Carotid intima-media thickness and coronary heart disease risk factors in a low-risk population.

abstract：OBJECTIVE:Few data are available comparing the effects of monotherapy and combination therapy on target organ damage. The PICXEL study compared the efficacy of a strategy based on first-line combination with perindopril/indapamide versus monotherapy with enalapril in reducing left ventricular hypertrophy (LVH) in hyper...

journal_title：Journal of hypertension

authors： Dahlöf B,Gosse P,Guéret P,Dubourg O,de Simone G,Schmieder R,Karpov Y,García-Puig J,Matos L,De Leeuw PW,Degaute JP,Magometschnigg D,PICXEL Investigators.

更新日期：2005-11-01 00:00:00

abstract：:The cardiovascular responses to selective alpha 1- and alpha 2-adrenoceptor antagonism (with prazosin and idazoxan, respectively) were assessed in rats 4 weeks after unilateral nephro-adrenalectomy, contralateral adrenal enucleation and the provision of a 1% NaCl solution as drinking fluid (AEN rats) and in sham-opera...

journal_title：Journal of hypertension

authors： Foulkes R,Gardiner SM,Bennett T

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing hypertension in primary care. METHODS:Two hundred and forty-seven consecutive participants with raised (≥130 mmHg systolic) BP measured by their general practitioner from four primary care practices in...

journal_title：Journal of hypertension

authors： Nunan D,Thompson M,Heneghan CJ,Perera R,McManus RJ,Ward A

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To evaluate endothelium-dependent vascular function in obstructive sleep apnoea patients. DESIGN AND METHODS:Forearm blood flow and vascular resistance were studied in eight normotensives and eight obstructive sleep apnoea patients and also in eight normotensive and eight hypertensive controls after graded b...

journal_title：Journal of hypertension

authors： Carlson JT,Rångemark C,Hedner JA

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To audit the performances of the analytes used in the diagnosis of pheochromocytoma and to present a graphical guideline to help the diagnosis. DESIGN:A 5 year retrospective study. SETTINGS:Laboratory and departments of a university hospital. PARTICIPANTS:In-patients, suspected of bearing a pheochromocytom...

journal_title：Journal of hypertension

authors： Gardet V,Gatta B,Simonnet G,Tabarin A,Chêne G,Ducassou D,Corcuff JB

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The aldosterone synthase gene (CYP1B2) locus is a candidate region involved in the development of hypertension. OBJECTIVE:To study the relationship between the C-344T CYP1B2 polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population. DESIGN:Population-based, cross-sect...

journal_title：Journal of hypertension

authors： Barbato A,Russo P,Siani A,Folkerd EJ,Miller MA,Venezia A,Grimaldi C,Strazzullo P,Cappuccio FP

更新日期：2004-10-01 00:00:00

abstract：:The relationships between five erythrocyte cation transport systems (Na(+)-K+ pump, Na(+)-K+ cotransport, Na(+)-Li+ countertransport and Na+ and K+ passive permeabilities) and plasma lipids (total plasma cholesterol, high-density lipoprotein cholesterol and triglycerides) were investigated in 129 male adult subjects w...

journal_title：Journal of hypertension

authors： Hajem S,Moreau T,Hannaert P,Lellouch J,Orssaud G,Huel G,Claude JR,Garay RP

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:To conduct a longitudinal evaluation of the central haemodynamic adaptations of normal pregnancy. METHODS:This was a prospective longitudinal study involving healthy, normotensive women who were having an uncomplicated, singleton pregnancy. Brachial and central SBP, DBP, mean arterial pressure (MAP), brachia...

journal_title：Journal of hypertension

authors： O' Callaghan KM,Hennessy Á,Malvisi L,Kiely M

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To determine whether automated blood pressure measuring devices can measure blood pressure accurately in patients with atrial fibrillation. DESIGN:Comparison of the accuracy of two electronic sphygmomanometers [Takeda UA-751 (Takeda) and Copal UA-251 (Copal)] and two ambulatory blood pressure monitors [Accut...

journal_title：Journal of hypertension

authors： Stewart MJ,Gough K,Padfield PL

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:The purposes of this study were: (1) to test whether intravenous infusion of norepinephrine can affect plasma dopamine levels; and (2) to explore to what extent dopamine-2 or alpha 2-receptors play a role in this response. DESIGN:Norepinephrine infusion in man was performed to test whether the increase in no...

