Neonatal sympathectomy of normotensive Wistar-Kyoto and spontaneously hypertensive rats with 6-hydroxydopamine: effects on resistance vessel structure and sensitivity to calcium.

abstract：RATIONALE:Cicletanine (CIC), an anti-hypertensive compound with direct vascular and natriuretic actions, is especially effective in salt-sensitive hypertension, in which dysregulation of the sodium pump plays an important pathogenic role, and digitalis-like cardiotonic steroids contribute to increased vascular tone. Th...

journal_title：Journal of hypertension

authors： Bagrov AY,Dmitrieva RI,Dorofeeva NA,Fedorova OV,Lopatin DA,Lakatta EG,Droy-Lefaix MT

更新日期：2000-02-01 00:00:00

abstract：:Angioplasty of renal artery stenosis has been used extensively in the last two decades for treating renovascular hypertension, and, more recently, for preserving the jeopardized renal function. A large body of evidence has accumulated indicating that this approach is by far the most convenient for patients with fibrom...

journal_title：Journal of hypertension

authors： Morganti A

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To examine the influence of genetic factors on plasma leptin levels. SUBJECTS AND METHODS:We measured plasma leptin levels, body mass index and body fat distribution in healthy young female monozygotic (n = 19) and dizygotic (n = 14) twins. The twin zygosity was verified by determination of short tandem repe...

journal_title：Journal of hypertension

authors： Narkiewicz K,Szczech R,Winnicki M,Chrostowska M,Pawlowski R,Lysiak-Szydlowska W,Choe I,Kato M,Sivitz WI,Krupa-Wojciechowska B,Somers VK

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the wave reflection characteristics in the aortic arch and common carotid artery of ex-preterm adolescents and assess their relationship to central blood pressure in a cohort followed prospectively since birth. METHODS:Central blood pressures, pulse wave velocity, augmentation index, microvascula...

journal_title：Journal of hypertension

authors： Kowalski RR,Beare R,Mynard JP,Cheong JLY,Doyle LW,Smolich JJ,Cheung MMH

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. The primary object of the paper is to verify this possible associati...

journal_title：Journal of hypertension

authors： Olivieri O,Stranieri C,Girelli D,Pizzolo F,Grazioli S,Russo C,Pignatti PF,Corrocher R

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:To study the relation between the blood pressure and the neurocognitive function within the full adult age range in a large population sample. DESIGN:A cross-sectional study of 936 healthy adults who were recruited from a register of family practices, stratified for age (24-81 years), sex, and occupational ...

journal_title：Journal of hypertension

authors： van Boxtel MP,Gaillard C,Houx PJ,Buntinx F,de Leeuw PW,Jolles J

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVES:Activation of the nuclear factor kappa B (NF kappaB) inflammatory pathway by angiotensin II and reactive oxygen species may play an important role in the development of insulin resistance and cardiovascular injury in hypertensive and metabolic diseases. We have shown that in hypertensive Dahl salt-sensitive ...

journal_title：Journal of hypertension

authors： Zhou MS,Schulman IH,Raij L

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:Blood pressure variability (BPV) within 24 h or between visits has been found to represent an independent risk factor for cardiovascular disease. The present study was aimed at determining whether a clinical significance can be given also to the BP variations occurring within a single clinica...

journal_title：Journal of hypertension

authors： Grassi G,Seravalle G,Maloberti A,Facchetti R,Cuspidi C,Bombelli M,Laurent S,Redon J,Mancia G

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Arterial hypertension is recurrently associated with inflammation of the endothelium as an effect of the upregulation of functional molecules, including cytokines, adhesion molecules and chemokines. However, the role of monocyte chemoattractant protein-1 (MCP-1) in maintaining the inflammatory state of endoth...

journal_title：Journal of hypertension

authors： Tucci M,Quatraro C,Frassanito MA,Silvestris F

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between stroke risk and blood pressure (BP) levels with regard to the usage of antihypertensive medications. METHODS:From the Japan arteriosclerosis longitudinal study, 11,371 participants from the four population-based cohort studies (aged 40-89) were followed up for a mean of 9....

journal_title：Journal of hypertension

authors： Asayama K,Ohkubo T,Yoshida S,Suzuki K,Metoki H,Harada A,Murakami Y,Ohashi Y,Ueshima H,Imai Y,Japan Arteriosclerosis Longitudinal Study (JALS) group.

