Increased vascular reactivity induced by essential fatty acid deficiency in rat autoperfused hindquarters.

abstract：OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple combination compared with the component dual combinations, in patients with moderate-to-severe hypertension. METHODS:This 8-week, double-blind, randomized, activ...

journal_title：Journal of hypertension

authors： Lacourcière Y,Taddei S,Konis G,Fang H,Severin T,Zhang J

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Activation of the nuclear factor kappa B (NF kappaB) inflammatory pathway by angiotensin II and reactive oxygen species may play an important role in the development of insulin resistance and cardiovascular injury in hypertensive and metabolic diseases. We have shown that in hypertensive Dahl salt-sensitive ...

journal_title：Journal of hypertension

authors： Zhou MS,Schulman IH,Raij L

更新日期：2010-03-01 00:00:00

abstract：:: Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of BP changes in AIS is complex and only partially understood. The available evidence indicates that extremely high BP during AIS is associated with a poor outcome. Im...

journal_title：Journal of hypertension

authors： Gąsecki D,Coca A,Cunha P,Hering D,Manios E,Lovic D,Zaninelli A,Sierra C,Kwarciany M,Narkiewicz K,Karaszewski B

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The Fas-Fas ligand (FasL) system is involved in apoptosis in many types of cells. Recently, the expression of FasL on endothelial cells was reported. FasL is cleaved by a metalloproteinase and released in serum as soluble FasL (sFasL). Vasoactive substances, including metalloproteinase, are modulated by endo...

journal_title：Journal of hypertension

authors： Okura T,Watanabe S,Jiang Y,Nakamura M,Takata Y,Yang ZH,Kohara K,Kitami Y,Hiwada K

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:To assess the consequences of malignant hypertension and its evolution with antihypertensive treatment. BACKGROUND:Malignant hypertension can be considered as a model of the effects of very high blood pressure and renin-angiotensin levels on target organs. However, the consequences on the heart have been li...

journal_title：Journal of hypertension

authors： Gosse P,Coulon P,Papaioannou G,Litalien J,Lemetayer P

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of the interaction between adenosine receptors and renal nerves on urinary sodium excretion and glomerular filtration rate. METHODS AND DESIGN:The effects on water and sodium excretion and glomerular filtration rate of A1 [2-chloro-N6-cyclopentyl-adenosine (CCPA)] and A2 [2-hesiny...

journal_title：Journal of hypertension

authors： Panzacchi G,Demarchi B,Busca G,Protasoni G,Golin R,Stella A

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:Hypertension and fractures related to osteoporosis are major public health problems that often coexist. This study examined the associations between exposure to different antihypertensive drug classes and the risk of hip fracture in hypertensive patients. METHOD:We included 59 246 individuals, 50 years and o...

journal_title：Journal of hypertension

authors： Bokrantz T,Schiöler L,Boström KB,Kahan T,Mellström D,Ljungman C,Hjerpe P,Hasselström J,Manhem K

更新日期：2020-01-01 00:00:00

abstract：AIMS:Baroreflex activation therapy (BAT) has recently been shown to reduce muscle sympathetic nerve activity and hospitalization rate while improving clinical variables through 6 months of therapy in patients with heart failure and reduced ejection fraction (HFrEF). The objective of the present study is to extend the i...

journal_title：Journal of hypertension

authors： Gronda E,Seravalle G,Trevano FQ,Costantino G,Casini A,Alsheraei A,Lovett EG,Vanoli E,Mancia G,Grassi G

更新日期：2015-08-01 00:00:00

abstract：:Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

journal_title：Journal of hypertension

authors： Lifton RP,Jeunemaitre X

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:The thiazide-sensitive Na-Cl cotransporter (TSC) is involved in the fine regulation of sodium excretion by the kidney, and an increase in its activity causes salt-sensitive hypertension and hypercalciuria. METHODS:To explore the possibility that activating mutations in the TSC gene may be involved in the pa...

