Weight status change from childhood to early adulthood and the risk of adult hypertension.


OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from childhood to early adulthood and adult hypertension in the Chinese population. METHODS:Data were from the China Health and Nutrition Survey cohort study including 2095 participants who had at least one measurement of BMI and blood pressure (BP) in childhood (6-17 years) and in early adulthood (aged 18-37 years) between 1991 and 2011. Poisson regression model was used to assess the effect of weight status change from childhood to early adulthood on risk of adult hypertension. RESULTS:There were 235 participants (11.2%) with high BP in childhood and 114 participants (5.4%) with hypertension in early adulthood after a median follow-up of 11.0 years. Compared with normal weight in both childhood and early adulthood (n = 1604), relative risk (RR) of adult hypertension was 3.79 [95% confidence interval (CI) = 1.94-7.41] for overweight/obesity in both childhood and early adulthood (n = 79), and 3.75 (95% CI = 2.49-5.64) for normal weight in childhood but overweight/obesity in early adulthood (n = 301). In contrast, participants who were overweight/obese as children but had normal weight as adults (n = 111) had no increased risk of adult hypertension (RR = 1.05, 95% CI = 0.33-3.40). CONCLUSION:Overweight/obesity in early adulthood was associated with adult hypertension irrespective of weight status in childhood. In contrast, the risk of adult hypertension could be reversed if overweight/obese children become normal weight adults.


J Hypertens


Journal of hypertension


Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B




Has Abstract


2019-06-01 00:00:00












  • Aldosterone-to-renin ratio depends on age and sex in children attending a clinic for cardiovascular risk assessment.

    abstract:OBJECTIVE:To determine plasma aldosterone concentration (PAC) and plasma renin concentration (PRC) and aldosterone-to-renin ratio (ARR) values in a population attending a Clinic for Cardiovascular Risk Assessment in Children. METHODS:We assessed ARR and associated factors in a cohort of 287 children (137 female, 4-18 ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Genovesi S,Antolini L,Orlando A,Tassistro E,Giussani M,Nava E,Turolo L,Manolopoulou J,Parati G,Morganti A

    更新日期:2018-02-01 00:00:00

  • Varying patterns of the antihypertensive and antialbuminuric response to higher doses of renin-angiotensin-aldosterone system blockade in albuminuric hypertensive type 2 diabetes mellitus patients.

    abstract:OBJECTIVE:In patients with type 2 diabetes mellitus (T2DM), blocking of the renin-angiotensin-aldosterone system (RAAS) has demonstrated efficacy in lowering blood pressure (BP) and urinary albumin excretion rate (UAER). Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Weir MR,Hollenberg NK,Remuzzi G,Zappe DH,Meng X,Parving HH

    更新日期:2011-10-01 00:00:00

  • Existence of renin in the endothelium of human artery.

    abstract:OBJECTIVE:The existence and localization of renin in situ was examined in human arteries under non-pathological conditions. DESIGN:Biochemical and immunohistochemical procedures were adopted to examine the existence of renin in human gastroepiploic arteries using an antibody raised against human recombinant renin or a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Okamura T,Aimi Y,Kimura H,Murakami K,Toda N

    更新日期:1992-01-01 00:00:00

  • The interplay between haemodynamic load, brain natriuretic peptide and left atrial size in the early stages of essential hypertension.

    abstract:OBJECTIVE:Left atrial (LA) enlargement is an index of adverse cardiovascular events. We sought to investigate any possible correlation between haemodynamic load, neurohumoral factors and LA size in the early stages of essential hypertension. METHODS:We studied 94 consecutive middle-aged subjects, with newly diagnosed ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Tsioufis C,Stougiannos P,Taxiarchou E,Skiadas I,Chatzis D,Thomopoulos C,Lalos S,Stefanadis C,Kallikazaros I

    更新日期:2006-05-01 00:00:00

  • Evaluation of reproducibility of spontaneous baroreflex sensitivity at rest and during laboratory tests.

    abstract:OBJECTIVE:The aim of the present study was to examine the reproducibility of arterial baroreflex sensitivity (BRS) provided by the spontaneous baroreflex method at rest and during laboratory tests. METHODS:Twenty healthy volunteers were studied 24 h apart, in the same laboratory and under the same environmental condit...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Iellamo F,Legramante JM,Raimondi G,Castrucci F,Massaro M,Peruzzi G

    更新日期:1996-09-01 00:00:00

  • Neurotrophin 3 is increased in the spontaneously hypertensive rat.

    abstract:OBJECTIVE:To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations. METHODS:NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Zhang SH,Rush RA

    更新日期:2001-12-01 00:00:00

  • Differential associations of dietary sodium and potassium intake with blood pressure: a focus on pulse pressure.

    abstract:OBJECTIVE:Dietary sodium and potassium intakes are factors known to influence blood pressure (BP) through different pathways. These mechanisms likely result in differential effects on parameters characterizing BP. The aim of the study was to evaluate relationships between both sodium and potassium intake and all BP par...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Buyck JF,Blacher J,Kesse-Guyot E,Castetbon K,Galan P,Safar M,Hercberg S,Czernichow S