journal_title：Journal of hypertension

authors： Musso NR,Gianrossi R,Vergassola C,Pende A,Ioverno A,Galbariggi G,Lotti G

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:An increased inter-arm SBP difference (IASBPD) is associated with mortality and cardiovascular events, as well as peripheral vascular disease, which is attributed to subclavian stenosis. The aim of the present study was to investigate the association between the IASBPD and incident chronic kidney disease (CKD...

journal_title：Journal of hypertension

authors： Kim GS,Byun YS,Lee HY,Jung IH,Rhee KJ,Kim BO

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:The rostral ventrolateral medulla (RVLM) of the brainstem and the paraventricular nucleus (PVN) of the hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance of excitatory and inhibitory inputs to the RVLM enhances central sympathetic outflow. Increased react...

journal_title：Journal of hypertension

authors： Nishihara M,Hirooka Y,Matsukawa R,Kishi T,Sunagawa K

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored. METHODS:We compared prevalence of brain infarcts, and severe white matter hyperintensitie...

journal_title：Journal of hypertension

authors： Shibata D,Tillin T,Beauchamp N,Heasman J,Hughes AD,Park C,Gedroyc W,Chaturvedi N

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:We hypothesized that downregulation of the antioxidant thioredoxin system contributes to oxidative stress in angiotensin II-induced hypertension. As oestrogen may protect against oxidative stress, we also evaluated whether the thioredoxin system, particularly in the heart, is differentially regulated between ...

journal_title：Journal of hypertension

authors： Ebrahimian T,He Y,Schiffrin EL,Touyz RM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Underlying pathophysiology of orthostatic hypotension has been poorly understood. We hypothesized that aortic pulse pressure (APP) reflecting aortic stiffness may be involved in the development of orthostatic hypotension. METHODS:A total of 200 patients (age 64.3 ± 10.9 years, 62.5% men) who underwent invasi...

journal_title：Journal of hypertension

authors： Chung J,Kim HL,Lim WH,Seo JB,Kim SH,Zo JH,Kim MA

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology. That ...

journal_title：Journal of hypertension

authors： Dell'Omo G,Penno G,Pucci L,Fotino C,Lucchesi D,Del Prato S,Pedrinelli R

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Aldosterone is produced in the ventricle of patients with hypertension. The present study was designed to examine whether adrenocorticotropic hormone (ACTH) and cortisol are also produced from the heart in patients with essential hypertension. METHODS:The study population consisted of 57 patients with essent...

journal_title：Journal of hypertension

authors： Mizuno Y,Yasue H,Yoshimura M,Harada E,Fujii H,Nakamura S,Yamamoto N,Ogawa H,Nakao K

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:The effect of nifedipine, a 1,4-dihydropyridine calcium antagonist, on the expression of monocyte chemoattractant protein 1 (MCP-1) induced by angiotensin II (Ang II) was examined using vascular smooth muscle cells (VSMC) isolated from rat thoracic aorta. METHODS AND RESULTS:Ang II increased the expression o...

journal_title：Journal of hypertension

authors： Wu L,Iwai M,Li Z,Li JM,Mogi M,Horiuchi M

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The existence and localization of renin in situ was examined in human arteries under non-pathological conditions. DESIGN:Biochemical and immunohistochemical procedures were adopted to examine the existence of renin in human gastroepiploic arteries using an antibody raised against human recombinant renin or a...

journal_title：Journal of hypertension

authors： Okamura T,Aimi Y,Kimura H,Murakami K,Toda N

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Hypertensive nephropathy is one of the major causes of chronic kidney disease (CKD). Bisphenol A (BPA) is associated with elevated blood pressure and urinary albuminuria. The aim of this study is to evaluate the association between serum BPA with the progression of CKD in patients with primary hypertension. ...

journal_title：Journal of hypertension

authors： Hu J,Wang Y,Xiang X,Peng C,Gao R,Goswami R,Zhou H,Zhang Y,Zhen Q,Cheng Q,Yang S,Li Q

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Excess oxidative stress is one of the major metabolic abnormalities on vascular walls in hypertension and atherosclerosis. In order to further elucidate the endothelial function under oxidative stress, the effect of hydrogen peroxide (H2O2) on expression of two novel endothelium-derived vasorelaxing peptides,...

