Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension.

abstract：OBJECTIVE:To determine adrenocorticotrophin dose-response relationships for increase of blood pressure and metabolic parameters of the Sprague-Dawley rat. METHODS:We injected 120 male Sprague-Dawley rats twice daily subcutaneously for 10 days with 0.5, 1, 5, 50, 100, 200 or 500 microg/kg synthetic adrenocorticotrophin...

journal_title：Journal of hypertension

authors： Turner SW,Wen C,Li M,Fraser TB,Whitworth JA

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:Patients with chronic renal failure are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of renal disease. Similarly, there are few animal models concerned with the effect of exercise train...

journal_title：Journal of hypertension

authors： Kohzuki M,Kamimoto M,Wu XM,Xu HL,Kawamura T,Mori N,Nagasaka M,Kurosawa H,Minami N,Kanazawa M,Saito T,Yoshida K

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of atherosclerosis, a chronic inflammatory disease, is influenced by the renin-angiotensin system and especially by angiotensin II subtype 1 (AT1) receptor activation. Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are w...

journal_title：Journal of hypertension

authors： Link A,Lenz M,Legner D,Böhm M,Nickenig G

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:To determine the effects of angiotensin II (AII) (1-8) on cytosolic free calcium concentrations in the absence and in the presence of the selective angiotensin subtype 1 (AT1) receptor antagonist losartan and of the selective angiotensin subtype 2-receptor antagonist P-186 in human peripheral blood mononuclea...

journal_title：Journal of hypertension

authors： Lijnen P,Fagard R,Petrov V

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVES:To establish whether safety and feasibility of dobutamine and dipyridamole stress echocardiography are affected by history of hypertension. METHODS:Data on 2200 consecutive pharmacologic stress echocardiography (959 dobutamine and 1241 dipyridamole) performed between October 1990 and February 2001 at a sing...

journal_title：Journal of hypertension

authors： Cortigiani L,Zanetti L,Bigi R,Desideri A,Fiorentini C,Nannini E

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:The platelet GPIIIa plays a pivotal role in platelet aggregation. Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. We explored the possibility that this polymorphism represents a risk fa...

journal_title：Journal of hypertension

authors： Lanni F,Santulli G,Izzo R,Rubattu S,Zanda B,Volpe M,Iaccarino G,Trimarco B

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Although several studies have reported an association between microalbuminuria and pulse wave velocity in patients with hypertension or diabetes, there have been no reports of their significance in apparently healthy individuals. METHODS:Microalbuminuria and brachial-ankle PWV (baPWV) were investigated in a ...

journal_title：Journal of hypertension

authors： Kim BJ,Lee HA,Kim NH,Kim MW,Kim BS,Kang JH

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor. METHO...

journal_title：Journal of hypertension

authors： Esler M,Lambert G,Esler D,Ika Sari C,Guo L,Jennings G

更新日期：2020-08-01 00:00:00

abstract：:Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure. Activation of nitrergic nerves innervating the systemic vasculature elicits vasodilatation, decreases peripheral resistance, and lowers b...

journal_title：Journal of hypertension

authors： Toda N,Ayajiki K,Okamura T

更新日期：2009-10-01 00:00:00

abstract：:To investigate the effects of changes in sodium balance on blood pressure and leucocyte sodium transport, normotensive first-degree relatives of hypertensive patients and control subjects were randomized to receive low- and high-salt diets for 2 weeks, separated by a wash-out period of 2 weeks. High-salt intake failed...

journal_title：Journal of hypertension

authors： Heagerty AM,Alton SM,el-Ashry A,Bing RF,Thurston H,Swales JD

更新日期：1986-06-01 00:00:00

abstract：:To evaluate factors influencing hemodynamic responses to psychological and physical stress, 117 normotensive college students were studied. The standardized tests included arithmetic, Stroop word-color, mirror draw, isometric handgrip and cold pressor challenges. The responses of blood pressure and pulse during the te...

journal_title：Journal of hypertension

authors： McAdoo WG,Weinberger MH,Miller JZ,Fineberg NS,Grim CE

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. OBJ...

journal_title：Journal of hypertension

authors： Fazan R Jr,Dias da Silva VJ,Ballejo G,Salgado HC

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Although 24-h urinary measure to estimate sodium and potassium excretion is the gold standard, it is not practical for large studies. We compared estimates of 24-h sodium and potassium excretion from a single morning fasting urine (MFU) using three different formulae in healthy individuals. M...

journal_title：Journal of hypertension

authors： Mente A,O'Donnell MJ,Dagenais G,Wielgosz A,Lear SA,McQueen MJ,Jiang Y,Xingyu W,Jian B,Calik KB,Akalin AA,Mony P,Devanath A,Yusufali AH,Lopez-Jaramillo P,Avezum A Jr,Yusoff K,Rosengren A,Kruger L,Orlandini A,Rangar

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine whether pulse pressure is a risk factor for coronary artery disease using data from the MRC trial of treatment of mild hypertension, and whether the effect of anti-hypertensive drug therapy on pulse pressure may be a determinant of outcome in treated patients. METHODS:...

journal_title：Journal of hypertension

authors： Millar JA,Lever AF,Burke V

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...

journal_title：Journal of hypertension

authors： Schmidlin O,Tanaka M,Sebastian A,Morris RC Jr

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To determine whether obese hypertensive patients manifest a diminished regional vasodilator response to an oral glucose challenge. METHODS:Nineteen obese hypertensives (body mass index 34.1 +/- 1.3 kg/m2, blood pressure 144 +/- 3/96 +/- 2 mmHg) and 13 lean controls (23.6 +/- 0.3 kg/m2, 127 +/- 4/83 +/- 3 mmH...

