Effects of changes in sodium balance on leucocyte sodium transport: qualitative differences in normotensive offspring of hypertensives and matched controls.

Abstract:

:To investigate the effects of changes in sodium balance on blood pressure and leucocyte sodium transport, normotensive first-degree relatives of hypertensive patients and control subjects were randomized to receive low- and high-salt diets for 2 weeks, separated by a wash-out period of 2 weeks. High-salt intake failed to alter blood pressure, whereas the low-salt diet produced significant falls in standing pressures in both groups. In the control subjects leucocyte sodium efflux was not changed by either manoeuvre, but in the relatives low-salt diet stimulated ouabain-insensitive sodium efflux rate constant. There was a significant qualitative difference in the pattern of response of total efflux rate constant to the two dietary periods between the two groups of subjects. These data are not compatible with the release of a humoral sodium pump inhibitor in response to sodium-induced volume expansion, and lend support to a disturbance of membrane permeability to sodium in subjects genetically prone to hypertension.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Heagerty AM,Alton SM,el-Ashry A,Bing RF,Thurston H,Swales JD

doi

10.1097/00004872-198606000-00012

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

333-7

issue

3

eissn

0263-6352

issn

1473-5598

journal_volume

4

pub_type

临床试验,杂志文章,随机对照试验
  • Radial late-SBP as a surrogate for central SBP.

    abstract:BACKGROUND:Recent studies indicated that central SBP could be estimated by radial late-SBP (rSBP2) with a small disparity. However, most of these studies were conducted by SphygmoCor with a transfer function. The agreement between rSBP2 and central SBP was also tested in several invasive studies, but with inconsistent ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328342f05f

    authors: Zhang Y,Agnoletti D,Protogerou AD,Wang JG,Topouchian J,Salvi P,Safar ME,Blacher J

    更新日期:2011-04-01 00:00:00

  • Predictive power of home blood pressure and clinic blood pressure in hypertensive patients with impaired glucose metabolism and diabetes.

    abstract:OBJECTIVES:We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD:The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blo...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/HJH.0b013e328361732c

    authors: Noguchi Y,Asayama K,Staessen JA,Inaba M,Ohkubo T,Hosaka M,Satoh M,Kamide K,Awata T,Katayama S,Imai Y,HOMED-BP study group.

    更新日期:2013-08-01 00:00:00

  • Evaluation of miR-34b/c polymorphisms to the risk of ischemic stroke.

    abstract:OBJECTIVES:Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. METHODS:MiR-34b/c rs2187473 and rs4938723 polymorphisms were genotyped by Snapshot assay among 495 controls and 492 ischemic ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002413

    authors: Wei G,Liao C,Jian C,Liang L,Liu J,Tang Y,Wei Y

    更新日期:2020-08-01 00:00:00

  • Computerized measurement of retinal blood vessel calibre: description, validation and use to determine the influence of ageing and hypertension.

    abstract:OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.hjh.0000163154.35577.8e

    authors: Pose-Reino A,Gomez-Ulla F,Hayik B,Rodriguez-Fernández M,Carreira-Nouche MJ,Mosquera-González A,González-Penedo M,Gude F

    更新日期:2005-04-01 00:00:00

  • Arterial stiffness in atherosclerotic renovascular hypertension.

    abstract:OBJECTIVE:Arterial stiffness is an independent cardiovascular risk factor. Aging, high blood pressure and increased renin-angiotensin system activity contribute to increased arterial stiffness in patients with atherosclerotic renovascular hypertension (aRVH). A literature search failed to identify any study related to ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000324

    authors: Fodor L,Premužić V,Ivković V,Perkov D,Laganović M,Vrkić TZ,Dika Z,Zivko M,Jelaković B

    更新日期:2014-11-01 00:00:00

  • Angiotensin converting enzyme inhibition prevents proto-oncogene expression in the vascular wall after injury.

    abstract:OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

    更新日期:1995-01-01 00:00:00

  • Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors.

    abstract:BACKGROUND:Enhanced oxidative stress has been observed in hypertension, but the underlying mechanism has not been fully clarified. OBJECTIVE:To study the relationship between oxygen free radicals and hypertension, using platelets as a tool to measure the cellular production of superoxide anion (O2). DESIGN:Forty pati...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200406000-00016

    authors: Germanò G,Sanguigni V,Pignatelli P,Caccese D,Lenti L,Ragazzo M,Lauro R,Violi F

    更新日期:2004-06-01 00:00:00

  • Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: results from the Global SYMPLICITY Registry.

    abstract:BACKGROUND:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluate...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001142

    authors: Linz D,Mancia G,Mahfoud F,Narkiewicz K,Ruilope L,Schlaich M,Kindermann I,Schmieder RE,Ewen S,Williams B,Böhm M,Global SYMPLICITY Registry Investigators.