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Considering the growing body of evidence that indicates the contribution of superoxide anions (O2) and other reactive oxygen species (ROS) to the development of hypertension, we assessed whether animal models of hypertension have a benefic effect with tempol, a superoxide dismutase mimetic, to help augment th...

journal_title：Journal of hypertension

authors： Dornas WC,Silva M,Tavares R,de Lima WG,dos Santos RC,Pedrosa ML,Silva ME

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The urinary isoflavonoid equol inhibits membrane Na-K-Cl cotransporters at similar concentrations to those at which furosemide inhibits them, but the significance of this action is not known. OBJECTIVE:To investigate the potential salidiuretic and vascular actions of equol in the rat. METHODS:Renal functio...

journal_title：Journal of hypertension

authors： Gimenez I,Lou M,Vargas F,Alvarez-Guerra M,Mayoral JA,Martinez RM,Garay RP,Alda JO

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:The screening for primary aldosteronism is based on the aldosterone-renin ratio calculated with the plasma renin activity (PRA) value as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains unclear. METHOD:We, therefore compar...

journal_title：Journal of hypertension

authors： Rossi GP,Barisa M,Belfiore A,Desideri G,Ferri C,Letizia C,Maccario M,Morganti A,Palumbo G,Patalano A,Roman E,Seccia TM,Pessina AC,Mantero F,PAPY study Investigators.

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To characterize an ATP-sensitive K+ channel at the single-channel and tissue level in the vascular smooth muscle of normotensive and genetically hypertensive rats. METHODS:Age- and sex-matched Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were used. Patch-clamp single-chann...

journal_title：Journal of hypertension

authors： Furspan PB,Webb RC

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:BPH/2J hypertensive mice have an exaggerated sympathetic contribution to blood pressure (BP). Premotor sympathetic neurons within the rostroventrolateral medulla (RVLM) are a major source of sympathetic vasomotor tone and major site of action of the centrally acting sympatholytic agent, rilmenidine. The relat...

journal_title：Journal of hypertension

authors： Jackson KL,Palma-Rigo K,Nguyen-Huu TP,Davern PJ,Head GA

更新日期：2014-03-01 00:00:00

abstract：:A10 vascular smooth muscle cells were placed in a flow chamber and exposed to the circulation of foetal calf serum at different rates and pressures. Under unidirectional laminar flow, physiological flow rates and pressures had almost no effect on internal sodium content. Indeed, pressure values greater than 150 mmHg w...

journal_title：Journal of hypertension

authors： Rosati C,Garay R

更新日期：1991-11-01 00:00:00

abstract：:The effects of age on the circadian blood pressure rhythm of patients with untreated essential hypertension (n = 133, World Health Organization stage I or II) were compared with those of normotensive subjects (n = 91). Subjects were classified into three groups by age: young (less than 40 years old), adult (40-59 year...

journal_title：Journal of hypertension

authors： Munakata M,Imai Y,Abe K,Sasaki S,Minami N,Hashimoto J,Sakuma H,Ichijo T,Yoshizawa M,Sekino H

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:Studies directly comparing the associations of intima-media thickness with blood pressure (BP) on manual sphygmomanometric blood pressure measurement (SBPM) and 24-h ambulatory blood pressure measurement (ABPM) are scarce and have a cross-sectional design. METHODS:At baseline, we measured systolic and diasto...

journal_title：Journal of hypertension

authors： Dechering DG,Wizner B,Adiyaman A,Nawrot T,Jin Y,Richart T,Kuznetsova T,Struijker-Boudier HA,Thien T,Staessen JA

更新日期：2009-04-01 00:00:00

abstract：:To assess the role of renal prostaglandin E in the hypotensive mechanism of MK-421, we evaluated the effects of chronic infusion of MK-421 (6 mg/kg/day i.p.) on systolic blood pressure and urinary prostaglandin E excretion in conscious rats in states of sodium repletion or depletion and also during chronic infusion of...

