Abstract：
:Medical records were examined for 1935 patients who presented sequentially to a hypertension clinic between 1971 and 1981. Patients were classified according to whether they were on a beta-blocker, methyldopa, a potassium-losing diuretic, or whether they had discontinued any of these treatments. Age-standardized mortality rates were calculated and the relative risks of stopping compared with non-stopping were computed. Those stopping a beta-blocker had a significantly higher mortality in the following year than those who continued, both in men [relative risk (RR) = 5.91, 95% confidence interval (Cl) 2.78-12.56] and women (RR = 5.67, 95% Cl 1.75-18.41). Moreover, women also had a significantly higher mortality when stopping methyldopa, compared with those who continued on the drug (RR = 4.91, 95% Cl 1.82-13.20). However, analysis of data from the years following withdrawal indicated that a high RR was not limited to the first year after the withdrawal of beta-blockers, but was still apparent in the fourth year after stopping. This indicates that the high mortality was not an early function of withdrawal. The high initial RR of mortality in women stopping methyldopa was followed by a substantial decrease in risk over the later years of follow-up. The high mortality in patients stopping particular antihypertensive drugs was not explained by known cardiovascular risk factors.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Franks PJ,Hartley K,Bulpitt PF,Bulpitt CJ,Dollery CTdoi
10.1097/00004872-198907000-00009subject
Has Abstractpub_date
1989-07-01 00:00:00pages
577-84issue
7eissn
0263-6352issn
1473-5598journal_volume
7pub_type
杂志文章abstract：:Using antibodies raised against angiotensin I and II, and high-performance liquid chromatography (HPLC) of plasma extracts, we have quantified six angiotensin peptides in venous (cubital vein) and arterial (brachial) plasma of normal male subjects. The concentrations of venous plasma (fmol/ml, mean +/- s.d., n = 29) f...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199002000-00011
更新日期：1990-02-01 00:00:00
abstract：OBJECTIVE:To determine whether automated blood pressure measuring devices can measure blood pressure accurately in patients with atrial fibrillation. DESIGN:Comparison of the accuracy of two electronic sphygmomanometers [Takeda UA-751 (Takeda) and Copal UA-251 (Copal)] and two ambulatory blood pressure monitors [Accut...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVES:Obstructive sleep apnoea (OSA) and hypertension frequently coexist, and both are associated with higher night-time than daytime urine sodium excretion rate (UNaV). However, the relative contribution of each condition is unknown. We compared the circadian pattern of UNaV in hypertensive and normotensive patie...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000327
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Hypertension in midlife has been associated with increased risk of stroke and neurocognitive decline. Few studies, however, have examined neurocognition among individuals with treatment-resistant hypertension or potential mechanisms by which treatment-resistant hypertension may impair neurocognition. METHOD...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000002002
更新日期：2019-05-01 00:00:00
abstract：:Cardiovascular risk increases with chronological as well as biological aging, and one marker of this might be telomere length. The telomere cap is located at the end of the DNA helix and serves to protect its end. This is an evolutionary adaptation which has resulted in stabilization of the DNA strand within the chrom...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/HJH.0b013e328353e512
更新日期：2012-06-01 00:00:00
abstract：AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000680
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:The objective is to evaluate the relationship between cholesterolemia, serum apolipoprotein B (apoB) level and blood pressure in a large sample of general population. METHODS:The Brisighella Heart Study (BHS) is a prospective, population-based longitudinal epidemiological investigation. For this study, we an...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32834f6b11
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:Recent studies in homogenized hearts suggest that chymase rather than angiotensin converting enzyme (ACE) is responsible for cardiac angiotensin I to angiotensin II conversion. We investigated in intact rat hearts whether (i) enzymes other than ACE contribute to angiotensin I to angiotensin II conversion and...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-200105000-00017
更新日期：2001-05-01 00:00:00
abstract：AIM:To examine the effect of renal denervation (RDN) on blood pressure (BP) and health-related quality of life (QoL) in patients with resistant hypertension, pseudoresistant hypertension due to a white-coat effect and in patients with uncontrolled masked hypertension. METHODS:Using the Medical Outcomes Study 36-Item S...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000698
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:The primary aim of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) is to determine the effects of a long-term angiotensin converting enzyme (ACE)-inhibitor-based blood-pressure-lowering regimen on the risk of stroke among patients with a history of stroke or transient ischaemic attack (TI...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty ac...
