Enhanced sympathoadrenal reactivity to haemorrhagic stress in DOCA-salt hypertensive rats.

abstract：OBJECTIVE:We examined the effects of a calcium antagonist and an angiotensin converting enzyme (ACE) inhibitor on contractile and non-contractile protein metabolism and cardiac function in a monocrotaline-induced right ventricular hypertrophy model, in order to define the effects of these drugs on cardiac hypertrophy. ...

journal_title：Journal of hypertension

authors： Tanaka K,Honda M,Kuramochi T,Hashimoto M,Masumura S,Mansoor AM,Ishikawa S,Morioka S

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:Hemodialysis patients have a cardiovascular mortality rate of 20-40 times that of the general population. Aldosterone inhibition by spironolactone has exerted beneficial, prognostically significant cardiovascular effects in patients with heart failure maintained on hemodialysis or peritoneal dialysis. Our ai...

journal_title：Journal of hypertension

authors： Flevari P,Kalogeropoulou S,Drakou A,Leftheriotis D,Panou F,Lekakis J,Kremastinos D,Vlahakos DV

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The oral contraceptive pill (OCP) is widely prescribed throughout the world. Although it is associated with a small but significant increase in blood pressure, the influence of the OCP on large artery stiffness and wave reflection is unclear. The aim of this study was to determine the relationship between us...

journal_title：Journal of hypertension

authors： Hickson SS,Miles KL,McDonnell BJ,Yasmin,Cockcroft JR,Wilkinson IB,McEniery CM,ENIGMA Study Investigators.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple combination compared with the component dual combinations, in patients with moderate-to-severe hypertension. METHODS:This 8-week, double-blind, randomized, activ...

journal_title：Journal of hypertension

authors： Lacourcière Y,Taddei S,Konis G,Fang H,Severin T,Zhang J

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Genetic variants that influence large conductance calcium-activated potassium channel's function may alter arterial function and contribute to the known heritability of arterial stiffness and blood pressure. The beta1-subunit (KCNMB1) of the large conductance calcium-activated potassium channel includes two ...

journal_title：Journal of hypertension

authors： Kelley-Hedgepeth A,Peter I,Montefusco MC,Levy D,Benjamin EJ,Vasan RS,Mendelsohn ME,Housman D,Huggins GS,Mitchell GF

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To conduct a longitudinal evaluation of the central haemodynamic adaptations of normal pregnancy. METHODS:This was a prospective longitudinal study involving healthy, normotensive women who were having an uncomplicated, singleton pregnancy. Brachial and central SBP, DBP, mean arterial pressure (MAP), brachia...

journal_title：Journal of hypertension

authors： O' Callaghan KM,Hennessy Á,Malvisi L,Kiely M

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Excess oxidative stress is one of the major metabolic abnormalities on vascular walls in hypertension and atherosclerosis. In order to further elucidate the endothelial function under oxidative stress, the effect of hydrogen peroxide (H2O2) on expression of two novel endothelium-derived vasorelaxing peptides,...

journal_title：Journal of hypertension

authors： Chun TH,Itoh H,Saito T,Yamahara K,Doi K,Mori Y,Ogawa Y,Yamashita J,Tanaka T,Inoue M,Masatsugu K,Sawada N,Fukunaga Y,Nakao K

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS:The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the A...

journal_title：Journal of hypertension

authors： Bengtsson K,Orho-Melander M,Lindblad U,Melander O,Bøg-Hansen E,Ranstam J,Råstam L,Groop L

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Secondary activation of the renin-angiotensin system plays a major role in the progression of chronic nephropathies, and blockade of endothelin (ET) receptors has been shown to confer nephroprotection in experimental models of proteinuric renal disease. We tested the nephroprotective potential of selective en...

journal_title：Journal of hypertension

authors： Rothermund L,Kossmehl P,Neumayer HH,Paul M,Kreutz R

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:p63RhoGEF, a guanine nucleotide exchange factor, has been reported 'in vitro' as key mediator of the angiotensin II-induced RhoA/Rho kinase activation leading to vasoconstriction and cardiovascular remodeling. We assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hyperten...