    更新日期:2009-06-01 00:00:00

  • Cardiovascular autonomic profile in women with constitutional hypotension.

    abstract:BACKGROUND:Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS:We investigated the autonomic cardiovascular control of 15 women w...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Jacob G,Barbic F,Glago M,Dipaola F,Porta A,Furlan R

    更新日期:2018-10-01 00:00:00

  • Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study.

    abstract:BACKGROUND:Nitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension. OBJECTIVE:To look for linkage and association of three di-allelic polymorphisms (Glu298Asp...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Persu A,Vinck WJ,El Khattabi O,Janssen RG,Paulussen AD,Devuyst O,Vlietinck R,Fagard RH

    更新日期:2005-04-01 00:00:00

  • Predictive power of home blood pressure and clinic blood pressure in hypertensive patients with impaired glucose metabolism and diabetes.

    abstract:OBJECTIVES:We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD:The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blo...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Noguchi Y,Asayama K,Staessen JA,Inaba M,Ohkubo T,Hosaka M,Satoh M,Kamide K,Awata T,Katayama S,Imai Y,HOMED-BP study group.

    更新日期:2013-08-01 00:00:00

  • Relationship between baroreflex sensitivity, renin suppression and natriuresis in salt-sensitive rabbits.

    abstract::This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Weinstock M,Borosh M,Kafri O,Kaczmarczyk G

    更新日期:1991-09-01 00:00:00

  • Alcohol intake and cardiovascular mortality in hypertensive patients: report from the Department of Health Hypertension Care Computing Project.

    abstract:OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Palmer AJ,Fletcher AE,Bulpitt CJ,Beevers DG,Coles EC,Ledingham JG,Petrie JC,Webster J,Dollery CT

    更新日期:1995-09-01 00:00:00

  • Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease.

    abstract:OBJECTIVE:Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. The primary object of the paper is to verify this possible associati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Olivieri O,Stranieri C,Girelli D,Pizzolo F,Grazioli S,Russo C,Pignatti PF,Corrocher R

    更新日期:2001-05-01 00:00:00

  • Influence of the renal medulla and early treatment with enalapril upon the development of hypertension in young spontaneously hypertensive rats.

    abstract:OBJECTIVE:To investigate the role of the renal medulla in early hypertension in spontaneously hypertensive rats (SHR), and to explore whether the attenuated increase of pressure induced by enalapril treatment is affected by chemical medullectomy. DESIGN:Forty-four male SHR were studied from 5 to 18 weeks of age: 22 re...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Bergström G,Bohman SO,Folkow B,Göthberg G,Rudenstam J,Karlström G

    更新日期:1992-11-01 00:00:00

  • Adjustment for current weight and the relationship between birth weight and blood pressure in childhood.

    abstract:OBJECTIVE:To determine the role of current weight in mediating the relationship between birth weight and blood pressure within the context of the 'fetal origins' hypothesis. DESIGN:Prospective cohort study of 2507 pregnant women and their singleton offspring, delivered live at term, in Perth, Western Australia between...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Blake KV,Gurrin LC,Evans SF,Beilin LJ,Stanley FJ,Landau LI,Newnham JP

    更新日期:2000-08-01 00:00:00

  • Systemic and renal effects of a new angiotensin converting enzyme inhibitor, benazepril, in essential hypertension.

    abstract::Seventeen essential hypertensive patients with normal renal function were treated with a new non-sulphydryl orally active angiotensin converting enzyme (ACE) inhibitor, benazepril, 10 mg given once or twice daily, according to diastolic blood pressure levels, for 6 weeks. In all patients, changes in blood pressure, sy...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Valvo E,Casagrande P,Bedogna V,Antiga L,Alberti D,Zamboni M,Perobelli L,Dal Santo F,Maschio G

    更新日期:1990-11-01 00:00:00

  • Plasma concentration of urotensin II is raised in hypertension.

    abstract:OBJECTIVES:Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects. DESIGN:A cross-sectional case-control study. SETTING:Hypertension clinic and research clinic of a university teachin...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Cheung BM,Leung R,Man YB,Wong LY

    更新日期:2004-07-01 00:00:00

  • Time-of-day of energy intake: association with hypertension and blood pressure 10 years later in the 1946 British Birth Cohort.

    abstract:OBJECTIVES:The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Almoosawi S,Prynne CJ,Hardy R,Stephen AM

    更新日期:2013-05-01 00:00:00

  • Initial left-ventricular mass predicts probability of uncontrolled blood pressure in arterial hypertension.

    abstract:BACKGROUND:Left-ventricular hypertrophy (LVH) is a marker of organ damage in hypertension and helps stratifying cardiovascular risk. Initial left-ventricular mass (LVM) is also a predictor of progression to hypertension, independently of initial blood pressure (BP) and other confounders. OBJECTIVES:To evaluate whether...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Izzo R,de Simone G,Devereux RB,Giudice R,De Marco M,Cimmino CS,Vasta A,De Luca N,Trimarco B

