Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type.

Abstract:

OBJECTIVE:The contribution of salt intake to the pathogenesis of hypertension holds longstanding interest. Recent studies employed the sensitivity of blood pressure (BP) to salt intake as an intermediate phenotype. The validity of this approach relative to the homogeneity of sodium-sensitive hypertension was investigated while simultaneously controlling multiple putative factors. METHODS:Blood pressure responses to shifts in salt intake were measured in 274 individuals with essential hypertension in steady-state sodium balance on high (200 mEq) and low (10 mEq) sodium intakes. Univariate and multivariate analyses predicted systolic and diastolic sodium sensitivity based on interactions among demographic factors (age, gender, race, body mass index) and hypertensive type [low-renin (LR), modulator (M), non-modulator (NM)]. RESULTS:The influence of hypertension type on systolic salt sensitivity (SSS) depended on gender (P = 0.03). In females, highest SSS was in LR (21, 14, 13 mmHg for LR, M, NM, P = 0.02), while in males highest SSS was in NM (11, 10, 16 mmHg for LR, M, NM, P = 0.07). Age predicted SSS without interacting with other factors, producing a 2.4 mmHg increase per decade (P = 0.02). Hypertension type affected diastolic salt sensitivity (DSS) (P = 0.002) without interacting with other factors. M had less DSS (6 mmHg) than LR (9 mmHg) and NM (11 mmHg) (P < 0.01). CONCLUSIONS:For subjects in sodium balance, the distributions of SSS and DSS were unimodal and the mechanisms mediating SSS and DSS were different. Controlling for multiple demographic factors, at least two hypertensive types have largest BP responses to sodium intake, reducing the usefulness of blood pressure sensitivity to salt intake as an intermediate phenotype.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Hurwitz S,Fisher ND,Ferri C,Hopkins PN,Williams GH,Hollenberg NK

doi

10.1097/00004872-200305000-00020

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

951-9

issue

5

eissn

0263-6352

issn

1473-5598

journal_volume

21

pub_type

杂志文章,多中心研究
  • Finding genes that cause human hypertension.

    abstract::Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199303000-00002

    authors: Lifton RP,Jeunemaitre X

    更新日期:1993-03-01 00:00:00

  • Exercise training delays renal disorders with decreasing oxidative stress and increasing production of 20-hydroxyeicosatetraenoic acid in Dahl salt-sensitive rats.

    abstract:OBJECTIVE:Exercise training has antihypertensive and renoprotective effects in humans and rats. However, the effects of exercise training on renal disorders that occur with salt-sensitive hypertension remains unclear. The study aim was to investigate the effects and mechanisms of exercise training on renal function in ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002409

    authors: Ogawa Y,Takahashi J,Sakuyama A,Xu L,Miura T,Muroya Y,Ito D,Kohzuki M,Ito O

    更新日期:2020-07-01 00:00:00

  • Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients.

    abstract:OBJECTIVE:A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy (LVH). We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833aa356

    authors: Huber M,Völler H,Jakob S,Reibis R,Do V,Bolbrinker J,Zergibel I,Schmieder RE,Treszl A,Wegscheider K,Kreutz R

    更新日期:2010-06-01 00:00:00

  • Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study.

    abstract:OBJECTIVE:The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR). DESIGN:SBP, heart: and left ventricle: body weight ratios, the cross-sectional area of cardiocytes, and the ultrastructur...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199206000-00002

    authors: Ferrante F,Bronzetti E,Ciriaco E,Felici L,Amenta F

    更新日期:1992-06-01 00:00:00

  • Altered myogenic responsiveness of the renal microvasculature in experimental hypertension.

    abstract::Recent investigations have delineated the renal microvascular responsiveness to pressure, by using isolated afferent arterioles, juxtamedullary nephrons, and isolated perfused hydronephrotic kidneys. Both afferent arterioles and interlobular arteries (ILA) manifest pressure-dependent vasoconstrictor responses to eleva...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199612000-00002

    authors: Hayashi K,Epstein M,Saruta T

    更新日期:1996-12-01 00:00:00

  • The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke.

