A randomized study of quality of life during multiple risk factor intervention in treated hypertensive men at high cardiovascular risk.

abstract：OBJECTIVES:We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS:We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HA...

journal_title：Journal of hypertension

authors： Parthasarathy HK,Alhashmi K,McMahon AD,Struthers AD,McInnes GT,Ford I,Connell JM,MacDonald TM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Uncontrolled hypertension notwithstanding the use of at least three drugs or hypertension controlled with at least four drugs, the widely accepted definition of treatment-resistant hypertension (TRH), is considered as a common problem in the hemodialysis population. However, to date there is no estimate of t...

journal_title：Journal of hypertension

authors： Mallamaci F,Torino C,Sarafidis P,Ekart R,Loutradis C,Siamopoulos K,Del Giudice A,Aucella F,Morosetti M,Raptis V,Bikos A,Papagianni A,Balafa O,Pappas E,Tripepi R,Marino C,Tripepi G,Ferro C,Malyszko J,Dekker FW,Jage

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:The effectiveness of renal sympathetic denervation (RDN) as a treatment for therapy-resistant hypertension has been doubted as the Simplicity-HTN-3 trial was unable to show any treatment benefit over sham procedure. This might partly be explained by a high procedural variability in treatment with radiofreq...

journal_title：Journal of hypertension

authors： Fengler K,Höllriegel R,Okon T,Stiermaier T,Rommel KP,Blazek S,Besler C,von Roeder M,Petzold M,Schuler G,Lurz P

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:We investigated the impact of renal function on outcomes after percutaneous transluminal angioplasty. METHODS:A total of 139 hypertensive patients with atherosclerotic renal artery stenosis (mean age, 70 years, 80.6% men) who underwent renal percutaneous transluminal angioplasty were included. Renal function...

journal_title：Journal of hypertension

authors： Iwashima Y,Fukuda T,Horio T,Hayashi SI,Kusunoki H,Kishida M,Nakamura S,Kamide K,Kawano Y,Yoshihara F

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD:Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the min...

journal_title：Journal of hypertension

authors： de las Heras N,Ruiz-Ortega M,Miana M,Rupérez M,Sanz-Rosa D,Aragoncillo P,Mezzano S,Cachofeiro V,Egido J,Lahera V

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:We examined whether the Rho/Rho-kinase pathway is involved in the pathogenesis of nephrosclerosis in severely hypertensive rats and assessed the effects of long-term treatment with a Rho-kinase inhibitor, fasudil, on kidney function, histological findings, gene expressions, and survival. We also attempted to...

journal_title：Journal of hypertension

authors： Nishikimi T,Koshikawa S,Ishikawa Y,Akimoto K,Inaba C,Ishimura K,Ono H,Matsuoka H

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored. METHODS:We compared prevalence of brain infarcts, and severe white matter hyperintensitie...

journal_title：Journal of hypertension

authors： Shibata D,Tillin T,Beauchamp N,Heasman J,Hughes AD,Park C,Gedroyc W,Chaturvedi N

更新日期：2013-12-01 00:00:00

abstract：:This study was designed to assess the contribution of thromboxane (Tx) A2 to the pathogenesis of renal dysfunction in rats with angiotensin II (Ang II)-salt hypertension. Hypertension was induced in rats drinking 0.15 mol/l NaCl by infusion of Ang II (125 ng/min, intraperitoneally) for 12 days. Relative to values in w...

journal_title：Journal of hypertension

authors： Mistry M,Muirhead EE,Yamaguchi Y,Nasjletti A

更新日期：1990-01-01 00:00:00

abstract：:The fall in blood pressure that is commonly observed when groups of hypertensive individuals are followed without treatment is usually ascribed to two sources: regression towards the mean and increasing familiarity of the subject with the assessment process. Any effect of the latter process could bias the results of c...

journal_title：Journal of hypertension

authors： Haynes RB,Logan AG,Flanagan PT,Milne BJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:We have previously reported that hearts from N-[omega]-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats exhibited an enhanced expression of Gi proteins. Since, losartan, an AT1 receptor antagonist, has been shown to attenuate the L-NAME-induced increase in blood pressure, we undertook the pres...

