Arterial hypertension and cerebral hemodynamics: impact of head-down tilt on cerebral blood flow (arterial spin-labeling-MRI) in healthy and hypertensive patients.

Abstract:

OBJECTIVE:Hypertension affects cerebrovascular autoregulation and increases the risk of cerebrovascular events and dementia. Notably, it is associated with cerebrovascular remodeling and lower resting cerebral blood flow (CBF). We wanted to determine, using arterial spin-labeling-MRI, the impact of a head-down tilt (HDT) dynamic maneuver on CBF in hypertensive patients. METHODS:The current prospective study measured 36 patients' CBFs (18 normotensive individuals; 18 hypertensive patients) on 1.5T arterial spin-labeling-MRI in the supine position and after 4 min at -15° HDT. We reconstructed CBF maps of left and right subcortical nuclear gray matter, cortical gray matter and white matter (16 structures) to explore cerebrovascular autoregulation modification under dynamic conditions. RESULTS:Normotensive and hypertensive participants had no significant CBF differences in the supine position. After HDT, CBF mean variations (CBF-mVs) across all structures declined (mean -5.8%) for the whole population (n = 36), with -6.6 and -7.6% decreases, respectively, in white matter and gray matter (P < 0.001). Left and right accumbens nuclei had the largest changes (-9.6 and -9.2%, respectively; P < 0.001). No CBF-mV difference (0/16) was found in hypertensive patients after HDT, whereas normotensive participants' CBF-mVs changed significantly in four structures (left and right accumbens, putamen and left caudate nucleus) and gray matter. Hypertensive patients exhibited fewer CBF-mVs in left caudate nuclei (P = 0.039) and cortical gray matter (P = 0.013). Among hypertensive patients, people with diabetes had smaller CBF-mVs than people without diabetes. CONCLUSION:Our results highlight the significantly different CBF reactions to HDT of normotensive and hypertensive participants. They support the hypothesis that hypertension is responsible for deficient cerebrovascular autoregulation.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Seiller I,Pavilla A,Ognard J,Ozier-Lafontaine N,Colombani S,Cepeda Ibarra Y,Mejdoubi M

doi

10.1097/HJH.0000000000002709

subject

Has Abstract

pub_date

2020-12-09 00:00:00

eissn

0263-6352

issn

1473-5598

pub_type

杂志文章
  • Compensatory hyperinsulinemia and the forearm vasodilator response during an oral glucose-tolerance test in obese hypertensives.

    abstract:OBJECTIVE:To determine whether obese hypertensive patients manifest a diminished regional vasodilator response to an oral glucose challenge. METHODS:Nineteen obese hypertensives (body mass index 34.1 +/- 1.3 kg/m2, blood pressure 144 +/- 3/96 +/- 2 mmHg) and 13 lean controls (23.6 +/- 0.3 kg/m2, 127 +/- 4/83 +/- 3 mmH...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Egan BM,Stepniakowski K

    更新日期:1994-09-01 00:00:00

  • Longing for clinical excellence: a critical outlook into the NICE recommendations on hypertension management--is nice always good?

    abstract::The European Society of Hypertension and the European Society of Cardiology have started the preparation of the third edition of their joint guidelines on the management of arterial hypertension. The authors have focused on the new edition of the UK NICE guidelines to learn about the difficulties of disentangling evid...

    journal_title:Journal of hypertension

    pub_type: 社论

    doi:10.1097/HJH.0b013e328351b4e4

    authors: Zanchetti A,Mancia G

    更新日期:2012-04-01 00:00:00

  • Nisoldipine. Central haemodynamics at rest and during exercise in essential hypertension: acute and chronic studies.

    abstract::Calcium blockers may reduce contractility of vascular smooth muscle as well as that of myocardial cells. Therefore, falls in both total peripheral vascular resistance (TPR) and cardiac output (CO) might be responsible for a fall in blood pressure (BP) caused by calcium blockers in essential hypertension. We have studi...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Omvik P,Lund-Johansen P,Haugland H

    更新日期:1988-02-01 00:00:00

  • Home device-monitored sleep blood pressure reflects large artery stiffness: the Nagahama study.

    abstract:BACKGROUND:High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS:We pe...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002576

    authors: Tabara Y,Matsumoto T,Murase K,Setoh K,Kawaguchi T,Kosugi S,Nakayama T,Hirai T,Wakamura T,Chin K,Matsuda F,Nagahama study group.

