Predictors for profound blood pressure response in patients undergoing renal sympathetic denervation.

Abstract:

BACKGROUND:Renal sympathetic denervation (RDN) as treatment for hypertension shows highly variable results. Although some patients do not show any blood pressure (BP) change and in most patients a BP reduction of at least 5 mmHg can be found, some show a reduction at least 20 mmHg. We sought to identify predictors for such a profound BP response. METHODS:Profound BP response was defined as drop of at least 20 mmHg in daytime systolic ambulatory BP measurement (ABPM) 3 months after catheter-based RDN. Three different denervation devices were used for RDN, and pulse wave velocity was determined invasively in a subgroup of patients. RESULTS:One hundred and ninety consecutive patients were included in this analysis. Profound BP response was found in 33 patients. Patients with profound BP response were younger (P = 0.04), presented with higher baseline ABPM values (P < 0.001), were treated with ultrasound-based RDN and received more often a combined treatment with two different diuretics (P = 0.005 for both). After 3 months, a treatment target of daytime BP less than 135 mmHg could be achieved more frequently in patients with profound BP response (61 vs. 17%, P < 0.001). Age, use of ultrasound RDN, combined diuretic therapy and baseline BP independently predicted pronounced BP reduction. A second multivariate logistic regression model including pulse wave velocity if available identified baseline BP, pulse wave velocity and use of ultrasound denervation as independent predictors for profound BP response. CONCLUSION:Younger vascular age, higher baseline BP, treatment with ultrasound RDN and combined diuretic therapy were found as predictors for a pronounced BP reduction following RDN, improving BP control at follow-up.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Fengler K,Rommel KP,Blazek S,von Roeder M,Besler C,Hartung P,Desch S,Thiele H,Lurz P

doi

10.1097/HJH.0000000000001739

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1578-1584

issue

7

eissn

0263-6352

issn

1473-5598

journal_volume

36

pub_type

杂志文章
  • Repeated administration of inorganic nitrate on blood pressure and arterial stiffness: a systematic review and meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arteri...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002524

    authors: Li D,Nishi SK,Jovanovski E,Zurbau A,Komishon A,Mejia SB,Khan TA,Sievenpiper JL,Milicic D,Jenkins A,Vuksan V

    更新日期:2020-11-01 00:00:00

  • Cardiovascular responsivity to stress in adolescents with and without persistently elevated blood pressure.

    abstract:OBJECTIVES:The goal of this study was to compare the cardiovascular responses to behavioural stressors of three groups of adolescents who differed in blood pressure status across assessments. DESIGN:Casual blood pressure of adolescents who were identified as having elevated blood pressure during a school screen was re...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200101000-00003

    authors: Saab PG,Llabre MM,Ma M,DiLillo V,McCalla JR,Fernander-Scott A,Copen R,Gellman M,Schneiderman N

    更新日期:2001-01-01 00:00:00

  • Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats.

    abstract:OBJECTIVE:To examine a possible involvement of a regulatory protein of Na+/H+ exchanger (NHE) in the increased renal NHE activity in spontaneously hypertensive rats (SHR), we investigated mRNA expression of inhibitory members of the NHE regulatory protein family, NHERF1 and NHERF2, in the kidney. DESIGN:Prehypertensiv...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200409000-00016

    authors: Kobayashi K,Monkawa T,Hayashi M,Saruta T

    更新日期:2004-09-01 00:00:00

  • Immunoreactive endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels.

    abstract:OBJECTIVE:To investigate the role of ouabain in human hypertension and to establish whether immunoreactive endogenous ouabain is secreted by the adrenal gland under the influence of dopaminergic regulation. METHODS:We measured plasma levels of endogenous ouabain by immunoassay, together with other variables, including...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199510000-00013

    authors: Rossi G,Manunta P,Hamlyn JM,Pavan E,De Toni R,Semplicini A,Pessina AC

    更新日期:1995-10-01 00:00:00

  • The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveform.

    abstract:BACKGROUND:Recent evidence suggests that central aortic blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central SBP (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform. We compared the second systolic peak of the radial waveform (pSBP(...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e32832e0b58

    authors: Hickson SS,Butlin M,Mir FA,Graggaber J,Cheriyan J,Khan F,Grace AA,Yasmin,Cockcroft JR,Wilkinson IB,McEniery CM,Anglo-Cardiff Collaboration Trial Investigators.