    更新日期:2017-01-01 00:00:00

  • Blood pressure reduction in acute ischemic stroke according to time to treatment: a subgroup analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial.

    abstract:OBJECTIVE:The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS:We randomly assigned...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/HJH.0000000000001288

    authors: Xu T,Zhang Y,Bu X,Wang D,Sun Y,Chen CS,Wang J,Peng H,Ju Z,Peng Y,Xu T,Li Q,Geng D,Zhang J,Li D,Zhang F,Guo L,Wang X,Cui Y,Li Y,Ma D,Zhang D,Yang G,Gao Y,Yuan X,Chen J,He J,CATIS investigators.

    更新日期:2017-06-01 00:00:00

  • Regional variations in hypertension prevalence and management in Germany: results from the German Health Interview and Examination Survey (DEGS1).

    abstract:OBJECTIVE:This study analyzed regional differences in blood pressure (BP) distribution and management in Germany 2008-2011 in a nationwide study. METHODS:The analyses were based on standardized BP measurements and anatomical therapeutic chemical classification-coded medication from the population-based German Health I...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000211

    authors: Diederichs C,Neuhauser H

    更新日期:2014-07-01 00:00:00

  • Changes of blood pressure patterns and target organ damage in patients with chronic kidney disease: results of the APrODiTe-2 study.

    abstract:OBJECTIVE:Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS:We recruited 378 hypertensive CKD ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001185

    authors: Cha RH,Lee H,Lee JP,Kang E,Song YR,Kim YS,Kim SG

    更新日期:2017-03-01 00:00:00

  • Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood.

    abstract:BACKGROUND:Small size at birth and greater BMI in childhood are associated with greater brachial blood pressure (BP) in later life. Aortic (central) BP differs from brachial BP and is more predictive of organ damage and cardiovascular events; the relationship between BMI in childhood and central BP is not known. METHO...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000269

    authors: Howe LD,Chaturvedi N,Lawlor DA,Ferreira DL,Fraser A,Davey Smith G,Tilling K,Hughes AD

    更新日期:2014-09-01 00:00:00

  • Health-related quality of life and blood pressure 12 months after renal denervation.

    abstract:AIM:To examine the effect of renal denervation (RDN) on blood pressure (BP) and health-related quality of life (QoL) in patients with resistant hypertension, pseudoresistant hypertension due to a white-coat effect and in patients with uncontrolled masked hypertension. METHODS:Using the Medical Outcomes Study 36-Item S...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000698

    authors: Lambert GW,Hering D,Marusic P,Thorp A,Sata Y,Lee R,Duval J,Hammond L,Head GA,Esler MD,Lambert EA,Dixon JB,Dhar AK,Barton DA,Schlaich MP

    更新日期:2015-11-01 00:00:00

  • The effect of vitamin D on renin-angiotensin system activation and blood pressure: a randomized control trial.

    abstract:OBJECTIVE:Disruption of vitamin D signaling in rodents causes activation of the rennin-angiotensin system (RAS) and development of hypertension. Observational studies in humans found lower circulating 25-hydroxyvitamin D [25(OH)D] is associated with increased RAS activity and blood pressure (BP). We performed the first...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/HJH.0000000000001220

    authors: McMullan CJ,Borgi L,Curhan GC,Fisher N,Forman JP

    更新日期:2017-04-01 00:00:00

  • Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial.

    abstract:OBJECTIVE:To verify the benefit of renin-angiotensin system blockade in hypertension, the effects of 24 weeks' losartan and ramipril treatment, both alone and in combination, on urinary albumin excretion (UAE) and circulating transforming growth factor beta1 (TGF beta1) have been evaluated in hypertensive subjects with...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.hjh.0000160225.01845.26

    authors: Scaglione R,Argano C,Corrao S,Di Chiara T,Licata A,Licata G

    更新日期:2005-03-01 00:00:00

  • Blood pressure and menopausal transition: the Atherosclerosis Risk in Communities study (1987-95).

    abstract:OBJECTIVE:Blood pressure changes during menopausal transition have not been studied previously using a biracial sample. We investigated whether menopausal transition was associated with change in blood pressure in African-American or white women. DESIGN, SETTING AND PARTICIPANTS:The prospective multicenter study, the ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00004872-200018010-00005

    authors: Luoto R,Sharrett AR,Schreiner P,Sorlie PD,Arnett D,Ephross S

    更新日期:2000-01-01 00:00:00

  • A comparative study of hypertension prevalence, awareness, treatment and control rates in St Lucia, Jamaica and Barbados.

    abstract:BACKGROUND:Cardiovascular diseases represent the most common cause of death in the English-speaking Caribbean, and hypertension represents the most important predisposing condition. However, direct between-country comparative studies in the Caribbean have not previously been undertaken. OBJECTIVE:To obtain estimates o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Freeman V,Fraser H,Forrester T,Wilks R,Cruickshank J,Rotimi C,Cooper R

    更新日期:1996-04-01 00:00:00

  • Supporting self-management for people with hypertension: a meta-review of quantitative and qualitative systematic reviews.

    abstract:OBJECTIVES:Globally, healthcare policy promotes supported self-management as a strategy for people with long-term conditions. This meta-review aimed to explore how people with hypertension make sense of their condition, to assess the effectiveness of supported self-management in hypertension, and to identify effective ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000001867

    authors: Shahaj O,Denneny D,Schwappach A,Pearce G,Epiphaniou E,Parke HL,Taylor SJC,Pinnock H

