Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function.

Abstract:

:The purpose of the present study was to characterize the etiology of bilateral perinephritis hypertension in the non-human primate. Hypertension was induced in female cynomolgus (Macaca fascicularis) monkeys by wrapping both kidneys under sterile surgical procedures. Mean arterial pressure (MAP), plasma renin activity (PRA), plasma aldosterone concentration (ALDO), para-aminohippurate (PAH) clearance, glomerular filtration rate (GFR), urine volume, and sodium and potassium excretion were measured before and weekly after induction of the hypertension. MAP increased progressively from 108 +/- 1 to 135 +/- 4 mmHg during the first 6 weeks; thereafter, MAP remained at this elevated level, PRA was elevated two- to fivefold for up to 10 weeks after the hypertension and ALDO was elevated during 1 (139%), 4 (60%), 6 (196%), 8 (249%) and 10 (148%) weeks of the hypertension. PAH clearance and GFR were significantly reduced during week 1 of the hypertension, but returned to control values by week 2. Urine volume was increased significantly during the first week of the hypertension, while sodium and potassium excretion were not changed. Captopril (15 mumol/kg, intravenously) normalized the blood pressure regardless of the severity or duration of the disease. Additionally, captopril lowered ALDO and increased PRA. It is concluded that bilateral perinephritis hypertension in the monkey is dependent on increased activity of the renin-angiotensin-aldosterone axis.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

DeForrest JM,Scalese RJ,Oehl RS,Waldron TL,Mitch S,Brittain RJ,Free CA,Asaad M,Burkett D

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

763-7

issue

9

eissn

0263-6352

issn

1473-5598

journal_volume

7

pub_type

杂志文章
  • Aortic arch mechanics measured with two-dimensional speckle tracking echocardiography.

    abstract:PURPOSE:To study the feasibility of vascular mechanics at the aortic arch with two-dimensional speckle tracking echocardiography, as well as to define normal values and to compare results between hypertensive patients and healthy patients. METHODS:We included 107 patients (61 healthy patients and 46 hypertensive patie...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001336

    authors: Teixeira R,Monteiro R,Baptista R,Pereira T,Ribeiro MA,Gonçalves A,Cardim N,Gonçalves L

    更新日期:2017-07-01 00:00:00

  • The prognostic value of blood pressure control delay in newly diagnosed hypertensive patients.

    abstract:OBJECTIVE:Various studies have suggested that a delay in the time between diagnosing hypertension and its correct control (D-C, diagnostic-control time) is linked to a worse prognosis. The aim of this study was to examine the relationship between D-C time and all-cause mortality, or the incidence of cardiovascular even...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001896

    authors: Martín-Fernández M,Vinyoles E,Real J,Soldevila N,Muñoz MÁ,Del-Val JL,Verdú JM,Domingo M,Mundet X

    更新日期:2019-02-01 00:00:00

  • Insulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake.

    abstract:OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00004872-200101000-00013

    authors: Raji A,Williams GH,Jeunemaitre X,Hopkins PN,Hunt SC,Hollenberg NK,Seely EW

    更新日期:2001-01-01 00:00:00

  • Morning blood pressure monitoring in the management of hypertension.

    abstract::: The aim of the current article is to review the current evidence on the role of morning blood pressure (BP) in the management of hypertension. Morning BP surge had been and will continue to be a hot topic of hypertension research. However, more evidence is needed to prove its clinical usefulness in the management of...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000001379

    authors: Wang JG,Kario K,Park JB,Chen CH

    更新日期:2017-08-01 00:00:00

  • Perspectives on hypertension's prevalence, treatment and control in a high cardiovascular risk East European country: data from the SEPHAR III survey.

    abstract:OBJECTIVES:To estimate the trend in arterial hypertension's prevalence, awareness, treatment, and control in Romania, starting from the latest national survey Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in Romania III that has a crucial importance for the development of prevention str...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001572

    authors: Dorobantu M,Tautu OF,Dimulescu D,Sinescu C,Gusbeth-Tatomir P,Arsenescu-Georgescu C,Mitu F,Lighezan D,Pop C,Babes K,Giuca A,Branza I,Udrescu M,Herdea V,Darabont R

    更新日期:2018-03-01 00:00:00

  • Noninvasive methods to assess pulse wave velocity: comparison with the invasive gold standard and relationship with organ damage.