journal_title：Journal of hypertension

authors： Calò LA,Davis PA,Pagnin E,Dal Maso L,Maiolino G,Seccia TM,Pessina AC,Rossi GP

更新日期：2014-02-01 00:00:00

abstract：:Endothelin-1 was infused into the non-dominant brachial artery in two male subjects. We then monitored intra-arterial mean blood pressure, right atrial pressure, the heart rate and forearm blood flow (by plethysmography). Endothelin-1 at a dose of 5 x 10(-14) to 5 x 10(-9) mol, infused over 5 min periods, elicited no ...

journal_title：Journal of hypertension

authors： Dahlöf B,Gustafsson D,Hedner T,Jern S,Hansson L

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVES:We compared the agreement between different techniques to estimate central SBP (cSBP) in children and the relative impact of different methods of measuring peripheral blood pressure (BP). METHODS:A total of 135 children, aged 12.9 ± 3.0 years including 67 boys, 85 with chronic kidney disease were studied. W...

journal_title：Journal of hypertension

authors： Rajalingam S,Milne L,Keehn L,Chowienczyk P,Sinha MD

更新日期：2019-12-01 00:00:00

abstract：:Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

journal_title：Journal of hypertension

authors： Williams B

更新日期：2012-06-01 00:00:00

abstract：:Systemic and regional haemodynamic effects of renal denervation were evaluated in adult (six-month-old) male spontaneously hypertensive rats (SHR) using the Fick procedure and electromagnetic flowmetry technique. Renal denervation (bilateral, 10% phenol in ethanol), performed five to eight days before the experiment, ...

journal_title：Journal of hypertension

authors： Lee JY,Walsh GM

更新日期：1983-12-01 00:00:00

abstract：:We compared the overflow of endogenous norepinephrine (NE) upon electrical stimulation, the associated pressor response and rate of initial neuronal uptake of 3H-I-NE in the perfused mesenteric arteries of Dahl salt-sensitive (DS) and salt-resistant (DR) rats on two dietary NaCl regimens (0.4 and 8.0% for 2 weeks) fro...

journal_title：Journal of hypertension

authors： Hano T,Jeng Y,Rho J

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:The apolipoprotein epsilon 4 allele (APOE/epsilon 4) increases plasma cholesterol level and the risk for the late onset type of Alzheimer's disease. However, the correlation between hypertension and APOE/epsilon 4 has not yet been clarified. To examine the APOE/epsilon 4 effect in the general population of J...

journal_title：Journal of hypertension

authors： Katsuya T,Baba S,Ishikawa K,Mannami T,Fu Y,Inamoto N,Asai T,Fukuda M,Higaki J,Ogata J,Ogihara T

更新日期：2002-10-01 00:00:00

abstract：:This paper describes the kinetics of the Na(+)-K+ pump and the Na(+)-K(+)-Cl- cotransport in sodium-loaded erythrocytes and of the Na(+)-K(+)-Cl- cotransport in erythrocyte inside-out vesicles (IOV) from Milan hypertensive (MHS) and normotensive (MNS) rats in order to evaluate the possible role of intracellular factor...

journal_title：Journal of hypertension

authors： Ferrari P,Torielli L,Cirillo M,Salardi S,Bianchi G

更新日期：1991-08-01 00:00:00

abstract：:This study was designed to assess the contribution of thromboxane (Tx) A2 to the pathogenesis of renal dysfunction in rats with angiotensin II (Ang II)-salt hypertension. Hypertension was induced in rats drinking 0.15 mol/l NaCl by infusion of Ang II (125 ng/min, intraperitoneally) for 12 days. Relative to values in w...

journal_title：Journal of hypertension

authors： Mistry M,Muirhead EE,Yamaguchi Y,Nasjletti A

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we study isolated and combined effects of hypertension and aging on central...

journal_title：Journal of hypertension

authors： Spronck B,Ferruzzi J,Bellini C,Caulk AW,Murtada SI,Humphrey JD

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS:We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HA...

journal_title：Journal of hypertension

authors： Parthasarathy HK,Alhashmi K,McMahon AD,Struthers AD,McInnes GT,Ford I,Connell JM,MacDonald TM

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS:Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimate...

journal_title：Journal of hypertension

authors： Viazzi F,Ceriello A,Fioretto P,Giorda C,Guida P,Russo G,Greco E,De Cosmo S,Pontremoli R,AMD-Annals Study Group.