    更新日期:2019-02-01 00:00:00

  • Evaluating interventions to reduce central aortic pressure, arterial stiffness and morbidity--mortality.

    abstract::Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e328353e523

    authors: Williams B

    更新日期:2012-06-01 00:00:00

  • Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension.

    abstract:OBJECTIVE:Angiotensin (Ang) II increases reactive oxygen species (ROS), decreases nitric oxide (NO) bioavailability and promotes cardiovascular remodeling. ROS have been identified as critical second messengers of the trophic responses by Ang II. In rats with Ang II-induced hypertension, we investigated the role of ROS...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000179513.71018.09

    authors: Zhou MS,Jaimes EA,Raij L

    更新日期:2005-09-01 00:00:00

  • Stress and sodium hypertension in baboons: neuroendocrine and pharmacotherapeutic assessments.

    abstract::Behavioral stress and high dietary salt have been reported to increase blood pressure additively in non-human primates. This study was designed to replicate this phenomenon and to assess neuroendocrine correlates and responses to two commonly used antihypertensives, a beta-adrenoceptor blocker and a thiazide diuretic....

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Turkkan JS,Goldstein DS

    更新日期:1991-10-01 00:00:00

  • Effect of acute and chronic captopril infusion on blood pressure in the two-kidney, one clip hypertensive rat.

    abstract::The effect on blood pressure (BP) of acute and chronic suppression of angiotensin (ANG) II was studied in the two-kidney, one clip hypertensive rat. Conscious, chronically catheterized rats were given a bolus injection of captopril (2.5 mg/kg) followed by a chronic infusion of either dextrose or captopril (1 mg/kg per...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198512000-00006

    authors: Wallace EC,Balmforth AJ,Morton JJ

    更新日期:1985-12-01 00:00:00

  • Evaluation of elevated heart rate as a sympathetic nervous system biomarker in essential hypertension.

    abstract:BACKGROUND:There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor. METHO...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002407

    authors: Esler M,Lambert G,Esler D,Ika Sari C,Guo L,Jennings G

    更新日期:2020-08-01 00:00:00

  • Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats.

    abstract:OBJECTIVE:To determine whether a diuretic can also reverse the clinical, systemic, renal and glomerular haemodynamic and pathological changes caused by nephrosclerosis. METHODS:Three groups of 20-week-old spontaneously hypertensive rats (SHR) were investigated: control male SHR; a similar group, administered 50 mg/l N...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199607000-00004

    authors: Ono Y,Ono H,Frohlich ED

    更新日期:1996-07-01 00:00:00

  • Withdrawal of hormonal therapy for 4 weeks decreases arterial compliance in postmenopausal women.

    abstract:BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917030-00015

    authors: Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

    更新日期:1999-03-01 00:00:00

  • Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension.

    abstract:BACKGROUND:Some patients with essential hypertension manifest greater than normal urinary excretion of albumin (UAE). Authors of a few retrospective studies have suggested that there is an association between microalbuminuria and cardiovascular risk. OBJECTIVE:To evaluate whether microalbuminuria is associated with a ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816090-00014

    authors: Bigazzi R,Bianchi S,Baldari D,Campese VM

    更新日期:1998-09-01 00:00:00

  • Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension.

    abstract:OBJECTIVES:We recently demonstrated that glucocorticoid increases the number of angiotensin II type 1 (AT1) receptors and their gene expression in cultured vascular smooth muscle cells. To clarify whether this mechanism participates in glucocorticoid-induced hypertension, we investigated the effect of dexamethasone on ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Sato A,Suzuki H,Nakazato Y,Shibata H,Inagami T,Saruta T

    更新日期:1994-05-01 00:00:00

  • Effects of angiotensin II on myocardial contractility during short-term pressor responses to angiotensin II.

    abstract:BACKGROUND:Cardiac angiotensin AT1 receptors have been found in several animal species. In-vitro studies performed on cardiac preparations have shown that angiotensin II (ANG II) exerts a positive inotropic effect; however, in-vivo results have allowed no definitive conclusion to be drawn. The reasons behind these cont...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715090-00013

    authors: Marano G,Formigari R,Vergari A

    更新日期:1997-09-01 00:00:00

  • Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.

    abstract:BACKGROUND:Elevated plasma glucocorticoid level is an independent predictor of increased mortality risk in chronic heart failure, but local biosynthesis and pathophysiological roles of glucocorticoids in the heart remain unclear. METHODS:Dahl salt-sensitive rats on high-salt diet and mice with transthoracic aortic ban...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328326cb04

    authors: Ohtani T,Mano T,Hikoso S,Sakata Y,Nishio M,Takeda Y,Otsu K,Miwa T,Masuyama T,Hori M,Yamamoto K

    更新日期:2009-05-01 00:00:00

  • The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats.

    abstract:OBJECTIVE:We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin recep...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000174972.46663.5e

    authors: Kopkan L,Kramer HJ,Husková Z,Vanourková Z,Skaroupková P,Thurmová M,Cervenka L

    更新日期:2005-08-01 00:00:00