Abstract:
BACKGROUND:The thiazide-sensitive Na-Cl cotransporter (TSC) is involved in the fine regulation of sodium excretion by the kidney, and an increase in its activity causes salt-sensitive hypertension and hypercalciuria. METHODS:To explore the possibility that activating mutations in the TSC gene may be involved in the pathogenesis of primary hypertension, we screened genomic DNA of 68 individuals from hypertensive families of patients with hypercalciuria for variations using single-strand conformation polymorphism and investigated the functional properties using the Xenopus laevis oocyte expression system. RESULTS:We identified 18 variants in the TSC and, of those, four were nonsynonymous. The A728T, R904Q and R919C variants were introduced into the human TSC cDNA and expressed in Xenopus oocytes to study their effect on Na transport. Although T728 and Q904 did not show any difference in Na uptake, the R919C mutant showed a 60% increase compared to wild-type human TSC and an exaggerated inhibitory action of hydrochlorothiazide. Immunocytochemical analysis revealed no difference in cell surface expression of R919C mutants compared to wild-type hTSC. There was no significant difference in the inhibitory effect of the carboxyl terminus of the serine-threonine kinase WNK4 on the R919C mutant and wild-type hTSC. CONCLUSIONS:Our results show that the substitution of arginine for cysteine at position 919 of TSC increases Na transport function, and provide support for the hypothesis that mutations in renal tubular sodium transporters may contribute to the development of primary hypertension, a polygenic disorder, by increasing renal sodium reabsorption.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Keszei AP,Tislér A,Backx PH,Andrulis IL,Bull SB,Logan AGdoi
10.1097/HJH.0b013e3282a9be1bsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
2074-81issue
10eissn
0263-6352issn
1473-5598pii
00004872-200710000-00017journal_volume
25pub_type
杂志文章abstract:OBJECTIVE:Studies directly comparing the associations of intima-media thickness with blood pressure (BP) on manual sphygmomanometric blood pressure measurement (SBPM) and 24-h ambulatory blood pressure measurement (ABPM) are scarce and have a cross-sectional design. METHODS:At baseline, we measured systolic and diasto...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328324ed6c
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:A cardiac angiotensin II-generating system has been suspected to be involved in various cardiac pathological conditions. Both angiotensin converting enzyme and human chymase can convert angiotensin I to angiotensin II. OBJECTIVE:To clarify the relative contributions of these two enzymatic pathways to angiot...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715090-00003
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Wide pulse pressure is a potent risk factor for atherosclerotic disease, and hypertension is induced by habitual alcohol drinking. This concise study investigated whether age affects the relationship between alcohol drinking and pulse pressure. METHODS:The participants were 99 661 male workers (20-69 years ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3280895b69
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Hypertension control is often inadequate in HIV patients. In a contemporary, nationwide cohort of Italian HIV-infected adults, we assessed time trends in hypertension prevalence, awareness, treatment, and control. We also evaluated predictors of cardiovascular events and of new-onset hypertension. METHODS:M...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/HJH.0000000000001150
更新日期:2017-02-01 00:00:00
abstract::Fish and fish oils have been reported to reduce blood pressure in normotensives and untreated hypertensives. The present study examined the effect of dietary supplementation with fish oil on blood pressure in 20 treated hypertensives with controlled blood pressures who continued their usual antihypertensive drug treat...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-199004000-00007
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:The sleep apnea syndrome (SAS) is a common health problem with a 30% prevalence among patients with so-called essential hypertension. OBJECTIVE:Prompted by this epidemiologic link we tried to find out whether there is a cause-effect relationship between SAS and systemic hypertension. DESIGN:We developed an...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715120-00060
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:We report the prevalence, awareness, treatment, and control of hypertension across four Middle Eastern countries (Iran, Occupied Palestinian Territory, Saudi Arabia, and United Arab Emirates), using a standardized and uniform method. METHODS:The Prospective Urban Rural Epidemiology study enrolled participant...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001326
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:Cardiovascular reactivity to mental stress has been used as a tool to predict short-term hypertension risk in adults but the impact of cardiovascular reactivity in childhood on hypertension in adulthood is unknown. Using the 1970 British Cohort study, we examined the association between pulse rate reactivity in...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001023
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:The primary aim of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) is to determine the effects of a long-term angiotensin converting enzyme (ACE)-inhibitor-based blood-pressure-lowering regimen on the risk of stroke among patients with a history of stroke or transient ischaemic attack (TI...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To evaluate endothelium-dependent vascular function in obstructive sleep apnoea patients. DESIGN AND METHODS:Forearm blood flow and vascular resistance were studied in eight normotensives and eight obstructive sleep apnoea patients and also in eight normotensive and eight hypertensive controls after graded b...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199605000-00006
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Adenosine dilates rabbit renal arteries by an endothelium-dependent, nitric oxide (NO)- and prostaglandin-independent mechanism. The aim was to identify the responsible P1-purinoceptor subtype and to investigate the involvement of K+-channels. METHODS:Rabbit renal arteries were perfused with medium containin...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917121-00032
