Abstract:
OBJECTIVE:The present study was performed to examine the role of superoxide (O2*) and its interaction with nitric oxide (NO) in the regulation of renal function in prehypertensive heterozygous Ren-2 transgenic rats (TGR). METHODS:Renal responses to the O2* scavenger, tempol (150 microg/min per 100 g), and/or the NO synthase inhibitor, nitro-L-arginine methylester (L-NAME; 5 microg/min per 100 g), infused alone or in combination directly into the renal artery were evaluated in anesthetized heterozygous male TGR and aged-matched Hanover Sprague-Dawley rats (HanSD). RESULTS:There were no differences in arterial pressure (122 +/- 3 versus 115 +/- 2 mmHg), renal plasma flow (RPF; 2.09 +/- 0.1 versus 2.07 +/- 0.1 ml/min per g), glomerular filtration rate (GFR; 0.73 +/- 0.1 versus 0.74 +/- 0.1 ml/min per g) or sodium excretion (0.63 +/- 0.13 versus 0.67 +/- 0.16 micromol/min per g) between TGR and HanSD. Tempol alone caused significant increases in RPF and GFR (10 +/- 4% and 12 +/- 2%, respectively) in TGR but not in HanSD. Tempol also caused greater sodium excretory responses in TGR compared to HanSD (112 +/- 16% versus 43 +/- 7%; P < 0.05). 8-Isoprostane excretion was significantly higher in TGR than in HanSD (10.2 +/- 0.8 versus 6.5 +/- 0.7 pg/min per g), which was attenuated by tempol. L-NAME caused greater decreases in RPF and GFR in TGR (-34 +/- 4% and -22 +/- 4%, respectively) than in HanSD (-19 +/- 3% and -10 +/- 4%, respectively). Co-infusion of tempol partially attenuated the renal hemodynamic and excretory responses to L-NAME in TGR. CONCLUSIONS:These data suggest that the enhanced O2* activity and its interaction with NO during the prehypertensive phase in TGR modulates renal hemodynamic and excretory function, which may contribute to the development of hypertension in this transgenic rat model.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Cervenka L,Majid DSdoi
10.1097/HJH.0b013e3282efb195subject
Has Abstractpub_date
2007-11-01 00:00:00pages
2257-65issue
11eissn
0263-6352issn
1473-5598pii
00004872-200711000-00013journal_volume
25pub_type
杂志文章abstract:OBJECTIVES:To examine: (1) in how many treated hypertensive patients it was possible to discontinue drug treatment; (2) the time-course for redevelopment of hypertension after discontinuation of therapy; and (3) whether drug withdrawal was associated with an increase in left ventricular mass (LVM). DESIGN:Fifty-four m...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199206000-00012
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Coffee is widely consumed in the Western diet and therefore has important implications for public health. Research findings pertaining to the effects of coffee consumption on cardiovascular health are conflicting, and the role of caffeine is not clear. OBJECTIVE:To examine the relationship between coffee in...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/01.hjh.0000249696.19360.be
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Losartan is a new angiotensin II type 1 (AT1) receptor antagonist and an antihypertensive drug. Nitric oxide is a vasodilating agent and endothelins are powerful vasoconstrictors, both synthesized by and released from endothelial cells. Angiotensin II promotes the release of endothelins in cultured cells and...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVES:Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. METHODS:MiR-34b/c rs2187473 and rs4938723 polymorphisms were genotyped by Snapshot assay among 495 controls and 492 ischemic ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002413
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:The platelet GPIIIa plays a pivotal role in platelet aggregation. Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. We explored the possibility that this polymorphism represents a risk fa...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328013cd67
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Current clinical guidelines of primary aldosteronism recommend adrenalectomy (AdX) for unilateral primary aldosteronism based on the studies showing the potential superiority of AdX over the medical treatment. However, since most medically treated cases consisted of bilateral primary aldosteronism and all su...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/HJH.0000000000002070
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. OBJ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917040-00006
更新日期:1999-04-01 00:00:00
abstract::Medical records were examined for 1935 patients who presented sequentially to a hypertension clinic between 1971 and 1981. Patients were classified according to whether they were on a beta-blocker, methyldopa, a potassium-losing diuretic, or whether they had discontinued any of these treatments. Age-standardized morta...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198907000-00009
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the capacity of norepinephrine (NE) to induce hypertrophic remodeling of small arteries in rats, and to determine the involvement of endothelin (ET) to initiate and maintain it. DESIGN AND RESULTS:Treatment with NE (2.5 microg/kg per min) for 14 or 28 days produced a simil...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200110000-00014
更新日期:2001-10-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198410000-00012
