Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: the ENIGMA study.

abstract：OBJECTIVES:Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established. METHODS:Herein, we report 12-month outcomes from the Global SYMPLICITY ...

journal_title：Journal of hypertension

authors： Böhm M,Ukena C,Ewen S,Linz D,Zivanovic I,Hoppe U,Narkiewicz K,Ruilope L,Schlaich M,Negoita M,Schmieder R,Williams B,Zeymer U,Zirlik A,Mancia G,Mahfoud F,Global SYMPLICITY Registry Investigators.

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Nephrin, a cytoskeletal protein which localizes to the slit pore of podocytes, may play a role in proteinuria. This study examines the possible relationship between nephrin expression and albuminuria in normotensive and hypertensive diabetic rats. METHODS:Streptozotocin diabetes was induced in both Wistar-Ky...

journal_title：Journal of hypertension

authors： Forbes JM,Bonnet F,Russo LM,Burns WC,Cao Z,Candido R,Kawachi H,Allen TJ,Cooper ME,Jerums G,Osicka TM

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels. METHODS AND RESULTS:To investigate whether this relates to differences in the contribution of the ACE C-domain and N-domain, we quantified, u...

journal_title：Journal of hypertension

authors： van Esch JH,van Gool JM,de Bruin RJ,Payne JR,Montgomery HE,Hectors M,Deinum J,Dive V,Jan Danser AH

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:Recent studies have revealed an association between coronary risk factors and both the number and function of bone marrow-derived endothelial progenitor cell (EPC). We investigated the effect of angiotensin II (Ang II) on EPC senescence, leading to the impairment of proliferative activity. METHODS AND RESUL...

journal_title：Journal of hypertension

authors： Imanishi T,Hano T,Nishio I

更新日期：2005-01-01 00:00:00

abstract：:Use of the aldosterone-to-renin ratio has controversially suggested that approximately 10% of hypertensives have primary aldosteronism, and most of these individuals are thought to have idiopathic hyperaldosteronism. The usual renin-angiotensin system control is intact in these individuals and is similar to that in lo...

journal_title：Journal of hypertension

authors： Lim PO,Struthers AD,MacDonald TM

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:To establish whether safety and feasibility of dobutamine and dipyridamole stress echocardiography are affected by history of hypertension. METHODS:Data on 2200 consecutive pharmacologic stress echocardiography (959 dobutamine and 1241 dipyridamole) performed between October 1990 and February 2001 at a sing...

journal_title：Journal of hypertension

authors： Cortigiani L,Zanetti L,Bigi R,Desideri A,Fiorentini C,Nannini E

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of prolonged hypertension in the absence of cardiac hypertrophy on the blood pressure-heart rate reflex during acute and chronic NO synthase blockade. METHODS:Male Wistar rats were treated acutely with N omega-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg intraperitoneally) or ch...

journal_title：Journal of hypertension

authors： Banting JD,Wiseman SL,Adams MA

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:BPH/2J hypertensive mice have an exaggerated sympathetic contribution to blood pressure (BP). Premotor sympathetic neurons within the rostroventrolateral medulla (RVLM) are a major source of sympathetic vasomotor tone and major site of action of the centrally acting sympatholytic agent, rilmenidine. The relat...

journal_title：Journal of hypertension

authors： Jackson KL,Palma-Rigo K,Nguyen-Huu TP,Davern PJ,Head GA

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology. That ...

journal_title：Journal of hypertension

authors： Dell'Omo G,Penno G,Pucci L,Fotino C,Lucchesi D,Del Prato S,Pedrinelli R

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Gap junctions, formed by connexins (Cx), are important in the regulation of vascular tone. Previously, we reported two closely linked polymorphisms (-44G --> A and +71A --> G) within regulatory regions of the gene for Cx40, a major connexin in the vascular wall and the kidney. In the present study, we examine...

journal_title：Journal of hypertension

authors： Firouzi M,Kok B,Spiering W,Busjahn A,Bezzina CR,Ruijter JM,Koeleman BP,Schipper M,Groenewegen WA,Jongsma HJ,de Leeuw PW