    更新日期:2020-12-01 00:00:00

  • Effects of prolonged and brief infusions of noradrenaline on arterial pressure and on the plasma concentrations of active renin, angiotensin II, aldosterone and potassium.

    abstract::Conscious male beagle dogs were given constant intravenous infusions of noradrenaline for 14 days, four receiving 125 ng/kg/min and four 250 ng/kg/min. Before, during and after these infusions dose-response studies were done in which additional noradrenaline was infused at 500, 1000 and 2000 ng/kg/min, each rate for 1...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Casals-Stenzel J,Tree M,Brown JJ,Fraser R,Lever AF,Millar JA,Morton JJ,Robertson JI,Reid JL,Hamilton C

    更新日期:1983-06-01 00:00:00

  • Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study.

    abstract:OBJECTIVE:The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR). DESIGN:SBP, heart: and left ventricle: body weight ratios, the cross-sectional area of cardiocytes, and the ultrastructur...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199206000-00002

    authors: Ferrante F,Bronzetti E,Ciriaco E,Felici L,Amenta F

    更新日期:1992-06-01 00:00:00

  • The accuracy of automated blood pressure measuring devices in patients with controlled atrial fibrillation.

    abstract:OBJECTIVE:To determine whether automated blood pressure measuring devices can measure blood pressure accurately in patients with atrial fibrillation. DESIGN:Comparison of the accuracy of two electronic sphygmomanometers [Takeda UA-751 (Takeda) and Copal UA-251 (Copal)] and two ambulatory blood pressure monitors [Accut...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Stewart MJ,Gough K,Padfield PL

    更新日期:1995-03-01 00:00:00

  • Age-dependent association of alcohol drinking with pulse pressure.

    abstract:BACKGROUND:Wide pulse pressure is a potent risk factor for atherosclerotic disease, and hypertension is induced by habitual alcohol drinking. This concise study investigated whether age affects the relationship between alcohol drinking and pulse pressure. METHODS:The participants were 99 661 male workers (20-69 years ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3280895b69

    authors: Wakabayashi I

    更新日期:2007-05-01 00:00:00

  • Heart rate and blood pressure dependence of aortic distensibility in rats: comparison of measured and calculated pulse wave velocity.

    abstract:OBJECTIVES:When assessing arterial stiffness, heart rate (HR) and blood pressure (BP) are potential confounders. It appears that the HR/BP dependences of pulse wave velocity (PWV) and distensibility are different, even though both assess arterial stiffness. This study aims to compare aortic PWV as measured using pulse ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002608

    authors: Spronck B,Tan I,Reesink KD,Georgevsky D,Delhaas T,Avolio AP,Butlin M

    更新日期:2021-01-01 00:00:00

  • Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats.

    abstract:BACKGROUND:In a previous study, we found that neonatal sympathectomy prevented the development of angiotensin II (ANG II)-induced hypertension but not the development of structural changes in small mesenteric arteries. OBJECTIVES:To investigate further the dissociation between hypertension and structural vascular chan...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816010-00012

    authors: Simon G,Csiky B

    更新日期:1998-01-01 00:00:00

  • Mortality in patients who have their antihypertensive therapy changed.

    abstract::Medical records were examined for 1935 patients who presented sequentially to a hypertension clinic between 1971 and 1981. Patients were classified according to whether they were on a beta-blocker, methyldopa, a potassium-losing diuretic, or whether they had discontinued any of these treatments. Age-standardized morta...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198907000-00009

    authors: Franks PJ,Hartley K,Bulpitt PF,Bulpitt CJ,Dollery CT

    更新日期:1989-07-01 00:00:00

  • A double-blind evaluation of captopril in elderly hypertensives.

    abstract::To establish the role of angiotensin converting enzyme inhibitors in the management of hypertension in the elderly, 16 patients were treated with captopril in a randomized double-blind placebo-controlled cross-over study. Clinic blood pressure, ambulatory blood pressure, renal function and mental performance, with emp...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Cox JP,Duggan J,O'Boyle CA,Mee F,Walsh JB,Coakley D,O'Brien E,O'Malley K

    更新日期:1989-04-01 00:00:00

  • Drug compliance among hypertensive patients in Tabuk, Saudi Arabia.

    abstract:OBJECTIVE:To estimate the compliance rate and associated factors among a population of hypertensive subjects registered in hospitals and primary health care centres. DESIGN:A prospective study carried out on a sample of hypertensive subjects. METHOD:Compliance with treatment by the study sample was measured using the...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715050-00013

    authors: Khalil SA,Elzubier AG

    更新日期:1997-05-01 00:00:00

  • QT interval in patients with primary aldosteronism and low-renin essential hypertension.

