Abstract:
OBJECTIVE:The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT1 receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, normal and high sodium diet on the antagonism of Ang II by Ang-(1-7). The role of angiotensin receptor subtypes and the endothelium was assessed. METHODS:Male Wistar rats received a normal sodium (0.3% NaCl), high sodium (2.0% NaCl) or low sodium (0.05% NaCl) diet for 10 days. Vascular responses were assessed ex vivo in thoracic aortic rings in the presence of the nitric oxide (NO) inhibitor N-monomethyl-l-arginine (l-NMMA) to avoid aspecific vasodilator effects of Ang-(1-7). RESULTS:After a normal or high salt diet, Ang-(1-7) significantly decreased maximal Ang II-induced vascular constrictions by 40-50%. After a low salt diet this non-competitive antagonism disappeared. The AT2 receptor antagonist PD 123319 and the Ang-(1-7) receptor antagonist A779 attenuated the effect of Ang-(1-7) found in rats fed with a normal or high sodium diet. Further, removal of endothelium and pretreatment with the prostaglandin synthesis inhibitor indomethacin (10 mol/l) abolished the non-competitive antagonism by Ang-(1-7). CONCLUSION:Ang-(1-7) elicits a specific, endothelium-dependent and non-competitive antagonism of Ang II, which involves AT2 and Ang-(1-7) receptors but is independent of NO production. This non-competitive antagonism of Ang-(1-7) is abolished by a low sodium intake in normotensive rats, suggesting that it serves as a negative feedback towards Ang II in response to an altered sodium intake.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Roks AJ,Nijholt J,van Buiten A,van Gilst WH,de Zeeuw D,Henning RHdoi
10.1097/00004872-200412000-00018subject
Has Abstractpub_date
2004-12-01 00:00:00pages
2355-61issue
12eissn
0263-6352issn
1473-5598pii
00004872-200412000-00018journal_volume
22pub_type
杂志文章abstract:OBJECTIVE:Currently, normative means and ranges of blood pressure (BP) and pulse rates in Japanese newborns are not available. The objective of the present study was to estimate BP, pulse rate, and their distribution among Japanese newborns. METHODS:Using oscillometric devices, arm or calf BP and pulse rate levels wer...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000976
更新日期:2016-08-01 00:00:00
abstract::: High blood pressure (BP) is a highly prevalent modifiable cause of cardiovascular disease, stroke, and death. Accurate BP measurement is critical, given that a 5-mmHg measurement error may lead to incorrect hypertension status classification in 84 million individuals worldwide. This position statement summarizes pro...
journal_title:Journal of hypertension
pub_type: 杂志文章,实务指引
doi:10.1097/HJH.0000000000002112
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To investigate the role of ouabain in human hypertension and to establish whether immunoreactive endogenous ouabain is secreted by the adrenal gland under the influence of dopaminergic regulation. METHODS:We measured plasma levels of endogenous ouabain by immunoassay, together with other variables, including...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199510000-00013
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify, describe, and evaluate the available cardiovascular disease risk prediction models developed or validated in the hypertensive population. METHODS:MEDLINE and the Web of Science were searched from database inception to March 2019, and all reference lists of included arti...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002442
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established. METHODS:Herein, we report 12-month outcomes from the Global SYMPLICITY ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001085
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy (LVH). We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32833aa356
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:Recent evidence indicates that reduced sleep duration may be associated with an increased risk of hypertension with possibly stronger effects among women than men. We therefore examined cross-sectional sex-specific associations of sleep duration with hypertension in a large population-based sample from the W...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328335d076
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Choice of antihypertensive drugs is also based on the expected burden of adverse events associated with each class of agents, and we have recently identified treatment discontinuation for adverse events as a measure of treatment tolerability frequently reported in randomized controlled trials (RCTs). OBJECT...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000001052
更新日期:2016-10-01 00:00:00
abstract::Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 week...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198712000-00015
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVES:Genetically hypertensive rats provide an excellent model to investigate the genetic mechanisms of hypertension. We previously identified three differentially expressed genes, Acadsb (short/branched chain acyl-CoA dehydrogenase), Comt (catecholamine-O-methyltransferase), and Pnpo (pyridoxine 5'-phosphate oxid...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3280103a40
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE(S):To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment. DESIGN:The study was carried out in a total of 25 subjects--11 healt...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-200403000-00027
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To assess the Accutracker II (version 30/23) ambulatory blood pressure monitor by nationally agreed protocols in order to resolve previous conflicting assessments, and to examine the feasibility of combining these protocols into one study. DESIGN:The protocols of the Association for the Advancement of Medica...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To investigate the factors affecting survival in patients with malignant hypertension by analysing the prognosis of all of the patients referred to the City Hospital, Birmingham, with malignant hypertension since 1965. RESULTS:We identified 315 patients with malignant hypertension (211 men, 104 women; mean a...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199508000-00013
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVES:Advanced diabetic nephropathy (DN) is characterized by a marked development of cardiovascular and renal disease. These patients are frequently managed by different health professionals with the consequence that the quality of care may differ substantially. To compare the management of cardiovascular risk fac...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/01.hjh.0000239303.93872.31
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Secondary prevention of stroke with antihypertensive drugs is now standard practice, but it is unclear how soon after a cerebrovascular event antihypertensive therapy should be initiated or re-started. Due to impaired cerebral autoregulation, changes in systemic blood pressure may be reflected in cerebral pe...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200405000-00022
更新日期:2004-05-01 00:00:00
abstract::The European Society of Hypertension and the European Society of Cardiology have started the preparation of the third edition of their joint guidelines on the management of arterial hypertension. The authors have focused on the new edition of the UK NICE guidelines to learn about the difficulties of disentangling evid...
