Platelet binding sites and plasma concentration of atrial natriuretic peptide in patients with essential hypertension.

abstract：:Using antibodies raised against angiotensin I and II, and high-performance liquid chromatography (HPLC) of plasma extracts, we have quantified six angiotensin peptides in venous (cubital vein) and arterial (brachial) plasma of normal male subjects. The concentrations of venous plasma (fmol/ml, mean +/- s.d., n = 29) f...

journal_title：Journal of hypertension

authors： Campbell DJ,Kladis A

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normotensive rats. We analyzed the effect of chronic ouabain (approximately 8.0 microg/day, 5 weeks) treatment on the blood pressure of spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats and the contribution of vascula...

journal_title：Journal of hypertension

authors： Xavier FE,Davel AP,Fukuda LE,Rossoni LV

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Remodeling of small resistance arteries is an early sign of target organ damage in hypertension. Peripheral capillary morphology abnormalities in hypertension are not well studied. The study objective was to determine whether altered capillary morphology is associated with SBP, DBP, or both in individuals wi...

journal_title：Journal of hypertension

authors： Cheng C,Daskalakis C,Falkner B

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Patients with type-2 diabetes have a high prevalence of hypertension and show an elevated incidence of cardiovascular events and nephropathy. OBJECTIVES:Recent randomized trials of antihypertensive therapy providing information about cardiovascular and renal risk in diabetes, blood pressure goals and best s...

journal_title：Journal of hypertension

authors： Zanchetti A,Ruilope LM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Age, hypertension, diabetes mellitus and a history of cardiovascular disease are the most important factors related to the presence of cerebral white matter lesions (WML), which are a common finding in elderly people. This study investigates which factors related to hypertension per se are associated with the...

journal_title：Journal of hypertension

authors： Sierra C,de La Sierra A,Mercader J,Gómez-Angelats E,Urbano-Márquez A,Coca A

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Results from previous studies suggested that a blunted response of renal plasma flow (RPF) to angiotensin II infusion during a high-sodium diet (a phenotype associated with nonmodulation) is an intermediate phenotype for essential hypertension. OBJECTIVE:To determine whether RPF traits used to investigate n...

journal_title：Journal of hypertension

authors： Kardia SL,Sing CF,Turner ST

更新日期：1997-05-01 00:00:00

abstract：UNLABELLED:PURPOSE IDENTIFICATION: Inter-individual variability in blood pressure response to treatment is well documented, but a clinically useful means to distinguish responders from non-responders has been elusive. With the advent of new technologies and genomic knowledge, more investigators are seeking to identify ...

journal_title：Journal of hypertension

authors： Mellen PB,Herrington DM

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...

journal_title：Journal of hypertension

authors： Schmidlin O,Tanaka M,Sebastian A,Morris RC Jr

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor (PPAR)-alpha has been implicated in the regulation of normal and pathological cellular functions, but the effect of specific gene silencing on PPARalpha-mediated function is not fully defined. AIM:This study evaluated the role of PPARalpha in hypertensive renal inj...

journal_title：Journal of hypertension

authors： Newaz M,Ranganna K,Truong LD,Oyekan A

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Obstructive sleep apnoea (OSA) and hypertension frequently coexist, and both are associated with higher night-time than daytime urine sodium excretion rate (UNaV). However, the relative contribution of each condition is unknown. We compared the circadian pattern of UNaV in hypertensive and normotensive patie...

journal_title：Journal of hypertension

authors： White LH,Bradley TD,Logan AG

更新日期：2014-11-01 00:00:00

abstract：:Plasma viscosity and fibrinogen concentrations were measured in 70 diabetics (35 hypertensive and 35 normotensive) and compared with those of 35 age- and sex-matched normotensive healthy subjects in relation to body weight. The body weight, body mass index, blood pressure (systolic and diastolic), mean arterial pressu...

journal_title：Journal of hypertension

authors： Memeh CU

更新日期：1990-08-01 00:00:00

abstract：:The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopress...

journal_title：Journal of hypertension

authors： Gnädinger MP,Weidmann P,Rascher W,Lang RE,Hellmüller B,Uehlinger DE

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVES:Whether the C-344T polymorphism of the aldosterone synthase gene is important for blood pressure control remains controversial. It has been proposed that an association between this polymorphism and blood pressure might be evident in elderly subjects. The aim of the present study was to test this hypothesis ...

journal_title：Journal of hypertension

authors： Casiglia E,Tikhonoff V,Mazza A,Rynkiewicz A,Limon J,Caffi S,Guglielmi F,Martini B,Basso G,Winnicki M,Pessina AC,Somers VK

更新日期：2005-11-01 00:00:00

abstract：:The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...

journal_title：Journal of hypertension

authors： Mann JF,Sis J,Ritz E

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:The present study was performed to examine the role of superoxide (O2*) and its interaction with nitric oxide (NO) in the regulation of renal function in prehypertensive heterozygous Ren-2 transgenic rats (TGR). METHODS:Renal responses to the O2* scavenger, tempol (150 microg/min per 100 g), and/or the NO sy...

journal_title：Journal of hypertension

authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Cervenka L,Majid DS

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the optimal schedule for home blood pressure (HBP) measurement based on a clinical approach. METHODS:Four hundred and sixty-four participants underwent HBP measurement for 7 days (duplicate measurements in the morning and in the evening), ambulatory blood pressure (ABP)...

journal_title：Journal of hypertension

authors： Johansson JK,Niiranen TJ,Puukka PJ,Jula AM

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Cardiac angiotensin AT1 receptors have been found in several animal species. In-vitro studies performed on cardiac preparations have shown that angiotensin II (ANG II) exerts a positive inotropic effect; however, in-vivo results have allowed no definitive conclusion to be drawn. The reasons behind these cont...

