Abstract:
OBJECTIVES:The long-term consequences of extreme prematurity are becoming increasingly important, given recent improvements in neonatal intensive care. The aim of the current study was to examine the cardiovascular consequences of extreme prematurity in 11-year-olds born at or before 25 completed weeks of gestation. METHODS:Age and sex-matched classmates were recruited as controls. Information concerning perinatal and maternal history was collected, and current anthropometric characteristics were measured in 219 children born extremely preterm and 153 classmates. A subset of the extremely preterm children (n = 68) and classmates (n = 90) then underwent detailed haemodynamic investigations, including measurement of supine blood pressure (BP), aortic pulse wave velocity (aPWV, a measure of aortic stiffness) and augmentation index (AIx, a measure of arterial pressure wave reflections). RESULTS:Seated brachial systolic and diastolic BP were not different between extremely preterm children and classmates (P = 0.3 for both), although there was a small, significant elevation in supine mean and diastolic BP in the extremely preterm children (P < 0.05 for both). Arterial pressure wave reflections were significantly elevated in the extremely preterm children (P < 0.001) and this persisted after adjusting for confounding variables. However, aortic stiffness was not different between the groups (P = 0.1). CONCLUSIONS:These data suggest that extreme prematurity is associated with altered arterial haemodynamics in children, not evident from the examination of brachial BP alone. Moreover, the smaller, preresistance and resistance vessels rather than large elastic arteries appear to be most affected. Children born extremely preterm may be at increased future cardiovascular risk.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
McEniery CM,Bolton CE,Fawke J,Hennessy E,Stocks J,Wilkinson IB,Cockcroft JR,Marlow Ndoi
10.1097/HJH.0b013e328347e333subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1367-73issue
7eissn
0263-6352issn
1473-5598journal_volume
29pub_type
杂志文章abstract::Thirty-two patients with mildly elevated blood pressure (BP), but without target organ damage, attended a BP measuring clinic where duplicate BP measurements were made on 12 visits. During visits 1-3, BP showed a systematic decrease which varied from patient to patient. During visits 4-12, no further systematic change...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198704000-00012
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:Studies of experimental animals show glomerular hypertension to be important in the progression of glomerular disease. We evaluated this connection clinically by examining the relationship between glomerular hemodynamics and histological changes in patients with immunoglobulin (Ig)A nephropathy. METHODS:The ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018010-00015
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:Treatment modifications--addition, uptitration, switching, and downtitration--are necessary to address issues such as unattained blood pressure goals, adverse drug events, drug cost, or patient dissatisfaction which lead to treatment discontinuation. This study assessed the patterns of treatment modification...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000806
更新日期:2016-03-01 00:00:00
abstract::We studied 56 patients with essential hypertension to determine whether responses to standardized laboratory mental and physical challenges accurately reflect blood pressure variability during routine daily activities. Four activities were performed in the laboratory: mental arithmetic, a reaction time test, isometric...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198712000-00014
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:The catalytic alpha and smaller beta subunits of the plasma membrane Na,K-ATPase occur in various molecular forms (alpha1, alpha2, alpha3, beta1 and beta2). The alpha isoforms of the enzyme have varying affinities for ouabain and exist in different tissues with particular distribution patterns. OBJECTIVE:To...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816020-00003
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVES:Many different stress echocardiographic and radionuclide perfusion imaging tests have been proposed for detecting epicardial coronary artery disease (CAD) in hypertensive patients. Their relative diagnostic and prognostic value has not been exactly established. BACKGROUND:A positive exercise electrocardiogr...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200103000-00018
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:Exercise training has antihypertensive and renoprotective effects in humans and rats. However, the effects of exercise training on renal disorders that occur with salt-sensitive hypertension remains unclear. The study aim was to investigate the effects and mechanisms of exercise training on renal function in ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002409
更新日期:2020-07-01 00:00:00
abstract::: High blood pressure (BP) is a highly prevalent modifiable cause of cardiovascular disease, stroke, and death. Accurate BP measurement is critical, given that a 5-mmHg measurement error may lead to incorrect hypertension status classification in 84 million individuals worldwide. This position statement summarizes pro...