    abstract:OBJECTIVES:To compare noninvasive methods to assess pulse wave velocity (PWV) with the invasive gold standard in terms of absolute values, age-related changes, and relationship with subclinical organ damage. METHODS:Invasive aortic PWV (aoPWVinv) was measured in 915 patients undergoing cardiac catheterization (mean ag...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000518

    authors: Weber T,Wassertheurer S,Hametner B,Parragh S,Eber B

    更新日期:2015-05-01 00:00:00

  • Blood pressure reduction and cardiovascular prevention: meta-regression using ordered categorical (ordinal) event data.

    abstract:BACKGROUND:Blood pressure (BP)-lowering trials studying efficacy mostly assesses binary outcome events, for example stroke/no stroke. Analysis of ordered categorical vascular events (e.g. three levels: fatal stroke/nonfatal stroke/no stroke) provides information on severity and is more powerful statistically than analy...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833c7a32

    authors: Geeganage CM,Tracy M,Bath MW,Bath PM

    更新日期:2010-10-01 00:00:00

  • Heart rate and blood pressure dependence of aortic distensibility in rats: comparison of measured and calculated pulse wave velocity.

    abstract:OBJECTIVES:When assessing arterial stiffness, heart rate (HR) and blood pressure (BP) are potential confounders. It appears that the HR/BP dependences of pulse wave velocity (PWV) and distensibility are different, even though both assess arterial stiffness. This study aims to compare aortic PWV as measured using pulse ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002608

    authors: Spronck B,Tan I,Reesink KD,Georgevsky D,Delhaas T,Avolio AP,Butlin M

    更新日期:2021-01-01 00:00:00

  • Rapid haemodynamic response to adrenocorticotrophin and the role of peripheral resistance in adrenocorticotrophin-induced hypertension in conscious sheep.

    abstract::The haemodynamic effects associated with the onset of hypertension induced by infusion of adrenocorticotrophin (ACTH) were investigated in sheep. Analysis of haemodynamic data collected over 24 h by a computer-based monitoring system revealed that mean arterial pressure (MAP) was significantly increased after 4 h. Car...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Spence CD,Brown A,Coghlan JP,Parkes DG,Whitworth JA,Scoggins BA

    更新日期:1989-04-01 00:00:00

  • Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension.

    abstract:OBJECTIVE:To assess the dilatory effectiveness of nitric oxide donors in resistance arteries of patients with arterial hypertension in comparison with that in those of normotensive controls. BACKGROUND:Endothelium-dependent vasodilation has been demonstrated to be impaired in arterial hypertension. Besides disturbance...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199607000-00014

    authors: Preik M,Kelm M,Feelisch M,Strauer BE

    更新日期:1996-07-01 00:00:00

  • Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.

    abstract:OBJECTIVE:Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in hypertension and the underlying mechanisms...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001654

    authors: Ling L,Chen D,Tong Y,Zang YH,Ren XS,Zhou H,Qi XH,Chen Q,Li YH,Kang YM,Zhu GQ

    更新日期:2018-05-01 00:00:00

  • Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.

    abstract:OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats with angiotensin II (ANG II)-dependent hypertension. METHODS:Ren-2 tra...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001708

    authors: Červenka L,Husková Z,Kopkan L,Kikerlová S,Sedláková L,Vaňourková Z,Alánová P,Kolář F,Hammock BD,Hwang SH,Imig JD,Falck JR,Sadowski J,Kompanowska-Jezierska E,Neckář J

    更新日期:2018-06-01 00:00:00

  • Superior hypertension control with betablockade in the European Sleep Apnea Database.

    abstract:AIMS:Arterial hypertension is highly prevalent and difficult to control in patients with obstructive sleep apnea (OSA). High sympathoadrenergic activity is a hallmark physiological phenomenon in OSA. We hypothesized that an antihypertensive drug with inhibitory properties on this activity, such as beta blockers (BBs), ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002629

    authors: Svedmyr S,Hedner J,Zou D,Parati G,Ryan S,Hein H,Pepin JL,Tkáčová R,Marrone O,Schiza S,Basoglu OK,Grote L,European Sleep Apnea Database (ESADA) study group.

    更新日期:2021-02-01 00:00:00

  • Predictive power of home blood pressure and clinic blood pressure in hypertensive patients with impaired glucose metabolism and diabetes.

    abstract:OBJECTIVES:We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD:The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blo...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/HJH.0b013e328361732c

    authors: Noguchi Y,Asayama K,Staessen JA,Inaba M,Ohkubo T,Hosaka M,Satoh M,Kamide K,Awata T,Katayama S,Imai Y,HOMED-BP study group.