更新日期:1984-10-01 00:00:00
abstract::Hypertension is a leading risk factor for mortality. Detecting, treating and monitoring hypertensive patients require accurate blood pressure measurements. Protocols for validation of automatic sphygmomanometers exist, but quality control of validations is limited to peer review of published reports, which has severe ...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0b013e32833e1011
更新日期:2010-12-01 00:00:00
abstract::Adequate evaluation of automated sphygmomanometers, in terms of safety, accuracy, mechanical reliability, patient acceptability and ability to record ambulatory blood pressure is essential before these devices are used in clinical practice and in clinical trials. We have evaluated the accuracy and performance of the A...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199007000-00003
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:The renin-angiotensin system plays an important role in blood pressure control. Recently the mouse Ren-2 renin gene was introduced into the genome of rats, producing low-renin hypertensive animals. The aim of the present study was to characterize the pharmacological and morphological properties of mesenteric ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199210000-00012
更新日期:1992-10-01 00:00:00
abstract:RATIONALE:Cicletanine (CIC), an anti-hypertensive compound with direct vascular and natriuretic actions, is especially effective in salt-sensitive hypertension, in which dysregulation of the sodium pump plays an important pathogenic role, and digitalis-like cardiotonic steroids contribute to increased vascular tone. Th...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018020-00012
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To gauge the effectiveness of a new Doppler test for renal artery stenosis (RAS), based on the pulsatility index of the blood flow velocity spectrum within several interlobar arteries of both kidneys. METHODS:Twenty normotensive volunteers and 49 hypertensive patients were investigated with ultrasound. Patie...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2. METHODS:We performed a large association study of polymorphisms in this region with blood pressure modulatio...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000166835.70935.3c
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:Urocortin 1 (Ucn1) and the sympathetic nervous system both participate in cardiac and circulatory regulation, but little is known about their possible interactions. METHODS:We report the effects of Ucn1 on the cardiac sympathetic nerve activity (CSNA), haemodynamics and plasma catecholamines in normal sheep...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f01428
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To describe several emerging concepts regarding the biosynthesis, metabolism and biological roles of adenosine and to illustrate the possible significance of these ideas to vascular biology by proposing a hypothesis pertaining to the role of erythrocyte-derived adenosine deaminase in vaso-occlusive diseases a...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000170377.00591.7e
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence and risk markers of arterial hypertension in the context of a rapidly growing urbanization in Africa. DESIGN:A cross-sectional study was performed on a representative sample of inhabitants of Pikine, an urban suburb of Dakar, Senegal. METHODS:Blood pressure was measured by properly ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328352573b
更新日期:2012-05-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001654
更新日期:2018-05-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/HJH.0000000000001844
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus is associated with an increased risk of hypertension, and cardiovascular and renal disease, and it has been recommended that management of hypertension should be more aggressive in presence than in absence of diabetes mellitus, but the matter is controversial at present. OBJECTIVES:...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000001276
更新日期:2017-05-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199210000-00022
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To estimate the compliance rate and associated factors among a population of hypertensive subjects registered in hospitals and primary health care centres. DESIGN:A prospective study carried out on a sample of hypertensive subjects. METHOD:Compliance with treatment by the study sample was measured using the...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715050-00013
更新日期:1997-05-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001670
更新日期:2018-05-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000244959.92856.7e
更新日期:2006-10-01 00:00:00
abstract::Two formulations of felodipine, conventional and extended release (ER) tablets, were compared in a double-blind, crossover study of patients whose blood pressure was not being controlled using metoprolol 100 mg once daily. Nineteen patients with a supine diastolic blood pressure greater than or equal to 95 mmHg after ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1097/00004872-198908000-00008
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholami...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-200207000-00020
更新日期:2002-07-01 00:00:00