    abstract:INTRODUCTION:QT interval prolongation increases the risk of sudden death in several medical conditions. Patients with primary aldosteronism and salt-sensitive hypertension experience more cardiovascular events than those with normal-renin essential hypertension. QT interval prolongation might represent one of the risk ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000251908.93298.a0

    authors: Maule S,Mulatero P,Milan A,Leotta G,Caserta M,Bertello C,Rabbia F,Veglio F

    更新日期:2006-12-01 00:00:00

  • Association of change in left ventricular mass with prognosis during long-term antihypertensive treatment.

    abstract:OBJECTIVE:The aim of the present study was to assess the prognostic value of changes in left ventricular hypertrophy in hypertensive patients with time. DESIGN:Two hundred and fifteen uncomplicated hypertensive patients underwent a high-quality baseline echocardiogram for left ventricular anatomy evaluation and in 151...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199510000-00003

    authors: Muiesan ML,Salvetti M,Rizzoni D,Castellano M,Donato F,Agabiti-Rosei E

    更新日期:1995-10-01 00:00:00

  • Sex differences in blood pressure after stroke: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Evidence about sex differences in blood pressure (BP) at the time of acute stroke presentation is scarce. We aimed to summarize available data on sex differences in BP at the time of acute stroke presentation, including stratification by prior history of hypertension and stroke subtype. METHODS:We performed...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1097/HJH.0000000000002116

    authors: Li J,Yang SC,Moullaali TJ,Chen R,Woodward M,Carcel C,Delcourt C,Sandset EC,Anderson C,Chen G,Wang X

    更新日期:2019-10-01 00:00:00

  • Can echocardiography identify mildly hypertensive patients at high risk, left untreated based on current guidelines?

    abstract:OBJECTIVE:To determine whether the decision to treat uncomplicated mild hypertension with drugs, in accordance with the World Health Organization - International Society of Hypertension (WHO/ISH) guidelines based on a series of blood pressure (BP) measurements over 6 months, resulted in the treatment of patients at hig...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917060-00014

    authors: Abergel E,Chatellier G,Battaglia C,Menard J

    更新日期:1999-06-01 00:00:00

  • A method of quantifying retinal microvascular alterations associated with blood pressure and age.

    abstract:OBJECTIVE:To find an objective, sensitive method for quantifying microvascular alterations associated with level of blood pressure and age. DESIGN:A prospective cross-sectional study. SUBJECTS AND METHODS:Seventy-four previously untreated hypertensive patients, referred to a hospital outpatients department, and 26 no...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Stanton AV,Mullaney P,Mee F,O'Brien ET,O'Malley K

    更新日期:1995-01-01 00:00:00

  • Masked hypertension in obstructive sleep apnea syndrome.

    abstract:BACKGROUND:Ambulatory blood pressure (BP) monitoring (ABPM) detects subjects with normal clinic but high ambulatory 24-h BP, that is, masked hypertension. METHODS:One hundred and thirty newly diagnosed obstructive sleep apnea syndrome (OSAS) patients, free of recognized cardiovascular disease were included (111 men, a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282f55049

    authors: Baguet JP,Lévy P,Barone-Rochette G,Tamisier R,Pierre H,Peeters M,Mallion JM,Pépin JL

    更新日期:2008-05-01 00:00:00

  • Aortic dilatation in Marfan syndrome: role of arterial stiffness and fibrillin-1 variants.

    abstract:OBJECTIVE:Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this observational study, we evaluated aortic stiffness in MFS and its association with ascending aorta diameters and fibrillin-1 genotype. METHODS:A ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001512

    authors: Salvi P,Grillo A,Marelli S,Gao L,Salvi L,Viecca M,Di Blasio AM,Carretta R,Pini A,Parati G

    更新日期:2018-01-01 00:00:00

  • Reference values and associated factors for Japanese newborns' blood pressure and pulse rate: the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study.

    abstract:OBJECTIVE:Currently, normative means and ranges of blood pressure (BP) and pulse rates in Japanese newborns are not available. The objective of the present study was to estimate BP, pulse rate, and their distribution among Japanese newborns. METHODS:Using oscillometric devices, arm or calf BP and pulse rate levels wer...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000976

    authors: Satoh M,Inoue R,Tada H,Hosaka M,Metoki H,Asayama K,Murakami T,Mano N,Ohkubo T,Yagihashi K,Hoshi K,Suzuki M,Imai Y

    更新日期:2016-08-01 00:00:00

  • Effects of angiotensin II on myocardial contractility during short-term pressor responses to angiotensin II.