    更新日期:2009-09-01 00:00:00

  • Angiotensin II type 2 receptor mediates sex differences in mice renal interlobar arteries response to angiotensin II.

    abstract:OBJECTIVE:Functional sex differences are described in several vascular beds. In the case of renal vessels, sex differences could influence processes like regulation of blood pressure and ion balance. Angiotensin II and nitric oxide are important regulators of renal vascular tone. Females have higher nitric oxide syntha...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835731dd

    authors: Viegas VU,Liu ZZ,Nikitina T,Perlewitz A,Zavaritskaya O,Schlichting J,Persson PB,Regitz-Zagrosek V,Patzak A,Sendeski MM

    更新日期:2012-09-01 00:00:00

  • Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease - the SFC BP multicentre study in China.

    abstract:OBJECTIVES:Cardiovascular dysautonomia can be present at early, late and even prodromal stages of Parkinson's disease. This study aimed to describe the characteristics of 24-h ambulatory blood pressure (BP) monitoring and investigate the frequency of cardiovascular dysautonomia in Parkinson's disease without an abnorma...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002536

    authors: Chen SW,Wang YK,Dou RH,Xie XY,Hu YB,Ding N,Zhang GH,Jing HF,Zhao WD,Xue Y,Li Y,Wang G

    更新日期:2020-11-01 00:00:00

  • Blood pressure in professional male football players in Norway.

    abstract:OBJECTIVES:Scarce data exist on blood pressure (BP) and secondary effects in young athletes. Hence, we aimed to study prevalence of high BP (≥140/90 mmHg) and the association to arterial compliance, left ventricle mass and left atrium volume. METHODS:A Norwegian preparticipation cardiac screening of male professional ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835eb5fe

    authors: Berge HM,Gjerdalen GF,Andersen TE,Solberg EE,Steine K

    更新日期:2013-04-01 00:00:00

  • Age-related changes in neuropeptide Y immunoreactivity (NPY-ir) in the cortex and spinal cord of spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats.

    abstract::The concentrations of neuropeptide Y immunoreactivity (NPY-ir) were measured in the cortex and cervical, thoracic and lumbar spinal cord of 8-, 18- and 31-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). This peptide was measured using a highly sensitive and specific radio-immun...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198608000-00012

    authors: Maccarrone C,Jarrott B

    更新日期:1986-08-01 00:00:00

  • Long-term effects of antihypertensive therapy on cardiovascular events and new-onset diabetes mellitus in high-risk hypertensive patients in Japan.

    abstract:OBJECTIVE:During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year fol...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001780

    authors: Liu J,Yasuno S,Oba K,Konda M,Ichihara C,Kitao H,Kuwabara Y,Ueshima K

    更新日期:2018-09-01 00:00:00

  • Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study.

    abstract:BACKGROUND:Nitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension. OBJECTIVE:To look for linkage and association of three di-allelic polymorphisms (Glu298Asp...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000163144.74588.ad

    authors: Persu A,Vinck WJ,El Khattabi O,Janssen RG,Paulussen AD,Devuyst O,Vlietinck R,Fagard RH

    更新日期:2005-04-01 00:00:00

  • Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension.

    abstract:OBJECTIVE:Hypertension is a major risk factor for cardiovascular disease. Polymorphism in the beta2-adrenergic receptor (ADRB2) and nitric oxide synthase 3 (NOS3) genes is associated with clinical cardiovascular phenotypes. The Arg16Gly and Glu298Asp polymorphisms of ADRB2 and NOS3 genes, respectively, have been report...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32832b7ead

    authors: Misono M,Maeda S,Iemitsu M,Nakata Y,Otsuki T,Sugawara J,Zempo H,Yoshizawa M,Miyaki A,Kuno S,Matsuda M,Ajisaka R

    更新日期:2009-07-01 00:00:00

  • Effects of prolonged and brief infusions of noradrenaline on arterial pressure and on the plasma concentrations of active renin, angiotensin II, aldosterone and potassium.

    abstract::Conscious male beagle dogs were given constant intravenous infusions of noradrenaline for 14 days, four receiving 125 ng/kg/min and four 250 ng/kg/min. Before, during and after these infusions dose-response studies were done in which additional noradrenaline was infused at 500, 1000 and 2000 ng/kg/min, each rate for 1...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Casals-Stenzel J,Tree M,Brown JJ,Fraser R,Lever AF,Millar JA,Morton JJ,Robertson JI,Reid JL,Hamilton C

