Renal prostaglandin E in the hypotensive mechanism of MK-421 in conscious rats.

Abstract:

:To assess the role of renal prostaglandin E in the hypotensive mechanism of MK-421, we evaluated the effects of chronic infusion of MK-421 (6 mg/kg/day i.p.) on systolic blood pressure and urinary prostaglandin E excretion in conscious rats in states of sodium repletion or depletion and also during chronic infusion of norepinephrine (1.8 mg/kg/day i.p.) or vasopressin (7.2 U/kg/day i.p.). The hypotensive effect of MK-421 was greater in sodium depleted than in sodium repleted rats. The hypertensive effect of norepinephrine or vasopressin was inhibited by the simultaneous administration of MK-421. MK-421 induced an increase in the excretion of urinary prostaglandin E, in both sodium repleted and depleted rats. However, simultaneous administration of MK-421 had no influence on the increase in urinary prostaglandin E excretion induced by norepinephrine or vasopressin. In addition, the combined administration of MK-421 with indomethacin (10 mg/kg/day s.c.) still abolished the hypertensive effect of norepinephrine or vasopressin. The disparate effect of MK-421 on urinary prostaglandin E excretion suggests that the renal prostaglandin system is not essential for the mechanism of the hypotensive effect of MK-421.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Yasujima M,Abe K,Tanno M,Kasai Y,Sato K,Tajima J,Kudo K,Tsunoda K,Yoshinaga K

doi

10.1097/00004872-198412000-00007

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

623-9

issue

6

eissn

0263-6352

issn

1473-5598

journal_volume

2

pub_type

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