Finding genes that cause human hypertension.

abstract：OBJECTIVE:The prognostic importance of the nocturnal blood pressure (BP) fall and early-morning surge were scarcely investigated in patients with resistant hypertension (RHT). We investigated them in a prospective cohort of 1726 RHT individuals. METHODS:The nocturnal fall and morning surge were calculated from the bas...

journal_title：Journal of hypertension

authors： Cardoso CRL,Salles GF

更新日期：2021-01-11 00:00:00

abstract：:We compared the overflow of endogenous norepinephrine (NE) upon electrical stimulation, the associated pressor response and rate of initial neuronal uptake of 3H-I-NE in the perfused mesenteric arteries of Dahl salt-sensitive (DS) and salt-resistant (DR) rats on two dietary NaCl regimens (0.4 and 8.0% for 2 weeks) fro...

journal_title：Journal of hypertension

authors： Hano T,Jeng Y,Rho J

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Construction of prognostically relevant endpoints for clinical trials in hypertension has increasingly included coronary revascularization with myocardial infarction (MI) as manifestations of coronary artery disease. However, whether coronary revascularization and MI predict other cardiovascular events simila...

journal_title：Journal of hypertension

authors： Cicala S,de Simone G,Gerdts E,Dahlöf B,Lindholm LH,Kjeldsen SE,Devereux RB

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To investigate whether glucose or insulin is the cause of increases in oxidative stress and blood pressure in insulin-resistant animals, and to evaluate the effects of alpha-lipoic acid (LA) on the production of the superoxide anion (O2-) in the aorta and blood pressure elevations in various models of diabet...

journal_title：Journal of hypertension

authors： El Midaoui A,de Champlain J

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...

journal_title：Journal of hypertension

authors： Chen X,Liu Y,Wang WE,Chen C,Ren H,Zheng S,Zhou L,Zeng C

更新日期：2016-08-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) was injected on alternate days from birth to 3 weeks of age into spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) control rats. The effects of this neonatal treatment on cardiovascular structure and mesenteric resistance vessel calcium sensitivity was studied in young (6 ...

journal_title：Journal of hypertension

authors： Nyborg NC,Korsgaard N,Mulvany MJ

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Increased arterial stiffness is associated with cardiovascular morbidity and mortality among hypertensive patients. OBJECTIVES:To assess the relationship between ambulatory arterial stiffness index (AASI) and subclinical left ventricular (LV) systolic dysfunction assessed by 2-D speckle-tracking echocardiog...

journal_title：Journal of hypertension

authors： Ahmed TAN,Shams-Eddin H,Fathy MA,El-Naggar HM,Kishk YT

更新日期：2020-05-01 00:00:00

abstract：UNLABELLED:PURPOSE IDENTIFICATION: Inter-individual variability in blood pressure response to treatment is well documented, but a clinically useful means to distinguish responders from non-responders has been elusive. With the advent of new technologies and genomic knowledge, more investigators are seeking to identify ...

journal_title：Journal of hypertension

authors： Mellen PB,Herrington DM

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:To compare the anti-hypertensive effect of combination therapy versus a single drug regimen schedule (dose-titration or switching to a different drug class) in type 2 diabetic hypertensive patients with inadequate blood pressure (BP) control on monotherapy. DESIGN:Prospective, randomized, open-fashion, paral...

journal_title：Journal of hypertension

authors： Ruilope LM,de la Sierra A,Moreno E,Fernández R,Garrido J,de la Figuera M,de la Cámara AG,Coca A,Luque-Otero M

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To determine whether obese hypertensive patients manifest a diminished regional vasodilator response to an oral glucose challenge. METHODS:Nineteen obese hypertensives (body mass index 34.1 +/- 1.3 kg/m2, blood pressure 144 +/- 3/96 +/- 2 mmHg) and 13 lean controls (23.6 +/- 0.3 kg/m2, 127 +/- 4/83 +/- 3 mmH...