    更新日期:2011-04-01 00:00:00

  • Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.

    abstract:OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH

    更新日期:2011-04-01 00:00:00

  • Can we trust automatic sphygmomanometer validations?

    abstract::Hypertension is a leading risk factor for mortality. Detecting, treating and monitoring hypertensive patients require accurate blood pressure measurements. Protocols for validation of automatic sphygmomanometers exist, but quality control of validations is limited to peer review of published reports, which has severe ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Turner MJ

    更新日期:2010-12-01 00:00:00

  • Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study.

    abstract:OBJECTIVE:Studies in genetically hypertensive rats and their normotensive Wistar-Kyoto control rats have revealed a linkage of a chromosomal region containing the angiotensin converting enzyme (ACE) gene with blood pressure. This led to the hypothesis that ACE is a possible candidate gene for primary hypertension in hu...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Schmidt S,van Hooft IM,Grobbee DE,Ganten D,Ritz E

    更新日期:1993-04-01 00:00:00

  • Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension.

    abstract:BACKGROUND:Some patients with essential hypertension manifest greater than normal urinary excretion of albumin (UAE). Authors of a few retrospective studies have suggested that there is an association between microalbuminuria and cardiovascular risk. OBJECTIVE:To evaluate whether microalbuminuria is associated with a ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Bigazzi R,Bianchi S,Baldari D,Campese VM

    更新日期:1998-09-01 00:00:00

  • Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study.

    abstract:AIMS:Selenium is an antioxidant micronutrient with potential associations with hypertension. Few studies have investigated the association of serum selenium concentrations with blood pressure and hypertension in countries with low dietary selenium intake such as Germany, with inconsistent findings. METHODS:We undertoo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Berthold HK,Michalke B,Krone W,Guallar E,Gouni-Berthold I

    更新日期:2012-07-01 00:00:00

  • Complications and survival of 315 patients with malignant-phase hypertension.

    abstract:OBJECTIVE:To investigate the factors affecting survival in patients with malignant hypertension by analysing the prognosis of all of the patients referred to the City Hospital, Birmingham, with malignant hypertension since 1965. RESULTS:We identified 315 patients with malignant hypertension (211 men, 104 women; mean a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Lip GY,Beevers M,Beevers DG

    更新日期:1995-08-01 00:00:00

  • Aortic dilatation in Marfan syndrome: role of arterial stiffness and fibrillin-1 variants.

    abstract:OBJECTIVE:Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this observational study, we evaluated aortic stiffness in MFS and its association with ascending aorta diameters and fibrillin-1 genotype. METHODS:A ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Salvi P,Grillo A,Marelli S,Gao L,Salvi L,Viecca M,Di Blasio AM,Carretta R,Pini A,Parati G

    更新日期:2018-01-01 00:00:00

  • Effect of self-measurement of blood pressure on adherence to treatment in patients with mild-to-moderate hypertension.

    abstract:BACKGROUND:Poor adherence to treatment is one of the major problems in the treatment of hypertension. Self blood pressure measurement may help patients to improve their adherence to treatment. METHOD:In this prospective, randomized, controlled study coordinated by a university hospital, a total of 228 mild-to-moderate...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: van Onzenoort HA,Verberk WJ,Kroon AA,Kessels AG,Nelemans PJ,van der Kuy PH,Neef C,de Leeuw PW

    更新日期:2010-03-01 00:00:00

  • Quinapril treatment enhances vascular sensitivity to insulin.

    abstract:OBJECTIVE:Insulin-mediated vasodilation has been shown to be impaired with hypertension and aggravated by dietary sodium restriction. Whether vascular insulin resistance in this setting could be improved by antihypertensive therapy was unknown. Therefore, we determined the effect of therapy with an angiotensin-converti...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Feldman RD,Schmidt ND

    更新日期:2001-01-01 00:00:00

  • Impact of genes related to immune tolerance and inflammation (tumour necrosis factor-alpha, interleukin-6) on blood pressure, protein excretion and oedema in pregnancy.

    abstract:OBJECTIVE:To test the hypothesis that genetically determined alterations of maternal immune tolerance to a foetal semi-allograft are important for the pathogenesis of hypertensive disorders in pregnancy. DESIGN:A genetic association study was performed to analyse the impact of genetic polymorphisms known to be involve...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Pfab T,Chen YP,Slowinski T,Richter CM,Godes M,Arck PC,Halle H,Hocher B

    更新日期:2005-12-01 00:00:00

  • Sympathetic activity and presynaptic adrenoceptor function in patients with longstanding essential hypertension.

    abstract:OBJECTIVE:To assess the contribution of the sympathetic nervous system to the hypertension in patients with longstanding essential hypertension. DESIGN:Overall sympathetic function, presynaptic adrenoceptors and neuronal re-uptake were examined after withdrawal of medication for at least 3 weeks in eight patients with...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Chang PC,Kriek E,van Brummelen P

    更新日期:1994-02-01 00:00:00