journal_title:Journal of hypertension
pub_type: 杂志文章,实务指引
doi:10.1097/HJH.0000000000002112
更新日期:2019-09-01 00:00:00
abstract::Angioplasty of renal artery stenosis has been used extensively in the last two decades for treating renovascular hypertension, and, more recently, for preserving the jeopardized renal function. A large body of evidence has accumulated indicating that this approach is by far the most convenient for patients with fibrom...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199917120-00001
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Correlations have been found between oxidative stress and hypertension. OBJECTIVE:To determine whether antioxidants can normalize sympathetic dysfunction at pre- or postsynaptic levels in spontaneously hypertensive rats (SHRs). METHODS AND RESULTS:Untreated SHRs and Wistar-Kyoto (WKY) rats were compared wi...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200301000-00028
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between long-term exposure to high-level urban traffic noise and blood pressure in preschool children. DESIGN:Normotensive children (n = 1542), aged 3-7 years and attending kindergartens, had their blood pressures and heart rate measured. Mean values of these circulatory variab...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To seek in hypertensive patients rhythmic variations of the systolic blood pressure signal obtained by ambulatory blood pressure monitoring of any inherent cycle of intermediate value between 1 and 24 h. DESIGN:Subjects (62 hypertensive, 39 normotensive) were evaluated by 24-h ambulatory blood pressure monit...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Familial hyperkalaemic hypertension (FHH) is a Mendelian form of low-renin hypertension characterized by hyperkalaemia and hyperchloraemic acidosis despite a normal glomerular filtration rate. To date, three different loci have been identified, on chromosomes 1, 17 and 12. OBJECTIVE:To test for genetic link...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200111000-00005
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:We investigated the contribution of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase-dependent reactive oxygen species (ROS) generation to the pathogenesis of diastolic heart failure (DHF) in Dahl salt-sensitive (DS) hypertensive rats, with the aim of testing our hypothesis that the cardiop...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000226200.73065.5d
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Inherited differences in renal function underlie the effect of high salt diets on blood pressure in Dahl rats. We probed the kidneys of inbred Dahl SS/Jr and SR/Jr for anonymous and candidate genes whose expression was regulated by dietary sodium. METHODS:mRNA quantitation of both candidate genes implicated ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000133719.94075.e2
更新日期:2004-08-01 00:00:00
abstract::We compared the overflow of endogenous norepinephrine (NE) upon electrical stimulation, the associated pressor response and rate of initial neuronal uptake of 3H-I-NE in the perfused mesenteric arteries of Dahl salt-sensitive (DS) and salt-resistant (DR) rats on two dietary NaCl regimens (0.4 and 8.0% for 2 weeks) fro...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198901000-00007
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Self-measurement of blood pressure (BP) is increasingly being used for the diagnosis of hypertension and to monitor BP at home. Whenever compared with ambulatory BP measurements, home BP values are frequently higher and less predictive for incident cardiovascular events. We hypothesized that this could be ca...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001775
更新日期:2018-09-01 00:00:00
abstract::The reported prevalence of left ventricular hypertrophy (LVH) in human hypertension is much lower than that among animals with experimental hypertension. With current methods of determining left ventricular mass by M-mode echocardiography, the standard error of a single estimate is high and consequently so is the SD o...
journal_title:Journal of hypertension
pub_type: 社论,评审
doi:10.1097/00004872-199816060-00001
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199509000-00004
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:We attempted to determine a valid pharmacological approach for the control of high blood pressure in obese hypertensive patients using two antihypertensive agents with different pharmacological actions. DESIGN:Thirty-two obese hypertensive black women were randomly treated with chlorthalidone or clonidine to...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-199205000-00013
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200104000-00014
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Poor adherence to treatment is one of the major problems in the treatment of hypertension. Self blood pressure measurement may help patients to improve their adherence to treatment. METHOD:In this prospective, randomized, controlled study coordinated by a university hospital, a total of 228 mild-to-moderate...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e328334f36b
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Endothelial dysfunction and arterial stiffness are early vascular alterations, linked to oxidative stress and inflammation, with prognostic significance in essential hypertensive patients. P2X7 receptors (P2X7R), responding to extracellular ATP, are encoded by a highly polymorphic gene and modulate inflammato...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283653ff5
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS:We recruited 378 hypertensive CKD ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001185
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To assess the expression of early cardiac genes, implicated in the hypertrophic growth response of the adult heart, in peripheral blood mononuclear cells in patients with essential hypertension and its relationship to ambulatory blood pressure monitoring (ABPM) parameters and to echocardiographic left ventri...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283424bc4
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Results from previous studies suggested that a blunted response of renal plasma flow (RPF) to angiotensin II infusion during a high-sodium diet (a phenotype associated with nonmodulation) is an intermediate phenotype for essential hypertension. OBJECTIVE:To determine whether RPF traits used to investigate n...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715050-00003
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004872-200101000-00013
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To provide estimates of the global burden of disease attributable to non-optimal blood pressure by age and sex for adults aged > or = 30 years, by WHO subregion. METHODS:Estimates of attributable burden were made using population impact fractions, which used data on mean systolic blood pressure levels, dise...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000209973.67746.f0
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischem...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000244959.92856.7e
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To compare blood pressure (BP) in adolescence (11-12 years) among the offspring of preeclamptic and normotensive pregnancies. METHOD:SBP and DBP of 181 girls and boys born after pregnancies with preeclampsia were measured and compared with the BP of 356 age-matched girls and boys of normotensive pregnancies....
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328330052a
更新日期:2009-10-01 00:00:00