journal_title：Journal of hypertension

authors： Egan BM,Stepniakowski K

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To compare the metabolite profiles of venous effluent from both kidneys of individuals with unilateral atherosclerotic renal artery stenosis (ARAS) in order to directly examine how impaired renal blood flow impacts small-molecule handling in humans. METHODS:We applied liquid chromatography-mass spectrometry ...

journal_title：Journal of hypertension

authors： Rhee EP,Clish CB,Pierce KA,Saad A,Lerman LO,Textor SC

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...

journal_title：Journal of hypertension

authors： Cohen-Solal A,Caviezel B,Himbert D,Gourgon R

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the influence of renal sympathetic nerves on the production of interleukin (IL)-6 in the kidney of normotensive Wistar rats and spontaneously hypertensive rats (SHR). DESIGN:In acute studies, the left kidney was exposed and the renal nerves were electrically stimulated to...

journal_title：Journal of hypertension

authors： Nakamura A,Kohsaka T,Johns EJ

更新日期：1993-05-01 00:00:00

abstract：:A10 vascular smooth muscle cells were placed in a flow chamber and exposed to the circulation of foetal calf serum at different rates and pressures. Under unidirectional laminar flow, physiological flow rates and pressures had almost no effect on internal sodium content. Indeed, pressure values greater than 150 mmHg w...

journal_title：Journal of hypertension

authors： Rosati C,Garay R

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVES:Scarce data exist on blood pressure (BP) and secondary effects in young athletes. Hence, we aimed to study prevalence of high BP (≥140/90 mmHg) and the association to arterial compliance, left ventricle mass and left atrium volume. METHODS:A Norwegian preparticipation cardiac screening of male professional ...

journal_title：Journal of hypertension

authors： Berge HM,Gjerdalen GF,Andersen TE,Solberg EE,Steine K

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the optimal schedule for home blood pressure (HBP) measurement based on a clinical approach. METHODS:Four hundred and sixty-four participants underwent HBP measurement for 7 days (duplicate measurements in the morning and in the evening), ambulatory blood pressure (ABP)...

journal_title：Journal of hypertension

authors： Johansson JK,Niiranen TJ,Puukka PJ,Jula AM

更新日期：2010-02-01 00:00:00

abstract：:The fall in blood pressure that is commonly observed when groups of hypertensive individuals are followed without treatment is usually ascribed to two sources: regression towards the mean and increasing familiarity of the subject with the assessment process. Any effect of the latter process could bias the results of c...

journal_title：Journal of hypertension

authors： Haynes RB,Logan AG,Flanagan PT,Milne BJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- ...

journal_title：Journal of hypertension

authors： Iso H,Harada S,Shimamoto T,Sato S,Kitamura A,Sankai T,Tanigawa T,Iida M,Komachi Y

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:The renin-angiotensin system plays an important role in blood pressure control. Recently the mouse Ren-2 renin gene was introduced into the genome of rats, producing low-renin hypertensive animals. The aim of the present study was to characterize the pharmacological and morphological properties of mesenteric ...

journal_title：Journal of hypertension

authors： Thybo NK,Korsgaard N,Mulvany MJ

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:The present study aimed to characterize the influence of salt intake on the gene expression of the kidney specific chloride channels CLC-K1 and CLC-K2 in the kidneys of salt-resistant and salt-sensitive Dahl rats. DESIGN:For this purpose Dahl salt-resistant (Dahl-R) and Dahl salt-sensitive rats (Dahl-S) were...

journal_title：Journal of hypertension

authors： Castrop H,Krämer BK,Riegger GA,Kurtz A,Wolf K

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Salt sensitivity and the magnitude of systolic blood pressure have been linked to haptoglobin (Hp) polymorphism in normotensives. The aim of the present study was to investigate the indices of hypertension, the severity of complications and the occurrence of coronary and peripheral artery disease for the vari...