journal_title：Journal of hypertension

authors： Chun TH,Itoh H,Saito T,Yamahara K,Doi K,Mori Y,Ogawa Y,Yamashita J,Tanaka T,Inoue M,Masatsugu K,Sawada N,Fukunaga Y,Nakao K

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To characterize an ATP-sensitive K+ channel at the single-channel and tissue level in the vascular smooth muscle of normotensive and genetically hypertensive rats. METHODS:Age- and sex-matched Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were used. Patch-clamp single-chann...

journal_title：Journal of hypertension

authors： Furspan PB,Webb RC

更新日期：1993-10-01 00:00:00

abstract：:To establish the role of angiotensin converting enzyme inhibitors in the management of hypertension in the elderly, 16 patients were treated with captopril in a randomized double-blind placebo-controlled cross-over study. Clinic blood pressure, ambulatory blood pressure, renal function and mental performance, with emp...

journal_title：Journal of hypertension

authors： Cox JP,Duggan J,O'Boyle CA,Mee F,Walsh JB,Coakley D,O'Brien E,O'Malley K

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:To determine whether 'slow pressor' hypertension from systemic angiotensin (Ang II) infusion was associated with renal vascular structural remodeling of the renal resistance vessels and glomerulus. METHODS:Ang II (4.5-10 ng/kg per min) or vehicle was infused for 10 days. Renal resistance vascular lumen chan...

journal_title：Journal of hypertension

authors： Edgley AJ,Kett MM,Anderson WP

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the role of transforming growth factor (TGF)-beta1 in the development of diabetes-associated mesenteric vascular hypertrophy and in the antitrophic effect of angiotensin converting enzyme inhibitors. DESIGN AND METHODS:Streptozotocin-induced diabetic and control Spragu...

journal_title：Journal of hypertension

authors： Rumble JR,Gilbert RE,Cox A,Wu L,Cooper ME

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:We attempted to determine a valid pharmacological approach for the control of high blood pressure in obese hypertensive patients using two antihypertensive agents with different pharmacological actions. DESIGN:Thirty-two obese hypertensive black women were randomly treated with chlorthalidone or clonidine to...

journal_title：Journal of hypertension

authors： Reisin E,Weed SG

更新日期：1992-05-01 00:00:00

abstract：CLINICAL STUDIES:In clinical renal transplantation studies, recipients of a renal graft from a donor with a genetic predisposition to hypertension had higher blood pressures and required more antihypertensive treatment than recipients of a renal graft from a normotensive donor. In addition, blood pressure normalization...

journal_title：Journal of hypertension

authors： Rettig R,Schmitt B,Pelzl B,Speck T

更新日期：1993-09-01 00:00:00

abstract：:Plasma atrial natriuretic peptide (ANP) concentrations were measured by both direct radio-immunoassay and with pre-extraction of the peptide from plasma using C18 reverse phase columns. Peptide concentrations were measured in normal subjects (including a group of eight volunteers who received an intravenous infusion o...

journal_title：Journal of hypertension

authors： Richards AM,Tonolo G,McIntyre GD,Leckie BJ,Robertson JI

更新日期：1987-04-01 00:00:00

abstract：:This study focuses on the relationship between some aspects of intra-erythrocytic sodium metabolism (intra-erythrocytic Na content, Na,Li-countertransport), blood pressure, and family history of hypertension, in a group of 84 randomly selected school children (45 males, 39 females). Na,Li-countertransport was signific...

journal_title：Journal of hypertension

authors： Trevisan M,Strazzullo P,Cappuccio FP,Di Muro MR,De Colle S,Franzese A,Iacone R,Krogh V

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:The Fas-Fas ligand (FasL) system is involved in apoptosis in many types of cells. Recently, the expression of FasL on endothelial cells was reported. FasL is cleaved by a metalloproteinase and released in serum as soluble FasL (sFasL). Vasoactive substances, including metalloproteinase, are modulated by endo...

journal_title：Journal of hypertension

authors： Okura T,Watanabe S,Jiang Y,Nakamura M,Takata Y,Yang ZH,Kohara K,Kitami Y,Hiwada K

更新日期：2002-05-01 00:00:00