    abstract:BACKGROUND:Secondary prevention of stroke with antihypertensive drugs is now standard practice, but it is unclear how soon after a cerebrovascular event antihypertensive therapy should be initiated or re-started. Due to impaired cerebral autoregulation, changes in systemic blood pressure may be reflected in cerebral pe...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200405000-00022

    authors: Nazir FS,Overell JR,Bolster A,Hilditch TE,Reid JL,Lees KR

    更新日期:2004-05-01 00:00:00

  • Effect of acute and chronic captopril infusion on blood pressure in the two-kidney, one clip hypertensive rat.

    abstract::The effect on blood pressure (BP) of acute and chronic suppression of angiotensin (ANG) II was studied in the two-kidney, one clip hypertensive rat. Conscious, chronically catheterized rats were given a bolus injection of captopril (2.5 mg/kg) followed by a chronic infusion of either dextrose or captopril (1 mg/kg per...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198512000-00006

    authors: Wallace EC,Balmforth AJ,Morton JJ

    更新日期:1985-12-01 00:00:00

  • Congenital defects and early childhood outcomes following in-utero exposure to antihypertensive medication.

    abstract:BACKGROUND:Hypertensive disorders during pregnancy are an important risk to mother and fetus, frequently necessitating antihypertensive treatment. Data describing the safety of in-utero exposure to antihypertensive treatment is conflicting with many studies suffering from significant methodological issues. METHOD:We c...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002670

    authors: Fitton CA,Fleming M,Aucott L,Pell JP,Mackay DF,McLay JS

    更新日期:2020-10-09 00:00:00

  • Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner.

    abstract:BACKGROUND:Enhanced mechanical forces, e.g. in arterial hypertension, stimulate the formation of reactive oxygen species (ROS) by the NAD(P)H oxidase. Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282f09f79

    authors: Salguero G,Akin E,Templin C,Kotlarz D,Doerries C,Landmesser U,Grote K,Schieffer B

    更新日期:2008-02-01 00:00:00

  • Pulse rate reactivity in childhood as a risk factor for adult hypertension: the 1970 British cohort study.

    abstract:PURPOSE:Cardiovascular reactivity to mental stress has been used as a tool to predict short-term hypertension risk in adults but the impact of cardiovascular reactivity in childhood on hypertension in adulthood is unknown. Using the 1970 British Cohort study, we examined the association between pulse rate reactivity in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001023

    authors: Hamer M,Kivimäki M,Batty GD

    更新日期:2016-09-01 00:00:00

  • The aldosterone-renin ratio based on the plasma renin activity and the direct renin assay for diagnosing aldosterone-producing adenoma.

    abstract:BACKGROUND:The screening for primary aldosteronism is based on the aldosterone-renin ratio calculated with the plasma renin activity (PRA) value as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains unclear. METHOD:We, therefore compar...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833d2192

    authors: Rossi GP,Barisa M,Belfiore A,Desideri G,Ferri C,Letizia C,Maccario M,Morganti A,Palumbo G,Patalano A,Roman E,Seccia TM,Pessina AC,Mantero F,PAPY study Investigators.

    更新日期:2010-09-01 00:00:00

  • Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension.

    abstract:OBJECTIVE:Angiotensin (Ang) II increases reactive oxygen species (ROS), decreases nitric oxide (NO) bioavailability and promotes cardiovascular remodeling. ROS have been identified as critical second messengers of the trophic responses by Ang II. In rats with Ang II-induced hypertension, we investigated the role of ROS...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000179513.71018.09

    authors: Zhou MS,Jaimes EA,Raij L

    更新日期:2005-09-01 00:00:00

  • Complications and survival of 315 patients with malignant-phase hypertension.

    abstract:OBJECTIVE:To investigate the factors affecting survival in patients with malignant hypertension by analysing the prognosis of all of the patients referred to the City Hospital, Birmingham, with malignant hypertension since 1965. RESULTS:We identified 315 patients with malignant hypertension (211 men, 104 women; mean a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199508000-00013

    authors: Lip GY,Beevers M,Beevers DG

    更新日期:1995-08-01 00:00:00

  • Adrenocorticotrophin dose-response relationships in the rat: haemodynamic, metabolic and hormonal effects.

