Evaluation of miR-34b/c polymorphisms to the risk of ischemic stroke.

Abstract:

OBJECTIVES:Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. METHODS:MiR-34b/c rs2187473 and rs4938723 polymorphisms were genotyped by Snapshot assay among 495 controls and 492 ischemic stroke patients. Expression levels of miR-34b and miR-34c were quantified by real-time PCR. Transcriptional activity of miR-34b/c promoter was measured by luciferase reporter assay. RESULTS:Rs4938723 was associated with an increased risk of ischemic stroke in our study (CC versus TT: OR = 2.34, 95% CI = 1.47-3.72, P = 0.001; C versus T: OR = 1.37, 95% CI = 1.12-1.68, P = 0.002; CC versus TT + TC: OR = 2.12, 95% CI = 1.37-3.29, P = 0.001). The expression levels of miR-34b and miR-34c were significantly downregulated in cases by contrast with controls (P < 0.05). Further analysis demonstrated that the expression levels of miR-34b and miR-34c were also downregulated in the individuals carrying rs4938723 CC genotype by contrast with that carrying TT + TC genotypes (P < 0.05). The result of luciferase reporter assay showed that rs4938723C allele decreased the transcriptional activity of miR-34b/c promoter compared with rs4938723 T allele. CONCLUSION:Our study showed a positive relation between the miR-34b/c rs4938723 polymorphism and the risk of ischemic stroke, which indicated that rs4938723 may be used for ischemic stroke prediction or therapy in the future.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Wei G,Liao C,Jian C,Liang L,Liu J,Tang Y,Wei Y

doi

10.1097/HJH.0000000000002413

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

1481-1487

issue

8

eissn

0263-6352

issn

1473-5598

journal_volume

38

pub_type

杂志文章
  • A systematic review of calcium channel blocker use and cognitive decline/dementia in the elderly.

    abstract:OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000000273

    authors: Peters R,Booth A,Peters J

    更新日期:2014-10-01 00:00:00

  • Association between hypertension and musculoskeletal complaints: a population-based study.

    abstract:OBJECTIVE:To investigate the association between hypertension and musculoskeletal complaints among men and women selected by a population-based sample. METHODS:A cross-sectional study, with participants selected using a multistage sampling procedure and interviewed at home, was conducted to investigate the association...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283588268

    authors: Kerkhoff AC,Moreira LB,Fuchs FD,Fuchs SC

    更新日期:2012-11-01 00:00:00

  • Influence of left ventricular mass, uremia and hypertension on vagal tachycardic reserve.

    abstract:BACKGROUND:Left ventricular (LV) hypertrophy, arterial hypertension and end-stage renal disease (ESRD) are associated with deranged cardiac parasympathetic regulation and increased cardiovascular risk. These conditions often co-exist but little is known about the relative contribution of LV mass, arterial blood pressur...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200308000-00020

    authors: Mircoli L,Rivera R,Bonforte G,Fedele L,Genovesi S,Surian M,Ferrari AU

    更新日期:2003-08-01 00:00:00

  • Atrial natriuretic peptide behaviour and myocyte hypertrophic profile in combined pressure and volume-induced cardiac hypertrophy.

    abstract:OBJECTIVE:To investigate cardiomyocyte hypertrophy and hormonal profile in cardiac hypertrophy resulting from sequentially applied overloads. METHODS:We studied Sprague-Dawley rats with renovascular hypertension (RV), where pressure overload predominates, or deoxycorticosterone acetate (DOCA)-salt (DS), where volume o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282435b1e

    authors: Cavallero S,González GE,Puyó AM,Rosón MI,Pérez S,Morales C,Hertig CM,Gelpi RJ,Fernández BE

    更新日期:2007-09-01 00:00:00

  • Left ventricular-arterial coupling in systemic hypertension: analysis by means of arterial effective and left ventricular elastances.

    abstract:OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Cohen-Solal A,Caviezel B,Himbert D,Gourgon R

    更新日期:1994-05-01 00:00:00

  • Persistence and adherence to antihypertensive treatment in relation to initial prescription: diuretics versus other classes of antihypertensive drugs.

    abstract:BACKGROUND:The use of thiazide diuretics in the treatment of hypertension is widely considered as a first-line treatment, given the efficacy and low cost of this class of drugs. This indication is not unanimous, because thiazides can cause metabolic alterations, and other side effects that reduce compliance and persist...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/HJH.0b013e328353398b

    authors: Trimarco V,de Simone G,Izzo R,De Luca N,Giudice R,Marino M,Damiano S,Rozza F,Trimarco B,Di Renzo G