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate whether nondipping and diabetes are independently related to metabolic risk profile and prevalence of target organ damage in a population setting. METHODS:A population-based cohort of 70-year-old men (n = 1057) was examined with 24-h ambulatory blood pressure monitoring, euglycemic hyperinsuli...

journal_title：Journal of hypertension

authors： Björklund K,Lind L,Andrén B,Lithell H

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD:Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the min...

journal_title：Journal of hypertension

authors： de las Heras N,Ruiz-Ortega M,Miana M,Rupérez M,Sanz-Rosa D,Aragoncillo P,Mezzano S,Cachofeiro V,Egido J,Lahera V

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:Advanced diabetic nephropathy (DN) is characterized by a marked development of cardiovascular and renal disease. These patients are frequently managed by different health professionals with the consequence that the quality of care may differ substantially. To compare the management of cardiovascular risk fac...

journal_title：Journal of hypertension

authors： Minutolo R,Sasso FC,Chiodini P,Cianciaruso B,Carbonara O,Zamboli P,Tirino G,Pota A,Torella R,Conte G,De Nicola L

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that combination therapy might be a powerful tool to reduce blood pressure variability (BPV) in the treatment of hypertension. METHODS:In chronic studies, male spontaneously hypertensive rats were given drugs in their rat chow for 18 weeks (n = 9 or 10 for each group of rats). Doses we...

journal_title：Journal of hypertension

authors： Xie HH,Shen FM,Xu LP,Han P,Miao CY,Su DF

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Hypertension in midlife has been associated with increased risk of stroke and neurocognitive decline. Few studies, however, have examined neurocognition among individuals with treatment-resistant hypertension or potential mechanisms by which treatment-resistant hypertension may impair neurocognition. METHOD...

journal_title：Journal of hypertension

authors： Smith PJ,Blumenthal JA,Hinderliter AL,Mabe SM,Schwartz JE,Avorgbedor F,Sherwood A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:In the nineteenth century, prior to the introduction of the cuff sphygmomanometer, stiffening of arteries was recognized as an indicator of vascular ageing and cardiovascular risk. Through the twentieth century, views on vascular ageing came to focus on brachial blood pressures and on occlusive atherosclerot...

journal_title：Journal of hypertension

authors： Safar ME,Nilsson PM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Nonsteroidal anti-inflammatory drugs vary in their impact on blood pressure and the effect of lumiracoxib 100 mg once daily has not been studied previously. To examine whether lumiracoxib 100 mg once daily would result in lower 24-h mean systolic ambulatory blood pressure than ibuprofen 600 mg three times da...

journal_title：Journal of hypertension

authors： MacDonald TM,Reginster JY,Littlejohn TW,Richard D,Lheritier K,Krammer G,Rebuli R

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Arterial stiffness is an independent cardiovascular risk factor. Aging, high blood pressure and increased renin-angiotensin system activity contribute to increased arterial stiffness in patients with atherosclerotic renovascular hypertension (aRVH). A literature search failed to identify any study related to ...

journal_title：Journal of hypertension

authors： Fodor L,Premužić V,Ivković V,Perkov D,Laganović M,Vrkić TZ,Dika Z,Zivko M,Jelaković B

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:Urocortin 1 (Ucn1) and the sympathetic nervous system both participate in cardiac and circulatory regulation, but little is known about their possible interactions. METHODS:We report the effects of Ucn1 on the cardiac sympathetic nerve activity (CSNA), haemodynamics and plasma catecholamines in normal sheep...

journal_title：Journal of hypertension

authors： Charles CJ,Jardine DL,Nicholls MG,Rademaker MT,Richards AM

更新日期：2008-01-01 00:00:00