A double-blind evaluation of captopril in elderly hypertensives.

Abstract:

:To establish the role of angiotensin converting enzyme inhibitors in the management of hypertension in the elderly, 16 patients were treated with captopril in a randomized double-blind placebo-controlled cross-over study. Clinic blood pressure, ambulatory blood pressure, renal function and mental performance, with emphasis on mood and psychological well-being, were assessed. Twelve patients, aged 73 (+/- 4.4) years, completed the study. The doses of captopril used were 50 mg (11 patients) and 25 mg (one patient) twice daily for 4 weeks. Mean (+/- s.e.m.) clinic sitting blood pressure during captopril therapy was significantly lower than during administration of placebo (172 +/- 4.5/83 +/- 25 versus 188 +/- 4.4/89 +/- 3.4 mmHg; P less than 0.001/P less than 0.05). Mean ambulatory blood pressure was also significantly lower on captopril treatment than during administration of placebo (166 +/- 5.3/87 +/- 1.6 versus 179 +/- 5.1/94 +/- 2.4 mmHg; P less than 0.02/P less than 0.02) and this effect was sustained over the dosing interval. Renal blood flow and mental performance were unaltered by treatment. Gastrointestinal discomfort occurred in two patients, one of whom was withdrawn and cough developed in one patient. We conclude that captopril is effective as monotherapy in lowering blood pressure in the elderly.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Cox JP,Duggan J,O'Boyle CA,Mee F,Walsh JB,Coakley D,O'Brien E,O'Malley K

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

299-303

issue

4

eissn

0263-6352

issn

1473-5598

journal_volume

7

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Turner MJ

    更新日期:2010-12-01 00:00:00

  • Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension.

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    authors: Preik M,Kelm M,Feelisch M,Strauer BE

    更新日期:1996-07-01 00:00:00

  • Clinical and biochemical criteria in the detection of renal artery stenosis.

    abstract:OBJECTIVE:To investigate methods to diagnose renal artery stenosis (RAS) among the general hypertensive population. METHODS:We studied the value of clinical and biochemical characteristics at the outpatient clinic to identify subjects with a renal artery narrowing of more than 50% of the luminal surface among 1047 hyp...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Bijlstra PJ,Postma CT,de Boo T,Thien T

    更新日期:1996-08-01 00:00:00

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    abstract::Neutrophils possess a plasma-membrane-bound reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which catalyzes superoxide (O2-) formation and is activated by a variety of stimuli. Recently, neutrophils of patients with essential hypertension (EHT) have been reported to generate O2- at rates up to four...

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    doi:10.1097/00004872-199102000-00008

    authors: Seifert R,Hilgenstock G,Fassbender M,Distler A

    更新日期:1991-02-01 00:00:00

  • Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Ganten U,Schröder G,Witt M,Zimmermann F,Ganten D,Stock G

    更新日期:1989-09-01 00:00:00

  • Neurotrophin 3 is increased in the spontaneously hypertensive rat.

    abstract:OBJECTIVE:To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations. METHODS:NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (...

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    pub_type: 杂志文章

    doi:10.1097/00004872-200112000-00019

    authors: Zhang SH,Rush RA

    更新日期:2001-12-01 00:00:00

  • 'Volume-expanded' hypertension: the effect of fluid overload and the role of the sympathetic nervous system in salt-dependent hypertension.

    abstract::It is widely believed that salt-dependent hypertension is induced and maintained by expansion of intravascular fluid volume resulting from excessive retention of sodium. The purpose of this brief article is to present a series of arguments in support of the thesis that volume overload per se does not raise the arteria...

