authors： Zhang SH,Rush RA

更新日期：2001-12-01 00:00:00

abstract：:: In 2010, 1.4 billion people globally had hypertension, with 14% controlled to systolic blood pressure (SBP, mmHg) below 140, which contributes to 18 million cardiovascular deaths annually. Recent hypertension guidelines endorsed SBP targets below 130 or lower for all or some hypertensive patients to reduce cardiovas...

journal_title：Journal of hypertension

authors： Egan BM,Kjeldsen SE,Grassi G,Esler M,Mancia G

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Optimal medication use obscures the impact of physical activity on traditional cardiometabolic risk factors. We evaluated the relationship between step counts and carotid-femoral pulse wave velocity (cfPWV), a summative risk indicator, in patients with type 2 diabetes and/or hypertension. RESEARCH DESIGN AND...

journal_title：Journal of hypertension

authors： Dasgupta K,Rosenberg E,Joseph L,Trudeau L,Garfield N,Chan D,Sherman M,Rabasa-Lhoret R,Daskalopoulou SS

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Smoking is a risk factor for increased carotid artery intima-media thickness (IMT). The apolipoprotein E (apoE) 4 allele has been associated with cardiovascular diseases, but the role of apoE in regard to intima-media thickness (IMT) has remained controversial. The objective was to investigate whether there i...

journal_title：Journal of hypertension

authors： Karvonen J,Kauma H,Kervinen K,Ukkola O,Rantala M,Päivänsalo M,Savolainen MJ,Kesäniemi YA

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Hypertension and fractures related to osteoporosis are major public health problems that often coexist. This study examined the associations between exposure to different antihypertensive drug classes and the risk of hip fracture in hypertensive patients. METHOD:We included 59 246 individuals, 50 years and o...

journal_title：Journal of hypertension

authors： Bokrantz T,Schiöler L,Boström KB,Kahan T,Mellström D,Ljungman C,Hjerpe P,Hasselström J,Manhem K

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:The radial artery pulse waveform is a continuous measure of pressure throughout the cardiac cycle, and thus can provide more information than just systolic and diastolic blood pressures. New indices based on a Windkessel model of the waveform, PTC1 and PTC2, are related to arterial compliance and add informa...

journal_title：Journal of hypertension

authors： Brumback LC,Andrews LIB,Jacobs DR Jr,Duprez DA,Shah SJ,Dougherty CM,Denenberg JO,Allison MA

更新日期：2020-11-24 00:00:00

abstract：OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats with angiotensin II (ANG II)-dependent hypertension. METHODS:Ren-2 tra...

journal_title：Journal of hypertension

authors： Červenka L,Husková Z,Kopkan L,Kikerlová S,Sedláková L,Vaňourková Z,Alánová P,Kolář F,Hammock BD,Hwang SH,Imig JD,Falck JR,Sadowski J,Kompanowska-Jezierska E,Neckář J

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:The antihypertensive effect of thiazide diuretics in angiotensin II induced hypertension has never been characterized. In the current study, we sought to determine the effect of a thiazide diuretic on arterial pressure and renal fluid excretion in rats receiving a chronic intravenous infusion of angiotensin ...

journal_title：Journal of hypertension

authors： Ballew JR,Fink GD

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity. AT1 receptor antagonists attenuate all these actions, but display some evidence o...

journal_title：Journal of hypertension

authors： Dendorfer A,Dominiak P,Tempel K,Raasch W

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To examine the changes in plasma brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and blood pressure in patients with essential hypertension on a low, normal and high sodium intake. DESIGN AND METHODS:Twelve patients with mild-to-moderate essential hypertension were studied. Plasma, urinary ...

journal_title：Journal of hypertension

authors： Buckley MG,Markandu ND,Sagnella GA,MacGregor GA

更新日期：1994-07-01 00:00:00

abstract：:The activity of renal Na-K-ATPase was compared in hypertension-prone (SBH) and hypertension-resistant (SBN) Sabra rats on regular sodium intake and 2-3 weeks after a high sodium diet. ATPase activity was determined in single nephron segments by a micromethod. The activity profile was found to be similar in the two sub...

journal_title：Journal of hypertension

authors： Doucet A,Mekler J,el Mernissi G,Ben-Ishay D

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:To explore the mechanisms for augmented neutral endopeptidase inhibitor-induced natriuresis in deoxycorticosterone acetate (DOCA)-salt rats. METHODS:We examined effects of a neutral endopeptidase-inhibitor, candoxatril, on plasma and urinary brain natriuretic peptide (BNP) levels, the influence of a specific...

journal_title：Journal of hypertension

authors： Hirata Y,Suzuki Y,Suzuki E,Hayakawa H,Kimura K,Goto A,Omata M,Minamino N,Kangawa K,Matsuo H