    更新日期:2012-06-01 00:00:00

  • Different effects of low and high doses of endothelin on haemodynamics and hormones in the normotensive conscious dog.

    abstract::The effects of low-dose endothelin on systemic haemodynamics and vasoactive hormones were examined in conscious dogs. In addition, we examined the effects of endothelin on pressor responses to noradrenaline and angiotensin II and the baroreflex regulation of heart rate in conscious dogs. Continuous infusion of 40 fmol...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199104000-00005

    authors: Nakamoto H,Suzuki H,Murakami M,Kageyama Y,Naitoh M,Sakamaki Y,Ohishi A,Saruta T

    更新日期:1991-04-01 00:00:00

  • Characteristics and expression of transforming growth factor-beta receptor subtypes on vascular smooth muscle cells from spontaneously hypertensive rats.

    abstract:OBJECTIVE:To investigate the characteristics and expression of transforming growth factor (TGF)-beta receptor subtypes on vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. METHODS:The effects of TGF-beta 1 on DNA synthesis were evaluated by [3H]-th...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199508000-00003

    authors: Fukuda N,Kubo A,Izumi Y,Soma M,Kanmatsuse K

    更新日期:1995-08-01 00:00:00

  • Influence of nebivolol and enalapril on metabolic parameters and arterial stiffness in hypertensive type 2 diabetic patients.

    abstract:OBJECTIVE:To compare the effects of a cardioselective beta-blocker (nebivolol) with those of an angiotensin-converting enzyme inhibitor (enalapril) on parameters of insulin sensitivity, peripheral blood flow and arterial stiffness during one extended glucose clamp experiment. DESIGN:A randomized, double-blind crossove...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.hjh.0000234121.48272.67

    authors: Kaiser T,Heise T,Nosek L,Eckers U,Sawicki PT

    更新日期:2006-07-01 00:00:00

  • Renal and vascular actions of equol in the rat.

    abstract:BACKGROUND:The urinary isoflavonoid equol inhibits membrane Na-K-Cl cotransporters at similar concentrations to those at which furosemide inhibits them, but the significance of this action is not known. OBJECTIVE:To investigate the potential salidiuretic and vascular actions of equol in the rat. METHODS:Renal functio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715110-00015

    authors: Gimenez I,Lou M,Vargas F,Alvarez-Guerra M,Mayoral JA,Martinez RM,Garay RP,Alda JO

    更新日期:1997-11-01 00:00:00

  • Hypertension and overweight/obesity in Ghanaians and Nigerians living in West Africa and industrialized countries: a systematic review.

    abstract:CONTEXT:There is a growing prevalence of cardiovascular disease (CVD) risk factors in West Africa and among its migrants to industrialized countries. Despite this, no study has reviewed CVD risk factor prevalence among West Africans in Africa and industrialized countries. OBJECTIVE:To appraise studies on the prevalenc...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000000061

    authors: Commodore-Mensah Y,Samuel LJ,Dennison-Himmelfarb CR,Agyemang C

    更新日期:2014-03-01 00:00:00

  • Nitric oxide production by human umbilical vessels in severe pre-eclampsia.

    abstract:OBJECTIVE:Pre-eclampsia is characterized by an increased vascular tone which might be related to an abnormal endothelial cell function. As representatives of the fetal circulation, we compared the nitric oxide (NO)-releasing capacity of human umbilical vessels from normal and pre-eclamptic pregnancies. METHODS:Normal ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Akar F,Ark M,Uydeş BS,Soysal ME,Saraçoğlu F,Abacioğlu N,Van de Voorde J,Kanzik I

    更新日期:1994-11-01 00:00:00

  • Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress.

    abstract:OBJECTIVES:Recent studies have revealed an association between coronary risk factors and both the number and function of bone marrow-derived endothelial progenitor cell (EPC). We investigated the effect of angiotensin II (Ang II) on EPC senescence, leading to the impairment of proliferative activity. METHODS AND RESUL...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200501000-00018

    authors: Imanishi T,Hano T,Nishio I

    更新日期:2005-01-01 00:00:00

  • Prediction of high blood pressure in young people: the limited usefulness of parental blood pressure data.

    abstract::Blood pressure was measured in 864 young people aged 16-24 years, 8 years after both of their parents had their blood pressures measured as part of the screening phase of the Medical Research Council Mild Hypertension Trial. Only 29% of offspring with a conventional 'family history of hypertension', defined in terms o...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Watt GC,Foy CJ,Holton DW,Edwards HE

    更新日期:1991-01-01 00:00:00

  • Analysis of retinal arteriolar structure in never-treated patients with essential hypertension.

