Decreased ATP sensitivity of a K+ channel and enhanced vascular smooth muscle relaxation in genetically hypertensive rats.

abstract：OBJECTIVE:Normotensive rats fed a high fructose diet (HFD) develop hypertriglyceridemia, hyperinsulinemia and hypertension. The glomerular changes observed in the kidneys of these animals are similar to those observed in diabetic rats. The aim of this study was to evaluate whether lacidipine could be effective not only...

journal_title：Journal of hypertension

authors： Cosenzi A,Bernobich E,Plazzotta N,Seculin P,Odoni G,Bellini G

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluate...

journal_title：Journal of hypertension

authors： Linz D,Mancia G,Mahfoud F,Narkiewicz K,Ruilope L,Schlaich M,Kindermann I,Schmieder RE,Ewen S,Williams B,Böhm M,Global SYMPLICITY Registry Investigators.

更新日期：2017-01-01 00:00:00

abstract：:The plasma concentration of atrial natriuretic peptide (ANP) and the density and affinity of binding sites for ANP in platelets was investigated in patients with essential hypertension. Severe hypertensives were studied whilst still on medication. All subjects were ambulatory and were investigated after 3 days on a 13...

journal_title：Journal of hypertension

authors： Schiffrin EL,St-Louis J,Essiambre R

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVES:The long-term consequences of extreme prematurity are becoming increasingly important, given recent improvements in neonatal intensive care. The aim of the current study was to examine the cardiovascular consequences of extreme prematurity in 11-year-olds born at or before 25 completed weeks of gestation. M...

journal_title：Journal of hypertension

authors： McEniery CM,Bolton CE,Fawke J,Hennessy E,Stocks J,Wilkinson IB,Cockcroft JR,Marlow N

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:The rostral ventrolateral medulla (RVLM) of the brainstem and the paraventricular nucleus (PVN) of the hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance of excitatory and inhibitory inputs to the RVLM enhances central sympathetic outflow. Increased react...

journal_title：Journal of hypertension

authors： Nishihara M,Hirooka Y,Matsukawa R,Kishi T,Sunagawa K

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent...

journal_title：Journal of hypertension

authors： Almoosawi S,Prynne CJ,Hardy R,Stephen AM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...

journal_title：Journal of hypertension

authors： Raji A,Williams GH,Jeunemaitre X,Hopkins PN,Hunt SC,Hollenberg NK,Seely EW

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that sleep-related breathing disorder (SRBD) is associated with increasing severity of cardiovascular risk markers. DESIGN:A cross-sectional study of sleep laboratory patients. SETTING:University Hospital Sleep Disorders Centre. PATIENTS:We studied 591 patients referred for a sleep s...

journal_title：Journal of hypertension

authors： Grote L,Hedner J,Peter JH

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To examine a possible involvement of a regulatory protein of Na+/H+ exchanger (NHE) in the increased renal NHE activity in spontaneously hypertensive rats (SHR), we investigated mRNA expression of inhibitory members of the NHE regulatory protein family, NHERF1 and NHERF2, in the kidney. DESIGN:Prehypertensiv...

journal_title：Journal of hypertension

authors： Kobayashi K,Monkawa T,Hayashi M,Saruta T

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To compare the effects of the angiotensin II receptor antagonist candesartan with the angiotensin-converting enzyme inhibitor enalapril on myocardial fibrosis evaluated by echoreflectivity analysis. METHODS:Hypertensive patients (n = 196) with echocardigraphically documented left ventricular hypertrophy were...

journal_title：Journal of hypertension

authors： Ciulla MM,Paliotti R,Esposito A,Cuspidi C,Muiesan ML,Rosei EA,Magrini F,Zanchetti A

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:To compare the reproducibility of clinic and ambulatory blood pressure measurements in elderly hypertensive subjects. SUBJECTS:Twenty-two untreated elderly hypertensives, with a clinic systolic blood pressure (SBP) > 160 mmHg and/or diastolic blood pressure (DBP) > 95 mmHg, and a mean age of 76 years (range...

