Abstract:
OBJECTIVE:Epidemiological studies suggest that intrauterine growth restriction (IUGR) due to maternal undernutrition during pregnancy represents a major risk factor for hypertension and diabetes in adult age. However, placental insufficiency, rather than maternal malnutrition, is the main cause of IUGR in the Western world. We therefore studied the relationship between birth weight and adult blood pressure and glucose tolerance in an established animal model of placental insufficiency. DESIGN:IUGR was induced by uterine artery ligation in pregnant rats and the offspring were studied at 3-4 months of age. METHODS:In one subgroup of animals (n = 41, birth weight range 3.2-6.6 g) blood pressure was recorded over 72 h using telemetry and hypothalamic tissue levels of noradrenaline was measured. In another subgroup (n = 30, birth weight range 3.0-6.8 g) the activity of the sympathetic nervous system (SNS) was assessed by noradrenaline isotope dilution techniques and glucose tolerance determined by an intravenous glucose load. RESULTS:Adult blood pressure was independent of birth weight Haemodynamic responses of IUGR rats to moderate sound stress was unaltered. In male rats neither SNS activity, hypothalamic noradrenaline concentrations nor glucose tolerance was associated with birth weight In contrast, IUGR in female rats was associated with increased SNS activity, elevated fasting blood glucose as well as lower insulin and higher glucose levels in response to a glucose load. CONCLUSION:IUGR is not linked to an elevated blood pressure at 3-4 months of age in this model. However, in female rats, IUGR is associated with increased SNS activity and impaired glucose tolerance in adult life.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Jansson T,Lambert GWdoi
10.1097/00004872-199917090-00002subject
Has Abstractpub_date
1999-09-01 00:00:00pages
1239-48issue
9eissn
0263-6352issn
1473-5598journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:The value of SBP during exercise and recovery period as a risk marker for sudden cardiac death (SCD) is not known. Thus, we assessed the association of SBP during recovery from exercise testing with the risk of SCD. METHODS:SBP was measured every 2 min during and at 2 min after a progressive cycle ergometer ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000066
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:In a previous study, we found that neonatal sympathectomy prevented the development of angiotensin II (ANG II)-induced hypertension but not the development of structural changes in small mesenteric arteries. OBJECTIVES:To investigate further the dissociation between hypertension and structural vascular chan...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816010-00012
更新日期:1998-01-01 00:00:00
abstract::The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopress...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198610000-00016
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:The mechanism of the association between obesity and hypertension is not clear. The recently discovered obese gene product, leptin, the levels of which increase in obese subjects, has been shown to reduce food intake and increase sympathetic nervous system activity in animal studies. The present study was und...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816121-00023
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:To investigate whether combined treatment with lisinopril, an angiotensin-converting enzyme (ACE) inhibitor and exercise training would have an additive effect in enhancing the capillary supply of the left ventricular (LV) myocardium in spontaneously hypertensive rats (SHR). DESIGN:Twelve-week-old male SHR ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000170387.61579.ab
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:We compared diurnal patterns of blood pressure in Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHRSP), and analyzed the relationship between the change in diurnal patterns of blood pressure and target-organ damage in SHRSP. MATERIALS AND MET...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917020-00005
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:We have previously described anatomical changes in pulmonary blood flow distribution in chronic hypoxic rats, associated with pulmonary arterial hypertension (PAH). METHOD:In this study, we utilized synchrotron radiation microangiography to compare these changes in pulmonary blood flow with a PAH-model indu...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832af6a1
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Spontaneously hypertensive rats (SHR) are sensitive to a high salt intake and we investigated the question of whether flow-induced dilation is affected by this type of diet, as flow responses are especially sensitive to small changes in extracellular sodium concentrations. METHODS:We evaluated the effects of...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816100-00013
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:To determine prevalence, awareness, treatment, and control of hypertension, and its risk factors in an urban Korean population. DESIGN AND SETTING:A cross-sectional survey in Ansan-city, Korea. SUBJECTS AND METHODS:Population-based samples of people aged 18-92 years in Ansan-city, Korea, were selected, yie...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200109000-00002
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Although several studies have reported an association between microalbuminuria and pulse wave velocity in patients with hypertension or diabetes, there have been no reports of their significance in apparently healthy individuals. METHODS:Microalbuminuria and brachial-ankle PWV (baPWV) were investigated in a ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834b5627
更新日期:2011-11-01 00:00:00
abstract::The cardiovascular responses to selective alpha 1- and alpha 2-adrenoceptor antagonism (with prazosin and idazoxan, respectively) were assessed in rats 4 weeks after unilateral nephro-adrenalectomy, contralateral adrenal enucleation and the provision of a 1% NaCl solution as drinking fluid (AEN rats) and in sham-opera...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:Blood pressure (BP) recovery after orthostatic hypotension might be important to prevent cerebral hypoperfusion episodes in older adults, and be related to better clinical outcome. The objective was to study the relationship between BP recovery and clinical outcome, that is physical and cognitive performance,...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002617