    abstract:OBJECTIVE:Increased wall-to-lumen ratio of small arteries is a predictor of adverse cardiovascular prognosis. We aimed to analyze retinal arteriolar structure in never-treated patients with essential hypertension and to test whether elevated blood pressure is associated with an increased wall-to-lumen ratio of retinal ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282ffdc66

    authors: Ritt M,Harazny JM,Ott C,Schlaich MP,Schneider MP,Michelson G,Schmieder RE

    更新日期:2008-07-01 00:00:00

  • Regression of left ventricular hypertrophy and microalbuminuria changes during antihypertensive treatment.

    abstract:OBJECTIVE:The objective of the present study was to assess the regression of left ventricular hypertrophy (LVH) during antihypertensive treatment, and its relationship with the changes in microalbuminuria. INDIVIDUALS AND METHODS:One hundred and sixty-eight previously untreated patients with echocardiographic LVH, 46 ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328361461e

    authors: Rodilla E,Pascual JM,Costa JA,Martin J,Gonzalez C,Redon J

    更新日期:2013-08-01 00:00:00

  • Evaluating interventions to reduce central aortic pressure, arterial stiffness and morbidity--mortality.

    abstract::Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e328353e523

    authors: Williams B

    更新日期:2012-06-01 00:00:00

  • Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension.

    abstract:OBJECTIVE:Secondary activation of the renin-angiotensin system plays a major role in the progression of chronic nephropathies, and blockade of endothelin (ET) receptors has been shown to confer nephroprotection in experimental models of proteinuric renal disease. We tested the nephroprotective potential of selective en...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200312000-00028

    authors: Rothermund L,Kossmehl P,Neumayer HH,Paul M,Kreutz R

    更新日期:2003-12-01 00:00:00

  • Plasma human atrial natriuretic peptide, endothelin-1, aldosterone and plasma-renin activity in pregnancy-induced hypertension.

    abstract:OBJECTIVE:To determine the relationship between endothelin-1 (ET-1), human atrial natriuretic peptide (hANP), plasma-renin activity (PRA) and 24-h urinary excretion of aldosterone (U-Ald) in pregnancy-induced hypertension (PIH). DESIGN AND METHODS:Plasma hANP (pg/ml), ET-1 (pg/ml), PRA (ng/ml per h) and U-Ald (microg/...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199917090-00012

    authors: Zafirovska KG,Maleska VT,Bogdanovska SV,Lozance LA,Masin-Paneva J,Gerasimovska BD

    更新日期:1999-09-01 00:00:00

  • Carotid femoral pulse wave velocity in type 2 diabetes and hypertension: capturing arterial health effects of step counts.

    abstract:OBJECTIVE:Optimal medication use obscures the impact of physical activity on traditional cardiometabolic risk factors. We evaluated the relationship between step counts and carotid-femoral pulse wave velocity (cfPWV), a summative risk indicator, in patients with type 2 diabetes and/or hypertension. RESEARCH DESIGN AND...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001277

    authors: Dasgupta K,Rosenberg E,Joseph L,Trudeau L,Garfield N,Chan D,Sherman M,Rabasa-Lhoret R,Daskalopoulou SS

    更新日期:2017-05-01 00:00:00

  • Sex differences in noninvasive vascular function in the community.

    abstract:OBJECTIVE:The relation of noninvasive vascular function to sex, sex hormones, and reproductive history in the general population is little understood. METHODS:We simultaneously assessed flow-mediated dilation (FMD) and peripheral arterial tonometry in 454 women (mean age 40.4±16.1 years, age range 19-78 years) and 100...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328360f755

    authors: Schnabel RB,Biener MP,Wilde S,Sinning CR,Ojeda FM,Zeller T,Lubos E,Lackner KJ,Warnholtz A,Gori T,Espinola-Klein C,Blankenberg S,Munzel T,Wild PS

    更新日期:2013-07-01 00:00:00

  • Lack of effect of fish oil supplementation on blood pressure in treated hypertensives.

    abstract::Fish and fish oils have been reported to reduce blood pressure in normotensives and untreated hypertensives. The present study examined the effect of dietary supplementation with fish oil on blood pressure in 20 treated hypertensives with controlled blood pressures who continued their usual antihypertensive drug treat...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-199004000-00007

    authors: Wing LM,Nestel PJ,Chalmers JP,Rouse I,West MJ,Bune AJ,Tonkin AL,Russell AE

    更新日期:1990-04-01 00:00:00

  • Association of physician's sex with risk factor control in treated hypertensive patients from Swedish primary healthcare.

    abstract:OBJECTIVE:To study the association of physician's sex with blood pressure, lipid control, and cardiovascular risk factors in treated hypertensive men and women, stratified for the sex of their physician. METHODS:In a cross-sectional survey of hypertensive patients, 264 primary care physicians (PCPs), 187 men and 77 wo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32830a4a3b

    authors: Journath G,Hellénius ML,Manhem K,Kjellgren KI,Nilsson PM,Hyper-Q Study Group, Sweden.