    abstract:OBJECTIVE:To determine adrenocorticotrophin dose-response relationships for increase of blood pressure and metabolic parameters of the Sprague-Dawley rat. METHODS:We injected 120 male Sprague-Dawley rats twice daily subcutaneously for 10 days with 0.5, 1, 5, 50, 100, 200 or 500 microg/kg synthetic adrenocorticotrophin...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816050-00006

    authors: Turner SW,Wen C,Li M,Fraser TB,Whitworth JA

    更新日期:1998-05-01 00:00:00

  • Noninvasive estimation of central blood pressure and the augmentation index in the seated position: a validation study of two commercially available methods.

    abstract:OBJECTIVES:The aim of this study was to examine the utility of the generalized transfer function (GTF) and the late systolic shoulder of the radial pressure waveform (SBP2) for estimating seated central systolic blood pressure (c-SBP) and seated c-augmentation index (c-AIx). METHODS:In 199 participants (182 cardiovasc...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835c1d45

    authors: Hirata K,Kojima I,Momomura S

    更新日期:2013-03-01 00:00:00

  • Kinetic properties of erythrocyte Na+-Li+ and Na+-H+ exchange in hypertensive patients.

    abstract:OBJECTIVE:To ascertain the relationships between the kinetic properties of erythrocyte Na+-H+ exchange [maximum kinetic energy (Vmax), Michaelis constant (Km) for internal H+ and Hill's coefficient], Na+-Li+ (Vmax and Km for external Na+), and metabolic parameters in normotensive controls and hypertensive subjects. MA...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Semplicini A,Ceolotto G,Felice M,Reato S,Valle R,Gebbin A,Fontebasso A,Serena L,Pessina AC

    更新日期:1995-12-01 00:00:00

  • Brain and atrial natriuretic peptides: a dual peptide system of potential importance in sodium balance and blood pressure regulation in patients with essential hypertension.

    abstract:OBJECTIVE:To examine the changes in plasma brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and blood pressure in patients with essential hypertension on a low, normal and high sodium intake. DESIGN AND METHODS:Twelve patients with mild-to-moderate essential hypertension were studied. Plasma, urinary ...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Buckley MG,Markandu ND,Sagnella GA,MacGregor GA

    更新日期:1994-07-01 00:00:00

  • Anthropometric and lifestyle factors associated with white-coat, masked and sustained hypertension in a Chinese population.

    abstract:OBJECTIVE:We investigated to what extent anthropometric and lifestyle factors contributed to the classification of Chinese individuals into groups with white-coat, masked and sustained hypertension (HT). METHODS:We measured the office and ambulatory blood pressure (BP) in 694 Chinese enrolled in the JingNing populatio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282efeee7

    authors: Wang GL,Li Y,Staessen JA,Lu L,Wang JG

    更新日期:2007-12-01 00:00:00

  • Night-time heart rate nondipping: clinical and prognostic significance in the general population.

    abstract:AIM:Studies addressing the association between a reduced drop of heart rate (HR) at night with subclinical organ damage and cardiovascular events in the general population are scanty. We evaluated this issue in individuals enrolled in the Pressioni Monitorate E Loro Associazioni study. METHODS:At entry, 2021 individua...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001703

    authors: Cuspidi C,Facchetti R,Bombelli M,Sala C,Tadic M,Grassi G,Mancia G

    更新日期:2018-06-01 00:00:00

  • The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse.

    abstract:BACKGROUND:Lacidipine is a widely used calcium-channel blocker, which has both long-lasting antihypertensive activity and also antioxidant properties. Previous studies have demonstrated the ability of lacidipine to reduce the development of atherosclerotic lesions in several animal models. OBJECTIVE:The present study ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018100-00010

    authors: Cristofori P,Lanzoni A,Quartaroli M,Pastorino AM,Zancanaro C,Cominacini L,Gaviraghi G,Turton J

    更新日期:2000-10-01 00:00:00

  • Cardiovascular responsivity to stress in adolescents with and without persistently elevated blood pressure.

    abstract:OBJECTIVES:The goal of this study was to compare the cardiovascular responses to behavioural stressors of three groups of adolescents who differed in blood pressure status across assessments. DESIGN:Casual blood pressure of adolescents who were identified as having elevated blood pressure during a school screen was re...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200101000-00003

    authors: Saab PG,Llabre MM,Ma M,DiLillo V,McCalla JR,Fernander-Scott A,Copen R,Gellman M,Schneiderman N

    更新日期:2001-01-01 00:00:00

  • Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.