    abstract:BACKGROUND:Cardiac angiotensin AT1 receptors have been found in several animal species. In-vitro studies performed on cardiac preparations have shown that angiotensin II (ANG II) exerts a positive inotropic effect; however, in-vivo results have allowed no definitive conclusion to be drawn. The reasons behind these cont...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715090-00013

    authors: Marano G,Formigari R,Vergari A

    更新日期:1997-09-01 00:00:00

  • Classes of antihypertensive medications and blood pressure control in relation to metabolic risk factors.

    abstract:OBJECTIVE:Metabolic syndrome (MetS) is associated with uncontrolled blood pressure (BP), despite use of aggressive therapy. This study was performed to assess whether the use of different classes of antihypertensive drugs might influence this association. METHODS:We evaluated risk of uncontrolled BP (BP ≥ 140/90 mmHg ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32834e1eda

    authors: De Marco M,de Simone G,Izzo R,Mancusi C,Sforza A,Giudice R,Trimarco B,De Luca N

    更新日期:2012-01-01 00:00:00

  • Chronic antioxidant treatment improves sympathetic functions and beta-adrenergic pathway in the spontaneously hypertensive rats.

    abstract:BACKGROUND:Correlations have been found between oxidative stress and hypertension. OBJECTIVE:To determine whether antioxidants can normalize sympathetic dysfunction at pre- or postsynaptic levels in spontaneously hypertensive rats (SHRs). METHODS AND RESULTS:Untreated SHRs and Wistar-Kyoto (WKY) rats were compared wi...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200301000-00028

    authors: Girouard H,Chulak C,LeJossec M,Lamontagne D,de Champlain J

    更新日期:2003-01-01 00:00:00

  • The prognostic value of blood pressure control delay in newly diagnosed hypertensive patients.

    abstract:OBJECTIVE:Various studies have suggested that a delay in the time between diagnosing hypertension and its correct control (D-C, diagnostic-control time) is linked to a worse prognosis. The aim of this study was to examine the relationship between D-C time and all-cause mortality, or the incidence of cardiovascular even...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001896

    authors: Martín-Fernández M,Vinyoles E,Real J,Soldevila N,Muñoz MÁ,Del-Val JL,Verdú JM,Domingo M,Mundet X

    更新日期:2019-02-01 00:00:00

  • Association between renal function and outcomes after percutaneous transluminal renal angioplasty in hypertensive patients with renal artery stenosis.

    abstract:OBJECTIVE:We investigated the impact of renal function on outcomes after percutaneous transluminal angioplasty. METHODS:A total of 139 hypertensive patients with atherosclerotic renal artery stenosis (mean age, 70 years, 80.6% men) who underwent renal percutaneous transluminal angioplasty were included. Renal function...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001499

    authors: Iwashima Y,Fukuda T,Horio T,Hayashi SI,Kusunoki H,Kishida M,Nakamura S,Kamide K,Kawano Y,Yoshihara F

    更新日期:2018-01-01 00:00:00

  • Angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers and pneumonia risk among stroke patients.

    abstract:OBJECTIVE:To investigate the effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pneumonia hospitalization in patients with stroke history in Taiwan. METHODS:We conducted a case-crossover study using the National Health Insurance Research Database in Taiwan during the period from...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328357a87a

    authors: Liu CL,Shau WY,Wu CS,Lai MS

    更新日期:2012-11-01 00:00:00

  • Varying patterns of the antihypertensive and antialbuminuric response to higher doses of renin-angiotensin-aldosterone system blockade in albuminuric hypertensive type 2 diabetes mellitus patients.

    abstract:OBJECTIVE:In patients with type 2 diabetes mellitus (T2DM), blocking of the renin-angiotensin-aldosterone system (RAAS) has demonstrated efficacy in lowering blood pressure (BP) and urinary albumin excretion rate (UAER). Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/HJH.0b013e32834a8a25

    authors: Weir MR,Hollenberg NK,Remuzzi G,Zappe DH,Meng X,Parving HH

    更新日期:2011-10-01 00:00:00

  • Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.

    abstract:OBJECTIVE:We have previously reported that hearts from N-[omega]-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats exhibited an enhanced expression of Gi proteins. Since, losartan, an AT1 receptor antagonist, has been shown to attenuate the L-NAME-induced increase in blood pressure, we undertook the pres...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200401000-00028

    authors: Hashim S,Anand-Srivastava MB

    更新日期:2004-01-01 00:00:00

  • Hypertension in blacks: insights from Africa.

    abstract::Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001171

    authors: Rayner BL,Spence JD

    更新日期:2017-02-01 00:00:00