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The thiazide-sensitive Na-Cl cotransporter (TSC) is involved in the fine regulation of sodium excretion by the kidney, and an increase in its activity causes salt-sensitive hypertension and hypercalciuria. METHODS:To explore the possibility that activating mutations in the TSC gene may be involved in the pa...

journal_title：Journal of hypertension

authors： Keszei AP,Tislér A,Backx PH,Andrulis IL,Bull SB,Logan AG

更新日期：2007-10-01 00:00:00

abstract：AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...

journal_title：Journal of hypertension

authors： Walraven I,Mast MR,Hoekstra T,Jansen AP,Rauh SP,Rutters FR,van der Heijden AA,Elders PJ,Moll AC,Polak BC,Dekker JM,Nijpels G

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Renal sympathetic denervation (RDN) as treatment for hypertension shows highly variable results. Although some patients do not show any blood pressure (BP) change and in most patients a BP reduction of at least 5 mmHg can be found, some show a reduction at least 20 mmHg. We sought to identify predictors for ...

journal_title：Journal of hypertension

authors： Fengler K,Rommel KP,Blazek S,von Roeder M,Besler C,Hartung P,Desch S,Thiele H,Lurz P

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) may lead to the development of hypertension and therapy with continuous positive airway pressure (CPAP) can promote reduction in blood pressure. OBJECTIVE:The objective of this study is to review systematically the effects of CPAP on blood pressure in patients with OSA. METHOD...

journal_title：Journal of hypertension

authors： Schein AS,Kerkhoff AC,Coronel CC,Plentz RD,Sbruzzi G

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:We previously showed that young transgenic mice overexpressing preproendothelin-1 specifically in endothelial cells had hypertrophic remodeling, endothelial dysfunction, increased vascular NADPH oxidase activity, and inflammation in mesenteric small arteries without blood pressure (BP) elevation compared to ...

journal_title：Journal of hypertension

authors： Amiri F,Ko EA,Javeshghani D,Reudelhuber TL,Schiffrin EL

更新日期：2010-06-01 00:00:00

abstract：:Isolated tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP), but not from normotensive Wistar-Kyoto rats (WKY), exhibit oscillatory contractions in response to norepinephrine. Previous studies indicate that the mechanism for these oscillations involves altered membrane calcium and/or potassium han...

journal_title：Journal of hypertension

authors： Bruner CA,Webb RC

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the relationship between physical activity and the magnitude of the percentage fall in blood pressure at night (nocturnal dip). METHODS:We simultaneously monitored 24-h ambulatory blood pressure and measured physical activity by actigraphy in 434 patients. Blood pressure w...

journal_title：Journal of hypertension

authors： Leary AC,Donnan PT,MacDonald TM,Murphy MB

更新日期：2000-04-01 00:00:00

abstract：:Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retent...

journal_title：Journal of hypertension

authors： Rayner BL,Spence JD

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The mechanisms underlying the relationship between the vascular complications of diabetes and the glycaemic control are not well understood. We tested whether glycaemic control influences the functioning of the nitric oxide system in type 1 diabetic patients and the role for oxidative stress. METHODS:The cha...

journal_title：Journal of hypertension

authors： Rodríguez-Mañas L,López-Dóriga P,Petidier R,Neira M,Solís J,Pavón I,Peiró C,Sánchez-Ferrer CF

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:To compare the effects of the angiotensin II receptor antagonist candesartan with the angiotensin-converting enzyme inhibitor enalapril on myocardial fibrosis evaluated by echoreflectivity analysis. METHODS:Hypertensive patients (n = 196) with echocardigraphically documented left ventricular hypertrophy were...

journal_title：Journal of hypertension

authors： Ciulla MM,Paliotti R,Esposito A,Cuspidi C,Muiesan ML,Rosei EA,Magrini F,Zanchetti A

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To determine whether acutely lowering insulin levels with somatostatin in obese, insulin-resistant hypertensive individuals reduces arterial pressure and forearm vascular resistance; and whether these changes are reversed by restoring insulin levels during continuing somatostatin infusion. SUBJECTS:Subjects ...