    abstract:OBJECTIVE:We aimed to test whether eight common recently identified single-nucleotide polymorphisms (SNPs), strongly associated with blood pressure (BP) in the population, also have impact on the degree of BP reduction by antihypertensive agents with different mechanisms. METHODS:In 3863 Swedish hypertensive patients,...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283536338

    authors: Hamrefors V,Sjögren M,Almgren P,Wahlstrand B,Kjeldsen S,Hedner T,Melander O

    更新日期:2012-06-01 00:00:00

  • Enhanced sympathoadrenal reactivity to haemorrhagic stress in DOCA-salt hypertensive rats.

    abstract::The effect of haemorrhagic hypotension on plasma catecholamine levels was studied in anesthetized normotensive and DOCA-salt hypertensive rats. The basal levels of plasma norepinephrine (NE) were significantly higher in DOCA-salt hypertensive rats than in normotensive rats. Moreover, the elevations in plasma NE and ep...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198903000-00011

    authors: Drolet G,Bouvier M,de Champlain J

    更新日期:1989-03-01 00:00:00

  • Carotid intima-media thickness and coronary heart disease risk factors in a low-risk population.

    abstract:OBJECTIVE:Coronary heart disease (CHD) risk factors have been consistently related to an increase in carotid intima-media thickness (IMT) in selected populations. However, few studies were population-based and furthermore little attention has been given to the influence of CHD risk factors on IMT in low-risk population...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917060-00004

    authors: Ferrières J,Elias A,Ruidavets JB,Cantet C,Bongard V,Fauvel J,Boccalon H

    更新日期:1999-06-01 00:00:00

  • 125I-Angiotensin II binding to human blood cells.

    abstract::The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198504000-00004

    authors: Mann JF,Sis J,Ritz E

    更新日期:1985-04-01 00:00:00

  • Renal angioplasty: better for treating hypertension or for rescuing renal function?

    abstract::Angioplasty of renal artery stenosis has been used extensively in the last two decades for treating renovascular hypertension, and, more recently, for preserving the jeopardized renal function. A large body of evidence has accumulated indicating that this approach is by far the most convenient for patients with fibrom...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199917120-00001

    authors: Morganti A

    更新日期:1999-12-01 00:00:00

  • The spectrum of circadian blood pressure changes in type I diabetic patients.

    abstract:BACKGROUND:The objective of the present study was to characterize the spectrum of circadian blood pressure changes in type I diabetes at different stages of nephropathy by using two monitorings in each patient in order to avoid intra-individual variability. PATIENTS AND METHODS:A total of 80 type I diabetic subjects a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200108000-00010

    authors: Lurbe E,Redon J,Pascual JM,Tacons J,Alvarez V

    更新日期:2001-08-01 00:00:00

  • Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study.

    abstract:OBJECTIVE:Primary aldosteronism (PA) is characterized by the onset of both cardiac and gluco-metabolic alterations. The aim of this study was to evaluate the impact of aldosterone excess on the development of such complications, and the effects of surgical and pharmacological treatment on their long-term outcome. METH...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3280108e6f

    authors: Giacchetti G,Ronconi V,Turchi F,Agostinelli L,Mantero F,Rilli S,Boscaro M

    更新日期:2007-01-01 00:00:00

  • Predictors for profound blood pressure response in patients undergoing renal sympathetic denervation.

    abstract:BACKGROUND:Renal sympathetic denervation (RDN) as treatment for hypertension shows highly variable results. Although some patients do not show any blood pressure (BP) change and in most patients a BP reduction of at least 5 mmHg can be found, some show a reduction at least 20 mmHg. We sought to identify predictors for ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001739

    authors: Fengler K,Rommel KP,Blazek S,von Roeder M,Besler C,Hartung P,Desch S,Thiele H,Lurz P

    更新日期:2018-07-01 00:00:00

  • Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh, Michigan.

    abstract:OBJECTIVE:To investigate the relationship between hematocrit, blood pressure and other known cardiovascular risk factors. DESIGN:The Tecumseh Blood Pressure Study includes a cohort of subjects of average age 29.5 years (346 male, 277 female) who reside in Tecumseh, Michigan, USA. METHODS:The body weight; home, work a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Smith S,Julius S,Jamerson K,Amerena J,Schork N

    更新日期:1994-04-01 00:00:00