journal_title：Journal of hypertension

authors： Keszei AP,Tislér A,Backx PH,Andrulis IL,Bull SB,Logan AG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To assess the effect of orlistat plus diet compared with diet alone in promoting weight loss and blood pressure reduction in hypertensive, overweight/obese patients. DESIGN:A pragmatic randomized, controlled trial. SETTING:Hypertension clinic of a university hospital. PATIENTS:Hypertensive patients aged 18...

journal_title：Journal of hypertension

authors： Bloch KV,Salles GF,Muxfeldt ES,Da Rocha Nogueira A

更新日期：2003-11-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), despite its adaptive nature, increases cardiovascular morbidity and mortality. Novel approaches for protection against pathological heart remodelling are presented in this supplement. Melatonin diminishes myocardial fibrosis in rats exposed to continuous light and N-nitro-L-arginine...

journal_title：Journal of hypertension

authors： Simko F,Pechanova O

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin recep...

journal_title：Journal of hypertension

authors： Kopkan L,Kramer HJ,Husková Z,Vanourková Z,Skaroupková P,Thurmová M,Cervenka L

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:The goal of this study was to compare the cardiovascular responses to behavioural stressors of three groups of adolescents who differed in blood pressure status across assessments. DESIGN:Casual blood pressure of adolescents who were identified as having elevated blood pressure during a school screen was re...

journal_title：Journal of hypertension

authors： Saab PG,Llabre MM,Ma M,DiLillo V,McCalla JR,Fernander-Scott A,Copen R,Gellman M,Schneiderman N

更新日期：2001-01-01 00:00:00

abstract：:Normotensives with hypertensive parents have been reported to exhibit enhanced cardiovascular reactions to mental stress. We have examined the question of why this result was not confirmed in all studies. In addition we have investigated whether appropriate tests can be performed under clinical rather than laboratory ...

journal_title：Journal of hypertension

authors： Neus H,Gödderz W,Otten H,Rüddel H,von Eiff AW

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To investigate the role of ouabain in human hypertension and to establish whether immunoreactive endogenous ouabain is secreted by the adrenal gland under the influence of dopaminergic regulation. METHODS:We measured plasma levels of endogenous ouabain by immunoassay, together with other variables, including...

journal_title：Journal of hypertension

authors： Rossi G,Manunta P,Hamlyn JM,Pavan E,De Toni R,Semplicini A,Pessina AC

更新日期：1995-10-01 00:00:00

abstract：INTRODUCTION:Several renal denervation (RDN) systems are currently under investigation for treatment of hypertension by ablation of renal sympathetic nerves. The procedural efficacy of devices, however, is variable and incompletely understood. This study aimed at investigating procedural and anatomical predictors of RD...

journal_title：Journal of hypertension

authors： Wolf M,Hubbard B,Sakaoka A,Rousselle S,Tellez A,Jiang X,Kario K,Hohl M,Böhm M,Mahfoud F

更新日期：2018-12-01 00:00:00

abstract：:This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...

journal_title：Journal of hypertension

authors： Weinstock M,Borosh M,Kafri O,Kaczmarczyk G

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...

journal_title：Journal of hypertension

authors： Raji A,Williams GH,Jeunemaitre X,Hopkins PN,Hunt SC,Hollenberg NK,Seely EW

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels. METHODS AND RESULTS:To investigate whether this relates to differences in the contribution of the ACE C-domain and N-domain, we quantified, u...

journal_title：Journal of hypertension

authors： van Esch JH,van Gool JM,de Bruin RJ,Payne JR,Montgomery HE,Hectors M,Deinum J,Dive V,Jan Danser AH

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys. METHODS:Eight Sprague-Dawley rats were divided into two groups. One group received a 6% salt (by weight) diet...

journal_title：Journal of hypertension

authors： Barta P,Monti J,Maass PG,Gorzelniak K,Müller DN,Dechend R,Luft FC,Hübner N,Sharma AM