journal_title：Journal of hypertension

authors： Delanghe JR,Duprez DA,De Buyzere ML,Bergez BM,Callens BY,Leroux-Roels GG,Clement DL

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVES:The rostral ventrolateral medulla (RVLM) of the brainstem and the paraventricular nucleus (PVN) of the hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance of excitatory and inhibitory inputs to the RVLM enhances central sympathetic outflow. Increased react...

journal_title：Journal of hypertension

authors： Nishihara M,Hirooka Y,Matsukawa R,Kishi T,Sunagawa K

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To examine a possible relationship between baseline albuminuria and effect of losartan versus atenolol on cardiovascular (CV) events in hypertensive patients with left ventricular hypertrophy, the effect of losartan versus atenolol on albuminuria, and whether the benefits of losartan versus atenolol could be...

journal_title：Journal of hypertension

authors： Ibsen H,Wachtell K,Olsen MH,Borch-Johnsen K,Lindholm LH,Mogensen CE,Dahlöf B,Devereux RB,de Faire U,Fyhrquist F,Julius S,Kjeldsen SE,Lederballe-Pedersen O,Nieminen MS,Omvik P,Oparil S,Wan Y,LIFE substudy.

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVES:Obstructive sleep apnoea (OSA) and hypertension frequently coexist, and both are associated with higher night-time than daytime urine sodium excretion rate (UNaV). However, the relative contribution of each condition is unknown. We compared the circadian pattern of UNaV in hypertensive and normotensive patie...

journal_title：Journal of hypertension

authors： White LH,Bradley TD,Logan AG

更新日期：2014-11-01 00:00:00

abstract：AIM:Since canine hereditary essential hypertension has been previously reported in a colony of Siberian husky dogs, we tested the suitability of this model for use in studies on the platelet defect identified in humans with essential hypertension. METHODS:Platelet aggregation and dense granule ATP secretion were measu...

journal_title：Journal of hypertension

authors： Thomas JS,McConnell MF,Bell TG,Padgett GA

更新日期：1992-12-01 00:00:00

abstract：:Haemorheological characteristics were measured in a group of 52 patients with essential arterial hypertension (HT), and were compared with those of a group of normotensive subjects. The relationships between the arterial blood pressure (BP), the echocardiographic indices of left ventricular hypertrophy (LVH), and the ...

journal_title：Journal of hypertension

authors： Zannad F,Voisin P,Brunotte F,Bruntz JF,Stoltz JF,Gilgenkrantz JM

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD:Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the min...

journal_title：Journal of hypertension

authors： de las Heras N,Ruiz-Ortega M,Miana M,Rupérez M,Sanz-Rosa D,Aragoncillo P,Mezzano S,Cachofeiro V,Egido J,Lahera V

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:We aimed to test whether eight common recently identified single-nucleotide polymorphisms (SNPs), strongly associated with blood pressure (BP) in the population, also have impact on the degree of BP reduction by antihypertensive agents with different mechanisms. METHODS:In 3863 Swedish hypertensive patients,...

journal_title：Journal of hypertension

authors： Hamrefors V,Sjögren M,Almgren P,Wahlstrand B,Kjeldsen S,Hedner T,Melander O

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...

journal_title：Journal of hypertension

authors： Nishikimi T,Horio T,Kohmoto Y,Yoshihara F,Nagaya N,Inenaga T,Saito M,Teranishi M,Nakamura M,Ohrui M,Kawano Y,Matsuo H,Ishimitsu T,Takishita S,Matsuoka H,Kangawa K

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Studies were undertaken to clarify the pathophysiologic significance of endogenous endothelin in the control of blood pressure and renal hemodynamics in spontaneously hypertensive rats (SHR). DESIGN:The technique of passive immunization was used to neutralize endogenous endothelin in order to estimate the co...

journal_title：Journal of hypertension

authors： Ohno A,Naruse M,Kato S,Hosaka M,Naruse K,Demura H,Sugino N

更新日期：1992-08-01 00:00:00