journal_title：Journal of hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/HJH.0b013e3283604016
更新日期：2013-06-01 00:00:00
abstract：:A previously described Pst I restriction fragment length polymorphism in Dahl rats at the Na+, K(+)-adenosine 5'-triphosphatase (ATPase) alpha 1 isoform locus was tested for cosegregation with blood pressure in segregating populations. Inbred Dahl salt-sensitive (S) and inbred Dahl salt-resistant (R) rats were crossed...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199005000-00010
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVE:Genome-wide association studies have linked variants of fat mass and obesity-associated protein (FTO) to obesity. However, the molecular function of FTO remains unclear. In this study, we sought to investigate the potential effects of FTO in modulating cholesterol deposition in macrophage foam cells, as well ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001255
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects. DESIGN:A cross-sectional case-control study. SETTING:Hypertension clinic and research clinic of a university teachin...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/01.hjh.0000125452.28861.f1
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. OBJ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199917040-00006
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:High sodium intake is associated with increased risk of end-organ damage, independent of blood pressure (BP) levels. The protective peptide adiponectin may play a role in the pathogenesis of hypertension and particularly in salt-loaded conditions. Furthermore, increased adiponectin levels were observed in sa...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3283325eee
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Cardiovascular diseases represent the most common cause of death in the English-speaking Caribbean, and hypertension represents the most important predisposing condition. However, direct between-country comparative studies in the Caribbean have not previously been undertaken. OBJECTIVE:To obtain estimates o...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:The usefulness of the hypertensive retinopathy classification by Keith-Wagener-Barker (KWB) in clinical practice remains controversial. The simplified Mitchell-Wong grading, combining the two initial KWB' grades in one stage, is proposed as an alternative method; both systems are poorly validated regarding t...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000702
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Cerebrovascular myogenic function, which protects the brain from hemorrhagic stroke, is impaired in stroke-prone spontaneously hypertensive rats. Furthermore, myogenic function contributes to very low frequency blood pressure variability and dynamic autoregulation of cerebral blood flow is most effective at ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3282fb81c8
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To assess the antihypertensive efficacy and safety of the novel AT1 receptor antagonist, telmisartan, compared with that of enalapril in elderly patients with mild to moderate hypertension. DESIGN:A 26-week, multicenter, double-blind, parallel-group, dosage titration study. METHODS:A total of 278 patients a...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00004872-199917020-00015
更新日期：1999-02-01 00:00:00
abstract：:Isolated tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP), but not from normotensive Wistar-Kyoto rats (WKY), exhibit oscillatory contractions in response to norepinephrine. Previous studies indicate that the mechanism for these oscillations involves altered membrane calcium and/or potassium han...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-198901000-00005
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS:We recruited 378 hypertensive CKD ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001185
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:The interactions between eNOS or oxidative stress and bradykinin under long-term treatment of angiotensin II type 1 receptor antagonists (ATRA) remain unknown. To elucidate the molecular mechanisms of the cardioprotective effect of ATRA, we evaluated whether valsartan affects the bradykinin-eNOS and nicotina...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32814db89f
更新日期：2007-08-01 00:00:00
abstract：:Calcium blockers may reduce contractility of vascular smooth muscle as well as that of myocardial cells. Therefore, falls in both total peripheral vascular resistance (TPR) and cardiac output (CO) might be responsible for a fall in blood pressure (BP) caused by calcium blockers in essential hypertension. We have studi...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：OBJECTIVE:Blood pressure changes during menopausal transition have not been studied previously using a biracial sample. We investigated whether menopausal transition was associated with change in blood pressure in African-American or white women. DESIGN, SETTING AND PARTICIPANTS:The prospective multicenter study, the ...
journal_title：Journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1097/00004872-200018010-00005
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To determine adrenocorticotrophin dose-response relationships for increase of blood pressure and metabolic parameters of the Sprague-Dawley rat. METHODS:We injected 120 male Sprague-Dawley rats twice daily subcutaneously for 10 days with 0.5, 1, 5, 50, 100, 200 or 500 microg/kg synthetic adrenocorticotrophin...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199816050-00006
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy (LVH). We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32833aa356
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVES:Renal tubular sodium handling was measured in healthy subjects submitted to acute and chronic salt-repletion/salt-depletion protocols. The goal was to compare the changes in proximal and distal sodium handling induced by the two procedures using the lithium clearance technique. METHODS:In nine subjects, acu...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004872-200018110-00018
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:To explore the mechanisms for augmented neutral endopeptidase inhibitor-induced natriuresis in deoxycorticosterone acetate (DOCA)-salt rats. METHODS:We examined effects of a neutral endopeptidase-inhibitor, candoxatril, on plasma and urinary brain natriuretic peptide (BNP) levels, the influence of a specific...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Telmisartan is a unique AT1 receptor blocker with a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonistic action. Activation of PPAR-gamma could prevent inflammation and brain damage. METHOD:We investigated the beneficial effect of telmisartan on ischemic brain damage via PPAR-gamma activa...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32833a551a
更新日期：2010-08-01 00:00:00