journal_title：Journal of hypertension

authors： Hashim S,Anand-Srivastava MB

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The present study was performed to examine the role of superoxide (O2*) and its interaction with nitric oxide (NO) in the regulation of renal function in prehypertensive heterozygous Ren-2 transgenic rats (TGR). METHODS:Renal responses to the O2* scavenger, tempol (150 microg/min per 100 g), and/or the NO sy...

journal_title：Journal of hypertension

authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Cervenka L,Majid DS

更新日期：2007-11-01 00:00:00

abstract：:Basal platelet function was measured in 35 40-year-old men with untreated mild essential hypertension and compared with 44 age-matched normotensive men. The groups differed significantly with respect to platelet size in venous blood (hypertensive, 7.46 +/- 0.10 X 10(-15) l versus normotensive, 7.11 +/- 0.09 X 10(-15) ...

journal_title：Journal of hypertension

authors： Lande K,Os I,Kjeldsen SE,Westheim A,Hjermann I,Eide I,Gjesdal K

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:To examine in a population with a high prevalence of hypertension, the association between six cardiovascular polymorphisms, arterial stiffness and medication use. METHODS:In this cross-sectional study (Hypertension: Interaction and Prevalence of POlymorphisms related to Cardiovascular Risk and the Associati...

journal_title：Journal of hypertension

authors： Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study was to examine pressor responsiveness in a rabbit model with adrenal perturbation. Adrenals in rabbits were stabbed with a needle, and the rabbits were given water (adrenal-water group) or 0.9% NaCl (adrenal-salt) to drink; additional rabbits were sham-operated and given water (sham-water gro...

journal_title：Journal of hypertension

authors： Siripaisarnpipat S,Johnson JA,Fowler WL Jr,Zeigler DW,Payne CG

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To identify predictors of pregnancy-induced hypertension and pre-eclampsia in 212 nulliparous women before 20 weeks' gestation and at approximately 28 weeks' gestation. STUDY DESIGN:A randomized, prospective study in a teaching hospital. We performed standardized measurements of systolic and diastolic arteri...

journal_title：Journal of hypertension

authors： Broughton Pipkin F,Sharif J,Lal S

更新日期：1998-02-01 00:00:00

abstract：:It is widely believed that salt-dependent hypertension is induced and maintained by expansion of intravascular fluid volume resulting from excessive retention of sodium. The purpose of this brief article is to present a series of arguments in support of the thesis that volume overload per se does not raise the arteria...

journal_title：Journal of hypertension

authors： Gavras I,Gavras H

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To investigate the role of angiotensin II in the pathogenesis of hyperinsulinemia-induced hypertension in rats. MATERIALS AND METHODS:Chronic hyperinsulinemia was achieved by infusing insulin (3 mU/kg per min) subcutaneously by an osmotic minipump for 6 weeks. An angiotensin converting enzyme inhibitor (fosi...

journal_title：Journal of hypertension

authors： Fang TC,Huang WC

更新日期：1998-12-01 00:00:00

abstract：:Diabetic nephropathy has developed into a worldwide epidemic and is responsible for the majority of end-stage renal disease in most countries. Antihypertensive treatment slows the progression of the disease. In addition, blockade of the renin-angiotensin system reduces the degree of albuminuria and angiotensin II rece...

journal_title：Journal of hypertension

authors： Haller H,Viberti GC,Mimran A,Remuzzi G,Rabelink AJ,Ritz E,Rump LC,Ruilope LM,Katayama S,Ito S,Izzo JL Jr,Januszewicz A

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine whether pulse pressure is a risk factor for coronary artery disease using data from the MRC trial of treatment of mild hypertension, and whether the effect of anti-hypertensive drug therapy on pulse pressure may be a determinant of outcome in treated patients. METHODS:...

journal_title：Journal of hypertension

authors： Millar JA,Lever AF,Burke V

更新日期：1999-08-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) plays a pivotal role in modulation of vascular function and it is also involved in the pathophysiology of several cardiovascular diseases. We provide an updated overview of the current appraisal of ANP vascular effects in both animal models and humans. We describe the physiological imp...