journal_title：Journal of hypertension

authors： Fotherby MD,Potter JF

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:To determine the degree to which hypertension is a risk factor for macrovascular and microvascular complications in type 2 diabetes. DESIGN:Observational prospective study. SUBJECTS:Newly diagnosed Type 2 diabetic patients recruited into the UK Prospective Diabetes Study (n = 3648; mean age 52 years), 40% o...

journal_title：Journal of hypertension

authors：

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies of the association between hypertension (HTN) and brain atrophy have shown reductions in prefrontal, temporal, and hippocampal volumes, and have identified thinner cortices across the cortical mantle. METHOD:In the current study, we followed 96 participants enrolled in the Baltimore ...

journal_title：Journal of hypertension

authors： Gonzalez CE,Pacheco J,Beason-Held LL,Resnick SM

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

journal_title：Journal of hypertension

authors： Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

更新日期：2019-06-01 00:00:00

abstract：:Ca2+ pump kinetics were investigated in erythrocytes from 22 essential hypertensive patients and 20 normotensive controls (under initial-rate and steady-state conditions, using Sr2+ as a Ca2+ analogue). The mean value of the apparent dissociation constant for total internal Ca2+ (KCa) was slightly but significantly in...

journal_title：Journal of hypertension

authors： de la Sierra A,Hannaert P,Ollivier JP,Senn N,Garay R

更新日期：1990-03-01 00:00:00

abstract：:: High blood pressure (BP) is a highly prevalent modifiable cause of cardiovascular disease, stroke, and death. Accurate BP measurement is critical, given that a 5-mmHg measurement error may lead to incorrect hypertension status classification in 84 million individuals worldwide. This position statement summarizes pro...

journal_title：Journal of hypertension

authors： Padwal R,Campbell NRC,Schutte AE,Olsen MH,Delles C,Etyang A,Cruickshank JK,Stergiou G,Rakotz MK,Wozniak G,Jaffe MG,Benjamin I,Parati G,Sharman JE

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To determine whether the development of arterial hypertension due to occlusion of the central adrenal vein in the rat is strain-dependent DESIGN AND METHODS:The experiments were performed on male rats weighing 300-400 g each, of the following strains: Wistar outbred, Wistar Glaxo, Lewis, Wistar-Kyoto (WKY) r...

journal_title：Journal of hypertension

authors： Abramczyk P,Lisiecka A,Papierski K,Ziecina R,Przybylski J

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To investigate the role of angiotensin II in the pathogenesis of hyperinsulinemia-induced hypertension in rats. MATERIALS AND METHODS:Chronic hyperinsulinemia was achieved by infusing insulin (3 mU/kg per min) subcutaneously by an osmotic minipump for 6 weeks. An angiotensin converting enzyme inhibitor (fosi...

journal_title：Journal of hypertension

authors： Fang TC,Huang WC

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To determine the blood pressure responses in elderly normotensive men and women to dietary sodium and to the diunsaturated fatty acid dihomogammalinolenic acid (DGLA), which is derived from linoleic acid. DESIGN:Blood pressure responses were assessed in 66 subjects (36 male, 30 female; mean age 65 years) on ...

journal_title：Journal of hypertension

authors： Nestel PJ,Clifton PM,Noakes M,McArthur R,Howe PR

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Abnormal vascular reactivity contributes to the pathophysiology of hypertension and hypertension-related organ damage. As the dietary content of fatty acids may affect the vascular responses, we investigated the relationship of endothelium-independent and endothelium-dependent vasodilation with the fatty acid...