    更新日期:2013-08-01 00:00:00

  • 45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension.

    abstract::Uptake of 45Ca was measured in rings of thoracic aorta from rabbits with hypertension, induced by cellophane perinephritis (Page hypertension: one-kidney, one wrap). Basal 45Ca uptake was increased significantly in the hypertensive group (sham: 100 +/- 3, hypertensive: 133 +/- 11 nmol/g wet weight, n = 6). 45Ca uptake...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198712000-00013

    authors: Dong Y,Wadsworth RM

    更新日期:1987-12-01 00:00:00

  • Weight status change from childhood to early adulthood and the risk of adult hypertension.

    abstract:OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002016

    authors: Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

    更新日期:2019-06-01 00:00:00

  • A method of quantifying retinal microvascular alterations associated with blood pressure and age.

    abstract:OBJECTIVE:To find an objective, sensitive method for quantifying microvascular alterations associated with level of blood pressure and age. DESIGN:A prospective cross-sectional study. SUBJECTS AND METHODS:Seventy-four previously untreated hypertensive patients, referred to a hospital outpatients department, and 26 no...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Stanton AV,Mullaney P,Mee F,O'Brien ET,O'Malley K

    更新日期:1995-01-01 00:00:00

  • Impaired expression of duodenal iron transporters in Dahl salt-sensitive heart failure rats.

    abstract:OBJECTIVE:Anemia is common in patients with heart failure and several factors have been thought to cause anemia in heart failure. Despite vigorous studies, the mechanism underlying the pathophysiology of anemia in heart failure is unknown. We investigated the iron regulating system in Dahl salt-sensitive heart failure ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283434784

    authors: Naito Y,Tsujino T,Fujimori Y,Sawada H,Akahori H,Hirotani S,Ohyanagi M,Masuyama T

    更新日期:2011-04-01 00:00:00

  • The smoothness index: a new, reproducible and clinically relevant measure of the homogeneity of the blood pressure reduction with treatment for hypertension.

    abstract:OBJECTIVE:To introduce a new method, the smoothness index, for assessing the homogeneity of 24 h blood pressure reduction by antihypertensive treatment and to compare it with the trough : peak ratio; and to assess the ability of both indices to predict a reduction in the left ventricular mass index induced by treatment...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199816110-00016

    authors: Parati G,Omboni S,Rizzoni D,Agabiti-Rosei E,Mancia G

    更新日期:1998-11-01 00:00:00

  • Blood pressure control and knowledge of target blood pressure in coronary patients across Europe: results from the EUROASPIRE III survey.

    abstract:BACKGROUND:Blood pressure management is a key issue among patients with coronary heart disease (CHD). The present study aimed to identify particular patient groups that may need to be specifically targeted in secondary prevention of CHD. METHODS:EUROASPIRE III is a cross-sectional study conducted in 2006-2007 among pa...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/HJH.0b013e328348efa7

    authors: Prugger C,Keil U,Wellmann J,de Bacquer D,de Backer G,Ambrosio GB,Reiner Z,Gaita D,Wood D,Kotseva K,Heidrich J,EUROASPIRE III Study Group.

    更新日期:2011-08-01 00:00:00

  • Linear periodization of strength training in blocks attenuates hypertension and diastolic dysfunction with normalization of myocardial collagen content in spontaneously hypertensive rats.

    abstract:BACKGROUND AND METHOD:This study evaluated the effects of a linear block strength training programme on the parameters of cardiac remodelling in spontaneously hypertensive rats. Thirty-nine rats were equally distributed in four groups: normotensive sedentary, normotensive trained, hypertensive sedentary and hypertensiv...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002188

    authors: Perilhão MS,Krause Neto W,da Silva AA,Alves LLS,Antonio EL,Medeiros A,Rica RL,Serra AJ,Tucci PJF,Bocalini DS

    更新日期:2020-01-01 00:00:00

  • Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity.

    abstract:OBJECTIVE:Based on results of in vitro studies, it has been hypothesized that blockade of the renin-angiotensin system (RAS) promotes the recruitment and differentiation of pre-adipocytes and that increased formation of small insulin-sensitive adipocytes counteracts ectopic deposition of lipids, thereby improving insul...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200410000-00021

    authors: Furuhashi M,Ura N,Takizawa H,Yoshida D,Moniwa N,Murakami H,Higashiura K,Shimamoto K

    更新日期:2004-10-01 00:00:00

  • Genetics of experimental hypertension.