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:Our aims were to assess the progression rate of normotension and prehypertension to hypertension in Japan, and the effect of the new-onset hypertension on chronic kidney disease (CKD). METHODS:This was a nationwide study of 45 378 Japanese aged 40-74 years (mean age 60 years, 37% men) without hypertension o...

journal_title：Journal of hypertension

authors： Yano Y,Fujimoto S,Sato Y,Konta T,Iseki K,Iseki C,Moriyama T,Yamagata K,Tsuruya K,Narita I,Kondo M,Kimura K,Asahi K,Kurahashi I,Ohashi Y,Watanabe T

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:This study presents a reliable index inspired by the total variability concept of real analysis in mathematics, called average real variability (ARV), for the prognostic significance of blood pressure variability (BPV) overcoming the pitfalls of the commonly used standard deviation (SD). BACKGROUND:Recent s...

journal_title：Journal of hypertension

authors： Mena L,Pintos S,Queipo NV,Aizpúrua JA,Maestre G,Sulbarán T

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:High sodium intake is associated with increased risk of end-organ damage, independent of blood pressure (BP) levels. The protective peptide adiponectin may play a role in the pathogenesis of hypertension and particularly in salt-loaded conditions. Furthermore, increased adiponectin levels were observed in sa...

journal_title：Journal of hypertension

authors： Kamari Y,Shimoni N,Koren F,Peleg E,Sharabi Y,Grossman E

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the prevalence and distribution of hypertension and to determine the status of hypertension awareness, treatment and control in the Portuguese adult population. METHODS:This study was conducted in 2003, and a multistage cluster sampling method was used to select a...

journal_title：Journal of hypertension

authors： Macedo ME,Lima MJ,Silva AO,Alcantara P,Ramalhinho V,Carmona J

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normotensive rats. We analyzed the effect of chronic ouabain (approximately 8.0 microg/day, 5 weeks) treatment on the blood pressure of spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats and the contribution of vascula...

journal_title：Journal of hypertension

authors： Xavier FE,Davel AP,Fukuda LE,Rossoni LV

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:p63RhoGEF, a guanine nucleotide exchange factor, has been reported 'in vitro' as key mediator of the angiotensin II-induced RhoA/Rho kinase activation leading to vasoconstriction and cardiovascular remodeling. We assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hyperten...

journal_title：Journal of hypertension

authors： Calò LA,Davis PA,Pagnin E,Dal Maso L,Maiolino G,Seccia TM,Pessina AC,Rossi GP

更新日期：2014-02-01 00:00:00

abstract：:Hypertension in children and adolescents has gained ground in cardiovascular medicine, thanks to the progress made in several areas of pathophysiological and clinical research. These guidelines represent a consensus among specialists involved in the detection and control of high blood pressure in children and adolesce...

journal_title：Journal of hypertension

authors： Lurbe E,Cifkova R,Cruickshank JK,Dillon MJ,Ferreira I,Invitti C,Kuznetsova T,Laurent S,Mancia G,Morales-Olivas F,Rascher W,Redon J,Schaefer F,Seeman T,Stergiou G,Wühl E,Zanchetti A,European Society of Hypertension.

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:We examined the effects of a calcium antagonist and an angiotensin converting enzyme (ACE) inhibitor on contractile and non-contractile protein metabolism and cardiac function in a monocrotaline-induced right ventricular hypertrophy model, in order to define the effects of these drugs on cardiac hypertrophy. ...

journal_title：Journal of hypertension

authors： Tanaka K,Honda M,Kuramochi T,Hashimoto M,Masumura S,Mansoor AM,Ishikawa S,Morioka S

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:Nifedipine, an L-type calcium channel blocker, is widely used in the treatment of hypertension and coronary heart diseases, and also exhibits an antiplatelet activity. Activation of peroxisome proliferator-activated receptors (PPARs; α, β/δ, and γ) inhibits the platelet aggregation. Therefore, the purpose of ...

journal_title：Journal of hypertension

authors： Shih CY,Lin MH,Fan HC,Chen FC,Chou TC

更新日期：2014-01-01 00:00:00