journal_title：Journal of hypertension

authors： Egan BM,Stepniakowski K

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To characterize the in vivo vascular properties of the spontaneously hypertensive rat (SHR) renal vascular bed by examining vascular conductance/resistance responsiveness to vasoactive agents in vivo and determining whether the filtration surface area of glomerular capillaries is reduced. DESIGN AND METHODS:...

journal_title：Journal of hypertension

authors： Kett MM,Bergström G,Alcorn D,Bertram JF,Anderson WP

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence of hypertension and the rate of decline in renal function in a sample of 47 Olivetti Heart Study (OHS) participants whose blood pressure (BP) salt-sensitivity and renal tubular sodium handling had been assessed in 1987-88. METHODS:During the 2002-04 OHS follow-up examination, medica...

journal_title：Journal of hypertension

authors： Barba G,Galletti F,Cappuccio FP,Siani A,Venezia A,Versiero M,Della Valle E,Sorrentino P,Tarantino G,Farinaro E,Strazzullo P

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:Treatment modifications--addition, uptitration, switching, and downtitration--are necessary to address issues such as unattained blood pressure goals, adverse drug events, drug cost, or patient dissatisfaction which lead to treatment discontinuation. This study assessed the patterns of treatment modification...

journal_title：Journal of hypertension

authors： Sonawane KB,Qian J,Garza KB,Wright BM,Zeng P,Ganduglia-Cazaban CM,Hansen RA

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). METHODS:We evaluated 96 patients with resistant hypertension, defined as clinic BP at least 140/90 mmHg despite treat...

journal_title：Journal of hypertension

authors： Lozano L,Tovar JL,Sampol G,Romero O,Jurado MJ,Segarra A,Espinel E,Ríos J,Untoria MD,Lloberes P

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To assess the clinical relevance of regression to the mean for clinical trials and clinical practice. METHODS:MEDLINE was searched until February 2018 for randomized trials of BP lowering with over 1000 patient-years follow-up per group. We estimated baseline mean BP, follow-up mean (usual) BP amongst patien...

journal_title：Journal of hypertension

authors： Salam A,Atkins E,Sundström J,Hirakawa Y,Ettehad D,Emdin C,Neal B,Woodward M,Chalmers J,Berge E,Yusuf S,Rahimi K,Rodgers A,Blood Pressure Lowering Treatment Trialists’ Collaboration.

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

journal_title：Journal of hypertension

authors： Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

更新日期：1999-03-01 00:00:00

abstract：AIMS:Monocyte/macrophages participate in inflammatory responses that may play an important role in mineralocorticoid-induced vascular damage. We hypothesized that monocyte/macrophages modulate aldosterone effects on oxidative stress, endothelial function, and ultimately vascular stiffness. METHODS:Adult heterozygous o...

journal_title：Journal of hypertension

authors： Leibovitz E,Ebrahimian T,Paradis P,Schiffrin EL

更新日期：2009-11-01 00:00:00

abstract：:Basal platelet function was measured in 35 40-year-old men with untreated mild essential hypertension and compared with 44 age-matched normotensive men. The groups differed significantly with respect to platelet size in venous blood (hypertensive, 7.46 +/- 0.10 X 10(-15) l versus normotensive, 7.11 +/- 0.09 X 10(-15) ...

journal_title：Journal of hypertension

authors： Lande K,Os I,Kjeldsen SE,Westheim A,Hjermann I,Eide I,Gjesdal K

更新日期：1987-08-01 00:00:00

abstract：:Reduction of large artery distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence obtained by measuring distensibility through quantification of changes in arterial diameter versus blood pressure changes at large elastic and middle size muscle artery sites. Eviden...

journal_title：Journal of hypertension

authors： Giannattasio C,Mancia G

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age. METHODS:Using a n...

journal_title：Journal of hypertension

authors： Spronck B,Heusinkveld MH,Vanmolkot FH,Roodt JO,Hermeling E,Delhaas T,Kroon AA,Reesink KD

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Spontaneously hypertensive rats (SHR) are sensitive to a high salt intake and we investigated the question of whether flow-induced dilation is affected by this type of diet, as flow responses are especially sensitive to small changes in extracellular sodium concentrations. METHODS:We evaluated the effects of...

journal_title：Journal of hypertension

authors： Matrougui K,Lévy BI,Schiavi P,Guez D,Henrion D

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans. METHODS:All non-rare single nucleotide polymorphisms (SNPs) in AGT were identified by resequencing 24 individuals. Five tagging SNPs wer...

journal_title：Journal of hypertension

authors： Wu X,Luke A,Rieder M,Lee K,Toth EJ,Nickerson D,Zhu X,Kan D,Cooper RS

更新日期：2003-10-01 00:00:00

abstract：:BMI represents an internal metabolic and physiological environment that plays a key role in development of high blood pressure (BP) for many Americans. African-American women have a higher prevalence of high BP and being overweight than men or other ethnic groups. This study examines the genetic-environmental interact...

journal_title：Journal of hypertension

authors： Taylor J,Sun YV,Chu J,Mosley TH,Kardia SL

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Uncontrolled hypertension notwithstanding the use of at least three drugs or hypertension controlled with at least four drugs, the widely accepted definition of treatment-resistant hypertension (TRH), is considered as a common problem in the hemodialysis population. However, to date there is no estimate of t...

journal_title：Journal of hypertension

authors： Mallamaci F,Torino C,Sarafidis P,Ekart R,Loutradis C,Siamopoulos K,Del Giudice A,Aucella F,Morosetti M,Raptis V,Bikos A,Papagianni A,Balafa O,Pappas E,Tripepi R,Marino C,Tripepi G,Ferro C,Malyszko J,Dekker FW,Jage

更新日期：2020-09-01 00:00:00