更新日期：1994-04-01 00:00:00

abstract：:Haemorheological characteristics were measured in a group of 52 patients with essential arterial hypertension (HT), and were compared with those of a group of normotensive subjects. The relationships between the arterial blood pressure (BP), the echocardiographic indices of left ventricular hypertrophy (LVH), and the ...

journal_title：Journal of hypertension

authors： Zannad F,Voisin P,Brunotte F,Bruntz JF,Stoltz JF,Gilgenkrantz JM

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Increased wall-to-lumen ratio of small arteries is a predictor of adverse cardiovascular prognosis. We aimed to analyze retinal arteriolar structure in never-treated patients with essential hypertension and to test whether elevated blood pressure is associated with an increased wall-to-lumen ratio of retinal ...

journal_title：Journal of hypertension

authors： Ritt M,Harazny JM,Ott C,Schlaich MP,Schneider MP,Michelson G,Schmieder RE

更新日期：2008-07-01 00:00:00

abstract：:The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...

journal_title：Journal of hypertension

authors： Mann JF,Sis J,Ritz E

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:To study the effect of oral magnesium supplementation on blood pressure, platelet aggregation and platelet calcium handling in deoxycorticosterone acetate (DOCA)-induced hypertension in rats. DESIGN AND METHODS:Rats were divided into four groups of 20 each. Drug treatments were given for a 6-week period. Con...

journal_title：Journal of hypertension

authors： Kh R,Khullar M,Kashyap M,Pandhi P,Uppal R

更新日期：2000-07-01 00:00:00

abstract：:: The term 'cardiorenal syndrome' (CRS) was introduced to describe problems related to the simultaneous existence of heart and renal insufficiency. The prevalence of anaemia in CRS is high and increases the risk of hospitalizations and death. Renin-angiotensin system (RAS) inhibition is the cornerstone therapy in card...

journal_title：Journal of hypertension

authors： Vlahakos DV,Tsioufis C,Manolis A,Filippatos G,Marathias KP,Papademetriou V,Mancia G

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:The upward trends in the prevalence and control of hypertension in Chinese adults have been described, but recent trends based on the most recent guidelines are unavailable. We examined recent trends in the prevalence, awareness, treatment and control of hypertension among Chinese adults from 1991 to 2015 bas...

journal_title：Journal of hypertension

authors： Ma S,Yang L,Zhao M,Magnussen CG,Xi B

更新日期：2020-11-11 00:00:00

abstract：OBJECTIVE:Daily exposure to air-jet stress (AJS) causes sustained elevations of blood pressure in borderline hypertensive rats (BHR). It is known that the renin-angiotensin system is activated during episodes of behavioral stress, and the purpose of this study was to assess the involvement of renin-angiotensin system i...

journal_title：Journal of hypertension

authors： Coste SC,Qi Y,Brooks VL,McCarron DA,Hatton DC

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Neuropeptide W (NPW), an endogenous ligand for the G protein-coupled receptor 7 (GPR7), was first found to make important roles in central nerve system. In periphery, NPW was also present and regulated intracellular calcium homeostasis by L-type calcium channels. This study was designed to discover the effect...

journal_title：Journal of hypertension

authors： Ji L,Zhu H,Chen H,Fan W,Chen J,Chen J,Zhu G,Wang J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:The global morbidity and mortality related to hypertension and associated disorders increases continuously and novel therapeutic strategies are still in high demand. Increasing evidence suggests the important role in blood pressure regulation of cytochrome P-450-dependent metabolites of arachidonic acid. Epo...

journal_title：Journal of hypertension

authors： Gawrys O,Husková Z,Baranowska I,Walkowska A,Sadowski J,Kikerlová S,Vaňourková Z,Honetschlägerová Z,Škaroupková P,Červenka L,Falck JR,Imig JD,Kompanowska-Jezierska E

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that the heptapeptide angiotensin-(1-7) [Ang-(1-7)] exerts important vasoactive actions and can act as an endogenous physiological antagonist of angiotensin II (Ang II) within the renin-angiotensin system (RAS). The present study was performed to evaluate the effects, first, of chron...

journal_title：Journal of hypertension

authors： Bürgelová M,Vanourková Z,Thumová M,Dvorák P,Opocenský M,Kramer HJ,Zelízko M,Malý J,Bader M,Cervenka L

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of the interaction between adenosine receptors and renal nerves on urinary sodium excretion and glomerular filtration rate. METHODS AND DESIGN:The effects on water and sodium excretion and glomerular filtration rate of A1 [2-chloro-N6-cyclopentyl-adenosine (CCPA)] and A2 [2-hesiny...

journal_title：Journal of hypertension

authors： Panzacchi G,Demarchi B,Busca G,Protasoni G,Golin R,Stella A

更新日期：1997-12-01 00:00:00