journal_title:Journal of hypertension
pub_type: 社论
doi:10.1097/HJH.0b013e328351b4e4
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The mechanism of the association between obesity and hypertension is not clear. The recently discovered obese gene product, leptin, the levels of which increase in obese subjects, has been shown to reduce food intake and increase sympathetic nervous system activity in animal studies. The present study was und...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816121-00023
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:Arterial hypertension is recurrently associated with inflammation of the endothelium as an effect of the upregulation of functional molecules, including cytokines, adhesion molecules and chemokines. However, the role of monocyte chemoattractant protein-1 (MCP-1) in maintaining the inflammatory state of endoth...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000234111.31239.c3
更新日期:2006-07-01 00:00:00
abstract::Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Me...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000000168
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:The contribution of salt intake to the pathogenesis of hypertension holds longstanding interest. Recent studies employed the sensitivity of blood pressure (BP) to salt intake as an intermediate phenotype. The validity of this approach relative to the homogeneity of sodium-sensitive hypertension was investigat...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/00004872-200305000-00020
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age. METHODS:Using a n...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000407
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:The prognostic importance of the nocturnal blood pressure (BP) fall and early-morning surge were scarcely investigated in patients with resistant hypertension (RHT). We investigated them in a prospective cohort of 1726 RHT individuals. METHODS:The nocturnal fall and morning surge were calculated from the bas...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002775
更新日期:2021-01-11 00:00:00
abstract::Use of the aldosterone-to-renin ratio has controversially suggested that approximately 10% of hypertensives have primary aldosteronism, and most of these individuals are thought to have idiopathic hyperaldosteronism. The usual renin-angiotensin system control is intact in these individuals and is similar to that in lo...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-200201000-00003
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:Studies regarding the effects of parity on blood pressure in later life produced conflicting results. The aim of our study is to analyse whether parity influences the prevalence of hypertension in perimenopausal and postmenopausal women. METHODS:One thousand perimenopausal and postmenopausal women (mean age...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835c1742
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001078
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of angiotensin II on cyclooxygenase-2 (COX-2) expression in aortic adventitial fibroblasts from normotensive [Wistar-Kyoto (WKY)] rats and spontaneously hypertensive rats (SHRs). METHODS:Protein expression was determined by western blot, mRNA levels by real-time PCR, transcriptional...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/hjh.0b013e328317a730
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Whether the C-344T polymorphism of the aldosterone synthase gene is important for blood pressure control remains controversial. It has been proposed that an association between this polymorphism and blood pressure might be evident in elderly subjects. The aim of the present study was to test this hypothesis ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000183119.92455.a7
更新日期:2005-11-01 00:00:00
abstract::The associations of obesity and alcohol consumption with blood pressure and the prevalence of hypertension were studied in 5550 male and female subjects aged 25 to 64 years, surveyed in the National Heart Foundation of Australia 1980 Risk Factor Prevalence Study. Body mass index was significantly and independently ass...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198402000-00015
更新日期:1984-02-01 00:00:00
abstract:OBJECTIVE:To investigate the role of the renal medulla in early hypertension in spontaneously hypertensive rats (SHR), and to explore whether the attenuated increase of pressure induced by enalapril treatment is affected by chemical medullectomy. DESIGN:Forty-four male SHR were studied from 5 to 18 weeks of age: 22 re...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199211000-00006
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Contrary to lay beliefs, current perceived stress is not consistently associated with the incidence of high blood pressure (BP) in prospective studies, possibly because of moderating factors. The present prospective study examined this association and explored the potential moderating effects of sex or occup...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000288
更新日期:2014-10-01 00:00:00