journal_title：Journal of hypertension

authors： Colussi G,Catena C,Dialti V,Mos L,Sechi LA

更新日期：2015-05-01 00:00:00

abstract：:Elevated large artery stiffness and pulse pressure have emerged as important risk factors for cardiovascular disease. The genders differ in large artery biomechanical properties throughout the lifespan with females displaying higher stiffness than males during the prepubertal years and a dramatic increase after menopa...

journal_title：Journal of hypertension

authors： Rossi P,Francès Y,Kingwell BA,Ahimastos AA

更新日期：2011-06-01 00:00:00

abstract：:Exogenous sex hormone use, including oral contraceptives, post-menopausal hormonal therapy and anabolic steroids, has been associated with blood pressure changes in both sexes, but little is known about the relationship between blood pressure and endogenous sex hormones. We examined this relationship in men in the Ran...

journal_title：Journal of hypertension

authors： Khaw KT,Barrett-Connor E

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:To compare the effects of a cardioselective beta-blocker (nebivolol) with those of an angiotensin-converting enzyme inhibitor (enalapril) on parameters of insulin sensitivity, peripheral blood flow and arterial stiffness during one extended glucose clamp experiment. DESIGN:A randomized, double-blind crossove...

journal_title：Journal of hypertension

authors： Kaiser T,Heise T,Nosek L,Eckers U,Sawicki PT

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Haemostatic factors may play a part in the development of acute coronary heart disease. OBJECTIVE:To evaluate as predictors of major coronary events (fatal and non-fatal myocardial infarctions and sudden death) levels of fibrinogen, von Willebrand factor, prothrombin fragment 1+2, thrombin-antithrombin comp...

journal_title：Journal of hypertension

authors： Agewall S,Wikstrand J,Fagerberg B

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Correlations have been found between oxidative stress and hypertension. OBJECTIVE:To determine whether antioxidants can normalize sympathetic dysfunction at pre- or postsynaptic levels in spontaneously hypertensive rats (SHRs). METHODS AND RESULTS:Untreated SHRs and Wistar-Kyoto (WKY) rats were compared wi...

journal_title：Journal of hypertension

authors： Girouard H,Chulak C,LeJossec M,Lamontagne D,de Champlain J

更新日期：2003-01-01 00:00:00

abstract：:A previously described Pst I restriction fragment length polymorphism in Dahl rats at the Na+, K(+)-adenosine 5'-triphosphatase (ATPase) alpha 1 isoform locus was tested for cosegregation with blood pressure in segregating populations. Inbred Dahl salt-sensitive (S) and inbred Dahl salt-resistant (R) rats were crossed...

journal_title：Journal of hypertension

authors： Rapp JP,Dene H

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVES:We aimed to determine the association of nonalcoholic fatty liver disease (NAFLD) with central and peripheral blood pressure (BP), in a general adolescent population and to examine whether associations are independent of adiposity. METHODS:Using cross-sectional data from a subsample (N = 1904) of a UK birth...

journal_title：Journal of hypertension

authors： Patel S,Lawlor DA,Ferreira DL,Hughes AD,Chaturvedi N,Callaway M,Day C,Sattar N,Fraser A

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to assess the regression of left ventricular hypertrophy (LVH) during antihypertensive treatment, and its relationship with the changes in microalbuminuria. INDIVIDUALS AND METHODS:One hundred and sixty-eight previously untreated patients with echocardiographic LVH, 46 ...

journal_title：Journal of hypertension

authors： Rodilla E,Pascual JM,Costa JA,Martin J,Gonzalez C,Redon J

更新日期：2013-08-01 00:00:00

abstract：:It is widely believed that salt-dependent hypertension is induced and maintained by expansion of intravascular fluid volume resulting from excessive retention of sodium. The purpose of this brief article is to present a series of arguments in support of the thesis that volume overload per se does not raise the arteria...

journal_title：Journal of hypertension

authors： Gavras I,Gavras H

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypert...

journal_title：Journal of hypertension

authors： Koton S,Tanne D,Grossman E

更新日期：2017-04-01 00:00:00