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:Evidence about sex differences in blood pressure (BP) at the time of acute stroke presentation is scarce. We aimed to summarize available data on sex differences in BP at the time of acute stroke presentation, including stratification by prior history of hypertension and stroke subtype. METHODS:We performed...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析
doi:10.1097/HJH.0000000000002116
更新日期:2019-10-01 00:00:00
abstract::Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198310000-00005
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVES:We recently demonstrated that glucocorticoid increases the number of angiotensin II type 1 (AT1) receptors and their gene expression in cultured vascular smooth muscle cells. To clarify whether this mechanism participates in glucocorticoid-induced hypertension, we investigated the effect of dexamethasone on ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:INTRODUCTION:Abnormalities of calcium metabolism independent of changes in intracellular calcium have been described in patients with essential hypertension. These include increased urinary calcium excretion for a given salt intake, a raised parathyroid hormone level, an increase in urinary cyclic AMP, a tendency for a...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199308000-00003
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:We examined the relation between cardiovascular reactivity (the response of the cardiovascular system to psychological stress) and the severity and progression of carotid atherosclerosis. METHODS:Using duplex ultrasonography, we measured the change in the area of all detectable plaques in the extracranial c...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715010-00004
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2. METHODS:We performed a large association study of polymorphisms in this region with blood pressure modulatio...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000166835.70935.3c
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Uncontrolled hypertension notwithstanding the use of at least three drugs or hypertension controlled with at least four drugs, the widely accepted definition of treatment-resistant hypertension (TRH), is considered as a common problem in the hemodialysis population. However, to date there is no estimate of t...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002448
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Despite the widespread use of multivitamin supplements, little is known regarding their effects on blood pressure (BP) and the development of hypertension. We, therefore, sought to prospectively investigate how multivitamin use was associated with incident hypertension among middle-aged and older women. METH...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000973
更新日期:2016-08-01 00:00:00
abstract::The function of the renin-angiotensin system (RAS) is influenced by changes in sodium balance and angiotensin II (ANG II) levels. In previous studies it has been difficult to assess the physiological effects on blood pressure homeostasis of different rates of ANG II infusion and of different levels of sodium in the di...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:It has been shown that angiotensin-converting enzyme inhibition or angiotensin receptor blockade may improve endothelial dysfunction, an early manifestation of atherosclerosis, in patients with diabetes. Whether this protective effect is mediated through blood pressure-lowering effects or other specific mecha...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e3280287a72
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:Mean blood pressure varies moderately with outdoor air temperature in many western populations. Substantial uncertainty exists, however, about the strength of the relationship in other populations and its relevance to age, adiposity, medical treatment, climate and housing conditions. METHODS:To investigate ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835465b5
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Left-ventricular hypertrophy (LVH) is a marker of organ damage in hypertension and helps stratifying cardiovascular risk. Initial left-ventricular mass (LVM) is also a predictor of progression to hypertension, independently of initial blood pressure (BP) and other confounders. OBJECTIVES:To evaluate whether...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328343ce32
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:The long-term consequences of extreme prematurity are becoming increasingly important, given recent improvements in neonatal intensive care. The aim of the current study was to examine the cardiovascular consequences of extreme prematurity in 11-year-olds born at or before 25 completed weeks of gestation. M...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328347e333
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:An increased inter-arm SBP difference (IASBPD) is associated with mortality and cardiovascular events, as well as peripheral vascular disease, which is attributed to subclavian stenosis. The aim of the present study was to investigate the association between the IASBPD and incident chronic kidney disease (CKD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001931
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:The role of the baroreflex function in the pathogenesis of hemodialysis-associated hypotension is controversial. Complex demodulation technique (CDM), providing continuous assessment of the amplitude of cardiovascular oscillation over time, is particularly suitable to assess dynamic changes in autonomic nerv...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328332b7af
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:We studied the vasoconstrictor effects of the thromboxane A2 (TxA2) analogue U46619 in the perfused hind limb of rats under constant flow before and after intravenous injection of irbesartan, an angiotensin II AT1 receptor antagonist, to test whether irbesartan interacts in vivo with the thromboxane A2/prosta...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200103001-00007
更新日期:2001-03-01 00:00:00
abstract::This paper describes the kinetics of the Na(+)-K+ pump and the Na(+)-K(+)-Cl- cotransport in sodium-loaded erythrocytes and of the Na(+)-K(+)-Cl- cotransport in erythrocyte inside-out vesicles (IOV) from Milan hypertensive (MHS) and normotensive (MNS) rats in order to evaluate the possible role of intracellular factor...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199108000-00003
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To gauge the effectiveness of a new Doppler test for renal artery stenosis (RAS), based on the pulsatility index of the blood flow velocity spectrum within several interlobar arteries of both kidneys. METHODS:Twenty normotensive volunteers and 49 hypertensive patients were investigated with ultrasound. Patie...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00