journal_title：Journal of hypertension

authors： Gudbjörnsdottir S,Elam M,Sellgren J,Anderson EA

更新日期：1996-01-01 00:00:00

abstract：:The present study investigated the roles of insulin on central cardiovascular regulation. When rats were fed with a high-salt diet for 4 weeks, hypothalamic and pituitary contents of insulin-like immunoreactive substance (ILI) significantly decreased. The plasma concentration of ILI remained unaltered, however. Intrac...

journal_title：Journal of hypertension

authors： Nishimura M,Takahashi H,Matsusawa M,Ikegaki I,Nakanishi T,Yoshimura M

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:Data from the Multiple Risk Factor Intervention Trial show an independent direct association between starch intake and blood pressure in American men at higher risk of coronary heart disease. Cross-sectional data from the International Study of Macronutrients and Micronutrients and Blood Pressure (INTERMAP) w...

journal_title：Journal of hypertension

authors： Brown IJ,Elliott P,Robertson CE,Chan Q,Daviglus ML,Dyer AR,Huang CC,Rodriguez BL,Sakata K,Ueshima H,Van Horn L,Zhao L,Stamler J,INTERMAP Research Group.

更新日期：2009-02-01 00:00:00

abstract：:: Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and sometimes life- threatening sequelae. Tremendous progress in biochemical testing, imaging, genetics and pathophysiological understanding of the tumours has far-...

journal_title：Journal of hypertension

authors： Lenders JWM,Kerstens MN,Amar L,Prejbisz A,Robledo M,Taieb D,Pacak K,Crona J,Zelinka T,Mannelli M,Deutschbein T,Timmers HJLM,Castinetti F,Dralle H,Widimský J,Gimenez-Roqueplo AP,Eisenhofer G

更新日期：2020-08-01 00:00:00

abstract：DESIGN:Because of uncertainties regarding the complete antihypertensive mechanism of action of beta-adrenoceptor antagonists, the present study determined whether vagal afferent neurons of humans and rats possess beta-adrenoceptors. Such a location would provide an appropriate target for beta-blockers to modulate neuro...

journal_title：Journal of hypertension

authors： Lawrence AJ,Watkins D,Jarrott B

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of the interaction between adenosine receptors and renal nerves on urinary sodium excretion and glomerular filtration rate. METHODS AND DESIGN:The effects on water and sodium excretion and glomerular filtration rate of A1 [2-chloro-N6-cyclopentyl-adenosine (CCPA)] and A2 [2-hesiny...

journal_title：Journal of hypertension

authors： Panzacchi G,Demarchi B,Busca G,Protasoni G,Golin R,Stella A

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To identify predictors of pregnancy-induced hypertension and pre-eclampsia in 212 nulliparous women before 20 weeks' gestation and at approximately 28 weeks' gestation. STUDY DESIGN:A randomized, prospective study in a teaching hospital. We performed standardized measurements of systolic and diastolic arteri...

journal_title：Journal of hypertension

authors： Broughton Pipkin F,Sharif J,Lal S

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes. OBJECTIVE:We therefore investigated the association between left ventricular structur...

journal_title：Journal of hypertension

authors： Kuznetsova T,Manunta P,Casamassima N,Messaggio E,Jin Y,Thijs L,Richart T,Fagard RH,Bianchi G,Staessen JA

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:When assessing arterial stiffness, heart rate (HR) and blood pressure (BP) are potential confounders. It appears that the HR/BP dependences of pulse wave velocity (PWV) and distensibility are different, even though both assess arterial stiffness. This study aims to compare aortic PWV as measured using pulse ...

journal_title：Journal of hypertension

authors： Spronck B,Tan I,Reesink KD,Georgevsky D,Delhaas T,Avolio AP,Butlin M

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing hypertension in primary care. METHODS:Two hundred and forty-seven consecutive participants with raised (≥130 mmHg systolic) BP measured by their general practitioner from four primary care practices in...

journal_title：Journal of hypertension

authors： Nunan D,Thompson M,Heneghan CJ,Perera R,McManus RJ,Ward A

更新日期：2015-04-01 00:00:00