    更新日期:1983-06-01 00:00:00

  • Genetic heterogeneity of familial hyperkalaemic hypertension.

    abstract:BACKGROUND:Familial hyperkalaemic hypertension (FHH) is a Mendelian form of low-renin hypertension characterized by hyperkalaemia and hyperchloraemic acidosis despite a normal glomerular filtration rate. To date, three different loci have been identified, on chromosomes 1, 17 and 12. OBJECTIVE:To test for genetic link...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200111000-00005

    authors: Disse-Nicodeme S,Desitter I,Fiquet-Kempf B,Houot AM,Stern N,Delahousse M,Potier J,Ader JL,Jeunemaitre X

    更新日期:2001-11-01 00:00:00

  • Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.

    abstract:BACKGROUND:Elevated plasma glucocorticoid level is an independent predictor of increased mortality risk in chronic heart failure, but local biosynthesis and pathophysiological roles of glucocorticoids in the heart remain unclear. METHODS:Dahl salt-sensitive rats on high-salt diet and mice with transthoracic aortic ban...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328326cb04

    authors: Ohtani T,Mano T,Hikoso S,Sakata Y,Nishio M,Takeda Y,Otsu K,Miwa T,Masuyama T,Hori M,Yamamoto K

    更新日期:2009-05-01 00:00:00

  • Withdrawal of hormonal therapy for 4 weeks decreases arterial compliance in postmenopausal women.

    abstract:BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917030-00015

    authors: Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

    更新日期:1999-03-01 00:00:00

  • Vascular albumin permeability and hypertrophy in a rat model combining streptozotocin-induced diabetes and genetic hypertension.

    abstract:OBJECTIVE:To investigate the effects of hypertension and diabetes mellitus on vascular albumin permeability and hypertrophy in 11-week-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with and without 3 weeks of streptozotocin-induced diabetes. METHODS:Vascular albumin permeability was measured as...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199505000-00008

    authors: Hulthén UL,Rumble J,Cooper ME,Johnston CI

    更新日期:1995-05-01 00:00:00

  • Interactions between metallopeptidase 3 polymorphism rs679620 and BMI in predicting blood pressure in African-American women with hypertension.

    abstract::BMI represents an internal metabolic and physiological environment that plays a key role in development of high blood pressure (BP) for many Americans. African-American women have a higher prevalence of high BP and being overweight than men or other ethnic groups. This study examines the genetic-environmental interact...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283110402

    authors: Taylor J,Sun YV,Chu J,Mosley TH,Kardia SL

    更新日期:2008-12-01 00:00:00

  • Nailfold capillary density in salt-sensitive and salt-resistant borderline hypertension.

    abstract:OBJECTIVE:Nailfold capillary density was measured at rest and after 4 min circulatory arrest in order to investigate the relationship between sodium-sensitive hypertension and microvessel density. DESIGN:Seventeen sodium-sensitive and 28 sodium-resistant young borderline hypertensive males and 10 normotensive controls...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Draaijer P,de Leeuw PW,van Hooff JP,Leunissen KM

    更新日期:1993-11-01 00:00:00

  • Sex difference of the prevalence and risk factors associated with prehypertension among urban Chinese adults from 33 communities of China: the CHPSNE study.

    abstract:BACKGROUND:As a new category of blood pressure (BP) classification according to the Seventh Report of The Joint National Committee, prehypertension has aroused people's great concern in recent years due to its associations with increased incidence of cardiovascular disease. However, there is little information about th...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32834f9dd3

    authors: Dong GH,Wang D,Liu MM,Liu YQ,Zhao Y,Yang M,Meng XJ,Tian S,Meng X,Zhang HY

    更新日期:2012-03-01 00:00:00

  • 125I-Angiotensin II binding to human blood cells.

    abstract::The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198504000-00004

    authors: Mann JF,Sis J,Ritz E

    更新日期:1985-04-01 00:00:00

  • A major difference of kallikrein-binding protein in spontaneously hypertensive versus normotensive rats.

    abstract::A unique tissue kallikrein-binding protein was identified and partially characterized in the brain and serum of Sprague-Dawley rats and in the serum-free conditioned media of mouse anterior pituitary cells (AtT 20) and rodent neuroblastoma x glioma hybrids (NG108-15). Kallikrein and kallikrein-binding protein(s) form ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198807000-00006

    authors: Chao J,Chao L

    更新日期:1988-07-01 00:00:00

  • Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase.

