Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats.

abstract：:The effect of haemorrhagic hypotension on plasma catecholamine levels was studied in anesthetized normotensive and DOCA-salt hypertensive rats. The basal levels of plasma norepinephrine (NE) were significantly higher in DOCA-salt hypertensive rats than in normotensive rats. Moreover, the elevations in plasma NE and ep...

journal_title：Journal of hypertension

authors： Drolet G,Bouvier M,de Champlain J

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:Exercise training has antihypertensive and renoprotective effects in humans and rats. However, the effects of exercise training on renal disorders that occur with salt-sensitive hypertension remains unclear. The study aim was to investigate the effects and mechanisms of exercise training on renal function in ...

journal_title：Journal of hypertension

authors： Ogawa Y,Takahashi J,Sakuyama A,Xu L,Miura T,Muroya Y,Ito D,Kohzuki M,Ito O

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To establish whether safety and feasibility of dobutamine and dipyridamole stress echocardiography are affected by history of hypertension. METHODS:Data on 2200 consecutive pharmacologic stress echocardiography (959 dobutamine and 1241 dipyridamole) performed between October 1990 and February 2001 at a sing...

journal_title：Journal of hypertension

authors： Cortigiani L,Zanetti L,Bigi R,Desideri A,Fiorentini C,Nannini E

更新日期：2002-07-01 00:00:00

abstract：:Over the last few years, much progress has been made in understanding the genetic basis of primary aldosteronism. This has led to the diagnosis of the familial forms and has aided the understanding of the basis of sporadic forms of the disease. Such information can be exploited to improve the therapeutic approaches us...

journal_title：Journal of hypertension

authors： Mulatero P,Morello F,Veglio F

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:This study was designed to evaluate the capacity of norepinephrine (NE) to induce hypertrophic remodeling of small arteries in rats, and to determine the involvement of endothelin (ET) to initiate and maintain it. DESIGN AND RESULTS:Treatment with NE (2.5 microg/kg per min) for 14 or 28 days produced a simil...

journal_title：Journal of hypertension

authors： Dao HH,Martens FM,Larivière R,Yamaguchi N,Cernacek P,de Champlain J,Moreau P

更新日期：2001-10-01 00:00:00

abstract：:The effects of essential fatty acid deficiency (EFAD) on vascular reactivity to vasoconstrictor stimuli were studied in rat autoperfused hindquarters. Weanling male Sprague-Dawley rats (aged 21 days) were fed diets containing 8% (weight/weight) of stearax plus 2% safflower oil (control diet) or 10% stearax (EFAD diet)...

journal_title：Journal of hypertension

authors： Kudo K,Dusting GJ,Loiacono RE,Sinclair AJ

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...

journal_title：Journal of hypertension

authors： Chen X,Liu Y,Wang WE,Chen C,Ren H,Zheng S,Zhou L,Zeng C

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to examine the reproducibility of arterial baroreflex sensitivity (BRS) provided by the spontaneous baroreflex method at rest and during laboratory tests. METHODS:Twenty healthy volunteers were studied 24 h apart, in the same laboratory and under the same environmental condit...

journal_title：Journal of hypertension

authors： Iellamo F,Legramante JM,Raimondi G,Castrucci F,Massaro M,Peruzzi G

更新日期：1996-09-01 00:00:00

abstract：:The fall in blood pressure that is commonly observed when groups of hypertensive individuals are followed without treatment is usually ascribed to two sources: regression towards the mean and increasing familiarity of the subject with the assessment process. Any effect of the latter process could bias the results of c...

journal_title：Journal of hypertension

authors： Haynes RB,Logan AG,Flanagan PT,Milne BJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:To investigate predictors of left ventricular mass corrected for height2.7 (LVMI) and left ventricular hypertrophy in patients who were found to be normotensive with both office and 24-h ambulatory blood pressure (BP) measurements. METHODS:A total of 805 consecutive patients were analyzed. All patients under...