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    doi:10.1097/HJH.0b013e32834f6de1

    authors: Gavras I,Gavras H

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  • Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: DeForrest JM,Scalese RJ,Oehl RS,Waldron TL,Mitch S,Brittain RJ,Free CA,Asaad M,Burkett D

    更新日期:1989-09-01 00:00:00

  • Home device-monitored sleep blood pressure reflects large artery stiffness: the Nagahama study.

    abstract:BACKGROUND:High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS:We pe...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002576

    authors: Tabara Y,Matsumoto T,Murase K,Setoh K,Kawaguchi T,Kosugi S,Nakayama T,Hirai T,Wakamura T,Chin K,Matsuda F,Nagahama study group.

    更新日期:2020-12-01 00:00:00

  • Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.

    abstract:OBJECTIVE:The objective of the present studies is to investigate if the enhanced expression of Gs alpha protein and their mRNA observed in various models of hypertensive rats is due to the expressed hypertrophy or hypertension. METHODS:Hypertension, in Sprague-Dawley rats was induced by the oral administration of the ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018080-00013

    authors: Di Fusco F,Anand-Srivastava MB

    更新日期:2000-08-01 00:00:00

  • Safety and feasibility of dobutamine and dipyridamole stress echocardiography in hypertensive patients.

    abstract:OBJECTIVES:To establish whether safety and feasibility of dobutamine and dipyridamole stress echocardiography are affected by history of hypertension. METHODS:Data on 2200 consecutive pharmacologic stress echocardiography (959 dobutamine and 1241 dipyridamole) performed between October 1990 and February 2001 at a sing...

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    pub_type: 杂志文章

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    authors: Cortigiani L,Zanetti L,Bigi R,Desideri A,Fiorentini C,Nannini E

    更新日期:2002-07-01 00:00:00

  • The predictive role of systolic, diastolic and mean blood pressures on cardiovascular and all causes of death.

    abstract::Systolic (SBP), diastolic (DBP) and mean [MBP = diastolic + 1/3 (systolic - diastolic)] blood pressures were compared as predictors of all causes of death (ALL) and of deaths from atherosclerotic cardiovascular disease (ACVD) in 2480 men, aged 40-59 years, belonging to three cohorts followed up for 20 years. Both univ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198907000-00011

    authors: Menotti A,Seccareccia F,Giampaoli S,Giuli B

    更新日期:1989-07-01 00:00:00

  • 45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension.

    abstract::Uptake of 45Ca was measured in rings of thoracic aorta from rabbits with hypertension, induced by cellophane perinephritis (Page hypertension: one-kidney, one wrap). Basal 45Ca uptake was increased significantly in the hypertensive group (sham: 100 +/- 3, hypertensive: 133 +/- 11 nmol/g wet weight, n = 6). 45Ca uptake...

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    pub_type: 杂志文章

    doi:10.1097/00004872-198712000-00013

    authors: Dong Y,Wadsworth RM

    更新日期:1987-12-01 00:00:00

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    更新日期:1990-10-01 00:00:00

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    authors: Temmar M,Watfa G,Joly L,Kearney-Schwartz A,Youcef M,Bensalah S,Mustapha Y,Salvi P,Gautier S,Safar M,Labat C,Benetos A

    更新日期:2013-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00004872-199917070-00003

    authors: Moore VM,Cockington RA,Ryan P,Robinson JS

    更新日期:1999-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328343ce32

    authors: Izzo R,de Simone G,Devereux RB,Giudice R,De Marco M,Cimmino CS,Vasta A,De Luca N,Trimarco B

    更新日期:2011-04-01 00:00:00

  • Angiotensin-converting enzyme inhibition restores endothelial but not medial connexin expression in hypertensive rats.

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    pub_type: 杂志文章

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    authors: Rummery NM,Grayson TH,Hill CE

    更新日期:2005-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1997-11-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2011-06-01 00:00:00

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    更新日期:2012-01-01 00:00:00

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    更新日期:2004-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2018-12-01 00:00:00

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    更新日期:2009-06-01 00:00:00

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    doi:10.1097/00004872-198704000-00014

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    pub_type: 杂志文章,多中心研究,随机对照试验

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