    abstract:OBJECTIVE:Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide family, is involved in maintaining circulatory homeostasis and is a protective factor of heart and vessel. Here, we investigated the effects of IMD on cardiac hypertrophy in vivo and in vitro and explored the mechanisms involve...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000597

    authors: Lu WW,Zhao L,Zhang JS,Hou YL,Yu YR,Jia MZ,Tang CS,Qi YF

    更新日期:2015-08-01 00:00:00

  • The spectrum of circadian blood pressure changes in type I diabetic patients.

    abstract:BACKGROUND:The objective of the present study was to characterize the spectrum of circadian blood pressure changes in type I diabetes at different stages of nephropathy by using two monitorings in each patient in order to avoid intra-individual variability. PATIENTS AND METHODS:A total of 80 type I diabetic subjects a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200108000-00010

    authors: Lurbe E,Redon J,Pascual JM,Tacons J,Alvarez V

    更新日期:2001-08-01 00:00:00

  • Aortic dilatation in Marfan syndrome: role of arterial stiffness and fibrillin-1 variants.

    abstract:OBJECTIVE:Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this observational study, we evaluated aortic stiffness in MFS and its association with ascending aorta diameters and fibrillin-1 genotype. METHODS:A ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001512

    authors: Salvi P,Grillo A,Marelli S,Gao L,Salvi L,Viecca M,Di Blasio AM,Carretta R,Pini A,Parati G

    更新日期:2018-01-01 00:00:00

  • Impact of vascular aging on cardiovascular disease: the role of telomere biology.

    abstract::Cardiovascular risk increases with chronological as well as biological aging, and one marker of this might be telomere length. The telomere cap is located at the end of the DNA helix and serves to protect its end. This is an evolutionary adaptation which has resulted in stabilization of the DNA strand within the chrom...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e328353e512

    authors: Nilsson PM

    更新日期:2012-06-01 00:00:00

  • Variation in cuff blood pressure in untreated outpatients with mild hypertension--implications for initiating antihypertensive treatment.

    abstract::Thirty-two patients with mildly elevated blood pressure (BP), but without target organ damage, attended a BP measuring clinic where duplicate BP measurements were made on 12 visits. During visits 1-3, BP showed a systematic decrease which varied from patient to patient. During visits 4-12, no further systematic change...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198704000-00012

    authors: Watson RD,Lumb R,Young MA,Stallard TJ,Davies P,Littler WA

    更新日期:1987-04-01 00:00:00

  • Influence of irbesartan and enalapril on changes of renal function associated with the established phase of l-NAME hypertension.

    abstract:OBJECTIVE:Reversibility of the systemic and renal alterations induced by N(omega)-nitro-L-arginine-methyl ester(L-NAME) was assessed by treatment with irbesartan and enalapril (30 and 10 mg/kg per 24 h, respectively) alone or in combination. DESIGN:L-NAME (20 mg/kg per 24 h) was given to rats for 6 weeks and treatment...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200111000-00015

    authors: Jover B,Herizi A,Casellas D,Mimran A

    更新日期:2001-11-01 00:00:00

  • Optimal schedule for home blood pressure monitoring based on a clinical approach.

    abstract:OBJECTIVE:The aim of this study was to determine the optimal schedule for home blood pressure (HBP) measurement based on a clinical approach. METHODS:Four hundred and sixty-four participants underwent HBP measurement for 7 days (duplicate measurements in the morning and in the evening), ambulatory blood pressure (ABP)...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328332fa5e

    authors: Johansson JK,Niiranen TJ,Puukka PJ,Jula AM

    更新日期:2010-02-01 00:00:00

  • Clinic-daytime blood pressure difference and cardiovascular damage.

    abstract:OBJECTIVE:To investigate whether the clinic-daytime blood pressure difference can provide information on vascular reactivity to stress comparable to that of simple noninvasive stimuli such as a cold pressor test and isometric exercise, and whether there is any relationship between this blood pressure difference and non...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917030-00005

    authors: Guida L,Iannuzzi R,Crivaro M,Gaeta I,Pasanisi F,Celentano A,Marotta T,Ferrara LA

    更新日期:1999-03-01 00:00:00