journal_title：Journal of hypertension

authors： Kotsis V,Stabouli S,Toumanidis S,Tsivgoulis G,Rizos Z,Trakateli C,Zakopoulos N,Sion M

更新日期：2010-05-01 00:00:00

abstract：:The reported prevalence of left ventricular hypertrophy (LVH) in human hypertension is much lower than that among animals with experimental hypertension. With current methods of determining left ventricular mass by M-mode echocardiography, the standard error of a single estimate is high and consequently so is the SD o...

journal_title：Journal of hypertension

authors： Korner PI,Jennings GL

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To compare the effects of the angiotensin II receptor antagonist candesartan with the angiotensin-converting enzyme inhibitor enalapril on myocardial fibrosis evaluated by echoreflectivity analysis. METHODS:Hypertensive patients (n = 196) with echocardigraphically documented left ventricular hypertrophy were...

journal_title：Journal of hypertension

authors： Ciulla MM,Paliotti R,Esposito A,Cuspidi C,Muiesan ML,Rosei EA,Magrini F,Zanchetti A

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:It has been postulated that hypertension in the spontaneously hypertensive rat (SHR) results from autoimmune damage to the SHR vasculature. The objective of this study was to isolate autoreactive T-cells specific for arterial antigens, and to characterize these cells. DESIGN:The presence of autoreactive T-ce...

journal_title：Journal of hypertension

authors： Ofosu-Appiah W,Ruggiero C,Huang LY

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVES:The interaction between trophoblasts and maternal endothelium is important for placental vascular modeling. Failure of uterine spiral artery transformation is linked to the etiopathology of preeclampsia. Antihypertensive medications used to control hypertension in early pregnancy can alter placental and circ...

journal_title：Journal of hypertension

authors： Xu B,Charlton F,Makris A,Hennessy A

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether the clinic-daytime blood pressure difference can provide information on vascular reactivity to stress comparable to that of simple noninvasive stimuli such as a cold pressor test and isometric exercise, and whether there is any relationship between this blood pressure difference and non...

journal_title：Journal of hypertension

authors： Guida L,Iannuzzi R,Crivaro M,Gaeta I,Pasanisi F,Celentano A,Marotta T,Ferrara LA

更新日期：1999-03-01 00:00:00

abstract：:Systemic and regional haemodynamic effects of renal denervation were evaluated in adult (six-month-old) male spontaneously hypertensive rats (SHR) using the Fick procedure and electromagnetic flowmetry technique. Renal denervation (bilateral, 10% phenol in ethanol), performed five to eight days before the experiment, ...

journal_title：Journal of hypertension

authors： Lee JY,Walsh GM

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVE:To assess the effect of orlistat plus diet compared with diet alone in promoting weight loss and blood pressure reduction in hypertensive, overweight/obese patients. DESIGN:A pragmatic randomized, controlled trial. SETTING:Hypertension clinic of a university hospital. PATIENTS:Hypertensive patients aged 18...

journal_title：Journal of hypertension

authors： Bloch KV,Salles GF,Muxfeldt ES,Da Rocha Nogueira A

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:We examined the effects of a calcium antagonist and an angiotensin converting enzyme (ACE) inhibitor on contractile and non-contractile protein metabolism and cardiac function in a monocrotaline-induced right ventricular hypertrophy model, in order to define the effects of these drugs on cardiac hypertrophy. ...

journal_title：Journal of hypertension

authors： Tanaka K,Honda M,Kuramochi T,Hashimoto M,Masumura S,Mansoor AM,Ishikawa S,Morioka S

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To examine the effect on quality of life in hypertensive men of a multiple risk factor intervention programme compared with that of usual care. DESIGN:A prospective, open, randomized, parallel-group study with allocation either to a comprehensive multiple risk factor modification programme or to usual care. ...