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:There is ongoing discussion on how best to screen for diabetes mellitus. Previous studies suggest that an abnormal oral glucose tolerance test (OGTT) is better than fasting glucose levels in predicting cardiovascular mortality, which is largely determined by macrovascular complications in type 2 diabetes. We ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834e38b6
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). METHODS:We evaluated 96 patients with resistant hypertension, defined as clinic BP at least 140/90 mmHg despite treat...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e32833b9c63
更新日期:2010-10-01 00:00:00
abstract:INTRODUCTION:Chronic kidney disease (CKD) in which the disease cannot be attributed to any known cause is named CKD of uncertain aetiology (CKDu). The main aims of this analysis were to estimate the prevalence of hypertension and to identify the associated factors in a rural community vulnerable to CKDu and to identify...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002107
更新日期:2019-09-01 00:00:00
abstract::Over the last few years, much progress has been made in understanding the genetic basis of primary aldosteronism. This has led to the diagnosis of the familial forms and has aided the understanding of the basis of sporadic forms of the disease. Such information can be exploited to improve the therapeutic approaches us...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-200404000-00001
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:International recommendations have classified brachial blood pressure (BP) in subgroups enabling better cardiovascular risk stratification. Central BP is an independent predictor of cardiovascular risk, differing from brachial BP through the predominant influence of arterial stiffness and wave reflections. C...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f16a9c
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of angiotensins acting at the rostral ventrolateral medulla (RVLM) on the cardiovascular adjustments following haemorrhage. DESIGN:Changes in mean arterial pressure (MAP) and heart rate (HR) produced by micro-injections of angiotensin II (Ang II) and angiotensin (Ang)-(1-7) and differ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917080-00014
更新日期:1999-08-01 00:00:00
abstract::Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199303000-00002
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:Transport activities of cardiac sodium-calcium exchange and sarcoplasmic reticulum calcium ATPase were measured biochemically in spontaneously hypertensive rats (SHR) with hypertrophied myocardium and in normotensive Wistar-Kyoto (WKY) rats and it was tested whether possible differences have consequences for ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199511000-00014
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:To test whether the Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene is of functional relevance in humans by altering endothelium-dependent vasodilation. BACKGROUND:The Asp298 variant of the eNOS gene product has been associated with arterial hypertension, coronary artery disease ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018120-00010
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To study 24-h ambulatory blood pressure (BP) and development of hypertension over four decades in women with childhood urinary tract infection (UTI) associated with renal damage. METHODS:A population-based group of 111 women was followed from their first UTI in childhood. The cohort was investigated at a med...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000234
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Aldosterone has essential roles in regulating intravascular volume and blood pressure, and is suggested to influence cardiac structure. However, the association of polymorphisms in the aldosterone synthase gene (CYP11B2) with hypertension or cardiac hypertrophy remains controversial. OBJECTIVE:To evaluate t...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000170377.00591.7e
更新日期:2005-06-01 00:00:00
abstract:AIM:We determined whether left ventricular hypertrophy (LVH) which exceeds that predicted from workload [inappropriate LV mass (LVM(inappr))] is associated with reduced left ventricle (LV) systolic chamber function independent of and more closely than absolute or indexed left ventricular mass (LVM). METHODS:In 626 ran...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835a8696
更新日期:2013-01-01 00:00:00
abstract::The European Society of Hypertension and the European Society of Cardiology have started the preparation of the third edition of their joint guidelines on the management of arterial hypertension. The authors have focused on the new edition of the UK NICE guidelines to learn about the difficulties of disentangling evid...
journal_title:Journal of hypertension
pub_type: 社论
doi:10.1097/HJH.0b013e328351b4e4
更新日期:2012-04-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002617
更新日期:2021-01-01 00:00:00
abstract::Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198310000-00005
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVES:To investigate whether NADPH oxidase 2 (NOX2), a major source of reactive oxygen species (ROS), contributes to the emergence of arterial hypertension in a murine model of sleep apnea. BACKGROUND:Obstructive sleep apnea (OSA) is a risk factor for arterial hypertension and it is linked to oxidative stress. M...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000016
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:Current evidence demonstrates that both genetic and environmental factors influence blood pressure. The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hype...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000209983.28735.33
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS:We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HA...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/HJH.0b013e328332b79b
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS:We recruited 378 hypertensive CKD ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001185
更新日期:2017-03-01 00:00:00