journal_title：Journal of hypertension

authors： Rubattu S,Calvieri C,Pagliaro B,Volpe M

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the prognostic significance of cardiovascular risk factors including 24-h ambulatory blood pressure level and rhythm for all-cause mortality in type 2 diabetic patients. METHODS:In a prospective observational study, 104 patients with type 2 diabetes were followed: 51 patients with diabetic nephro...

journal_title：Journal of hypertension

authors： Astrup AS,Nielsen FS,Rossing P,Ali S,Kastrup J,Smidt UM,Parving HH

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...

journal_title：Journal of hypertension

authors： Pose-Reino A,Gomez-Ulla F,Hayik B,Rodriguez-Fernández M,Carreira-Nouche MJ,Mosquera-González A,González-Penedo M,Gude F

更新日期：2005-04-01 00:00:00

abstract：:Several myosin isoforms are expressed in smooth muscle, based upon both heavy and light chain polymorphisms. These myosin isoenzymes reveal distinct detachment rate constants, thus regulating the responsiveness of the VSMC contractile apparatus to Ca2+, as well as its energetical and mechanical behavior. ...

journal_title：Journal of hypertension

authors： Morano IL

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes. OBJECTIVE:We therefore investigated the association between left ventricular structur...

journal_title：Journal of hypertension

authors： Kuznetsova T,Manunta P,Casamassima N,Messaggio E,Jin Y,Thijs L,Richart T,Fagard RH,Bianchi G,Staessen JA

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Development of internally quenched fluorogenic substrates for sensitive and continuous assays of angiotensin I-converting enzyme (ACE). DESIGN:We synthesized internally quenched fluorogenic bradykinin-related peptides introducing Abz (ortho-aminobenzoic acid) and EDDnp (N-[2,4-dinitrophenyl]-ethylenediamine)...

journal_title：Journal of hypertension

authors： Araujo MC,Melo RI,Del Nery E,Alves MF,Juliano MA,Casarini DE,Juliano L,Carmona AK

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether and how renin-angiotensin inhibition attenuates renal injury seen in salt-induced hypertension in Dahl salt-sensitive (Dahl-S) rats. METHODS:Dahl-S rats fed a high-salt (4% sodium chloride) diet for 6 weeks were treated with the angiotensin converting enzyme (ACE) inhibitor alacepril o...

journal_title：Journal of hypertension

authors： Hirawa N,Uehara Y,Kawabata Y,Ohshima N,Ono H,Nagata T,Gomi T,Ikeda T,Goto A,Yagi S

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between stroke risk and blood pressure (BP) levels with regard to the usage of antihypertensive medications. METHODS:From the Japan arteriosclerosis longitudinal study, 11,371 participants from the four population-based cohort studies (aged 40-89) were followed up for a mean of 9....

journal_title：Journal of hypertension

authors： Asayama K,Ohkubo T,Yoshida S,Suzuki K,Metoki H,Harada A,Murakami Y,Ohashi Y,Ueshima H,Imai Y,Japan Arteriosclerosis Longitudinal Study (JALS) group.

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Poor adherence to treatment is one of the major problems in the treatment of hypertension. Self blood pressure measurement may help patients to improve their adherence to treatment. METHOD:In this prospective, randomized, controlled study coordinated by a university hospital, a total of 228 mild-to-moderate...

journal_title：Journal of hypertension

authors： van Onzenoort HA,Verberk WJ,Kroon AA,Kessels AG,Nelemans PJ,van der Kuy PH,Neef C,de Leeuw PW

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. AngIII, one of the main effector peptides of the brain renin-Ang system, exerts a tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopepti...

journal_title：Journal of hypertension

authors： Marc Y,Hmazzou R,Balavoine F,Flahault A,Llorens-Cortes C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The difference between clinic and ambulatory blood pressure (BP) is a poor estimate of the true white-coat effect (WCE) measured with beat-to-beat recording. METHOD:We investigated whether the difference between clinic and home BP (home WCE) was a better estimate of true WCE than ambulatory WCE. In 73 young...

journal_title：Journal of hypertension

authors： Saladini F,Benetti E,Malipiero G,Casiglia E,Palatini P

更新日期：2012-11-01 00:00:00