    abstract::Experimental models of genetic hypertension are used to develop paradigms to study human essential hypertension while removing some of the complexity inherent in the study of human subjects. Since 1991 several quantitative trait loci responsible for blood pressure regulation have been identified in various rat crosses...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199816121-00003

    authors: Dominiczak AF,Clark JS,Jeffs B,Anderson NH,Negrin CD,Lee WK,Brosnan MJ

    更新日期:1998-12-01 00:00:00

  • Reproducibility of peripheral arterial tonometry for the assessment of endothelial function in adults.

    abstract:OBJECTIVES:Endothelial dysfunction is associated to cardiovascular risk factors and predicts cardiovascular events. Peripheral arterial tonometry (PAT) is a novel noninvasive method to assess endothelial function. However, there is a paucity of data about its reproducibility. The aim of this study was to assess the fea...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328362d913

    authors: Brant LC,Barreto SM,Passos VM,Ribeiro AL

    更新日期:2013-10-01 00:00:00

  • The effects of insulin and insulin-like materials in the brain on central cardiovascular regulation: with special reference to the central effects of sodium chloride.

    abstract::The present study investigated the roles of insulin on central cardiovascular regulation. When rats were fed with a high-salt diet for 4 weeks, hypothalamic and pituitary contents of insulin-like immunoreactive substance (ILI) significantly decreased. The plasma concentration of ILI remained unaltered, however. Intrac...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199106000-00006

    authors: Nishimura M,Takahashi H,Matsusawa M,Ikegaki I,Nakanishi T,Yoshimura M

    更新日期:1991-06-01 00:00:00

  • Sphygmomanometric and ambulatory blood pressures as forerunners of carotid and femoral intima-media thickness.

    abstract:OBJECTIVE:Studies directly comparing the associations of intima-media thickness with blood pressure (BP) on manual sphygmomanometric blood pressure measurement (SBPM) and 24-h ambulatory blood pressure measurement (ABPM) are scarce and have a cross-sectional design. METHODS:At baseline, we measured systolic and diasto...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328324ed6c

    authors: Dechering DG,Wizner B,Adiyaman A,Nawrot T,Jin Y,Richart T,Kuznetsova T,Struijker-Boudier HA,Thien T,Staessen JA

    更新日期:2009-04-01 00:00:00

  • Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertension.

    abstract:OBJECTIVE:Aldosterone is produced in the ventricle of patients with hypertension. The present study was designed to examine whether adrenocorticotropic hormone (ACTH) and cortisol are also produced from the heart in patients with essential hypertension. METHODS:The study population consisted of 57 patients with essent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200502000-00024

    authors: Mizuno Y,Yasue H,Yoshimura M,Harada E,Fujii H,Nakamura S,Yamamoto N,Ogawa H,Nakao K

    更新日期:2005-02-01 00:00:00

  • Blood pressure variability in subacute stage and risk of major vascular events in ischemic stroke survivors.

    abstract:BACKGROUND:We aimed to investigate whether blood pressure (BP) in the subacute stage of ischemic stroke affects subsequent vascular events after acute ischemic stroke. METHODS:From a prospective stroke registry database, consecutive ischemic stroke patients arriving within 48 h of onset were identified. The mean and S...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002126

    authors: Kang J,Kim BJ,Yang MH,Jang MS,Han MK,Lee JS,Gorelick PB,Lee J,Bae HJ

    更新日期:2019-10-01 00:00:00

  • Remodelling of the heart and vessels in experimental hypertension: advances in protection.

    abstract::Left ventricular hypertrophy (LVH), despite its adaptive nature, increases cardiovascular morbidity and mortality. Novel approaches for protection against pathological heart remodelling are presented in this supplement. Melatonin diminishes myocardial fibrosis in rats exposed to continuous light and N-nitro-L-arginine...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000388487.43460.db

    authors: Simko F,Pechanova O

    更新日期:2010-09-01 00:00:00

  • Myocardial Na,K-ATPase activity in rats with steroid and spontaneous hypertension.

    abstract::Vascular Na-K pump activity (ouabain-sensitive 86Rb uptake) and cardiac Na,K-ATPase activity are decreased in rats with one-kidney, one clip and reduced renal mass-saline hypertension. In the present study we measured left ventricular, microsomal Na,K-ATPase activity in rats with two steroid forms of hypertension; one...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198404000-00004

    authors: Clough DL,Pamnani MB,Haddy FJ

    更新日期:1984-04-01 00:00:00