当前位置： SCI文献检索 > JOURNAL OF HYPERTENSION期刊下所有文献 > Neurocognition in treatment-resistant hypertension: profile and associations with cardiovascular biomarkers.

Neurocognition in treatment-resistant hypertension: profile and associations with cardiovascular biomarkers.

Abstract：

BACKGROUND:Hypertension in midlife has been associated with increased risk of stroke and neurocognitive decline. Few studies, however, have examined neurocognition among individuals with treatment-resistant hypertension or potential mechanisms by which treatment-resistant hypertension may impair neurocognition. METHODS:We examined the pattern of neurocognitive impairment and potential mechanisms in a sample of 96 overweight adults with treatment-resistant hypertension, aged 41-81 years. Neurocognitive function was assessed using a 45-min test battery consisting of executive function and memory. Vascular and metabolic mechanisms examined included cerebrovascular risk factors (CVRFs: Framingham Stroke Risk Profile), insulin sensitivity (homeostatic model assessment of insulin resistance), waist-to-hip ratio, microvascular function (hyperemic response), and peak oxygen consumption from an exercise treadmill test. Simple path analyses were used to assess the association between potential vascular and metabolic mechanisms and neurocognition. RESULTS:Neurocognitive impairments were common, with 70% of the sample exhibiting impaired performance on at least one executive function subtest and 38% on at least one measure of memory. Higher levels of aerobic fitness, greater insulin sensitivity, and better microvascular function, as well as lower CVRFs and waist-to-hip ratio were associated with better neurocognition. In path analyses, aerobic fitness, microvascular function, and CVRFs all were independently associated with neurocognitive performance. Insulin resistance associated with worse executive function but better memory performance among older participants. CONCLUSION:Neurocognitive impairments are common in adults with treatment-resistant hypertension, particularly on tests of executive function. Better neurocognition is independently associated with aerobic fitness, microvascular function, and CVRFs.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Smith PJ,Blumenthal JA,Hinderliter AL,Mabe SM,Schwartz JE,Avorgbedor F,Sherwood A

doi

10.1097/HJH.0000000000002002

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

1040-1047

issue

eissn

0263-6352

issn

1473-5598

pii

00004872-201905000-00022

journal_volume

pub_type

杂志文章

在线工具

Neurocognition in treatment-resistant hypertension: profile and associations with cardiovascular biomarkers.