journal_title：Journal of hypertension

authors： Yasujima M,Abe K,Tanno M,Kasai Y,Sato K,Tajima J,Kudo K,Tsunoda K,Yoshinaga K

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVE:Some cases of pseudopheochromocytoma have been described among hypertensive patients with obstructive sleep apnea (OSA). This study examined whether a pathological rise of urinary metanephrines is a common feature in hypertensive OSA patients and, in such a case, whether the ventilation treatment during sleep...

journal_title：Journal of hypertension

authors： Gilardini L,Lombardi C,Redaelli G,Mattaliano P,Fanari P,Cornacchia M,Scacchi M,Mai S,Ferronato P,Parati G,Invitti C

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To explore the repercussion of cardiac denervation on the short-term blood pressure variability in humans, in order to assess the extent to which the variability of blood pressure is linked to the variability of heart rate. METHODS:Beat-to-beat blood pressure and RR interval time were recorded in 16 heart-tr...

journal_title：Journal of hypertension

authors： van de Borne P,Schintgen M,Niset G,Schoenfeld P,Nguyen H,Degré S,Degaute JP

更新日期：1994-12-01 00:00:00

abstract：:We have examined the mechanisms mediating the release of renin elicited in man by reduction of renal perfusion pressure. Fifteen patients with essential hypertension and six normotensive subjects were investigated during diagnostic renal arteriography. Renal neural receptors were inhibited by propranolol (10 mg i.v.) ...

journal_title：Journal of hypertension

authors： Guazzi MD,Barbier P,Loaldi A,Montorsi P,Polese A,Tosi E,Fiorentini C

更新日期：1985-02-01 00:00:00

abstract：:Systemic and regional haemodynamic effects of renal denervation were evaluated in adult (six-month-old) male spontaneously hypertensive rats (SHR) using the Fick procedure and electromagnetic flowmetry technique. Renal denervation (bilateral, 10% phenol in ethanol), performed five to eight days before the experiment, ...

journal_title：Journal of hypertension

authors： Lee JY,Walsh GM

更新日期：1983-12-01 00:00:00

abstract：:: Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and sometimes life- threatening sequelae. Tremendous progress in biochemical testing, imaging, genetics and pathophysiological understanding of the tumours has far-...

journal_title：Journal of hypertension

authors： Lenders JWM,Kerstens MN,Amar L,Prejbisz A,Robledo M,Taieb D,Pacak K,Crona J,Zelinka T,Mannelli M,Deutschbein T,Timmers HJLM,Castinetti F,Dralle H,Widimský J,Gimenez-Roqueplo AP,Eisenhofer G

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Hemodialysis patients have a cardiovascular mortality rate of 20-40 times that of the general population. Aldosterone inhibition by spironolactone has exerted beneficial, prognostically significant cardiovascular effects in patients with heart failure maintained on hemodialysis or peritoneal dialysis. Our ai...

journal_title：Journal of hypertension

authors： Flevari P,Kalogeropoulou S,Drakou A,Leftheriotis D,Panou F,Lekakis J,Kremastinos D,Vlahakos DV

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity. AT1 receptor antagonists attenuate all these actions, but display some evidence o...

journal_title：Journal of hypertension

authors： Dendorfer A,Dominiak P,Tempel K,Raasch W

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypert...

journal_title：Journal of hypertension

authors： Koton S,Tanne D,Grossman E

更新日期：2017-04-01 00:00:00

abstract：:Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

journal_title：Journal of hypertension

authors： Lifton RP,Jeunemaitre X

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

journal_title：Journal of hypertension

authors： Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:A causal relationship has been established between hyperglycemia and cardiovascular diseases, but no threshold has been retained to determine a 'glycemia-associated' cardiovascular risk. Carotid intima-media thickness (CIMT) is an independent predictor for cardiovascular events. High blood pressure is a majo...

journal_title：Journal of hypertension

authors： Tropeano AI,Boutouyrie P,Katsahian S,Laloux B,Laurent S

更新日期：2004-11-01 00:00:00