journal_title：Journal of hypertension

authors： Marano G,Formigari R,Vergari A

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:Nonsteroidal anti-inflammatory drugs vary in their impact on blood pressure and the effect of lumiracoxib 100 mg once daily has not been studied previously. To examine whether lumiracoxib 100 mg once daily would result in lower 24-h mean systolic ambulatory blood pressure than ibuprofen 600 mg three times da...

journal_title：Journal of hypertension

authors： MacDonald TM,Reginster JY,Littlejohn TW,Richard D,Lheritier K,Krammer G,Rebuli R

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:The increase in blood pressure that accompanies the obese state is almost invariably associated with alterations in metabolism (insulin resistance and dyslipidaemia) and the neurohumoral profile (activation of the renin-angiotensin system, sympathetic overactivity), which potentiate the cardiovascular risk as...

journal_title：Journal of hypertension

authors： Grassi G,Seravalle G,Dell'Oro R,Trevano FQ,Bombelli M,Scopelliti F,Facchini A,Mancia G,CROSS Study.

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:To assess the consequences of malignant hypertension and its evolution with antihypertensive treatment. BACKGROUND:Malignant hypertension can be considered as a model of the effects of very high blood pressure and renin-angiotensin levels on target organs. However, the consequences on the heart have been li...

journal_title：Journal of hypertension

authors： Gosse P,Coulon P,Papaioannou G,Litalien J,Lemetayer P

更新日期：2011-04-01 00:00:00

abstract：:: Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of BP changes in AIS is complex and only partially understood. The available evidence indicates that extremely high BP during AIS is associated with a poor outcome. Im...

journal_title：Journal of hypertension

authors： Gąsecki D,Coca A,Cunha P,Hering D,Manios E,Lovic D,Zaninelli A,Sierra C,Kwarciany M,Narkiewicz K,Karaszewski B

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT1 receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, n...

journal_title：Journal of hypertension

authors： Roks AJ,Nijholt J,van Buiten A,van Gilst WH,de Zeeuw D,Henning RH

更新日期：2004-12-01 00:00:00

abstract：:This study was designed to assess the contribution of thromboxane (Tx) A2 to the pathogenesis of renal dysfunction in rats with angiotensin II (Ang II)-salt hypertension. Hypertension was induced in rats drinking 0.15 mol/l NaCl by infusion of Ang II (125 ng/min, intraperitoneally) for 12 days. Relative to values in w...

journal_title：Journal of hypertension

authors： Mistry M,Muirhead EE,Yamaguchi Y,Nasjletti A

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Renal infarction can cause abrupt and severe hypertension and less frequently renal failure. Renal infarction results from disruption of renal blood flow in the main ipsilateral renal artery or in a segmental branch. Underlying mechanism is either general, 'embolic' or 'thrombophilic', or local related to pr...

journal_title：Journal of hypertension

authors： Faucon AL,Bobrie G,Jannot AS,Azarine A,Plouin PF,Azizi M,Amar L

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Contrary to lay beliefs, current perceived stress is not consistently associated with the incidence of high blood pressure (BP) in prospective studies, possibly because of moderating factors. The present prospective study examined this association and explored the potential moderating effects of sex or occup...

journal_title：Journal of hypertension

authors： Wiernik E,Nabi H,Pannier B,Czernichow S,Hanon O,Simon T,Simon JM,Thomas F,Ducolombier C,Danchin N,Limosin F,Consoli SM,Lemogne C

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Activation of the nuclear factor kappa B (NF kappaB) inflammatory pathway by angiotensin II and reactive oxygen species may play an important role in the development of insulin resistance and cardiovascular injury in hypertensive and metabolic diseases. We have shown that in hypertensive Dahl salt-sensitive ...

journal_title：Journal of hypertension

authors： Zhou MS,Schulman IH,Raij L

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:In some patients with aortic stenosis left-ventricular hypertrophy exceeds what is needed to sustain the hemodynamic load imposed by the aortic stenosis, a condition named inappropriately high left-ventricular mass (iLVM). Although iLVM is associated with increased mortality after aortic valve replacement, pr...

journal_title：Journal of hypertension

authors： Cioffi G,de Simone G,Cramariuc D,Mureddu GF,Gerdts E

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Hypertensive nephrosclerosis is one of the most frequent causes of chronic kidney failure. Proteome analysis potentially improves the pathophysiological understanding and diagnostic precision of this disorder. In the present exploratory study, we investigated experimental nephrosclerosis in the two-kidney, o...

journal_title：Journal of hypertension

authors： Vethe H,Finne K,Skogstrand T,Vaudel M,Vikse BE,Hultström M,Placier S,Scherer A,Tenstad O,Marti HP

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Arterial stiffness is associated with excess morbidity and mortality, independently of other cardiovascular risk factors. Age is the main determinant responsible for arterial wall changes leading to arterial stiffening. Environmental and genetic factors may however influence the magnitude of the effects of a...

journal_title：Journal of hypertension

authors： Lajemi M,Labat C,Gautier S,Lacolley P,Safar M,Asmar R,Cambien F,Benetos A

更新日期：2001-03-01 00:00:00

abstract：:Hypertension is a leading risk factor for mortality. Detecting, treating and monitoring hypertensive patients require accurate blood pressure measurements. Protocols for validation of automatic sphygmomanometers exist, but quality control of validations is limited to peer review of published reports, which has severe ...

journal_title：Journal of hypertension

authors： Turner MJ

更新日期：2010-12-01 00:00:00