journal_title：Journal of hypertension

authors： Agewall S,Wikstrand J,Dahlöf C,Fagerberg B

更新日期：1995-12-01 00:00:00

abstract：:Ca2+ pump kinetics were investigated in erythrocytes from 22 essential hypertensive patients and 20 normotensive controls (under initial-rate and steady-state conditions, using Sr2+ as a Ca2+ analogue). The mean value of the apparent dissociation constant for total internal Ca2+ (KCa) was slightly but significantly in...

journal_title：Journal of hypertension

authors： de la Sierra A,Hannaert P,Ollivier JP,Senn N,Garay R

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVES:Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we study isolated and combined effects of hypertension and aging on central...

journal_title：Journal of hypertension

authors： Spronck B,Ferruzzi J,Bellini C,Caulk AW,Murtada SI,Humphrey JD

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure ...

journal_title：Journal of hypertension

authors： Chua J,Chin CWL,Hong J,Chee ML,Le TT,Ting DSW,Wong TY,Schmetterer L

更新日期：2019-03-01 00:00:00

abstract：:Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

journal_title：Journal of hypertension

authors： Lifton RP,Jeunemaitre X

更新日期：1993-03-01 00:00:00

abstract：AIM:Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exoge...

journal_title：Journal of hypertension

authors： Montero D,Pierce GL,Stehouwer CD,Padilla J,Thijssen DH

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Nephrin, a cytoskeletal protein which localizes to the slit pore of podocytes, may play a role in proteinuria. This study examines the possible relationship between nephrin expression and albuminuria in normotensive and hypertensive diabetic rats. METHODS:Streptozotocin diabetes was induced in both Wistar-Ky...

journal_title：Journal of hypertension

authors： Forbes JM,Bonnet F,Russo LM,Burns WC,Cao Z,Candido R,Kawachi H,Allen TJ,Cooper ME,Jerums G,Osicka TM

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of angiotensin II on cyclooxygenase-2 (COX-2) expression in aortic adventitial fibroblasts from normotensive [Wistar-Kyoto (WKY)] rats and spontaneously hypertensive rats (SHRs). METHODS:Protein expression was determined by western blot, mRNA levels by real-time PCR, transcriptional...

journal_title：Journal of hypertension

authors： Beltrán AE,Briones AM,García-Redondo AB,Rodríguez C,Miguel M,Alvarez Y,Alonso MJ,Martínez-González J,Salaices M

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD:Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the min...

journal_title：Journal of hypertension

authors： de las Heras N,Ruiz-Ortega M,Miana M,Rupérez M,Sanz-Rosa D,Aragoncillo P,Mezzano S,Cachofeiro V,Egido J,Lahera V

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Although an exaggerated systolic blood pressure (SBP) response to exercise is a predictor of future hypertension and cardiovascular mortality, the underlying mechanisms are not fully understood. We tested the hypothesis that an exaggerated SBP response is associated with carotid atherosclerosis in a cross-sec...

journal_title：Journal of hypertension

authors： Jae SY,Fernhall B,Heffernan KS,Kang M,Lee MK,Choi YH,Hong KP,Ahn ES,Park WH

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Underlying pathophysiology of orthostatic hypotension has been poorly understood. We hypothesized that aortic pulse pressure (APP) reflecting aortic stiffness may be involved in the development of orthostatic hypotension. METHODS:A total of 200 patients (age 64.3 ± 10.9 years, 62.5% men) who underwent invasi...

journal_title：Journal of hypertension

authors： Chung J,Kim HL,Lim WH,Seo JB,Kim SH,Zo JH,Kim MA

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Reversibility of the systemic and renal alterations induced by N(omega)-nitro-L-arginine-methyl ester(L-NAME) was assessed by treatment with irbesartan and enalapril (30 and 10 mg/kg per 24 h, respectively) alone or in combination. DESIGN:L-NAME (20 mg/kg per 24 h) was given to rats for 6 weeks and treatment...

journal_title：Journal of hypertension

authors： Jover B,Herizi A,Casellas D,Mimran A

更新日期：2001-11-01 00:00:00