    更新日期:2008-10-01 00:00:00

  • Associations of the nocturnal blood pressure fall and morning surge with cardiovascular events and mortality in individuals with resistant hypertension.

    abstract:OBJECTIVE:The prognostic importance of the nocturnal blood pressure (BP) fall and early-morning surge were scarcely investigated in patients with resistant hypertension (RHT). We investigated them in a prospective cohort of 1726 RHT individuals. METHODS:The nocturnal fall and morning surge were calculated from the bas...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002775

    authors: Cardoso CRL,Salles GF

    更新日期:2021-01-11 00:00:00

  • Multiparametric carotid and cardiac ultrasound compared with clinical risk scores for the prediction of angiographic coronary artery disease: a multicenter prospective study.

    abstract:OBJECTIVE:Cardiovascular risk prediction is deemed fundamental and the assessment of organ damage is emerging as a potentially 'downstream' picture of individual risk. Our aim was to assess the feasibility and value of prediction of coronaropathy [coronary artery disease (CAD)] of integrated cardiovascular ultrasound e...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/HJH.0000000000000543

    authors: Moreo A,Gaibazzi N,Faggiano P,Mohammed M,Carerj S,Mureddu G,Pigazzani F,Muiesan L,Salvetti M,Cesana F,Faden G,Facchetti R,Giannattasio C,Rigo F

    更新日期:2015-06-01 00:00:00

  • Physical activity level is an independent predictor of the diurnal variation in blood pressure.

    abstract:OBJECTIVE:The aim of this study was to define the relationship between physical activity and the magnitude of the percentage fall in blood pressure at night (nocturnal dip). METHODS:We simultaneously monitored 24-h ambulatory blood pressure and measured physical activity by actigraphy in 434 patients. Blood pressure w...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018040-00008

    authors: Leary AC,Donnan PT,MacDonald TM,Murphy MB

    更新日期:2000-04-01 00:00:00

  • Eating frequency predicts new onset hypertension and the rate of progression of blood pressure, arterial stiffness, and wave reflections.

    abstract:BACKGROUND:Cross-sectional evidence indicates that eating frequency correlates with blood pressure, hypertension, and related target organ damage. The aim of the present study was to prospectively assess eating frequency as a predictor of arteriosclerosis progression and new onset hypertension over a follow-up period o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000822

    authors: Karatzi K,Georgiopoulos G,Yannakoulia M,Efthimiou E,Voidonikola P,Mitrakou A,Manios E,Alevizaki M,Papamichael C,Stamatelopoulos K

    更新日期:2016-03-01 00:00:00

  • Reference values and associated factors for Japanese newborns' blood pressure and pulse rate: the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study.

    abstract:OBJECTIVE:Currently, normative means and ranges of blood pressure (BP) and pulse rates in Japanese newborns are not available. The objective of the present study was to estimate BP, pulse rate, and their distribution among Japanese newborns. METHODS:Using oscillometric devices, arm or calf BP and pulse rate levels wer...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000976

    authors: Satoh M,Inoue R,Tada H,Hosaka M,Metoki H,Asayama K,Murakami T,Mano N,Ohkubo T,Yagihashi K,Hoshi K,Suzuki M,Imai Y

    更新日期:2016-08-01 00:00:00

  • Can we trust automatic sphygmomanometer validations?

    abstract::Hypertension is a leading risk factor for mortality. Detecting, treating and monitoring hypertensive patients require accurate blood pressure measurements. Protocols for validation of automatic sphygmomanometers exist, but quality control of validations is limited to peer review of published reports, which has severe ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e32833e1011

    authors: Turner MJ

    更新日期:2010-12-01 00:00:00

  • The vascular response to vasodilators is related to the membrane content of polyunsaturated fatty acids in hypertensive patients.

    abstract:OBJECTIVE:Abnormal vascular reactivity contributes to the pathophysiology of hypertension and hypertension-related organ damage. As the dietary content of fatty acids may affect the vascular responses, we investigated the relationship of endothelium-independent and endothelium-dependent vasodilation with the fatty acid...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000495

    authors: Colussi G,Catena C,Dialti V,Mos L,Sechi LA

    更新日期:2015-05-01 00:00:00